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FORMULASI DAN UJI STABILITAS FISIK TABLET KEMPA EKSTRAK DAUN PEPAYA ( Carica Papaya. L) Beta Herilla Sekti; Agung Permata; Neysa Oktadiva S. P
HERBAPHARMA : Journal of Herb Farmacological Vol 4 No 1 (2022): Volume 4 Nomor 1 Juni 2022
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v4i1.289

Abstract

Papaya leaf (Carica Papaya L.) is a plant that contains alkaloids, flavonoids, tripertinoids, saponins and tannins that are useful for treating diabetes. This study aims to obtain compressed tablets of papaya leaf extract and determine the effect of the concentration of PVP K30 as a binder on the physical properties of compressed tablets. The study used an experimental method, with a comparison of formula 1 = 1%, formula 2 = 3% and formula 3 = 5% and tested the physical properties of tablets. The results showed that the tablets met the requirements and only one formula did not meet the tablet friability test. The conclusion of the research on compressed tablets of papaya leaf extract with different concentrations of PVP K30 as a binder met the requirements for the physical test of tablets
Evaluasi Penggunaan Antibiotik pada Pasien Pneumonia di Rumah Sakit X Kota Malang Magdalena Tania Tnesi; Agung Permata; Rakhmadani Gadis Aprilianti; Jessica Choirunniswah
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22100

Abstract

Pneumonia is an infection that occurs at the end of the bronchi and alveoli caused by bacteria, fungi, viruses or parasites. This disease is an inflammatory infection that usually consists of a cough and runny nose along with shortness of breath or an increase in the respiratory rate becoming faster. All ages are often affected by this condition, but toddlers are more often affected. One way to treat pneumonia is to use antibiotics, where resistance often occurs if not monitored properly. The aim of this research is to examine the use of the Gyssens technique in accordance with the Republic of Indonesia Minister of Health Regulation No. 8 of 2015 for the use of antibiotics in pneumonia patients at X Hospital, Malang. This type of research is non-experimental qualitative with a descriptive design with a retrospective data collection method. In this research, a purposive sample method was used for the sampling process. The sample used was 80 people. Based on research findings, 95% (76 cases) of antibiotics were given correctly, while only 5% (4 cases) of antibiotics were used incorrectly.
Monitoring Efek Samping Obat Antituberkulosis terhadap Pasien Tuberkulosis Paru di Rumah Sakit X Malang Sindi Wahyu Arianti; Agung Permata; Novyananda Salmasfattah; Magdalena Tania Tnesi
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22194

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis which spreads through the air and can be a major cause of poor health and is even one of the main causes of death throughout the world. The recommended treatment for TB is the use of antibiotics, but some patients experience side effects, both severe and mild. Patients diagnosed with pulmonary TB at X Hospital Malang who experienced pharmacological side effects based on medical record data will be used in this study. There will be 55 pulmonary TB patients in 2022 at X Hospital in Malang. Patients who were more likely to contract TB in this study were men (54.5%) with a maximum age range of 60 years (29.1%), and the most frequent impact was shortness of breath (43.6%). Meanwhile, the number of patients who did not experience side effects was 7.2%. Other effects that often occur are reduced appetite, nausea and coughing. Therefore, side effects that occur when using OAT, both frequent and rare effects, still need to be watched out for by health workers. This needs to be done so that the side effects that occur can be minimized and patient compliance also increases because of the minimal side effects experienced.
Analisis Kuantitatif Hidrokuinon pada Krim Pemutih di Kota X Menggunakan Spektrofotometri UV–Vis Maria Istiqomah; Ratih Tyas Widara; Agung Permata; Marshela Anjani
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4417

