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Horasdia Saragih
Universitas Advent Indonesia
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Nanoemulsi Campuran Minyak Flower Musk dan Minyak Atsiri Lili Menggunakan Surfaktan PEG 40 Hydrogenated Castor Oil dan Uji Stabilitas Ukurannya Flora Angelita; Horasdia Saragih
Jurnal Fisika Unand Vol 14 No 6 (2025)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.14.6.595-605.2025

Abstract

The use of alcohol-based perfumes often causes skin irritation, prompting the development of water-based perfumes. However, the challenge is that essential oils, the main ingredient in perfumes, are hydrophobic. Nanoemulsion technology offers a solution to this problem. Perfume ingredients are formulated in nanometer sizes, then encapsulated with a surfactant so that they can be dispersed homogeneously in water. This study aims to develop a nanoemulsion mixture of flower musk oil and lily essential oil as a water-based perfume and test its stability. Stability is measured by average diameter, standard deviation, and zeta potential. The nanoemulsion is made using PEG-40 HCO surfactant with the atomization technique. Stability was tested by measuring the average diameter and standard deviation on day 0 and after 120 days of storage. In addition, heating tests were conducted at temperatures of 35°C, 40°C, and 45°C. The results showed that after 120 days of storage, there was an increase in the average diameter and a widening of the size distribution. This was due to the Ostwald ripening phenomenon, whereby smaller nanoemulsion molecules diffused and merged with larger ones. The zeta potential of the nanoemulsion was low (-6.6 to -8.1 mV), which was insufficient to prevent instability. However, when the nanoemulsion was heated, its average diameter decreased. Thermal restructuring occurs in the molecules that make up the nanoemulsion and the PEG-40 HCO molecules that encapsulate the nanoemulsion.
Stabilitas Ukuran Nanoemulsi Parfum Campuran Minyak Atsiri Black Musk dan Lili yang Dienkapsulasi dengan Polimer Tween 80 Endru Saperlin Lawren Ginting; Horasdia Saragih
Jurnal Fisika Unand Vol 15 No 1 (2026)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.15.1.24-33.2026

Abstract

In this study, a perfume mixture of black musk and lily essential oils was nanoemulsified using a tween 80 polymer encapsulator and dispersed in water to produce a water-based perfume. Water was used as a base to replace alcohol, which often causes side effects on the skin. Its size stability was tested, both as a result of storage time and as a result of heating. The purpose of this study was to produce a water-based perfume from a nanoemulsion mixture of black musk and lily essential oils, and to test its size stability. Nanoemulsion was carried out using an atomization technique. The results showed that the average diameter and standard deviation of the nanoemulsion changed after being stored for 120 days and when heated to a temperature of 45oC. The size change during storage was mainly caused by the very small zeta potential, which did not produce sufficient electrostatic repulsion between the nanoemulsions to prevent Ostwald ripening and coalition. The size change due to heating, in addition to the above, was also caused by the increasing kinetic energy of the tween 80 polymer molecules on the surface of the nanoemulsion, which caused a reorganization (solidification) of its structure. Thus, the stability of the size of the nanoemulsion perfume mixture of black musk and lily essential oils produced in this study was greatly influenced by storage time and heating temperature.
Stabilisasi Sterik Polimer Non-Ionik Tween 80 pada Nanopartikel Senyawa Bioaktif Buah Kapulaga Horasdia Saragih
Jurnal Fisika Unand Vol 15 No 2 (2026)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.15.2.164-173.2026

Abstract

The bioactive compounds in cardamom fruit are highly beneficial to health, as they possess anticancer, antioxidant, antibacterial, anti-inflammatory, and antibiotic properties. Therefore, they have great potential to be developed as oral medicines in the future. However, they are highly hydrophobic and consequently insoluble in water. This poses an obstacle to their development. To overcome this problem, bioactive compounds from cardamom fruit have been synthesized into nanometer-sized particles (13.13-19.75 nm) and encapsulated with the nonionic polymer surfactant Tween 80. The results show that Tween 80 surfactant not only acts as an encapsulant for nanoparticles so that they can be dispersed in an aqueous medium, but also acts as a steric stabilizer so that the nanoparticles can remain stable for a long time. Four concentrations of bioactive compounds from cardamom fruit were used, namely: 6, 8, 10, and 12 mg to observe their effect on size stability. All nanoparticles produced from the four concentrations had excellent size stability.
Enkapsulasi Ganda Nanopartikel ZnO dengan Polimer Tween 80 dan Niacinamide: Karakterisasi Ukuran dan Sifat Optik Horasdia Saragih; Donn Richard Ricky; Josua E. Sagala; Endru S. L. Ginting; William Yustian; Jendri Korisano; Josephine H. Ruskandi; Zahra Mediana; Siska Ari; Ovi S. Humau
Jurnal Mandala Pharmacon Indonesia Vol. 12 No. 1 (2026): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v12i1.1256

