Febrina Mahmudah
Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia

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Studi Literatur: Aktivitas Imunomodulator Tanaman Jintan Hitam (Nigella sativa L.) Tanti Dwi Gunawati; Febrina Mahmudah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.179 KB) | DOI: 10.25026/mpc.v12i1.427

Abstract

An immunomodulator is a substance or agent that can cause immunomodulatory activity by changing or affecting the immune system or producing an unwanted immune response through dynamic regulation of the target immune system. Black cumin (Nigella sativa L.) or better known to the public with Habbatus saudah already included in the Ranunculaceae plant family has properties to treat various diseases such as strengthening the immune system, asthma, bronchitis, diabetes, anti-histamine, anti-oxidant, anti-tumor. digestive tract and bacteria. This study aims to analyze the literature related to the immunomodulatory activity of black cumin plants. The research method used is a literature study. Data searches were carried out using online search engine instruments such as Google Scholar, Pubmed, Science Direct, Elsevier, NCBI without any time limit for cited journals. The results of research from 10 journals that have been analyzed show that black cumin (Nigella sativa L.) has acted as an immunomodulator.
Formulasi Sediaan Lip Cream dengan Pewarna Alami Ekstrak Buah Senggani (Melastoma malabathricum L.): Lip Cream Formulation with Natural Coloring Senggani Fruit Extract (Melastoma malabathricum L.) Khoiriyah Anbar Mufidah; Febrina Mahmudah; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.416 KB) | DOI: 10.25026/mpc.v13i1.451

Abstract

Senggani (Melastoma malabathricum L.) is a wild plant that has anthocyanin compounds which are red, purple and blue pigments in plants that can be used as natural dyes. So, to increase the use value of the senggani plant, senggani fruit extract is used as a natural coloring agent in lip cream preparations. Senggani fruit was extracted, then formulated. The quality of the preparation is determined through evaluation of physical characteristics (organoleptic test, homogeneity test, dispersion test, adhesion test, viscosity test and pH test), physical stability test (freeze thaw method and room temperature) for 16 days, evaluation of the safety of the irritation test (method patch test) and acceptability (hedonic test method). The results obtained were the lip cream preparation formula using senggani fruit extract with a concentration of 5%, 10%, and 15% producing purple, reddish purple, and purplish red colors, respectively. The results of the evaluation of the physical characteristics of all preparations included the aroma of rose flowers, semisolid consistency, homogeneous and has a viscosity, dispersibility, adhesion, and pH that meet the pharmaceutical requirements of lip cream preparations. The results of the physical stability test of the three formulas showed that all preparations were stable, with organoleptic, homogeneity, pH, and viscosity that met the range and there was no phase separation. The results of the irritation test of the preparations showed that the preparations did not irritate and the results of the acceptability of the preparations in terms of color and texture of the preparations were preferably panelists at a concentration of 10% and in terms of aroma, preferably panelists at a concentration of 5%.
Uji Aktivitas Mukolitik Perasan Daun Miana (Plectranthus scutellarioides (L.) R.Br.) Secara In Vitro: Mucolytic Activity Test of a Squeeze of Miana leaves (Plectranthus scutellarioides (L.) R.Br.) by in Vitro Krismayani Krismayani; Fajar Prasetya; Febrina Mahmudah
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.816 KB) | DOI: 10.25026/mpc.v13i1.452

Abstract

Mucolytics are drugs that can dilute airway secretions by preventing mucoprotein and mucopolysaccharide threads from being sputum. Empirically, the juice of miana leaves is used by the Toraja people to treat cough with pHlegm. There has been no testing of miana leaf juice as a mucolytic agent, therefore this study was conducted to see the mucolytic activity of miana leaf juice. The test was carried out in vitro using bovine intestinal mucus as a negative control and acetyl as a positive control. Mucolytic activity can be seen from the decrease in viscosity produced by each test sample. Samples were tested using a Rheosys viscometer with a temperature and pH that matched the pHysiological conditions of the body. The results showed that the concentration of 1% miana juice had a large mucolytic activity, compared to concentrations of 0.5%, 1.5, and 2%. The results of pHytochemical screening showed that miana leaf juice was positive for saponins and flavonoids which were thought to work in decreasing the viscosity of mucus.
Karakteristik Pasien Terkonfirmasi Coronavirus disease (COVID-19) di RS X Samarinda Periode Maret-Desember 2020: The Characteristics of Confirmed Patients Coronavirus disease (COVID-19) at RS X Samarinda in March-December 2020 Ridha Siti Ruhama; Febrina Mahmudah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.692 KB) | DOI: 10.25026/mpc.v14i1.582

Abstract

Coronavirus disease (COVID-19) is a virus that has become a world pandemic including Indonesia. East Kalimantan is a province with a total of 71,092 confirmed cases of covid-19 as of March 28, 2020. The RS X Samarinda has 660 confirmed cases covid-19 during march - December period in 2020. This research aims to identify characteristics of patients covid-19 at RS X Samarinda in March - December 2020. This research is descriptive by retrospective methods. Data collection is conducted quantitatively with a sampling technique. Research instruments are 100 data inclusions of patient medical records. The results of this research show that the dominant 51% are male and 49% are female. The most age groups 34% in the early aged (46-55 years old), with further treatments >7 days as much as 65%. Patients who have 31% komorbides and without comorbidity as much as 69% in the category 87.09% diabetes mellitus. Patients data of 58,82% experienced one of the clinical symptoms of coughing/sniffles/throat pain.
Kajian Potensi Interaksi Obat pada Pasien COVID-19 di Rumah Sakit X Kota Samarinda: Study of Potential Drug Interactions in COVID-19 Patients at Hospital X Samarinda City Shofia Siza Maulidia; Febrina Mahmudah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.193 KB) | DOI: 10.25026/mpc.v14i1.587

Abstract

Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by a coronavirus known as SARS-CoV-2 and is currently a worldwide pandemic. Treatment management for COVID-19 patients is grouped based on the level of symptoms experienced by the patient. The use of large amounts of drugs (polypharmacy) in COVID-19 patients with moderate and severe symptoms can increase the possibility of drug interactions. This study aims to determine patient characteristics and the potential for drug interactions in COVID-19 patients at Hospital X Samarinda City. The data collection method was conducted retrospectively based on the medical records of COVID-19 patients hospitalized from March to December 2020. Data on potential drug interactions were analyzed using the Drugs.com application. The results showed that of the 30 patients with COVID-19, male-dominated (60%) and aged between 46 and 55 years (50%). Data on potential drug interactions showed that 28 out of 30 patients had the potential to experience drug interactions in the categories of severe (9,23%), moderate (74,62%), and mild (16,15%).
Observasi Klinik Kombinasi Ekstrak Mentimun (Cucumis sativus L.) dan Labu Siam (Sechium edule) terhadap Tekanan Darah pada Pasien Hipertensi: Clinical Observation on Effect of Combinations Extract Cucumber (Cucumis sativus L.) and Chayote (Sechium edule) on Blood Pressure in Patient of Hypertension Susan Susan; Febrina Mahmudah; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.639

Abstract