Abstract

Whitening cream is a cosmetic product containing organic chemicals or other substances which are used to whiten the face or remove black spots on the skin. Whitening cream has many benefits for sufferers of skin disorders, namely being able to whiten and remove black marks. Meanwhile, the concept of beauty circulating in society is having white skin. This stigma makes people, especially teenagers, justify any means to get white skin. One way to beautify your skin is to use skin whitening and lightening products. The aim of this research was to determine hydroquinone levels in whitening cream in X City using UV–vis spectrophotometry. The method used in this research is quantitative using the UV–vis spectrophotometric method. The research results showed that all of the 15 samples tested were positive for containing hydroquinone with the highest percentage of hydroquinone found in S1, S5, and S10 with a percentage of 0.0581%; 0.062%; and 0.0501%. Meanwhile, samples with low percentages were in S4, S6, S7, and S12 with a percentage gain of 0.011%; 0.0134; 0.0103%; and 0.0105%. It can be concluded that the hydroquinone levels of the 15 whitening cream samples do not meet the requirements permitted by BPOM No. 23 of 2019, namely 0%.
Hubungan Tingkat Kepatuhan Minum OHO dengan Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2 di RS Lavalette Malang Tahun 2023 Agung Permata; Rossy rahmawati; Mayang Aditya Ayuning Siwi
Jurnal Kesehatan Medika Udayana Vol. 9 No. 02 (2023): Oktober: Jurnal Kesehatan Medika Udayana
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesdam IX/Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47859/jmu.v9i02.371

Abstract

Latar Belakang: Diabetes melitus ialah salah satu penyakit kronik yang memiliki karakteristik atas adanya peningkatan dari kadar glukosa darah yang secara nyata keadaan ini melebihi dari batas normal yang ada. Terlebih dari pada itu terdapat  metabolisme karbohidrat yang cenderung menjadi penyebab utama dari efek defek sekresi insulin yang ada. Untuk menurunkan kadar glukosa diperlukan kepatuhan tinggi oleh pasien. Tujuan: tujuan dari penelitian ini yaitu untuk mengetahui hubungan antara tingkat kepatuhan minum OHO (obat hipoglikemik oral) dengan kadar glukosa dalam darah pada pasien diabetes melitus tipe 2. Metode: Implementasi pelaksanaan mengutamakan dari metode penelitian non eksperimental kuantitatif di mana menekankan kepada pendekatan deskriptif. Terlebih daripada itu instrumen dari pengumpulan data yang dilakukan ialah berupa kuesioner utamanya dengan implementasi dari MMAS-8, serta lembar observasi pelaksanaan pemeriksaan dari gula darah puasa (GDP). Hingga penentuan sampel yang telah diambil dalam pelaksanaan penelitian ini sejumlah 80 responden menggunakan teknik purposive sampling. Terlebih daripada itu Pemilihan dari analisis yang nantinya akan diterapkan yaitu univariat dan bivariat utamanya melalui ujian spearman. Hasil: Ditemukan temuan yaitu 40 (50%) responden memiliki tingkat kepatuhan tinggi, 31 (38,75%) memiliki ranah tingkat kepatuhan yang sedang, serta pada 9 (11,25%) cenderung tingkat kepatuhan rendah. Dalam kesesuaian tersebut menunjukkan temuan yang nyata terdapat keterkaitan yang kuat yang tidak dapat dipisahkan atas hubungan dari tingkat kepatuhan pada kadar glukosa darah pada pasien DM tipe 2 dengan P value 0,000 (p<0,05). Kesimpulan: Dengan begitu pada pemahaman ini terdapat hubungan antara kepatuhan minum OHO (obat hipoglikemik oral) dengan kadar glukosa darah pada pasien diabetes melitus tipe 2
Penilaian Tingkat Kecemasan Pasien Program Rujuk Balik di Fasilitas Kesehatan Tingkat Pertama Kota Malang Permata, Agung; Fitri, Aldesra; Abdullah, Muhammad Rizal; Salmasfattah, Novyananda
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1591

