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Ekstraksi dan Identifikasi Kandungan Senyawa Bioaktif Daun Saga Rambat (Abrus precatorius) Rumanti, Agustina Tri; Saragih, Horasdia
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 2 (2023): June 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i2.6417

Daun saga rambat telah banyak digunakan oleh masyarakat untuk mengobati beragam jenis penyakit. Bioaktivitas ini berkaitan dengan kandungan senyawa metabolit. Selama ini, aktivitas farmakologis daun saga rambat di masyarakat masih berdasarkan bukti empiris. Selain itu, informasi terkait kandungan senyawa bioaktif di daun saga rambut masih terbatas. Pada penelitian ini senyawa metabolit yang terkandung di dalam daun saga rambat diekstrak dan diidentifikasi. Senyawa metabolit diekstraksi dengan metode maserasi menggunakan tiga jenis pelarut, yaitu etanol, metanol dan air. Senyawa pada ketiga ekstrak diidentifikasi dengan gas chromatography – mass spectroscopy (GC-MS). Hasil analisis menunjukkan terdapat 23 senyawa di ekstrak etanol, 9 senyawa di ekstrak metanol, dan 9 senyawa di ekstrak air. Diantara seluruh senyawa pada ketiga ekstrak tersebut, senyawa yang memiliki konsentrasi tinggi adalah (1) octadecenyl aldehyde; (2) n-octadecanoic acid; (3) methyl 6,7-methylene octadecanoate (from trans); dan (4) pentadecanoic acid, 14-methyl-, methyl ester. Dari hasil penelusuran pustaka, keempat senyawa tersebut memiliki aktivitas antioksidan, antibakteri, antivirus dan antiinflamasi. Oleh karena itu, daun saga rambat memiliki potensi untuk dikembangkan sebagai obat herbal dalam pengatasan penyakit-penyakit yang disebabkan oleh bakteri, radikal bebas, virus, dan inflamasi.

Identifikasi Kandungan Senyawa Bioaktif Buah Kapulaga (Amomum compactum) Tarigan, Andesmeta; Saragih, Horasdia
Jurnal Gizi Vol 12, No 1 (2023): Jurnal Gizi UNIMUS
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jg.12.1.2023.46-51

Traditionally, cardamom seed has been widely used by the community as herbal medicine. Cardamom seed has been phenomenologically proven to cure several types of diseases. This property is determined by the type of compounds contained in cardamon seed. The purpose of this research isidentification of the types of bioactive compounds contained in cardamom seed. These bioactive compounds are extracted using solvents: ethanol, methanol and water. Then, these bioactive compounds were identified using gas chromatography-mass spectroscopy (GC-MS) technique. The results obtained indicated that there were 13 types of compounds produced from ethanol extract, 6 types of compounds from methanol extract, and 2 types of compounds from aqueous extracts. From all these compounds, 1,8-cineole and alpha-terpineol compounds are the two most dominantsequentially. Referring to these results and the literature search that has been done, cardamom seed is potential to be developed in the future as herbal medicine to treat diseases, such as: diarrhea, cardiovascular disease, digestive disease, Alzheimer's, tumors, inflammation, cancer, pneumonia, neurodegenerative and respiratory diseases.Keywords : Compound identification, extract, cardamom seed, cineole, terpineol.

Sintesa Nanopartikel Senyawa Bioaktif Daun Pegagan (Centella asiatica) dan Uji Pengaruh Pemanasan dan Tekanan Terhadap Diameter dan Indeks Polidispersitasnya Horasdia Saragih
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.74982

Senyawa bioaktif daun pegagan memiliki banyak manfaat. Senyawa ini memiliki sifat antioksidan, antimikroba dan antiinflamasi. Senyawa ini telah banyak digunakan untuk menyembuhkan beragam jenis penyakit. Oleh karena itu sangat berpotensi untuk dikembangkan sebagai bahan obat-obatan. Namun sifatnya sangat hidrofobik dan mudah terdegradasi. Untuk mengatasi masalah ini, pendekatan baru yaitu memperkecil ukuran partikelnya berorde nanometer, dapat dilakukan. Tujuan penelitian ini adalah mensintesa partikel senyawa bioaktif daun pegagan berukuran nanometer dan menguji pengaruh pemanasan dan tekanan terhadap diameter dan indeks polidispersitasnya. Senyawa bioaktif daun pegagan diekstrak menggunakan pelarut etanol. Nanopartikelnya disintesa menggunakan surfaktan tween 80. Pengaruh pemberian pemanasan dan tekanan terhadap diameter rata-rata dan indeks polidispersitasnya, diuji. Dari hasil yang diperoleh dengan menggunakan 6 ragam massa konsentrat hasil ekstrak: 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, dan 9 mg yang masing-masing dilarutkan ke dalam 100 mL etanol, diameter rata-rata nanopartikelnya (dan indeks polidispersitas) masing-masing adalah 10,7 nm (0,266); 11,1 nm (0,240); 11,8 nm (0,395); 12,7 nm (0,086); 12,8 nm (0,299); dan 13,2 nm (0,464). Ketika nanopartikel ini dipanaskan pada temperatur 121oC dan tekanan 2 bar selama 15 menit, diameter rata-ratanya menjadi lebih besar: 11,0 nm; 11,3 nm; 12,4 nm; 12,9 nm; 13,5 nm; 14,1 nm; dan indeks polidispersitasnya menjadi lebih kecil: 0,196; 0,202; 0,242; 0,058; 0,274; dan 0,303. Hasil ini menunjukkan bahwa semakin besar massa konsentrat yang digunakan, semakin besar diameter rata-rata nanopartikel yang dihasilkan. Pemberian pemanasan dan tekanan, memperbesar diameter rata-rata nanopartikel dan memperkecil indeks polidispersitasnya.

