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All Journal Jurnal Kedokteran Diponegoro Universa Medicina Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Media Keperawatan Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Indian Journal of Forensic Medicine & Toxicology Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Global Pharma Technology Jurnal Keperawatan Notokusumo
Muhamad Thohar Arifin
Fakultas Kedokteran, Universitas Diponegoro
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The survival benefits of adjuvant radiotherapy for malignant meningioma: a retrospective cohort study Bakhtiar, Yuriz; Eka Setiawan, Fariz; Ilmansyah, Rafi; Prihastomo, Krisna Tsaniadi; Priambada, Dody; Rizky Aryani Septarina, Faiza; Arifin, Muhamad Thohar; Muttaqin, Zainal
Universa Medicina Vol. 44 No. 3 (2025): Ahead Of Print
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.318-327

Abstract

BackgroundMalignant meningiomas (MM) are rare aggressive tumors associated with poor survival outcomes. Due to their rarity, there is limited data on the outcomes and prognostic factors of MM patients, particularly on adjuvant radiotherapy roles in this tumor population. This study aims to investigate the clinical characteristics, prognostic factors, and survival outcomes of MM with focus on survival benefits of adjuvant radiotherapy. MethodsThis retrospective cohort study analyzed 19 MM patients, who were initially subjected to postoperative radiotherapy, at Dr. Kariadi General Hospital, Semarang, from 2013 to 2023. Kaplan-Meier analysis was used to estimate survival rates at 1, 2, and 5 years. Univariate and multivariate Cox regression analyses were performed to identify factors associated with overall survival (OS). Variables with a p-value ≤ 0.25 in univariate analysis were included in the multivariate models. ResultsThe median OS was 16 months (95% CI 0.0–40.2), with estimated 1-year, 2-year, and 5-year survival rates of 52.6%, 42.1%, and 15.8%, respectively. Adjuvant radiotherapy (RDT) was associated with a significantly improved OS (p<0.001). However, sex, age, tumor location, and extent of resection did not show a significant association with OS. Cox regression showed that RDT had no statistically significant effect on OS in the multivariate model (HR = 0, 95% CI 0–1.8, p=0.923). ConclusionAdjuvant radiotherapy is critical for improving OS in MM patients, and gross-total resection (GTR) alone does not guarantee better long-term outcomes. Further studies with larger cohorts and molecular analysis are necessary to refine treatment strategies for MM.
Co-Authors Agus Santoso Alfin Ihza Trimahendra Bakhtiar, Yuriz Eka Setiawan, Fariz Evan Sebastian Gunawan Fernando Fernando Fuji Istiana Fujio, Shingo Giri Susilo Adi Handayani, Fitria Ika Pawitra Miranti Ilmansyah, Rafi James Otniel Kesumayadi, Irfan Mochamad Ali Sobirin Muhammad Nur Priambada, Dody Prihastomo, Krisna Tsaniadi Rizky Aryani Septarina, Faiza Sukesi . Untung Sujianto Vega Karlowee Yan Wisnu Pradjoko Yora Nindita Yuriz Bakhtiar Zainal Muttaqin