Article Per Year (5 Year)
p-Index From 2021 - 2026
2.994
P-Index
This Author published in this journals
All Journal Jurnal Gizi BERKALA FISIKA Jurnal Sains Materi Indonesia Teika Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Biologi dan Pembelajarannya (JBP) Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences Jurnal Fisika Unand Industria: Jurnal Teknologi dan Manajemen Agroindustri INDONESIAN JOURNAL OF APPLIED PHYSICS Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Biologi Tropis JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Mandala Pharmacon Indonesia Journal of Pharmaceutical and Sciences. Jurnal Pharmacia Mandala Waluya
Horasdia Saragih
Universitas Advent Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

Published : 37 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 37 Documents
Search

 1   2   3   4 
Ekstraksi dan Identifikasi Kandungan Senyawa Bioaktif Daun Saga Rambat (Abrus precatorius) Rumanti, Agustina Tri; Saragih, Horasdia
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 2 (2023): June 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i2.6417

Abstract

Daun saga rambat telah banyak digunakan oleh masyarakat untuk mengobati beragam jenis penyakit. Bioaktivitas ini berkaitan dengan kandungan senyawa metabolit. Selama ini, aktivitas farmakologis daun saga rambat di masyarakat masih berdasarkan bukti empiris. Selain itu, informasi terkait kandungan senyawa bioaktif di daun saga rambut masih terbatas. Pada penelitian ini senyawa metabolit yang terkandung di dalam daun saga rambat diekstrak dan diidentifikasi. Senyawa metabolit diekstraksi dengan metode maserasi menggunakan tiga jenis pelarut, yaitu etanol, metanol dan air. Senyawa pada ketiga ekstrak diidentifikasi dengan gas chromatography – mass spectroscopy (GC-MS). Hasil analisis menunjukkan terdapat 23 senyawa di ekstrak etanol, 9 senyawa di ekstrak metanol, dan 9 senyawa di ekstrak air. Diantara seluruh senyawa pada ketiga ekstrak tersebut, senyawa yang memiliki konsentrasi tinggi adalah (1) octadecenyl aldehyde; (2) n-octadecanoic acid; (3) methyl 6,7-methylene octadecanoate (from trans); dan (4) pentadecanoic acid, 14-methyl-, methyl ester. Dari hasil penelusuran pustaka, keempat senyawa tersebut memiliki aktivitas antioksidan, antibakteri, antivirus dan antiinflamasi. Oleh karena itu, daun saga rambat memiliki potensi untuk dikembangkan sebagai obat herbal dalam pengatasan penyakit-penyakit yang disebabkan oleh bakteri, radikal bebas, virus, dan inflamasi. 
Identifikasi Kandungan Senyawa Bioaktif Buah Kapulaga (Amomum compactum) Tarigan, Andesmeta; Saragih, Horasdia
Jurnal Gizi Vol 12, No 1 (2023): Jurnal Gizi UNIMUS
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jg.12.1.2023.46-51

Abstract

Traditionally, cardamom seed has been widely used by the community as herbal medicine. Cardamom seed has been phenomenologically proven to cure several types of diseases. This property is determined by the type of compounds contained in cardamon seed. The purpose of this research isidentification of the types of bioactive compounds contained in cardamom seed. These bioactive compounds are extracted using solvents: ethanol, methanol and water. Then, these bioactive compounds were identified using gas chromatography-mass spectroscopy (GC-MS) technique. The results obtained indicated that there were 13 types of compounds produced from ethanol extract, 6 types of compounds from methanol extract, and 2 types of compounds from aqueous extracts. From all these compounds, 1,8-cineole and alpha-terpineol compounds are the two most dominantsequentially. Referring to these results and the literature search that has been done, cardamom seed is potential to be developed in the future as herbal medicine to treat diseases, such as: diarrhea, cardiovascular disease, digestive disease, Alzheimer's, tumors, inflammation, cancer, pneumonia, neurodegenerative and respiratory diseases.Keywords : Compound identification, extract, cardamom seed, cineole, terpineol.
Nanoemulsion of Cardamom Fruit Extract (Amomum compactum) and its Characterization Ina, Febi Rambu; Saragih, Horasdia
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8902