Nanoemulsion of Cardamom Fruit Extract (Amomum compactum) and its Characterization Ina, Febi Rambu; Saragih, Horasdia
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8902

The development of medicinal materials from bioactive compounds of plants continues to be carried out. Various problems that occur in it continue to be overcome. Bioactive compounds of plants are known to be hydrophobic, including bioactive compounds from cardamom fruit, so that these compounds are difficult to deliver into the organs of the body. To overcome this problem, nanoemulsion techniques have been carried out. The purpose of this study was to produce nanoemulsions of bioactive compounds of cardamom fruit and to study their characteristics. Nanoemulsions of bioactive compounds of cardamom fruit have been synthesized using a microtube equipment system by utilizing the characteristics of the flow pattern of its liquid segment which is circulative forming a vortex in a very small size. The nanoemulsions obtained have a diameter ranging from 15.2 nm to 19.7 nm. The diameter increases when the mass of the bioactive compound concentrate of cardamom fruit is increased. The polydispersity index ranges from 0.341 to 0.637; the average electrophoretic mobility ranges from -0.000010 cm2/V.s to -0.000062 cm2/V.s and the zeta potential from -1.3 mV to -8.1 mV. From the results obtained, it shows that the obtained nanoemulsions have a relatively very small average diameter, their size distribution is relatively heterogeneous and the surface charge surrounding the nanoemulsions is negative. However, the zeta potential is still relatively small so that it has the potential to be less stable. Therefore, an effort to increase the magnitude of the zeta potential in the future needs to be done.

Pengaruh Penyimpanan dan Pemanasan Terhadap Perubahan Ukuran Nanopartikel Parfum Campuran Minyak Royal Musk dan Minyak Atsiri Lili yang Disintesis Menggunakan Surfaktan Polimer PEG-40 HCO Winarti, Ratu Sesillia; Saragih, Horasdia
Jurnal Fisika Unand Vol 14 No 5 (2025)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.14.5.516-525.2025

The purpose of this study was to produce perfume nanoparticles made from a mixture of royal musk oil and lily essential oil that can be dispersed in an aqueous medium and to investigate their size stability after storage and heating. The perfume nanoparticles were synthesized using an atomization technique with PEG-40 HCO as a surfactant, and their stability was evaluated through storage for up to 120 days and heating at temperature up to 45 °C. The results showed that storage for 120 days significantly increased the average particle diameter and its standard deviation. Heating also caused a significant increase in nanoparticle size. These findings indicate that the size of the perfume nanoparticles was not stable, as the zeta potential and the presence of PEG-40 HCO surfactant could not provide sufficient electrostatic and steric protection. Consequently, coalescence and Ostwald ripening occurred in the nanoparticles.

Ekstraksi dan Identifikasi Kandungan Senyawa Bioaktif Daun Saga Rambat (Abrus precatorius) Rumanti, Agustina Tri; Saragih, Horasdia
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 2 (2023): June 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i2.6417

Daun saga rambat telah banyak digunakan oleh masyarakat untuk mengobati beragam jenis penyakit. Bioaktivitas ini berkaitan dengan kandungan senyawa metabolit. Selama ini, aktivitas farmakologis daun saga rambat di masyarakat masih berdasarkan bukti empiris. Selain itu, informasi terkait kandungan senyawa bioaktif di daun saga rambut masih terbatas. Pada penelitian ini senyawa metabolit yang terkandung di dalam daun saga rambat diekstrak dan diidentifikasi. Senyawa metabolit diekstraksi dengan metode maserasi menggunakan tiga jenis pelarut, yaitu etanol, metanol dan air. Senyawa pada ketiga ekstrak diidentifikasi dengan gas chromatography – mass spectroscopy (GC-MS). Hasil analisis menunjukkan terdapat 23 senyawa di ekstrak etanol, 9 senyawa di ekstrak metanol, dan 9 senyawa di ekstrak air. Diantara seluruh senyawa pada ketiga ekstrak tersebut, senyawa yang memiliki konsentrasi tinggi adalah (1) octadecenyl aldehyde; (2) n-octadecanoic acid; (3) methyl 6,7-methylene octadecanoate (from trans); dan (4) pentadecanoic acid, 14-methyl-, methyl ester. Dari hasil penelusuran pustaka, keempat senyawa tersebut memiliki aktivitas antioksidan, antibakteri, antivirus dan antiinflamasi. Oleh karena itu, daun saga rambat memiliki potensi untuk dikembangkan sebagai obat herbal dalam pengatasan penyakit-penyakit yang disebabkan oleh bakteri, radikal bebas, virus, dan inflamasi.