Abstract

Permasalahan utama penggunaan ZnO sebagai bahan aktif tabir surya adalah munculnya efek white cast akibat ukuran partikel yang besar. Selain itu, ZnO dapat pula menghasilkan oksidan ketika terpapar radiasi ultraviolet. Penelitian ini bertujuan untuk menyintesis nanopartikel ZnO berukuran sangat kecil (skala nanometer) melalui mekanisme enkapsulasi ganda yang mengintegrasikan Tween 80 dan Niacinamide sebagai lapisan pelindung fungsional. Kebaruan utama studi ini terletak pada peran strategis Niacinamide yang diintegrasikan secara molekuler yang bertujuan untuk menghambat aktivitas fotokatalitik nanopartikel ZnO langsung pada permukaannya. Metode enkapsulasi dilakukan dengan variasi konsentrasi Tween 80 (1, 2, 3, dan 4 mL) dalam pelarut etanol, yang dilanjutkan dengan enkapsulasi menggunakan Niacinamide. Hasil penelitian menunjukkan bahwa peningkatan volume Tween 80 secara efektif menurunkan diameter rata-rata hidrodinamik nanopartikel dan meningkatkan homogenitas ukurannya. Sampel dengan 4 mL Tween 80 menunjukkan performa terbaik dengan diameter rata-rata hidrodinamik terkecil sebesar 11,6 nm dan standar deviasi terendah. Karakteristik optik mengonfirmasi bahwa seluruh sampel memiliki transparansi tinggi (>90%) pada spektrum sinar tampak serta penyerapan energi UV yang tajam pada panjang gelombang <450 nm. Penambahan Niacinamide meningkatkan ketebalan lapisan enkapsulasi dan diameter rata-rata hidrodinamik, namun secara bersamaan memperkecil diameter rata-rata inti nanopartikel ZnO. Temuan ini menyimpulkan bahwa sistem enkapsulasi ganda ZnO-Tween 80-Niacinamide merupakan kandidat unggul untuk formulasi tabir surya transparan berperforma tinggi yang bebas dari efek lapisan putih serta diperkaya dengan manfaat antioksidan dari Niacinamide.
Sintesis Dan Karakterisasi Nanopartikel Minyak Atsiri Apel Merah untuk Formulasi Nanoparfum Berbasis Air Yulianita Cristy Anjawati Simalango; Horasdia Saragih
Jurnal Pharmacia Mandala Waluya Vol. 5 No. 3 (2026): Jurnal Pharmacia Mandala Waluya
Publisher : Prodi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54883/jpmw.v5i3.703

Abstract

Kebutuhan parfum berbasis air dan menggunakan bahan pewangi minyak atsiri alami sangat diperlukan karenaparfum berbasis alkohol dan bahan pewangi sintetis cenderung membuat kulit kering dan iritasi. Namun, minyakatsiri alami bersifat hidrofobik sehinggaa tidak larut dalam air. Untuk mengatasi masalah ini teknologi nanopartikeltelah digunakan. Penelitian ini bertujuan untuk mensintesis dan mengkarakterisasi nanopartikel minyak atsiri apelmerah yang dikembangkan untuk formulasi nanoparfum berbasis air. Tujuan penelitian ini adalah untukmenghasilkan nanoparfum berbasis air dari bahan pewangi minyak atsiri apel merah. Sintesis dilakukan denganmenggunakan teknik atomisasi dan polimer PEG-40 HCO digunakan sebagai surfaktan. Dari hasil yang diperolehmenunjukkan bahwa konsentrasi minyak atsiri yang digunakan saat sintesis sangat mempengaruhi banyaknyapopulasi nanopartikel yang dihasilkan, mempengaruhi distribusi ukurannya, diameter rata-rata dan potensialzeta. Diameter rata-rata nanopartikel yang dihasilkan adalah ≤ 296,7 nm. Potensial zetanya terentang dari -1,4mV sampai -5,4 mV, yang tergolong sangat rendah dan mengindikasikan stabilitas elektrostatik yang lemah. Padasebagian formula, ditemukan terbentuknya dua populasi nanopartikel dengan ukuran yang berbeda secarasignifikan, yang merupakan temuan penting dalam penelitian ini. Penelitian ini berada pada tahap sintesis dankarakterisasi nanopartikel, belum mencakup evaluasi performa parfum seperti stabilitas aroma atau uji sensorik.
Sintesa Nanopartikel Senyawa Bioaktif Daun Pegagan (Centella asiatica) dan Uji Pengaruh Pemanasan dan Tekanan Terhadap Diameter dan Indeks Polidispersitasnya Horasdia Saragih
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.74982