Abstract

The development of medicinal materials from bioactive compounds of plants continues to be carried out. Various problems that occur in it continue to be overcome. Bioactive compounds of plants are known to be hydrophobic, including bioactive compounds from cardamom fruit, so that these compounds are difficult to deliver into the organs of the body. To overcome this problem, nanoemulsion techniques have been carried out. The purpose of this study was to produce nanoemulsions of bioactive compounds of cardamom fruit and to study their characteristics. Nanoemulsions of bioactive compounds of cardamom fruit have been synthesized using a microtube equipment system by utilizing the characteristics of the flow pattern of its liquid segment which is circulative forming a vortex in a very small size. The nanoemulsions obtained have a diameter ranging from 15.2 nm to 19.7 nm. The diameter increases when the mass of the bioactive compound concentrate of cardamom fruit is increased. The polydispersity index ranges from 0.341 to 0.637; the average electrophoretic mobility ranges from -0.000010 cm2/V.s to -0.000062 cm2/V.s and the zeta potential from -1.3 mV to -8.1 mV. From the results obtained, it shows that the obtained nanoemulsions have a relatively very small average diameter, their size distribution is relatively heterogeneous and the surface charge surrounding the nanoemulsions is negative. However, the zeta potential is still relatively small so that it has the potential to be less stable. Therefore, an effort to increase the magnitude of the zeta potential in the future needs to be done.
Pengaruh Penyimpanan dan Pemanasan Terhadap Perubahan Ukuran Nanopartikel Parfum Campuran Minyak Royal Musk dan Minyak Atsiri Lili yang Disintesis Menggunakan Surfaktan Polimer PEG-40 HCO Winarti, Ratu Sesillia; Saragih, Horasdia
Jurnal Fisika Unand Vol 14 No 5 (2025)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.14.5.516-525.2025

Abstract

The purpose of this study was to produce perfume nanoparticles made from a mixture of royal musk oil and lily essential oil that can be dispersed in an aqueous medium and to investigate their size stability after storage and heating. The perfume nanoparticles were synthesized using an atomization technique with PEG-40 HCO as a surfactant, and their stability was evaluated through storage for up to 120 days and heating at temperature up to 45 °C. The results showed that storage for 120 days significantly increased the average particle diameter and its standard deviation. Heating also caused a significant increase in nanoparticle size. These findings indicate that the size of the perfume nanoparticles was not stable, as the zeta potential and the presence of PEG-40 HCO surfactant could not provide sufficient electrostatic and steric protection. Consequently, coalescence and Ostwald ripening occurred in the nanoparticles.
Ekstraksi dan Identifikasi Kandungan Senyawa Bioaktif Daun Saga Rambat (Abrus precatorius) Rumanti, Agustina Tri; Saragih, Horasdia
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 2 (2023): June 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i2.6417

Abstract

Daun saga rambat telah banyak digunakan oleh masyarakat untuk mengobati beragam jenis penyakit. Bioaktivitas ini berkaitan dengan kandungan senyawa metabolit. Selama ini, aktivitas farmakologis daun saga rambat di masyarakat masih berdasarkan bukti empiris. Selain itu, informasi terkait kandungan senyawa bioaktif di daun saga rambut masih terbatas. Pada penelitian ini senyawa metabolit yang terkandung di dalam daun saga rambat diekstrak dan diidentifikasi. Senyawa metabolit diekstraksi dengan metode maserasi menggunakan tiga jenis pelarut, yaitu etanol, metanol dan air. Senyawa pada ketiga ekstrak diidentifikasi dengan gas chromatography – mass spectroscopy (GC-MS). Hasil analisis menunjukkan terdapat 23 senyawa di ekstrak etanol, 9 senyawa di ekstrak metanol, dan 9 senyawa di ekstrak air. Diantara seluruh senyawa pada ketiga ekstrak tersebut, senyawa yang memiliki konsentrasi tinggi adalah (1) octadecenyl aldehyde; (2) n-octadecanoic acid; (3) methyl 6,7-methylene octadecanoate (from trans); dan (4) pentadecanoic acid, 14-methyl-, methyl ester. Dari hasil penelusuran pustaka, keempat senyawa tersebut memiliki aktivitas antioksidan, antibakteri, antivirus dan antiinflamasi. Oleh karena itu, daun saga rambat memiliki potensi untuk dikembangkan sebagai obat herbal dalam pengatasan penyakit-penyakit yang disebabkan oleh bakteri, radikal bebas, virus, dan inflamasi. 
Konsentrasi dan Energi Urbach Nanopartikel ZnO yang Disintesis Menggunakan Enkapsulan Tween 80 Horasdia Saragih; William Yustian; Ananda E.J. Lingga; Anggraini O. Simanjuntak; Brianna D. Marcia; Dea R. Manalu; Gefriella B. Oumaro; Jeanet G.R. Leo; Karin Kusminarti; Ladyos D. Silalahi; Michelle A. La'lang; Rima S. Nurbayanti; Ruly Y.R.R. Leo; Santika Situmorang; Widya A. Siahaan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1527

