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All Journal STOMATOGNATIC- Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Indonesian Journal of Cancer Mandala of Health : A Scientific Journal Medical and Health Journal Linggamas: Jurnal Pengabdian Masyarakat
Tirta Wardana
Universitas Jenderal Soedirman
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Laporan Kasus: Kandidiasis Akut Eritematous pada Penderita Diabetes Melitus Aris Aji Kurniawan; Tirta Wardana; Arif Rachman Darmawan
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 15 No 1 (2018)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v15i1.17909

Abstract

Oral Candidiasis is infectious that caused by fungi Candida albican. Candida infection can happen on Diabetes mellitus patients (DM) because of glucose high level on oral cavity fluid and decreasing immunity patient. The purpose was to discuss and management acute erythematous candidiasis on DM patient. A 63-year-old male patient arrives at the Dental Hospital with dorsal pain, heat and pain when eating and drinking. Pain has been felt since about 2 months ago after the patient experienced heart disease. The patient has a history of controlled diabetes mellitus, controlled hypertension, asthma and gastritis. The patient feels pain in his tongue getting worse accompanied by a burning sensation and pain when the body was unhealthy. The patient was diagnosed with acute erythematous candidiasis and treated with systemic antifungal, mouthwash and topical antiseptic for oral cavity cases and was referred to an internal medicine specialist for blood sugar control. The patient was declared cured after 36 days of treatment. Knowing the predisposing factors in this case (DM) is very important in the management of erythematous acute candidiasis therapy. Patients with diabetes mellitus must routinely control blood glucose levels, maintain oral hygiene and not worsen by adding other predisposing factors.
Peningkatan Peran Guru Sekolah Dasar Dalam Pengobatan Darurat untuk Menghilangkan Rasa Sakit Gigi dan Mulut Ryana Budi Purnama; Helmi Hirawan; Tirta Wardana; Mutia Rochmawati; Pratiwi Nur Widyaningsih; Dian Noviyanti; Desi Rachmawati; Rakhmawati Rakhmawati; Shahnaz Dwi Permata Putri; Minda Anita; Kunthi Isri Wulandari; Dani Intan Prabawati
JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Vol 5 No 1 (2021): Jati Emas (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat)
Publisher : Dewan Pimpinan Daerah (DPD) Perkumpulan Dosen Indonesia Semesta (DIS) Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36339/je.v5i1.341

Abstract

Abstract - Oral and dental health is a condition that needs to be considered and maintained to improve the quality of life. One of the efforts made to maintain dental and oral health in the school environment is by conducting UKGS (Usaha Kesehatan Gigi Sekolah). In UKGS activities, teachers have a role in providing emergency treatment to relieve pain. The emergency treatment administered by teachers in schools can perform in cases such as avulsions, choking, and abscesses. This community service aims to increase the role of elementary school teachers through UKGS to maintain, improve the oral health of all students at SDN in the Karangtengah area, Baturaden District, Purwokerto. The method of implementation was basely on optimizing the potential of UKGS teacher cadres, including identification of target schools and participants, pre-test implementation, maturation, coaching, enhancement of UKGS teacher cadres. Coaching and training have been carried out for UKGS supervisors for abscess, choking and avelse conditions. Post-test activities to gain insight into emergency medicine and relieve tooth and mouth pain. Results: p data analysis using the Wilcoxon asymp test.sig.(2-tailed) of 0.001 (<0.05), this value indicates that there is an influence on the level of knowledge about emergency medicine. The analysis performed with the Wilcoxon Test; there was a significant difference (sig = 0.001, p <0.05). There was an increase in the average pre-test value of 76.92 and post-test of 97.85.Conclusion: There is increasing knowledge about emergency medicine to relieve tooth and mouth pain in elementary school teachers.
Immunohistochemical differential expression of p16 proteins in follicular type and plexiform type ameloblastoma Haris Budi Widodo; Anung Saptiwulan; Helmi Hirawan; Christiana Cahyani Prihastuti; Tirta Wardana
Dental Journal Vol. 55 No. 3 (2022): September 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i3.p137-141

