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All Journal HAYATI Journal of Biosciences VALENSI The Journal of Pure and Applied Chemistry Research ALCHEMY Jurnal Penelitian Kimia JPSCR : Journal of Pharmaceutical Science and Clinical Research PRIMA: Journal of Community Empowering and Services SEMAR Molekul: Jurnal Ilmiah Kimia
Desi Suci Handayani
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Synthesis and Characterization of Anethole-lauryl Methacrylate Copolymer via Cationic Polymerization Handayani, Desi Suci; Tahara, Alfia Uke; Firdaus, Maulidan; Suryanti, Venty; Kusumaningsih, Triana; Marliyana, Soerya Dewi; Wibowo, Fajar Rakhman; Wartono, Muhammad Widyo
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.7078

Abstract

The synthesis of anethole-lauryl methacrylate (LMA) copolymer had been carried out by cationic polymerization using BF3O(C2H5)2 as the initiator without the use of solvent at room temperature (28-30 °C) over atmospheric N2 conditions. Polymerization was conducted by varying LMA concentration i.e. 2%, 4%, and 6%, (w/w) with respect to the anethole weight. Structural determination of co-poly(anethole-LMA) was done using FTIR and 1H-NMR spectrophotometer. The relative molecular weight (Mv) of co-poly (anethole-LMA) was measured by an Ostwald Viscometer at room temperature. Morphological characterization and surface area analysis of co-poly(anethole-LMA) was performed using SEM and SAA, respectively. The successful synthesis of co-poly(anethole-LMA) was proven by the disappearance of vinyl group absorption at 1696, 1638, 965, and 938 cm-1 of the FTIR spectra, as well as the loss of vinyl group proton signals at 6.4-5.5 ppm in the 1H-NMR spectra. Increasing the weight of the LMA affected the characteristics of co-poly(anethole-LMA). The relative molecular weight of co-poly(anethole-LMA) was found to rise by increasing the weight of LMA. The Mv of co-poly(anethole-LMA) 2%, 4%, and 6% were 32378.62, 50611.05, and 65133.79 g/mol, respectively. The morphology of co-poly(anethole-LMA) showed that the surface distance between particles was getting tighter and the highest surface area in co-poly(Anethole-LMA) 6% was 233.80 m2/g.
Labdane Aldehyde Diterpenoids from Curcuma mangga Rhizome Wartono, Muhammad Widyo; Aini, Qurotul; Suryanti, Venty; Firdaus, Maulidan; Rakhman Wibowo, Fajar; Dewi Marliyana, Soerya; Kusumaningsih, Triana; Suci Handayani, Desi
The Journal of Pure and Applied Chemistry Research Vol. 12 No. 3 (2023): September-December 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.03.694

Abstract

Curcuma mangga val. (Zingiberaceae) is one of the plants that used as traditional medicine by Indonesian. Several studies have been reported on the content of compounds of C. mangga, but it is not yet known which compounds have medicinal properties. In this study, two labdane diterpenes were isolated from the extract of rhizome of C. mangga. Determination of the structure conducted by NMR (1H, 13C, HSQC and HMBC) that obtained two compounds, calcaratarin A (1) and labda-8(17),12-diene-15,16-dial (2). Both compounds have an aldehyde functional group. However, both compounds did not show antibacterial activity on Escherichia coli.
Antioxidant, Antidiabetic, and Antibacterial Activities of Terminalia bellerica Seed Extracts in Various Solvent Polarities Atmira Sariwati; Fita Sari; Venty Suryanti; Desi Suci Handayani; Ichiro Kamei; Ninis Yuliati
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.854-866