Abstract

Excessive exposure to ultraviolet (UV) radiation can cause skin damage, necessitating the development of effective and transparent sunscreen materials. ZnO nanoparticles are a promising candidate; however, they often suffer from agglomeration, which degrades their optical performance. This study aims to investigate the effect of varying concentrations of Tween 80 as an encapsulating agent on the optical and structural characteristics of ZnO nanoparticles. The nanoparticles were synthesized using a rotor–stator homogenization method with Tween 80 concentrations ranging from 2 to 5 mL (each dissolved in 50 mL of ethanol), followed by characterization using UV–Vis spectroscopy. The results indicate that increasing the concentration of Tween 80 enhances the concentration of ZnO nanoparticles without significantly altering the average particle size (~2.44 nm), resulting in a monodisperse system. Urbach energy analysis reveals that crystal order improves up to an optimum at 4 mL of Tween 80, followed by a slight decrease at higher concentrations. Optically, all samples exhibit strong absorption in the UV region and high transmittance in the visible range (95–100%). These findings demonstrate that the synthesized ZnO nanoparticles have strong potential as a sunscreen. It is concluded that Tween 80 plays a crucial role in controlling the growth, crystal structure, and optical properties of ZnO nanoparticles, with the optimum concentration yielding the best performance.
Stabilitas Ukuran dan Sifat Optik Nanopartikel ZnO yang Dilapisi Polimer Tween 80 Mirthelia Endah Oywari; Donn Richard Ricky; Horasdia Saragih
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1542

Abstract

Background: ZnO nanoparticles are widely used as UV filters in sunscreens due to their broad-spectrum protection and aesthetic transparency. However, agglomeration caused by high surface energy often compromises their efficacy. Coating with non-ionic polymers such as Tween 80 represents a potential stabilization strategy. Objective: This study aims to investigate the effect of varying Tween 80 concentrations on the size stability and optical properties of ZnO nanoparticles. Methods: Tween 80-coated ZnO nanoparticles were synthesized via a solvolysis method assisted by a rotor-stator homogenizer at Tween 80 volume variations of 1, 2, 3, and 4 mL in 50 mL of ethanol. Characterization was performed using a Particle Size Analyzer (PSA) and a UV-Vis spectrophotometer at day 0 and day 60. Results: Increasing Tween 80 concentration significantly reduced the mean diameter of nanoparticles from 17.9 nm to 11.4 nm and narrowed the size distribution (standard deviation decreased from 13.2 nm to 2.8 nm). The zeta potential remained near zero (-0.1 to -0.2 mV) due to the non-ionic nature of Tween 80, yet colloidal stability was maintained through a steric hindrance mechanism. After 60 days of storage, the 4 mL Tween 80 concentration was the most effective in limiting size growth (only 2.6%), compared to 83.7% for the 1 mL concentration. All samples exhibited high transmittance (>87%) in the visible light spectrum while maintaining strong UV absorption. Conclusion: An optimal Tween 80 concentration (4 mL in 50 mL ethanol) is crucial for producing ZnO nanoparticles with long-term size stability and superior optical properties, making them promising for next-generation sunscreen cosmetic formulations.
Chemical Fingerprint and Initial Physicochemical Behavior of Tween 80-Assisted Nanoscale Aqueous Dispersion of Bioactive Java Cardamom Extract: Hydrodynamic Size and Near-Neutral Electrokinetic Profile Saragih, Horasdia
Industria: Jurnal Teknologi dan Manajemen Agroindustri Vol 15, No 1 (2026): IN PROGRESS
Publisher : Department of Agro-industrial Technology, University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.industria.2026.015.01.1