Abstract

Background: Differences in histopathological features that describe the growth mechanism and biological behaviour of follicular and plexiform ameloblastomas are associated with benign, aggressive and destructive tumour markers. p16 has inhibitory interactions between cyclin D and CDK 4/6 to block the cell cycle and alterations related to severity. Purpose: This study intends to evaluate and determine differential expressions of p16 protein in follicular and plexiform ameloblastomas. Methods: This is a descriptive analytics study. A total of 21 specimens consisting of follicular and plexiform ameloblastomas and healthy gingiva tissues as the negative control were examined using the immunohistochemistry assay. The analysis of p16 protein expression was interpreted by immunoreactive scoring. Statistical analysis was conducted using SPSS software with the Mann–Whitney test. A p-value <0.05 shows the significance of the change in expression. Results: An increased expression of p16 protein was found in the follicular ameloblastoma type (2.13 ± 1.808) and the plexiform type (4.44 ± 2.506) in comparison to the negative control group (0 ± 0). The increase of p16 expression in the follicular and plexiform ameloblastomas was significant compared to the negative control group (p-value <0.05); however, there was no significant difference between either type of ameloblastoma (p-value >0.05). Conclusion: The highest intensity of p16 protein expression was found in the plexiform type, even though it was not significantly different from the follicular type ameloblastoma.
Wound healing induces VEGF expression stimulated by forest honey in palatoplasty Sprague Dawley Reine Zhafirah; Alifah Nur Aida; Helmi Hirawan; Tirta Wardana
Dental Journal Vol. 56 No. 1 (2023): March 2023
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i1.p48-52

Abstract

Background: Cleft palate is a craniofacial disorder with definitive therapy using the V–Y pushback technique palatoplasty, which has the impact of leaving the bone exposed on the palate with long wound healing and a high risk of infection. Forest honey has high antioxidants and the ability to accelerate wound healing. Purpose: This study aims to determine the effect of forest honey on vascular endothelial growth factor (VEGF) expression to accelerate the wound healing process after palatoplasty biopsy. Methods: Posttest only control group design using Sprague Dawley palatoplasty was performed on 15 rats which were divided into three groups, namely the honey treatment (KP), Aloclair as a positive control (KPP), and aquadest as a negative control (KKN). As much as 25 mg of honey was given therapeutically, and VEGF expression analysis post-biopsy palatoplasty was measured using the ELISA test. ANOVA analysis was carried out to determine the significant differences between each treatment, and in silico analysis was conducted to determine the compounds’ role in honey on the mechanism of VEGF expression. Results: Statistical analysis of VEGF expression in the KP group was 41.10 ng/ml ± 0.26, the KKP was 39.57 ± 0.27, while the KKN was 33.26 ± 0.62 (p≤ 0.01). In silico study, genistein (C15H10O5) targets several signaling pathways such as PI3K-Akt, AMPK, and mTOR, affecting accelerated proliferation and angiogenesis. Conclusion: In wound healing acceleration, forest honey induced VEGF expression through the genistein mechanism of angiogenesis and cell proliferation.
IN SILICO PHYLOGENETIC ANALYSIS, CHEMORECEPTOR AND SIGNAL TRANSDUCTION OF BACTERIAL CONTAMINATION DENTAL UNIT tirta wardana
Mandala Of Health Vol 14 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (591.959 KB) | DOI: 10.20884/1.mandala.2021.14.2.5161