Abstract

Terminalia bellerica is well-known for producing edible fruits with pharmacotherapeutic properties. Traditional healers use these species to treat and control diabetes mellitus, its side effects, and other illnesses. Involved in this disease's pathophysiological process, extensive research has been conducted to validate and comprehend these bioactive claims scientifically. This research aims to ascertain the bioactive metabolite contents of different solvent polarities, including ethyl acetate, hexane, distilled water, and methanol. The phenol concentration was determined using the Follin-Ciocalteu procedure to be between 23.45 and 160.41 mg GAE/g. The aluminum chloride colorimetric technique measured flavonoid concentration from 88.52 to 7.12 mg QE/g. The quantitative values of tannic acid, which spanned from 0.78 to 5.32 mg TAE/g, were determined by spectrophotometry UV-VIS. The extracts' capacity to reduce free radical damage ABTS (2, 2' azinobis (3-ethylbenzene-thiazoline-6-sulfonic-acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) was examined. The extract ethyl acetate exhibited the most significant level of antioxidant activity, with IC50 values for DPPH and ABTS of 28.17 and 22.22 g/ml, respectively. Staphylococcus aureus (23 mm) and were tested for antibacterial and antifungal activity in a methanol extract (21 mm). In vitro, antidiabetic activities were assessed using α-glucoside and α-amylase inhibition. The ethyl acetate extract has α-glucoside inhibition IC50 of 23.04 g/ml and α-amylase inhibition IC50 of 25.35 g/ml. T. bellerica seed includes secondary metabolites that show promise as lead chemicals in creating potent medications.
Synthesis and Characterization of Copoly(Anethole-Stearyl Acrylate) as Phenol Adsorbent Handayani, Desi Suci; Pramono, Edi; Dewi, Anita Kusuma
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46484

Abstract

This study aims to synthesize copoly (Anethole-stearyl acrylate, SA) through cationic polymerization at room temperature (28–36°C) under a nitrogen atmosphere. The synthesis was carried out without a solvent using BF3O(C2H5)2 as the initiator. SA was added in varying weights of 2%, 4%, and 6% relative to anethole. The product obtained from the synthesis was then applied as a phenol adsorbent using the batch method at different contact times. FTIR (Fourier Transform Infrared) analysis showed that methoxy group (-OCH3) termination occurred at wavenumber 1147 cm-1, followed by the loss of vinyl group (C=C) at 1633–1654 cm-1. In addition, the loss of =C-H vinyl bending and stretching group absorption occurred at 964–998 cm-1 and 3025–3095 cm-1, respectively. Structural analysis using 1H-NMR showed the loss of the vinyl group proton signal at a chemical shift (δH) of 5.8–39 ppm. The addition of 2%, 4%, and 6% SA led to an increase in intrinsic viscosity of 26.891, 41.093, and 55.336, respectively. The morphology of copoly showed the presence of various cavities. The degradation temperature of the product increased with the addition of SA. During the application of copoly as a phenol adsorbent, the 6% (w/w) concentration had the largest adsorption capacity of 2.22 mg/g.
Synthesis and Characterization Of C-Hexyl Calix[4]Resorcinarena from Resorcinol-Heptanal Condensation Handayani, Desi Suci; Amin, Zainal Arifin Almaqqomul; Kusumaningsih, Triana; Masykur, Abu
ALCHEMY Jurnal Penelitian Kimia Vol 10, No 1 (2014): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.10.1.730.49-53

Abstract

Synthesis of  C-hexyl  calix[4]resorcinarene  through condensation reaction between resorcinol  and  heptanal  with  HCl  catalyst  has  been  investigated.  Synthesis  conducted  by the ratio of resorcinol: heptanal (1:1) using reflux for 6 hours in ethanol. Structural  analysis of  the  product  was  done  by  FTIR  and 1 H-NMR  spectroscopy,  while  the  characterization was  done  by  determining  melting  point.  The  product  was  golden  brown  powder  with  a yield 99.43%  and  melting point more than 300 °C.  Structural analysis with FTIR and 1 HNMR  known  vibration  and  signals  characteristic  of  calix[4]resorcinarena  group, the vibrations of the CH  bridge. Vibration of CH bridge appearance at wave number 1445 cm-1 and 1456  cm-1, while signal of CH bridge appearance at chemical shifts from  4.17 to 4.21 ppm.
Sintesis Kopoli(Anetol-Stearil Akrilat-Divinilbenzena) sebagai Material Alternatif Adsorben Handayani, Desi Suci; Pramono, Edi; Suwaji, Bagus Indra
ALCHEMY Jurnal Penelitian Kimia Vol 20, No 1 (2024): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.20.1.77588.82-97

