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All Journal Majalah Kedokteran Paediatrica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Pediatric Sciences Journal
Niken Wahyu Puspaningtyas
Departemen Ilmu Kesehatan Anak FKUI-RSCM Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Kriteria RIFLE pada Acute Kidney Injury Sudung O. Pardede; Niken Wahyu Puspaningtyas
Majalah Kedokteran UKI Vol. 28 No. 2 (2012): APRIL - JUNI
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Acute kidney injury (AKI) merupakan masalah yang menyulitkan dalam dunia kedokteran. Acute kidney injury diartikan sebagai peningkatan kreatinin serum ataupun produk metabolisme nitrogen yang bersifat reversibel dan ketidakmampuan ginjal untuk meregulasi cairan dan elektrolit kekeadaan homeostasis tubuh. Kriteria risk, injury, failure, loss, and end stage renal disease (RIFLE) telah ditetapkan sebagai kriteria standar AKI pada orang dewasa. Pada anak telah digunakan klasifikasi RIFLE yang dimodifikasi yang disebut dengan pediatric RIFLE (pRIFLE). Perbedaan antara RIFLE pada dewasa dan pRIFLE pada anak adalah nilai cut-off kreatinin serum yang lebih rendah untuk mencapai kategori F (failure), dan waktu pengeluaran urin yang diperlukan untuk menentukan risk dan injury. Penyebab AKI dibedakan menjadi penyebab pre renal, renal, dan uropati obstruktif. Beberapa biomarker seperti neutrophil gelatinase-associated lipocalin (NGAL) plasma, kadar sistatin C dan perubahan kadar urin NGAL, interleukin 18, kidney injury molecule-1 (KIM-1) dan KIM-3 sedang dalam tahap penelitian. Mortalitas pada pasien dengan AKI (31,2%) lebih tinggi dibandingkan dengan pasien tanpa AKI (6,9%). Angka mortalitas meningkat seiring peningkatan stadium yaitu R sebesar 18,9%, I sebesar 36,1% serta F sebesar 46,5%.Kata kunci: gagal ginjal akut, RIFLE, oliguria, laju filtrasi glomerulus, kreatinin Abstract Acute kidney injury (AKI) is a complicated problem in medicine. Acute kidney injury is defined as a reversible increase in serum creatinine or nitrogen metabolism products and inability of kidney to regulate fluid and electrolyte to homeostatic state. Risk, injury, failure, loss, and end stage renal disease (RIFLE) has been established as a standard criteria of AKI in adults. In children, there is a modified RIFLE classification called pediatric RIFLE (pRIFLE). The differences between adult RIFLE and child pRIFLE are lower cut-off point of serum creatinine to reach F (failure) category and diuresis time to establish risk and injury. Causes of AKI can be divided into prerenal, renal and obstructive uropathy. Several biomarkers for AKI such as plasma neutrophil gelatinase-associated lipocalin (NGAL), cystatin C level and changes in urinary level of NGAL, interleukin 18, kidney injurymolecule-1 (KIM-1) and KIM-3 are still on research. The mortality of patients with AKI (31,2%) is higherthan those without AKI (6,9%). The mortality rate increases along with the increase of AKI stages, stage R:18,9%, stage I:36,1% and stage F:46,5%.Key words: acute kidney injury, RIFLE, oliguria, glomerular filtration rate, creatinin
Global climate change issues, natural disasters and their impact on Indonesian children Kurniawan Taufiq Kadafi; Dimas Dwi Saputro; Martinus M. Leman; Aslinar; Badai Buana Nasution; Dimas Tri Anantyo; Niken Wahyu Puspaningtyas; Fathy Zuandy Pohan; I Nyoman Arie Purwana; Muhammad Reza; Jaya Ariheryanto Effendy; Yogi Prawira; Piprim Basarah Yanuarso,
Pediatric Sciences Journal Vol. 3 No. 1 (2022): (Available online 1 June 2022)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i1.35

Abstract

Climate change that contributes to the destruction of the earth is one of the impacts of human behavior. One example of damage to the earth due to human behavior is global warming. One of the effects of global warming is the melting of permafrost. Melting of glaciers due to global warming will result in an isostatic rebound phenomenon, where melting glaciers will cause the weight of the earth's crust to decrease and it is easy to move and bounce, resulting in the movement of earth faults and increased activity in the magma chamber (increased seismic activity). The big impact is the occurrence of natural disasters that not only occur in parts of the world where glaciers melt but in other parts of the world far from where glaciers melt. Natural disasters that can occur are earthquakes, volcanic eruptions, tsunamis, and landslides. Global warming will also have an impact on the emergence of disease outbreaks. Indonesia is the meeting place of three major tectonic plates in the world, namely the Eurasian plate, the Indo-Australian plate and the Pacific plate. In addition, Indonesia is also located in the Pacific ring of fire, making Indonesia an area with high volcanic activity and seismic activity. Climate change will increase the risk of disasters in Indonesia. The long experience of the Indonesian people in dealing with natural disasters that often occur should be used as a strategy to prevent and reduce the impact of disasters in the future.
Gigitan Ular: Manajemen Terkini Niken Wahyu Puspaningtyas; Rismala Dewi; Ashfahani Imanadhia
Majalah Kedokteran Indonesia Vol 72 No 2 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.2-2022-386

