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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Sains dan Teknologi Pangan Science and Technology Indonesia JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) AL MUNIR : Jurnal Komunikasi dan Penyiaran Islam
Lili Fitriani
Faculty Of Pharmacy, Univ. Of Andalas, Padang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Formulation and evaluation of orally disintegrating film (ODF) containing piperine-succinic acid cocrystal Uswatul Hasanah; Lili Fitriani; Verlia Nisrina Putri; Erizal Zaini
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (537.336 KB) | DOI: 10.12928/pharmaciana.v13i1.25286

Abstract

Piperine is a type of alkaloid found in plants of the Piperaceae family, including Piper nigrum and Piper longum, which has numerous pharmacological properties and is being developed as a nutraceutical. However, its poor solubility makes delivering in effective doses for therapeutic purposes challenging. To overcome this limitation, the cocrystals of piperine and succinic acid was prepared, which are more soluble, and then formulated into orally disintegrating films (ODFs) for better delivery. The cocrystals were formed using the slurry method, while the ODFs were made using the solvent-casting method with different concentrations of hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG) 400. The resulting films were evaluated for various parameters, such as their organoleptic characteristics, weight and thickness uniformity, pH, moisture content, swelling properties, and disintegration time. The results showed that the ODF with 6% HPMC as a film-forming polymer and 0.6% PEG 400 as a plasticizer loaded with 10 mg of piperine in the form of piperine-succinic acid cocrystal was the best formula. This ODF formulation disintegrated in less than one minute and was found to be a good film with uniform content.
Pembentukan dan Karakterisasi Multikomponen Kristal Aseklofenak – Asam Suksinat Dengan Metode Solvent Drop Grinding. Adhitya Jessica; Annisa Agustina; Lili Fitriani; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.138-145.2022

Abstract

Aseklofenak merupakan obat golongan antiinflamasi nonsteroid (OAINS) yang mempunyai efek farmakologi utama sebagai antiinflamasi dan analgesik, turunan asam fenil asetat. Namun, aseklofenak memiliki kelarutan yang rendah sehingga mempengaruhi bioavaibilitasnya. Penelitian ini bertujuan untuk memperbaiki laju disolusi aseklofenak melalui pembentukan multikomponen kristal dengan metode pembuatan solvent drop grinding dan asam suksinat sebagai koformer. Multikomponen kristal yang terbentuk dikarakterisasi menggunakan instrumen Powder X-ray Diffractor (PXRD), Differential Scanning Calorimeter (DSC), Fourier Transform Infrared (FT-IR) spectrometer, dan Scanning Electron Microscope (SEM). Aseklofenak yang terlarut dan terdisolusi ditentukan dengan spektrofotometer UV-Vis. Hasil karakterisasi dari multikomponen kristal: penurunan intensitas puncak pada difraktogram, penurunan titik lebur dan nilai entalpi peleburan pada  termogram, pergeseran yang tidak signifikan pada bilangan gelombang spektrum spektroskopi FT-IR, dan habit kristal baru pada hasil SEM. Hasil uji disolusi aseklofenak murni, campuran fisik dan multikomponen kristal aseklofenak-asam suksinat dalam medium dapar fosfat pH 6,8 dengan sodium lauril sulfat 0,1 % pada menit ke-60 secara berturut-turut adalah 8,43 %, 26,60 % dan 34,14 %. Dari hasil penelitian ini dapat disimpulkan bahwa multikomponen kristal aseklofenak - asam suksinat yang terbentuk merupakan tipe campuran eutektik dan dapat meningkatkan laju disolusi aseklofenak 4,09 kali dibandingkan aseklofenak murni.
PELATIHAN PEMBUATAN JAMU JAHE MERAH INSTAN DI PASIE JAMBAK KOTA PADANG Nova Syafni; Wiwik Hanifah; Ryan Fajri Kurniawan; Lili Fitriani; Suryati Suryati
Jurnal Hilirisasi IPTEKS Vol 6 No 3 (2023)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v6i3.675