Abstract

The importance of patient safety when carrying out dental and oral care processes is essential. However, the high levels of contamination that have been reported in dental units are of particular concern, so it is necessary to identify and study the patterns of bacterial contaminants and the transduction mechanisms of bacterial responses to their environment. This study investigates the diversity of bacterial contamination in dental units, chemotaxtic signals, and pathways from chemoreceptors through in silico approched. In silico research was carried out using several online and offline software tools utilizing a genomic sequence database from bacteria-contaminated with dental units. Phylogenetic analysis of the tree based on the 16s rRNA gene using MEGA 6 software, protein signaling interactions were analyzed using MiST 3.0 (https://mistdb.com/), signal transduction and protein structure (https://pfam.xfam.org/), the role of chemotaxis using interPro Ebi (https://www.ebi.ac.uk/interpro/structure/), dan biological process using Ebi QuickGo (https://www.ebi.ac.uk/QuickGO/). The analysis showed that 58 species of bacterial contamination showed a similarity test > 95%. Chemosensory pathway analysis of P. aeruginosa with a genome length of 6.538 Mbp through 8 signaling mechanism pathways for a total of 48 MCP. Signaling pathways.MCP signaling analysis classes are 24H, 36H, 40H, and 44H, while the identification of MCP classes is grouped based on chemosensory classes, namely CheW, CheA, CheR, CheB, Chev, CheD, and CheZ. The conclusion of this study, the complexity of the chemoreceptor interaction pathway in adapting quickly to the environment.
Morphological Changes and Apoptosis of Buccal Mucosa Basal Epithelium in Heads and Necks during Cancer Radiotherapy Christiana Cahyani Prihastuti; A. Haris Budi Widodo; Nabila Prandita Bagasworo; Arundito Widikusumo; Dody Novrial; Daniel Joko Wahyono; Tirta Wardana
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.944

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Background: Radiotherapy is generally used to treat head and neck malignancy through high radiation, focusing on killing cancer cells. However, some adverse effects in oral mucosal tissue, including cell morphology changes and apoptosis, are commonly found. This study aims to determine the morphological changes and apoptosis of buccal mucosa epithelium after radiotherapy in head and neck cancer (HNC) patients.Methods: This study involved 8 subjects of patients diagnosed with HNC. Buccal mucosal smear samples were collected using cytobrush two times, before and after radiotherapy, with a dose of 70 Gy in 7 weeks. The specimens were prepared and stained using Feulgen and Rosenbeck technique. Observations were made using a light microscope with a count per 1000 epithelial cells. Statistical analysis was performed using statistical software with Pearson’s correlation test and significance t-test (p < 0.05) between irradiated and non-irradiated samples.Results: Data analysis showed significant changes in cell morphological damage and apoptosis in patients before and after radiotherapy. It increases in the number of micronuclei (p = 0.001), broken egg (p = 0.001), binuclei (p = 0.003), pyknosis (p = 0.033), karyorrhexis (p = 0.020), and karyolysis (p = 0,004). Conclusions: The effects of radiation reflect morphological changes and apoptosis in the buccal mucosa basal epithelium in HNC patients.
DISTRIBUSI SPASIAL KUALITAS AIR TANAH DAN DESKRIPSI PENYAKIT YANG BERKAITAN DENGAN AIR DI DESA BRINGKENG, KECAMATAN KAWUNGANTEN, KABUPATEN CILACAP Siti Munfiah; Hajid Rahmadianto Mardihusodo; Tirta Wardana; Yudhi Wibowo; Joko Mulyanto
Medical and Health Journal Vol 2 No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.431 KB) | DOI: 10.20884/1.mhj.2023.2.2.8361