Abstract

Referral Program Services (PRB) are health services provided to patients in health facilities based on referrals from specialist doctors or sub-specialists who treat these patients. This study aims to look at the characteristics and assess the level of anxiety of the Referral Patient Program at the First Level Health Facility in Malang City. Anxiety level assessment used the Generalized anxiety disorder-7 (GAD-7) questionnaire. This type of research is analytic observational with cross sectional design. The sampling technique was carried out using the convenience sample method. The sample of this study were Patients of the Referral Program (PRB) at First Level Health Facilities in Malang City, to be precise in the outpatient unit during May 2023 who met the inclusive and exclusion criteria. The data collected was analyzed descriptively according to the number of categories for each variable and determined the level of anxiety using the GAD-7 questionnaire to obtain an overview of the data in the form of frequency and proportion (%). The results of the study showed that there were 37 (37%) males and 63 (63%) females, the highest age was >60, namely 36 patients (36%), the highest diagnosis of hypertension was 58 patients (58%), last education the highest was at the senior high school level, namely 42 patients (42%), in the employment status of the highest DRR patients, namely not working, 51 patients (51%), in marital status, 100 patients were married (100%), and the highest monthly income was <Rp. 2,500,000 ie 66 patients (66%). The anxiety level of PRB patients at FKTP Malang City obtained the highest level of anxiety at the mild anxiety level (48%) and the lowest at the severe anxiety level (2%).
Rencana Anggaran Biaya dan Metode Pelaksanaan Pengaspalan Ulang AC-WC pada jalan Aramiah Peureulak Kabupaten Aceh Timur Ismail, Ismail; Permata, Agung
Jurnal Rekayasa Teknik dan Teknologi Vol 7 No 2: Jurnal Rekayasa Teknik dan Teknologi (Rekatek), Juli, 2023
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Almuslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51179/rkt.v7i2.2120

Abstract

Untuk meningkatkan efesiensi dan efektifitas kegiatan pengaspalan ulang di bidang kontruksi, diperlukan sarana dasar untuk menghitung harga satuan pekerjaan yaitu Analisa Biaya Konstruksi (ABK). Keberhasilan proyek konstruksi ditentukan oleh teraturnya manajemen Konstruksi sesuai dengan pentahapannya, (perencanaan, pelaksanaan, dan pengawasan). Pengaspalan dilakukan pada pekerjaan mulai dari STA 420+250 s/d 421+300. Pada jalan Aramiah.Dalam tugas akhir ini penulis menghitung rencana anggaran biaya yang meliputi Devisi 6. Perkersan Aspal (lapis perekat-aspal cair, dan laston lapis Aus). Tujuan penulisan tugas akhir ini dapat mengetahui besarnya biaya pekerjaan, pada pekerjaan pengaspalan ulang dan metode pelaksanaan pada pekerjaan pengaspalan AC-WC jalan aramiah Kabupaten Aceh Timur. Metode pelaksanaan adalah program kerja yang terukur suatu cara kerja untuk menerapkan sebuah pekerjaan, menerapkan anggaran biaya yang terukur pada pelaksanaan didalamnya terdapat metode kerja, menyangkut dengan anggaran biaya dan metode pelaksanaan. Metode yang digunakan dalam penulisan ini adalah (AHSP) 2016. Hasil keseluruhan yang diperoleh Rp. 3,070,293,600.00. (Tiga Miliar Tujuh puluh Juta Dua Ratus  Sembilan PuluhTiga ribu Enam Ratus Rupiah).
Hubungan Pola Makan dengan Kejadian Gastroesophageal Reflux Disease pada Mahasiswa di ITSK RS dr.Soepraoen Malang Alaya, Vandela Nikita; Permata, Agung; Rahmawati, Siti
Journal Syifa Sciences and Clinical Research Vol 7, No 1 (2025): Volume 7 Edisi 1 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i1.30681

