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All Journal Journal of Language and Literature Prosiding PESAT MNJ (Malang Neurology Journal) Langkawi: Journal of The Association for Arabic and English Eralingua : Jurnal Pendidikan Bahasa Asing dan Sastra JEdu: Journal of English Education Jurnal Abdi Masyarakat Multidisiplin
Agung Prasetyo Wibowo
Faculty of Letters, Gunadarma University
Arts Humanities Education Languange, Linguistic, Communication & Media Neuroscience Social Sciences

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Journal : MNJ (Malang Neurology Journal)

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THE ROLE OF TNF-α AND IL-6 CYTOKINE IN CHILDREN WITH STATUS EPILEPTICUS Wibowo, Agung Prasetyo; Sujuti, Hidayat; Rahayu, Masruroh; Muid, Masdar; Kawuryan, Siti Lintang
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (682.222 KB) | DOI: 10.21776/ub.mnj.2018.004.02.2

Abstract

Background. One of pediatric emergencies that has high mortality is status epilepticus (SE). Correlation between tumor necrosis factor (TNF)-α, interleukin (IL)-6, and SE had been reported but human study of it is limited. Objective. To compare TNF-α and IL-6 level in children with SE to those of children without SE and to find correlation between both cytokines.Methods. Cross-sectional study was conducted in dr.Saiful Anwar Hospital Malang with 48 children were enrolled in this study. All subjects were divided into three groups, including children who had SE; children who had seizure but not SE; and children who have no seizure. The levels of TNF-α and IL-6 serum were measured by ELISA.Results. TNF-α and IL-6 serum level were not significantly different between groups (p=0.920, p=0.829). We found interesting fact that the level of IL-6 in children with SE who have no disability was significantly higher than that of children who died or had disability (p=0.015). There was strong correlation between TNF-α and IL-6 in SE group (R 2 = 0.841 and p = 0.0001).Conclusion. IL-6 serum level was higher in SE children who have no disability and correlate with TNF-α serum level.
Co-Authors Ali, Ahmad Jum’a Khatib Nur Amalia, Desthia Dian Wulandari Firstiyanti, Aulia Haris Hendro Firmawan Hidayat Sujuti Khatib, Ahmad Juma Masdar Muid Masruroh Rahayu, Masruroh Mawarni, Titis Nurfatimah , Eva Nurochman Nurochman, Nurochman Sari, Wati Purnama SF Luthfie Arguby Purnomo Siti Lintang Kawuryan Suyudi , Ichwan Yosiana, Meriska