Abstract

Senyawa bioaktif daun pegagan memiliki banyak manfaat. Senyawa ini memiliki sifat antioksidan, antimikroba dan antiinflamasi. Senyawa ini telah banyak digunakan untuk menyembuhkan beragam jenis penyakit. Oleh karena itu sangat berpotensi untuk dikembangkan sebagai bahan obat-obatan. Namun sifatnya sangat hidrofobik dan mudah terdegradasi. Untuk mengatasi masalah ini, pendekatan baru yaitu memperkecil ukuran partikelnya berorde nanometer, dapat dilakukan. Tujuan penelitian ini adalah mensintesa partikel senyawa bioaktif daun pegagan berukuran nanometer dan menguji pengaruh pemanasan dan tekanan terhadap diameter dan indeks polidispersitasnya. Senyawa bioaktif daun pegagan diekstrak menggunakan pelarut etanol. Nanopartikelnya disintesa menggunakan surfaktan tween 80. Pengaruh pemberian pemanasan dan tekanan terhadap diameter rata-rata dan indeks polidispersitasnya, diuji. Dari hasil yang diperoleh dengan menggunakan 6 ragam massa konsentrat hasil ekstrak: 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, dan 9 mg yang masing-masing dilarutkan ke dalam 100 mL etanol, diameter rata-rata nanopartikelnya (dan indeks polidispersitas) masing-masing adalah 10,7 nm (0,266); 11,1 nm (0,240); 11,8 nm (0,395); 12,7 nm (0,086); 12,8 nm (0,299); dan 13,2 nm (0,464). Ketika nanopartikel ini dipanaskan pada temperatur 121oC dan tekanan 2 bar selama 15 menit, diameter rata-ratanya menjadi lebih besar: 11,0 nm; 11,3 nm; 12,4 nm; 12,9 nm; 13,5 nm; 14,1 nm; dan indeks polidispersitasnya menjadi lebih kecil: 0,196; 0,202; 0,242; 0,058; 0,274; dan 0,303. Hasil ini menunjukkan bahwa semakin besar massa konsentrat yang digunakan, semakin besar diameter rata-rata nanopartikel yang dihasilkan. Pemberian pemanasan dan tekanan, memperbesar diameter rata-rata nanopartikel dan memperkecil indeks polidispersitasnya.
Sintesis Nanopartikel Minyak Atsiri Gardenia Menggunakan Lapisan Pelindung PolimerPeg-40 Hydrogenated Castor Oil Dan Karakterisasinya Mario Epindonta; Horasdia Saragih
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1547

Abstract

This study focused on the preparation of Gardenia essential oil nanoemulsions using PEG-40 Hydrogenated Castor Oil (PEG-40 HCO) as a surfactant through an atomization method to evaluate the effect of oil concentration on the physical characteristics and electrokinetic properties of the resulting system. Four oil volumes, namely 4, 6, 8, and 10 mL in 80 mL of water, were used as precursors and subsequently analyzed to determine particle size, polydispersity index (PDI), electrophoretic mobility, and zeta potential. The results showed that increasing oil concentration tended to increase the average particle diameter. The obtained PDI values were relatively low; however, their interpretation was conducted cautiously because the system exhibited a bimodal particle size distribution. The zeta potential values ranged from −2.3 to −7.8 mV, while the electrophoretic mobility values ranged from −0.000017 to −0.000060 cm²/Vs. These results indicate changes in particle surface characteristics with increasing essential oil concentration. The characteristics of the resulting nanoemulsion suggest that PEG-40 HCO plays a role in the formation and dispersion of oil droplets in an aqueous medium. Overall, the findings indicate that PEG-40 HCO has potential for the preparation of Gardenia essential oil nanoemulsions with particle sizes in the nanometer range and relatively favorable size distribution characteristics, making them promising for further development in water-based perfume formulations and other cosmetic applications. However, the long-term stability of the system still requires further stability evaluation.
Co-Authors Agus Subagio Agus Subagio Akhiruddin Maddu Albert Manggading Hutapea Albinur Limbong, Albinur Ananda E.J. Lingga Anggraini O. Simanjuntak Anisa Nurraeni Rozi Brianna D. Marcia Dea R. Manalu Donn Richard Ricky Edy Supriyanto Endru S. L. Ginting Endru Saperlin Lawren Ginting Euis Sustini Flora Angelita Gefriella B. Oumaro Hasniah Aliah Hery Sutanto Ina, Febi Rambu Jeanet G.R. Leo Jendri Korisano Josephine H. Ruskandi Josua E. Sagala Karin Kusminarti Ladyos D. Silalahi Maman Budiman Mario Epindonta Marissa Rijoice Mersi Kurniati Michelle A. La'lang Mirthelia Endah Oywari Moehamad Barmawi Moehammad Barmawi Mohamad Barmawi Mohamad Barmawi Mohamad Barmawi Mohamad Barmawi Mohamad Barmawi Mohammad Barmawi Mujamilah Mujamilah Mujamilah Mujamilah Mujamilah Mujamilah Ovi S. Humau Pearlyta Chrisophras Situmorang Pepen Arifin Ridwan Ridwan Ridwan Ridwan Rima S. Nurbayanti RR. Ella Evrita Hestiandari Ruly Y.R.R. Leo Rumanti, Agustina Tri Santika Situmorang Siska Ari Sukirno Sukirno Sukirno Sukirno Sukirno Sukirno Tarigan, Andesmeta Widya A. Siahaan William Yustian William Yustian Winarti, Ratu Sesillia Yulianita Cristy Anjawati Simalango Zahra Mediana