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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) International Journal of Biosciences and Biotechnology Buletin Udayana Mengabdi Ecotrophic, Journal of Environmental Science Journal of Science and Applicative Technology Chimica et Natura Acta ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Media Sains Journal of Multidisciplinary Applied Natural Science Jurnal Ilmu Pendidikan Indonesia
N. W. Bogoriani
Program Studi Kimia FMIPA Universitas Udayana, Jimbaran, Bali, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Physics

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Phytochemical Profiling, Antibacterial Properties and Toxicity of Amla Fruit Tea (Phyllanthus emblica L.): An In Vitro and In Silico Study Cahyaningrum, Putu Lakustini; Sudaryati, Ni Luh Gede; Bogoriani, Ni Wayan; Asih, Ida Ayu Raka Astiti; Adnyana, I Made Dwi Mertha; Jenar, Putut Dewantha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.284

Abstract

Antimicrobial resistance represents a critical global health challenge, necessitating the exploration of alternative therapeutic agents. This study investigated the antimicrobial potential of amla fruit tea (Phyllanthus emblica L.) through comprehensive phytochemical characterization, antibacterial assessment, and computational modeling to identify potential mechanisms of action. LC-HRMS analysis was employed for phytochemical profiling, antibacterial activity was evaluated via disk diffusion method against Staphylococcus aureus and Escherichia coli, and molecular docking studies were conducted against tyrosyl-tRNA synthetase and FimH adhesin proteins. Analysis identified 89 bioactive compounds, with oxidized hydroxytetrahydrofuranyl acetate, L-α-palmitin, and ellagic acid predominating. Antibacterial activity against S. aureus and E. coli was evaluated via the disk diffusion method, revealing that moderate inhibition increased at higher concentrations (25%) and with extended exposure, with E. coli exhibiting greater susceptibility than S. aureus. Molecular docking studies against tyrosyl-tRNA synthetase (S. aureus) and FimH adhesin protein (E. coli) identified the W-18 benzenesulfonamide derivative as the most promising compound, which demonstrated strong binding affinities of -11.01 and -7.48 kcal/mol, respectively. While all five principal compounds met Lipinski's drug-likeness criteria, toxicological assessment revealed varying safety profiles, with two compounds classified as "possibly hazardous" and two as "toxic when swallowed." These findings suggest that amla fruit tea has antibacterial properties through two mechanisms: disruption of protein synthesis and bacterial adhesion. However, its efficacy remains considerably lower than that of conventional antibiotics, suggesting potential applications as complementary therapy rather than antibiotic replacement.
Co-Authors A. A. Bawa Putra A. Intan Saridewi Abd. Rasyid Syamsuri Adnyana , I Made Dwi Mertha Anak Agung Istri Agung Mayun Laksmiwati Dwi Cahya Putra I M E. P. Siregar I M, Sukadana I Nengah Wirajana I Wayan Suirta I. A. R. Astiti Asih Jeane, Magda Mahayani, Putu Ayu Erna Miftakul Sururi N. M. T. Juliasari Ni Komang Ariati Ni Luh Gede Sudaryati Ni Luh Rustini Ni Luh Utari Sumadewi Ni Made Puspawati Ni Made Suaniti Ni Pt. Pande Mirah Surya Dewi Ni Putu Diantariani Nur Hafsia P. P. Dewi P. Suarya Putu Lakustini Cahyaningrum Putut Dewantha Jenar Sri Rahayu Santi Sri Wahjuni Sri Wardani