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All Journal e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI Sari Pediatri Paediatrica Indonesiana Jurnal Kedokteran Klinik
Rocky Wilar
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sam Ratulangi / RSUP Prof.Dr.R.D.Kandou, Manado
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology

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Journal : Jurnal Kedokteran Klinik

 1 
HUBUNGAN MATRIXMETALLOPROTEINASES-9 DAN THROMBOSPONDIN-1 DENGAN TEKANAN DARAH PADA ANAKDENGAN RIWAYAT BERAT LAHIR RENDAH Umboh, Adrian; Wilar, Rocky; Bernadus, Janno B. B.
JKK (Jurnal Kedokteran Klinik) Vol 3, No 1 (2019): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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AbstractDisorders of endothelial function that occur in low-weight infants can result in increased levels of Metallo proteinases-9 (MMP-9) and Thrombospondin-1 (TSP-1) and are associated with increased blood pressure. MMP-9 is a family of endopeptidaseszinc-dependent that is responsible for tissue remodeling, both physiological and pathophysiological. The purpose of this study was to see the relationship between MMP-9 and TSP-1 with birth weight and blood pressure in children with a history of low birth weight. This study was a correlational observational analytic with cross sectional approach, namely by looking at the relationship between MMP-9 and TSP-1 levels with birth weight and blood pressure. This research was conducted from April to October 2018 at RSUP Prof. Dr. R. D Kandou Manado, North Sulawesi in children aged 7-9 years with a history of low birth weight. Blood pressure is measured by sfigmano meter. Inclusion criteria are children in good health with good nutritional status, having birth weight records in medical records, and parents willing to sign informed consent. Exclusion criteria were children in sick condition, taking drugs in 2 weeks before the study, obesity and suffering from kidney disease. MMP-9 levels measured by the enzyme-linked Quantikine Human MMP-9 method and TSP-1 levels were measured by the R & D System human thrombospondin-1 immunosorbent assay method.Keywords: Metallo proteinases-9 Matrix, Thrombospondin-1, low birth weight, blood pressure AbstrakGangguan fungsi endotel yang terjadi pada bayi berat lahi rrendah dapat mengakibatkan  terjadinya  meningkatnya  kadar  Matrix  Metallo  proteinases-9 (MMP-9) dan Thrombospondin-1(TSP-1) serta berhubungan dengan   peningkatan tekanan  darah.  MMP-9  adalah keluarga dari endopeptidaseszinc-dependent  yang bertanggungjawab untuk remodeling jaringan, baik fisiologis maupun patofisiologis. Tujuan penelitian ini untuk Melihat hubungan MMP-9 danTSP-1 dengan berat badan lahir dan tekanan darah pada anak dengan riwayat berat lahir rendah. Penelitian ini bersifat observasional analitik korelatif dengan pendekatan potong lintang yaitu dengan melihat hubungan kadar MMP-9 dan TSP- 1 dengasn berat lahir dan tekanan darah. Penelitian ini dilakukan mulai bulan April sampai  Oktober  2018  pada RSUP Prof. Dr. R. D Kandou Manado, Sulawesi Utara pada anak usia7-9 tahun dengan riwayat  berat  lahir rendah. Tekanan darah diukur dengan sfigmano meter. Kriteria inklusi adalah anak dalam keadaan sehat dengan status gizi baik, memiliki catatan berat lahir dalam rekam medis, dan orang tua bersedia untuk menanda tangani informed consent. Kriteria eksklusi adalah anak dalam kondisi sakit, mengkonsumsi obat- obatan dalam 2 minggu sebelum penelitian, obesitas dan menderita penyakit ginjal. Kadar MMP-9 diukur dengan metode Human MMP-9 enzyme-linked Quantikine dan kadar TSP-1   diukur   dengan   metode   R&D   System   human   thrombospondin- 1immunosorbent assay kit.Katakunci: Matrix Metallo proteinases-9,Thrombospondin-1, berat lahir rendah,tekanan darah
Analisis Hubungan Angka Kejadian, Gambaran Klinik Dan Laboratorium Anak Dengan Sindrom Nefrotik Resisten Steroid Di RSUP Prof. Dr. R. D. Kandou Manado Suwontopo, Marvin Leonardo; Umboh, Adrian; Wilar, Rocky
JKK (Jurnal Kedokteran Klinik) Vol 4, No 1 (2020): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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Abstract