Abstract

College students are a vulnerable group that experiences gastroesophageal reflux disease (GERD), because it is influenced by factors such as psychological stress and unhealthy eating habits. Factors that make students susceptible to GERD are influenced by unhealthy eating habits. This is caused by a fairly heavy academic load, such as a busy lecture schedule, high frequency of exams and assignments, and limited rest time. This disease is characterized by the entry of stomach acid into the esophagus, which is caused by dysfunction in the lower part of the esophagus. which is characterized by symptoms of chest pain such as heartburn, regurgitation, difficulty swallowing, and sore throat. This condition contributes to digestive system disorders, so that the incidence of GERD is increasing. This study aims to reveal the relationship between diet and the incidence of gastroesophageal reflux disease (GERD) among college students. This study applies a non-experimental correlative quantitative approach and uses a cross-sectional design. Data were collected using a purposive sampling technique, involving 75 respondents who were final year students at the Faculty of Science and Health, dr. Soepraoen Hospital Malang. The measuring instruments used in this study were the Gastroesophageal Reflux Disease Questionnaire (GERDQ) and the Diet History Questionnaire (DHQ), which were distributed via Google Form. The results of the statistical analysis showed that 30 students (40.00%) had gastroesophageal reflux disease (GERD), 45 students (60.00%) did not have GERD, while 32 students (42.67%) had poor diet and 43 students had good diet with a percentage (57.33%). Data analysis using the Spearman rank correlation test found that there was a significant relationship between diet and the incidence of GERD, with a significance value of 0.000, 0.05. The results of the indicated correlation strength were strong, with a value of 0.638
Accuracy of Antibiotic use in Pediatric ISPA Patients at Hospital X Malang City Larasati, Debby Ayu; Permata, Agung; Herlila Sekti, Beta
Jurnal Multidisiplin Indonesia Vol. 3 No. 9 (2024): Jurnal Multidisiplin Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jmi.v3i9.1815

Abstract

Acute Respiratory Tract Infections (ARI) are one of the most serious health problems in the world. According to UNICEF and WHO, ISPA is one of the leading causes of death in humans compared to the number of deaths from AIDS, malaria and measles. The prevalence period of ISPA, which is calculated within two years, according to the diagnosis by health workers in 2018, is known to reach 1,017,290, of which as many as 182,338 cases occur in children aged 12 years and under. Acute Respiratory Tract Infection (ARI) generally occurs in children and adults and is the main cause of mild morbidity. This study aims to determine the rationale for the use of antibiotics in pediatric patients with upper respiratory tract infections at Hospital X Malang City with parameters that include the right patient, the right indication, the right dose, and the right duration. This type of research is a type of non-experimental research with a descriptive research design and retrospective data collection. The results of the demographic data obtained were more male patients, namely 37 patients (52.8%), the highest age range of 1-5 years (50%), the most common diagnosis, namely pharyngitis (58.6%), and the suitability of the use of antibiotics in pediatric ARIA patients at Hospital X Malang City was in accordance with the guidelines of Pharmaceutical Care for respiratory diseases in 2005. and 100% right doe, and 100% right duration.
Effect of Most Favored Regions of Estrogen Receptor β (ERβ) Molecules on MolDock Score Using Tamoxifen Ligand Salmasfattah, Novyananda; Permata, Agung; Prasetyawan, Fendy
JIKES : Jurnal Ilmu Kesehatan Vol. 3 No. 1 (2024): Juli-Desember 2024
Publisher : Yayasan Pendidikan Tanggui Baimbaian

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The estrogen receptor β (ERβ) molecule is one of the target proteins in cancer treatment. The type of ERβ molecule in the protein data bank (PDB) determines the value of most favored regions and MolDock score. The purpose of this study was to determine the effect of most favored regions of ERβ molecules on MolDock score using Tamoxifen ligand. There are 37 molecules that have ERβ protein, 7 molecules were selected to be analyzed for the value of most favored regions and MolDock score, based on the r table value, pearson correlation value 0.548 < 0.754 (r table). This is also the same when viewed from the significance value of 0.203 > 0.05. It can be concluded that there is no correlation between the value of most favored regions and MolDock score.