Abstract

The majority of the population in the Pasie Jambak area depends on fishing as their livelihood, which requires them to be in excellent physical condition to carry out their work. Red ginger is one of the most commonly found plants in the market and is known to have benefits in maintaining bodily stamina. Therefore, the Student Executive Board of the Faculty of Pharmacy, Andalas University, in collaboration with faculty members and students, conducted training in the production of instant red ginger herbal drinks with the aim of making it a convenient health beverage for the fishing community, suitable for consumption during their fishing trips. This training was attended by a large number of women residing in the vicinity of Pasie Jambak, Padang City. The training process consisted of several stages. The first stage involved an explanation of the benefits of red ginger, followed by the second stage, which was a practical session on the production of instant red ginger herbal drinks using red ginger rhizomes, sugar, and water. The subsequent stage focused on the packaging of the red ginger product and the proper method of preparing the beverage. The training activities concluded with a discussion session and the completion of questionnaires regarding the implementation of the training. The results of this training demonstrated that the participants were able to smoothly produce and package instant red ginger herbal drinks. The questionnaire results also indicated that overall, all participants were satisfied with the training activities. Therefore, it is expected that this training will provide significant benefits to the community in the Pasie Jambak area, helping to improve their health and offering a practical solution for fishermen who require good physical stamina to carry out their work.
Improvement of Solubility Usnic Acid Loaded on Mesoporous Silica SBA-15 and Physicochemical Characterization Fitriani, Lili; Azzahra, Cindy Maynia; Jessica, Adhitya; Hasanah, Uswatul; Zaini, Erizal
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.251-259

Abstract

Usnic acid, a secondary metabolite of lichen Usnea sp., has several pharmacological activities, but it is poorly soluble in water. This study aimed to improve the solubility and dissolution rate of usnic acid loaded in mesoporous silica SBA-15 at a mass ratio of 1:1. and evaluate its physical stability. Physicochemical characterization was carried out via the nitrogen adsorption desorption isotherm, differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, and powder X-ray diffraction (PXRD). Usnic acid-loaded SBA-15 was stored at 40 °C with various relative humidities (RH) and then analyzed by PXRD for the physical stability. Usnic acid adsorbed well in the pores of SBA-15, as shown by a decrease in the volume pore and surface area of SBA-15 according to the nitrogen adsorption. Moreover, usnic acid-SBA-15 showed a decrease in the degree of crystallinity according to PXRD analysis and no melting point based on DSC analysis. The FTIR spectrum of usnic acid–SBA-15 corresponds to the spectra of each raw material. The solubility of usnic acid increased 5.15 times after adsorbed on SBA-15. The dissolution rate also showed a significant increase (p < 0.05) from 19.51% to 84.27%. Usnic acid–SBA-15 was relatively stable at RH 75%. Thus, the adsorption of usnic acid on SBA-15 can increase its solubility, dissolution rate, and physical stability.
Enhancing the Solubility and Dissolution Rate of Tenoxicam through Co-Amorphous Formation with Meglumine by a Solvent Dropped Grinding Method Fitriani, Lili; Arif, Zhafira; Hasanah, Uswatul; Zaini, Erizal
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.131-138

Abstract

Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID), one of the oxicam group. It is categorized as Biopharmaceutical Classification System class II, as its low solubility and high permeability. The aims of this research were to enhance the solubility and dissolution rate of tenoxicam by its modification into a co-amorphous phase with meglumine at a molar 1:1 ratio. The co amorphous form of tenoxicam-meglumine was prepared by a solvent drop grinding method, and characterized by thermal analysis using differential scanning calorimetry (DSC), solid phase by powder X-ray diffraction (PXRD), identification of functional group by Fourier-transform infrared (FT-IR) spectroscopy, and morphology by polarized light microscopy (PLM) and scanning electron microscopy (SEM). The solubility test was conducted in water, whereas the dissolution test was performed in 0.1 N HCl solution and water. The DSC thermogram demonstrated a decrease in the endothermic peak of the co-amorphous tenoxicam-meglumine. The PXRD diffractogram revealed a reduction in the peak intensity of the X-ray diffraction, which formed a halo pattern. The FT-IR spectroscopy analysis indicated the formation of the co-amorphous system. The co-amorphous of tenoxicam-meglumine solubility’s increased by 42.71-fold as compared to intact tenoxicam. The co-amorphous tenoxicam meglumine exhibited a dissolution rate of 92.71% and 100% in 0.1 N HCl and distilled water, respectively, after 60 minutes, and resulting in separate increases in dissolution efficiency by 3.05 and 9.12-times in 0.1 N HCl and distilled water. In summary, the formation of the co-amorphous phase of tenoxicam and meglumine successfully enhanced the solubility and dissolution of tenoxicam.
Co-Authors Adhitya Jessica Annisa Agustina Arif, Zhafira Azzahra, Cindy Maynia Ben, Elfi Sahlan Deni Noviza Dhea Sultana Lutfiyah Erizal Zaini Fauzi Saputra HENI RACHMAWATI Jessica, Adhitya Melisa Melisa Muhammad Taher Nova Syafni Riana Zikra Fauzi Rifka Naura Rudi Abdillah Ryan Fajri Kurniawan Sadimantara, Muhammad Syukri Suryati Suryati Tamrin Tamrin Tri Suciati Ulfi Rahmi Uswatul Hasanah Uswatul Hasanah, Uswatul Verlia Nisrina Putri Wiwik Hanifah Yundari, Yundari