Abstract

AbstractThis study evaluated the chemical profile, hydrodynamic diameter, polydispersity index, electrophoretic mobility, and zeta potential of cardamom extract dispersions. Concentrates were obtained by ethanol extraction of dried cardamom, analyzed using gas chromatography–mass spectrometry, and dispersed at masses of 6, 8, 10, and 12 mg using a liquid–gas flow system. Particle characteristics were determined using a particle size and zeta analyzer. The analysis revealed 14 peaks and 12 identified compounds, with 1,8-cineole, α-terpineol, 3-pentanol (diethyl carbinol), and piperine as the major components. Hydrodynamic diameter increased from 12.0 to 19.2 nm, while polydispersity index increased from 0.084 to 0.492, indicating greater size heterogeneity. Zeta potential ranged from 0.0 to −0.8 mV, indicating weak electrostatic stabilization. Tween 80 likely promoted initial dispersion through steric hindrance and surface hydration rather than strong charge repulsion. These findings do not indicate morphology, encapsulation, temporal stability, or bioavailability. These findings provide a physicochemical basis for developing aqueous cardamom extract dispersions while avoiding overinterpretation of near-neutral zeta potential as evidence of long-term colloidal stability.Keywords: Amomum compactum, cardamom extract, Tween 80, hydrodynamic diameter, zeta potential AbstrakPenelitian ini mengevaluasi profil kimia, diameter hidrodinamik, indeks polidispersitas, mobilitas elektroporetik, dan zeta potential dispersi ekstrak kapulaga. Konsentrat diperoleh melalui ekstraksi etanol kapulaga kering, dianalisis memakai kromatografi gas-spektrometri massa, lalu didispersikan pada massa 6, 8, 10, dan 12 mg melalui sistem alir cair-gas dalam tabung mikro. Karakter diukur menggunakan penganalisis ukuran partikel dan zeta. Analisis kimia menghasilkan 14 puncak dan 12 senyawa teridentifikasi, dengan 1,8-cineole, alpha-terpineol, 3-pentanol atau diethyl carbinol, serta piperine sebagai komponen dominan. Diameter hidrodinamik meningkat dari 12,0 menjadi 19,2 nm. Indeks polidispersitas naik dari 0,084 menjadi 0,492, menandakan distribusi ukuran heterogen. Zeta potential berada dekat netral, yaitu 0,0 sampai -0,8 mV, sehingga stabilisasi elektrostatik diperkirakan lemah. Pendispersian awal mungkin dibantu Tween 80 melalui penghalang sterik dan hidrasi permukaan, bukan tolakan muatan kuat. Temuan ini tidak menyimpulkan morfologi, enkapsulasi, stabilitas temporal, atau bioavailabilitas. Temuan ini memberikan dasar fisikokimia awal untuk mengembangkan sistem dispersi berair dari ekstrak bioaktif kapulaga, sekaligus menghindari interpretasi berlebihan terhadap potensi zeta yang mendekati netral sebagai bukti stabilitas koloid jangka panjang.Kata kunci: Amomum compactum, diameter hidrodinamik, ekstrak kapulaga, Tween 80, zeta potential
Mengekstrak Senyawa Bioaktif yang Terkandung pada Kulit Kayu Manis dan Mengidentifikasinya dengan Teknik Gas Chromatography – Mass Spectroscopy (GC-MS) Marissa Rijoice; Horasdia Saragih
Jurnal Biologi dan Pembelajarannya (JB&P) Vol 9 No 1 (2022): APRIL 2022
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/jbp.v9i1.17633