Abstract

Snakebite is declared as neglected tropical disease by WHO in 2009. Limited report and collection data about the exact number of snakebite national incidents shows that this case lacking of attention. Moreover, control program, management, also proper treatment have not been understood by public and health workers. In fact, snakebite is a medical emergency that can lead to permanent disability, limb amputation, and even death. For this reason, effort are needed to reduce morbidity and mortality that arise through preventive, curative, including comprehensive understanding of related proper, safe, and effective case management.
Global impact of climate change on children's health in the world Kurniawan Taufiq Kadafi; Dimas Dwi Saputro; Martinus Martin Leman; Aslinar; Badai Buana Nasution; Dimas Tri Anantyo; Niken Wahyu Puspaningtyas; Fathy Zuandy Pohan; I Nyoman Arie Purwana; Muhammad Reza; Jaya Ariheryanto Effendy; Yogi Prawira; Piprim Basarah Yanuarso
Pediatric Sciences Journal Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v4i1.57

Abstract

Climate change has a close relationship with the greenhouse effect. The greenhouse effect is needed by the earth, but if there are too many greenhouse gases in the atmosphere this will increase the earth's temperature. Children are a group of people who have a high vulnerability to climate change. Climate change will affect children's health through 4 impacts, namely direct impacts on children's health, impacts on children's health through ecosystems, impacts on children's health through human behavior, and health impacts on children due to natural disasters. To anticipate the impact of climate change on children's health, parents and the government must take anticipatory steps so that children can be saved from the extreme dangers of climate change.
H1N1pdm09 infection in children: A case report of reemerging disease in COVID-19 pandemic Puspaningtyas, Niken Wahyu; Nagrani, Dimple Gobind; Karyanti, Mulya Rahma; Fauzie, Rifan; Imanadhia, Ashfahani; Sarita, Raisa Cecilia; Putra, Reynaldo Rahima
Paediatrica Indonesiana Vol. 64 No. 4 (2024): July 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.4.2024.363-8

Abstract

An outbreak of H1N1 infection was first declared by the World Health Organization in 2009 and confirmed in the post-pandemic phase in 2010. Amid the COVID-19 pandemic, we found a confirmed case of H1N1pdm09 in Bunda Women and Children Hospital Jakarta. A 13-year-old boy was referred to our hospital after four days of hospitalization due to worsening tachypnea following a productive cough and fever. The patient had severe dyspnea with inspiratory effort and oxygen desaturation to 80%, therefore admitted to our pediatric intensive care unit. On physical examination, the patient had increased work of breathing, looked irritable, had a respiratory rate of about 40x/minute with non-rebreathing mask support, and crackles were heard in both lungs. Chest x-ray showed right bronchopneumonia. There was a history of a generalized seizure for less than 1 minute, which stopped spontaneously in previous hospital care. The patient was diagnosed with mucopolysaccharidosis at age six years old and has never received enzyme replacement therapy. Laboratory results revealed thrombocytopenia, leukopenia, neutrophilia, monocytosis, high c-reactive protein and procalcitonin, and elevated liver enzymes. The investigation of etiology was performed using the respiratory panel test and showed a positive real-time polymerase chain reaction for H1N1pdm09 and Influenza A. The patient was given oxygen therapy with a high-flow nasal cannula with an oxygen fraction of 40% and a flow of 20 liters per minute, fluid maintenance while fasting, antibiotics, inhaled beta-2 agonists, and a neuraminidase inhibitor (oseltamivir). The patient's clinical and laboratory markers improved on the third day of treatment, and he was discharged two days later.
Tandem therapeutic plasma exchange and continuous kidney replacement therapy in a pediatric post-liver transplant patient: a case report Fahlevi, Reza; Puspitasari, Henny Adriani; Hidayati, Eka Laksmi; Pardede, Sudung Oloan; Trihono, Partini Pudjiastuti; Puspaningtyas, Niken Wahyu; Oswari, Hanifah; Sanstiono, Sastiono
Paediatrica Indonesiana Vol. 65 No. 6 (2025): November 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In critical condition, sometimes continuous kidney replacement therapy (CKRT) treatment should not be held while therapeutic plasma exchange (TPE) is needed. Simultaneous use of both modalities is defined as tandem therapy, available as an option.  
Co-Authors Ashfahani Imanadhia Aslinar Dimas Dwi Saputro Dimas Tri Anantyo Eka Laksmi Hidayati, Eka Laksmi Fathy Zuandy Pohan Hanifah Oswari Henny Adriani Puspitasari, Henny Adriani I Nyoman Arie Purwana Imanadhia, Ashfahani Jaya Ariheryanto Effendy Kurniawan Taufiq Kadafi Martinus M. Leman Martinus Martin Leman Muhammad Reza Mulya Rahma Karyanti, Mulya Rahma Nagrani, Dimple Gobind Nasution, Badai Buana Pardede, Sudung Oloan Partini Pudjiastuti Trihono, Partini Pudjiastuti Piprim Basarah Yanuarso Piprim Basarah Yanuarso, Putra, Reynaldo Rahima REZA FAHLEVI Rifan Fauzie, Rifan Rismala Dewi Sanstiono, Sastiono Sarita, Raisa Cecilia Sudung O Pardede, Sudung O Yogi Prawira