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All Journal e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI Sari Pediatri Paediatrica Indonesiana Jurnal Kedokteran Klinik
Rocky Wilar
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sam Ratulangi / RSUP Prof.Dr.R.D.Kandou, Manado
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology

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Journal : Paediatrica Indonesiana

 1 
Toxoplasma gondii immunoglobulin G in paired infant-and-mother sera Ayling Sanjaya; Nurhayati Masloman; Rocky Wilar; Josef Tuda
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.829 KB) | DOI: 10.14238/pi49.2.2009.65-8

Abstract

Background  Toxoplasmosis  is  a worldwide zoonotic diseasecaused  by  Toxoplasma  gondii.  Congenital toxoplasmosis (CT)is  the  result  of  vertical transmission  during  pregnancy  thatmay cause pathologic effects  on  the newborn such  as  classicaltriad  of  congenital toxoplasmosis.  Newborn  humans  are  notimmunologically  competent  and the infant must be protected  by passive lgG antibodies  that  are selectively transported across the placenta during development.  We  studied the transfer  of  passive lgG from the  mother  to developing infant using blood specimen taken from the infant within one  month  of  birth.Objective  To  determine the seropositivity  of  lgG to  T.  gondii  in paired sera  of  infants and mothers.Methods  A cross sectional study was carried  out  on  50 pairedsera  of  infants  of  less  than  one  month  of  age and their mothers. The  study was carried  out  between November 2007 and January 2008  at  Prof.  R.  D.  Kandou Hospital in Manado.  T.  gondii  lgG was detected using the Latex Agglutination method.  The  seropositivity ofT.  gondii  lgG was analyzed descriptively.Results  A total  of  28 mothers from 50 infant-mother pairs wereseropositive for  T.  gondii  IgG.  Of  the 28 seropositive mothers, 22  of their paired infants were seropositive.  The  remaining six seropositive mothers  had  infants  that  were  not  seropositive for T.  gondii.Conclusions  The  identification  of  seropositive lgG for  T.  gondii in infants less  than  one  months  age indicates  that  the lgGs in infants are mostly derived from their mothers.  CT  must be considered  and  further  examinations  are needed.
Platelet-to-lymphocyte ratio in early onset neonatal Rocky Wilar; Johnny Lambert Rompis; Gregory Joey; Raynald Octavianus Takumansang; Hesti Lestari
Paediatrica Indonesiana Vol 63 No 3 (2023): May 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.3.2023.202-7

Abstract

Objectives Neonatal sepsis is a major contributor to morbidity and mortality worldwide. Although blood culture is the gold standard of sepsis diagnosis, it often lacks sensitivity and diagnostic speed. Platelet-to-lymphocyte ratio (PLR) is a widely available, effective, simple, and affordable marker that can predict early onset neonatal sepsis (EONS). Objective To assess the correlation between PLR and EONS as well as the diagnostic value of PLR for predicting EONS. Methods This study included all inpatient neonates with suspected early-onset neonatal sepsis at Dr. R. D. Kandou Hospital, Manado, North Sulawesi, Indonesia. Neonates were categorized into sepsis (confirmed by positive blood culture results) and non-sepsis (negative blood culture results) groups. Bivariate analysis, including the chi-square test for categorical data and independent t-test for numerical data, was performed to identify any significant associations between the platelet-to-lymphocyte ratio (PLR) and EONS. The sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve were calculated to determine the optimal PLR cut-off point to predict EONS. Results In this study, we investigated the relationship between PLR and early-onset neonatal sepsis (EONS) in 176 neonates with suspected EONS. Blood cultures confirmed sepsis in 84 neonates (47.7%), with Klebsiella pneumoniae being the most common causative organism. We found a significant positive correlation between PLR and EONS (p<0.001), and a PLR cut-off point of 61.806 was identified to predict EONS with high sensitivity (90.2%) and specificity (85.7%) Conclusion Our study demonstrates a strong positive correlation between PLR and EONS, and a PLR cut-off point of 61.806 can be used as a valuable marker for predicting EONS in neonates with suspected sepsis. These findings could aid in the early identification and treatment of neonates with sepsis, ultimately improving patient outcomes.
Co-Authors Aaltje E. Manampiring Adriaan W. Kaunang Adrian Umboh Agus Wijata Algi Reafanny Batara Anak Agung Gede Sugianthara Angie G. Roring, Angie G. Ari L. Runtunuwu Audrey Wahani Ayling Sanjaya Bella Rumangkang, Bella Bernadus, Janno Berty Bradly Deafira, Angel Diana Yuliani Suryanto Edelwina Umboh Elia A. P. Hutapea Ellen Kumalasari Erling D. Kaunang Ester Caroline Wowor Gregory Joey Gunawan, Gregorius Helene Aneke Tangkilisan Hery Susanto Hesti Lestari Hesti Lestari Hesti Lestari H J. M. Wantania Jeanette I. Ch. Manoppo Jeanette I. Ch. Manoppo, Johnny Lambert Rompis Johnny Rompis Johnny Rompis Johnny Rompis Johnny Rompis Jose M. Mandei Josef Tuda Juhtisari Jufri Kereh, Tesalonika Leny Angkawijaya Mantik, Keren E.K. Marlina G. O. Soentpiet, Marlina G. O. Matthew, Febriano Max F. J. Mantik Max F. J. Mantik Mona C. U. Aman Moonik P Novie H. Rampengan Nurhayati Masloman Nurhayati Masloman Nurhayati Masloman Polii, Evan G. Praevilia Salendu, Praevilia Raynald Octavianus Takumansang Reifanli M. Pai, Reifanli M. Ricky Hartanto Rompis, Yulke R. Y. Ronald Chandra Rudy Ciulianto Sarah M. Warouw Silfy Welly Stefanus Gunawan Stevry Mathindas Suryadi N. N. Tatura, Suryadi N. N. Suryadi N.N. Tatura Suwontopo, Marvin Leonardo Tansil, Melissa G. Vivekenanda Pateda Winny Carolus