Sintesis Nanopartikel ZnO Menggunakan Prekursor ZnCl2 dan Polimer Penstabil Tween 80 untuk Aplikasi Tabir Surya Rozi, Anisa Nurraeni; Saragih, Horasdia
Jurnal Fisika Unand Vol 14 No 6 (2025)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.14.6.585-594.2025

ZnO nanoparticles are semiconductor materials with a wide energy band gap (3.37 eV), making them excellent for use as sunscreen ingredients due to their superior ultraviolet protection properties. ZnO nanoparticles are superior to other conventional sunscreen materials because they do not cause skin irritation or allergies. The purpose of this study was to synthesize ZnO nanoparticles as a sunscreen material using Tween 80 stabilizing polymer and to comprehensively examine the effect of Tween 80 concentration on the characteristics of the resulting ZnO nanoparticle sunscreen. ZnO nanoparticles were synthesized using ZnCl2 and Tween 80 precursors with a Rotor Stator Homogenizer equipment system. Four different concentrations of Tween 80 were used to observe their effect on the characteristics of the resulting ZnO nanoparticles. The results showed that the average diameter of ZnO nanoparticles, their polydispersity index, and their zeta potential decreased as the concentration of Tween 80 used increased. Their optical transmittance was very high in the visible light spectrum and very low in the ultraviolet spectrum, especially for ZnO nanoparticles with the smallest average diameter (11.6 nm). This means that the visible light transmission and ultraviolet light absorption are excellent. In addition, the absorption edge is also very sharp. These three properties indicate that the ZnO nanoparticles produced are very suitable and have great potential for use as a sunscreen material.

Nanoemulsi Campuran Minyak Flower Musk dan Minyak Atsiri Lili Menggunakan Surfaktan PEG 40 Hydrogenated Castor Oil dan Uji Stabilitas Ukurannya Angelita, Flora; Saragih, Horasdia
Jurnal Fisika Unand Vol 14 No 6 (2025)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.14.6.595-605.2025

The use of alcohol-based perfumes often causes skin irritation, prompting the development of water-based perfumes. However, the challenge is that essential oils, the main ingredient in perfumes, are hydrophobic. Nanoemulsion technology offers a solution to this problem. Perfume ingredients are formulated in nanometer sizes, then encapsulated with a surfactant so that they can be dispersed homogeneously in water. This study aims to develop a nanoemulsion mixture of flower musk oil and lily essential oil as a water-based perfume and test its stability. Stability is measured by average diameter, standard deviation, and zeta potential. The nanoemulsion is made using PEG-40 HCO surfactant with the atomization technique. Stability was tested by measuring the average diameter and standard deviation on day 0 and after 120 days of storage. In addition, heating tests were conducted at temperatures of 35°C, 40°C, and 45°C. The results showed that after 120 days of storage, there was an increase in the average diameter and a widening of the size distribution. This was due to the Ostwald ripening phenomenon, whereby smaller nanoemulsion molecules diffused and merged with larger ones. The zeta potential of the nanoemulsion was low (-6.6 to -8.1 mV), which was insufficient to prevent instability. However, when the nanoemulsion was heated, its average diameter decreased. Thermal restructuring occurs in the molecules that make up the nanoemulsion and the PEG-40 HCO molecules that encapsulate the nanoemulsion.

Mengekstrak Senyawa Bioaktif yang Terkandung pada Kulit Kayu Manis dan Mengidentifikasinya dengan Teknik Gas Chromatography – Mass Spectroscopy (GC-MS) Marissa Rijoice; Saragih, Horasdia
Jurnal Biologi dan Pembelajarannya (JB&P) Vol 9 No 1 (2022): APRIL 2022
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/jbp.v9i1.17633

The bioactive compounds contained in cinnamon bark have been extracted. Extraction carried out using ethanol, methanol and water as solvents. The type of compound extracted identified by gas chromatography - mass spectroscopy (GC-MS) technique. From result the identification carried out, obtained as many as eight types of compounds, namely: using ethanol as solvent: (1) cinnamaldehyde, (2) bornylester of acrylic acid, (3) alpha-copaene, (4)Cumarine, and (5) methyl isoheptadecanoate; generated with using methanol as solvent: (6) trioctanoin and (7) 1-hydroxy-2,2-dimethyldecane; and that produced using water as a solvent is (8) 2,5-cyclooctadienol. of the eight Of these compounds, the most dominant is cinnamaldehyde. This shows that the bark Sweet has the main content, cinnamaldehyde. Because the main content is cinnamaldehyde, then cinnamon bark has the potential to be developed in the future as an ingredient herbs for, among others, as anti-diabetic and anti-viral therapy, due to cinnamaldehyde has the character of being able to lower blood sugar levels and is very attractive to weaken the virus. Keywords: Extract, bioactive compounds, cinnamon bark, Gas Chromatography, Mass Spectroscopy.

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