ABSTRAKSindrom Nefrotik (SN) adalah penyakit Ginjal paling sering pada anak yang ditandai dengan Edema beserta Proteinuria, Hipoalbuminemia dan Hiperkolesterolemia. Menurut Respon Pengobatan, SN dibagi menjadi Sindrom Nefrotik Resisten Steroid (SNRS), dan Sindrom Nefrotik Sensitif Steroid (SNSS). Penelitian ini bertujuan untuk mengetahui hubungan Angka Kejadian, Gambaran Klinik dan Hasil Laboratorium pasien anak dengan Sindrom Nefrotik Resisten Steroid. Penelitian ini adalah penelitian Retrospektif Analitik yang dilaksanakan di  Bagian Ilmu Kesehatan Anak RSUP Prof Dr. R. D. Kandou Manado dengan mengambil data Rekam Medik dari periode Juli 2016 – Juni 2019. Perhitungan angka kejadian dengan menggunakan Period Prevalence dan variabel yang diteliti yaitu: Umur, Jenis Kelamin, Edema, Hipertensi, Hematuria, kadar Protein Urin, kadar Albumin Serum, kadar Kolesterol Serum, kadar Ureum Serum, dan kadar Creatinine Serum. Analisis Statistik dilakukan dengan menggunakan Uji Chi Square dan Uji Korelasi Spearman. Hasil Penelitian menunjukkan terdapat 35 pasien SN terdiri dari 21 pasien (60%) SNRS dan 14 pasien (40%) SNSS. Angka Kejadian SNRS dalam penelitian ini sebanyak 18,1%. Tidak didapatkan hubungan pada Variabel Umur (p=0.568), Edema (p=1.000), Hipertensi (p=0.392), Hematuria (p=0.058), Albumin Serum (p=0.324), Kolesterol Serum (p=0.234), Ureum Serum (p=0.445), Creatinine Serum (p=0.445). Hubungan didapatkan pada Variabel Jenis Kelamin (p=0.028) (r=0.371), dan Protein Urin (p=0.001) (r=0.557). Kesimpulan Jenis Kelamin Laki – laki dan Protein Urin ≥ +3 berpengaruh terhadap terjadinya Resistensi Steroid pada pasien anak dengan SN.Kata Kunci: Sindrom Nefrotik, SNSS, SNRS, Jenis Kelamin, Proteinuria. ABSTRACTNephrotic Syndrome (SN) is the most common Kidney Diseases in children characterized by Edema with Proteinuria, Hypoalbuminemia and Hypercholesterolemia. Based on Treatment Response, SN is divided into Steroid Resistant Nephrotic Syndrome (SRNS), and Steroid Sensitive Nephrotic Syndrome (SSNS). This study aims to determine the relationship of Prevalence, Clinical and laboratory features of Children with Steroid Resistant Nephrotic Syndrome. This is an Analytical Retrospective study carried out in the Department of Pediatric Medicine in Prof. Dr. R. D. Kandou General Hospital Manado by taking Medical Record data from the period of July 2016 - June 2019. Period Prevalence is used to calculate the Prevalence of SRNS. Studied Variables are: Age, Gender, Edema, Hypertension, Hematuria, Urine Protein level, Serum Albumin level, Serum Cholesterol level, Serum Ureum level, and Serum Creatinine level. Statistical analysis was performed using the Chi Square Test and the Spearman Correlation Test. Results showed there were 35 NS patients consisting of 21 SRNS patients (60%) and 14 SSNS patients (40%) SNSS. The Period Prevalence of SRNS  in this study was 18.1%. No Significant Correlation was found in Age (p = 0.568), Edema (p = 1,000), Hypertension (p = 0.392), Hematuria (p = 0.058), Albumin (p = 0.324), Cholesterol (p = 0.234) Ureum (p = 0.445), Creatinine  (p = 0.445). Significant Correlation were found in Gender (p = 0.028) (r = 0.371), and Urine Protein (p = 0.001) (r = 0.557). Conclusion. Male Gender and Urine Protein ≥ + 3 are associated with Steroid Resistance in NS patients.Keywords= Nephrotic Syndrome, SSNS, SRNS, Gender, Urine Protein.
Co-Authors Aaltje E. Manampiring Adriaan W. Kaunang Adrian Umboh Agus Wijata Algi Reafanny Batara Anak Agung Gede Sugianthara Angie G. Roring, Angie G. Ari L. Runtunuwu Audrey Wahani Ayling Sanjaya Bella Rumangkang, Bella Bernadus, Janno Berty Bradly Deafira, Angel Diana Yuliani Suryanto Edelwina Umboh Elia A. P. Hutapea Ellen Kumalasari Erling D. Kaunang Ester Caroline Wowor Gregory Joey Gunawan, Gregorius Helene Aneke Tangkilisan Hery Susanto Hesti Lestari Hesti Lestari Hesti Lestari H J. M. Wantania Jeanette I. Ch. Manoppo Jeanette I. Ch. Manoppo, Johnny Lambert Rompis Johnny Rompis Johnny Rompis Johnny Rompis Johnny Rompis Jose M. Mandei Josef Tuda Juhtisari Jufri Kereh, Tesalonika Leny Angkawijaya Mantik, Keren E.K. Marlina G. O. Soentpiet, Marlina G. O. Matthew, Febriano Max F. J. Mantik Max F. J. Mantik Mona C. U. Aman Moonik P Novie H. Rampengan Nurhayati Masloman Nurhayati Masloman Nurhayati Masloman Polii, Evan G. Praevilia Salendu, Praevilia Raynald Octavianus Takumansang Reifanli M. Pai, Reifanli M. Ricky Hartanto Rompis, Yulke R. Y. Ronald Chandra Rudy Ciulianto Sarah M. Warouw Silfy Welly Stefanus Gunawan Stevry Mathindas Suryadi N. N. Tatura, Suryadi N. N. Suryadi N.N. Tatura Suwontopo, Marvin Leonardo Tansil, Melissa G. Vivekenanda Pateda Winny Carolus