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All Journal HAYATI Journal of Biosciences Microbiology Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology UNEJ e-Proceeding Indonesian Journal of Chemistry Jurnal Aplikasi Teknologi Pangan Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
ADI YULANDI
Faculty Of Biotechnology Atma Jaya Catholic University Of Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Veterinary

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CURRENT UNDERSTANDING IN THE ROLES OF WNT/RYK SIGNALING IN DEVELOPMENT AND HOMEOSTASIS Wijaya, Natalie Chandra; Suryadi, Jimmy; Yulandi, Adi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.12608

Abstract

Wnt/Ryk signaling represents a critical yet underexplored branch of the Wnt pathway, with significant roles in embryonic development and tissue homeostasis. While canonical Wnt/β-catenin signaling has been extensively studied, emerging research highlights Ryk as a key noncanonical Wnt co-receptor influencing processes such as convergent extension, organogenesis, stem cell regulation, and inflammation. Wnt/Ryk signaling mediates diverse cellular outcomes through interactions with ligands like Wnt5a and Wnt11 and exhibits complex crosstalk with canonical pathways. Its dysregulation has been linked to developmental disorders, neurodegenerative diseases, and cancer progression. This review summarizes current insights into Wnt/Ryk function during development and homeostasis, highlights its relevance in human health, and identifies open questions regarding its molecular mechanisms and therapeutic potential. A deeper understanding of this pathway may offer novel strategies for regenerative medicine and targeted treatments for Wnt-related diseases.
CURRENT UNDERSTANDING IN THE ROLES OF WNT/RYK SIGNALING IN DEVELOPMENT AND HOMEOSTASIS Wijaya, Natalie Chandra; Suryadi, Jimmy; Yulandi, Adi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.12608

Abstract

Wnt/Ryk signaling represents a critical yet underexplored branch of the Wnt pathway, with significant roles in embryonic development and tissue homeostasis. While canonical Wnt/β-catenin signaling has been extensively studied, emerging research highlights Ryk as a key noncanonical Wnt co-receptor influencing processes such as convergent extension, organogenesis, stem cell regulation, and inflammation. Wnt/Ryk signaling mediates diverse cellular outcomes through interactions with ligands like Wnt5a and Wnt11 and exhibits complex crosstalk with canonical pathways. Its dysregulation has been linked to developmental disorders, neurodegenerative diseases, and cancer progression. This review summarizes current insights into Wnt/Ryk function during development and homeostasis, highlights its relevance in human health, and identifies open questions regarding its molecular mechanisms and therapeutic potential. A deeper understanding of this pathway may offer novel strategies for regenerative medicine and targeted treatments for Wnt-related diseases.
Co-Authors A A Hermosaningtyas A A Hermosaningtyas, A A AMANDA KRISTANI Anastasia Tatik Hartanti Antonius Suwanto Anugrah, Daru Seto Bagus BIBIANA W LAY David Tandjung DIANA ELIZABETH WATURANGI Diana Lestari, Diana IVAN HANJAYA Jason Wiranata Sanjaya JOANITA SADELI Kartini Kramadibrata Laura Virdy Darmalim Liana Dewi Nuratikah Maulani, Nail Izzatul Nampiah Sukarno Nurita Toruan-Mathius Nurwarrohman Andre Sasongko Parsaoran Siahaan Permono Adi Putro Sabrina, Feliciana Sheila Sutanto Sheila Sutanto, Sheila Sri Listiyowati Stella Magdalena Subagya, Mahmud Suryadi, Jimmy Syaiful Anwar Tati Barus Vanessa, Valencia Vivitri Dewi Prasasty Wahyunanto, Irang Waturangi, Diana E Wijaya, Laura Wijaya, Natalie Chandra Yogiara Yogiara