Abstract

The bioactive compounds contained in cinnamon bark have been extracted. Extraction carried out using ethanol, methanol and water as solvents. The type of compound extracted identified by gas chromatography - mass spectroscopy (GC-MS) technique. From result the identification carried out, obtained as many as eight types of compounds, namely: using ethanol as solvent: (1) cinnamaldehyde, (2) bornylester of acrylic acid, (3) alpha-copaene, (4)Cumarine, and (5) methyl isoheptadecanoate; generated with using methanol as solvent: (6) trioctanoin and (7) 1-hydroxy-2,2-dimethyldecane; and that produced using water as a solvent is (8) 2,5-cyclooctadienol. of the eight Of these compounds, the most dominant is cinnamaldehyde. This shows that the bark Sweet has the main content, cinnamaldehyde. Because the main content is cinnamaldehyde, then cinnamon bark has the potential to be developed in the future as an ingredient herbs for, among others, as anti-diabetic and anti-viral therapy, due to cinnamaldehyde has the character of being able to lower blood sugar levels and is very attractive to weaken the virus. Keywords: Extract, bioactive compounds, cinnamon bark, Gas Chromatography, Mass Spectroscopy.
Sintesis Nanopartikel ZnO Menggunakan Prekursor ZnCl2 dan Polimer Penstabil Tween 80 untuk Aplikasi Tabir Surya Anisa Nurraeni Rozi; Horasdia Saragih
Jurnal Fisika Unand Vol 14 No 6 (2025)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.14.6.585-594.2025

Abstract

ZnO nanoparticles are semiconductor materials with a wide energy band gap (3.37 eV), making them excellent for use as sunscreen ingredients due to their superior ultraviolet protection properties. ZnO nanoparticles are superior to other conventional sunscreen materials because they do not cause skin irritation or allergies. The purpose of this study was to synthesize ZnO nanoparticles as a sunscreen material using Tween 80 stabilizing polymer and to comprehensively examine the effect of Tween 80 concentration on the characteristics of the resulting ZnO nanoparticle sunscreen. ZnO nanoparticles were synthesized using ZnCl2 and Tween 80 precursors with a Rotor Stator Homogenizer equipment system. Four different concentrations of Tween 80 were used to observe their effect on the characteristics of the resulting ZnO nanoparticles. The results showed that the average diameter of ZnO nanoparticles, their polydispersity index, and their zeta potential decreased as the concentration of Tween 80 used increased. Their optical transmittance was very high in the visible light spectrum and very low in the ultraviolet spectrum, especially for ZnO nanoparticles with the smallest average diameter (11.6 nm). This means that the visible light transmission and ultraviolet light absorption are excellent. In addition, the absorption edge is also very sharp. These three properties indicate that the ZnO nanoparticles produced are very suitable and have great potential for use as a sunscreen material.
Co-Authors Agus Subagio Agus Subagio Akhiruddin Maddu Albert Manggading Hutapea Albinur Limbong, Albinur Ananda E.J. Lingga Anggraini O. Simanjuntak Anisa Nurraeni Rozi Brianna D. Marcia Dea R. Manalu Donn Richard Ricky Edy Supriyanto Endru S. L. Ginting Endru Saperlin Lawren Ginting Euis Sustini Flora Angelita Gefriella B. Oumaro Hasniah Aliah Hery Sutanto Ina, Febi Rambu Jeanet G.R. Leo Jendri Korisano Josephine H. Ruskandi Josua E. Sagala Karin Kusminarti Ladyos D. Silalahi Maman Budiman Mario Epindonta Marissa Rijoice Mersi Kurniati Michelle A. La'lang Mirthelia Endah Oywari Moehamad Barmawi Moehammad Barmawi Mohamad Barmawi Mohamad Barmawi Mohamad Barmawi Mohamad Barmawi Mohamad Barmawi Mohammad Barmawi Mujamilah Mujamilah Mujamilah Mujamilah Mujamilah Mujamilah Ovi S. Humau Pearlyta Chrisophras Situmorang Pepen Arifin Ridwan Ridwan Ridwan Ridwan Rima S. Nurbayanti RR. Ella Evrita Hestiandari Ruly Y.R.R. Leo Rumanti, Agustina Tri Santika Situmorang Siska Ari Sukirno Sukirno Sukirno Sukirno Sukirno Sukirno Tarigan, Andesmeta Widya A. Siahaan William Yustian William Yustian Winarti, Ratu Sesillia Yulianita Cristy Anjawati Simalango Zahra Mediana