Abstract

Access to clean water is fundamental for the population health, but for many rural and remote areas in Indonesia include Cilacap Regency those accesses are still limited. Furthermore, studies that assess the water quality in remote and rural areas in Indonesia are still lacking. Most of the people in Cilacap regency use dug wells and ponds as sources of clean water. Preliminary observations indicate that well and pond water smells fishy, reddish-yellow, or brownish. This condition indicates high iron levels. The test results showed that the iron content exceeded the standard in the pond in Sumbereja Hamlet, RT 03 RW 02, which was 9.8 mg/l (standard quality of 1 mg/l). This study aims to determine the spatial distribution of the water quality and the health-related problems in the rural areas of Cilacap Regency, Central Java, Indonesia. This was a descriptive observational study with a cross-sectional approach. We purposely sampled 40 wells and ponds located in Bringkeng Village, Cilacap Regency, Indonesia and assess the water quality by measuring the level. The results showed the lowest and the highest level of TDS (125.90-5090 mg/l), color (40 -2047 TCU), iron (0.16-6.45 mg/l), manganese (<0.1- 3.61 mg/l). Health problems experienced by respondents and or their families during the last three months, namely 3 people with diarrhea, 7 people with diabetes, 12 people with gout arthritis, 10 people with hypertension, 1 person with nervous system disorders, and 7 people with dry skin disorders/scaly. All dug wells and ponds did not meet the quality standards based on TDS, color, iron, and manganese levels. Water from dug wells and ponds needs special treatment to obtain water that is suitable for hygiene and sanitation purposes.
Prediktor Penyakit Jantung Koroner (PJK) Melalui Pemeriksaan Profil Lipid (HDL, LDL, Trigliserid) Menggunakan Rumus Castelli Dan Indeks Aterogenik Plasma (AIP) di Desa Srowot Kecamatan Kalibagor Kabupaten Banyumas Wahyudin Wahyudin; Tirta Wardana; Rizak Tiara Yusan; Fitranto Arjadi; Kasum Kasum; Nursan Saad
Linggamas: Jurnal Pengabdian Masyarakat Vol 1 No 2 (2024): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2024.1.2.10363

Abstract

Kolesterol berkaitan erat dengan kejadian penyakit jantung koroner atau PJK. Kolesterol yang terlalu banyak di dalam pembuluh darah akan menyebabkan akumulasi plak kolesterol atau sering disebut aterosklerosis. Pemeriksaan kolesterol lengkap yang meliputi low density lipoprotein (LDL), high density lipoprotein (HDL), trigliserida, dan kolesterol total dapat memberikan gambaran atau prediktor resiko PJK dengan menggunakan rumus indeks Castelli dan Indeks aterogenik plasma (IAP). Pemeriksaan kolesterol lengkap dilaksanakan bekerja sama dengan Kader Posyandu, Bidan Desa, dan Perangkat Desa dengan jumlah responden sebanyak 48 orang yang terdiri dari 40 perempuan dan laki-laki sebanyak 8 orang. Hasil pemeriksaan menunjukkan bahwa resiko PJK dengan menggunakan indeks Castelli sebagian besar warga memiliki resiko rendah sebanyak 69% dibanding resiko sedang 27% dan resiko tinggi sebanyak 4 %. Sedangkan dengan menggunakan IAP, menunjukkan bahwa sebagian besar mengalami resiko tinggi PJK sebanyak 38%, resiko sedang 52%, dan resiko rendah hanya mencapai 10%. Kegiatan ini diharapkan menjadi bahan evaluasi bagi warga agar lebih memperhatikan pola makan yang dapat meningkatkan resiko terjadinya PJK, dengan mengurangi makanan-makanan yang mengandung kolesterol yang tinggi
Co-Authors A. Haris Budi Widodo Alifah Nur Aida Anung Saptiwulan Arif Rachman Darmawan Aris Aji Kurniawan Arundito Widikusumo Christiana Cahyani Prihastuti Christiana Cahyani Prihastuti Dani Intan Prabawati Daniel Joko Wahyono Desi Rachmawati Dian Noviyanti Dody Novrial, Dody Fitranto Arjadi Hajid Rahmadianto Mardihusodo Haris Budi Widodo Helmi Hirawan Helmi Hirawan Helmi Hirawan Joko Mulyanto Kasum Kasum Kunthi Isri Wulandari Minda Anita Mutia Rochmawati Nabila Prandita Bagasworo Nursan Saad Rakhmawati Rakhmawati Reine Zhafirah Rizak Tiara Yusan Ryana Budi Purnama Shahnaz Dwi Permata Putri Siti Munfiah Wahyudin Wahyudin Widyaningsih, Pratiwi Nur Yudhi Wibowo