Abstract

Sintesis kopoli(Anetol-Stearil Akrilat-Divinilbenzena) atau KASA-DVB berhasil dilakukan melalui reaksi kopolimerisasi kationik menggunakan inisiator BF3O(C2H5)2 dan Stearil Akrilat (SA) dengan variasi 2, 4, dan 6 (b/b), pada jumlah anetol dan DVB tetap. Produk yang dihasilkan dikarakterisasi gugus fungsi, struktur, morfologi, viskositas intrinsik dan sifat termalnya berturut-turut menggunakan spektroskopi Fourier-transform infrared (FT-IR), proton nuclear magnetic resonance (1H-NMR), scanning electron microscopy dengan energy dispersive X-ray (SEM-EDX), viskometer Ostwald dan analisis thermogravimetric-differential thermal-differential scanning calorimetry (TG/DTA-DSC). Uji kinerja adsorpsi senyawa dilakukan dengan metode batch dan konsentrasi adsorbat ditentukan dengan Spektrofotometer UV-Vis. Data FT-IR menunjukkan hilangnya serapan gugus alil dan vinil sementara data 1H-NMR menunjukkan hilangnya H-alil dan H-vinil yang mengindikasikan KASA-DVB berhasil disintesis. Penambahan konsentrasi SA dapat meningkatkan nilai viskositas intrinsik. Analisis morfologi KASA-DVB diperoleh padatan dengan permukaan yang relatif kasar dan jumlah rongga semakin sedikit. Analisis termogram TG/DTA-DSC menunjukkan penurunan sifat termal yaitu diperoleh titik inisiasi degradasi massa yang lebih rendah. Nilai kapasitas adsorpsi tertinggi diperoleh dari hasil uji kinerja adsorpsi pada waktu kontak ke-60 menit dan variasi berat SA 2%. Berdasarkan data kinerja adsorpsi, menunjukkan bahwa KASA-DVB memiliki potensi sebagai adsorben. Uji adsorpsi menunjukkan kapasitas adsorpsi terbesar adalah 23,22 (mg/g) pada KASA-DVB 2%. Synthesis of Copoly(Anethol-Styryl Acrylate-Divinylbenzene) as an Alternative Adsorbent Material. Synthesis of copoly(Anethole-Stearyl Acrylate-Divinylbenzene) or KASA-DVB was successfully carried out by a cationic copolymerization reaction using BF3O(C2H5)2 initiator and various concentrations of Stearyl Acrylate (SA) are 2, 4, and 6 wt. The resulting products were characterized by functional groups, structure, morphology, intrinsic viscosity, and thermal properties using Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H-NMR), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), Ostwald Viscometer, and thermogravimetric-differential thermal-differential scanning calorimetry analysis (TG/DTA-DSC), respectively. The adsorption performance was analyzed using the batch method, and the adsorbate concentration was determined using a UV-Vis spectrophotometer. The FT-IR data showed loss of allyl and vinyl groups absorption, while 1H-NMR data showed loss of H-allyl and H-vinyl, indicating that KASA-DVB was successfully synthesized. The increase in SA concentration can increase the intrinsic viscosity value. Morphological analysis of KASA-DVB obtained solid materials with a relatively rough surface and fewer cavities. Thermogram analysis of TG/DTA-DSC showed a decrease in thermal properties, which was a lower mass degradation initiation point. The highest adsorption capacity was obtained from the adsorption performance with a contact time of 60 minutes and 2% SA weight variation. The adsorption performance data shows that KASA-DVB is potent as an adsorbent. The adsorption showed that the largest adsorption capacity was 23.22 (mg/g) on KASA-DVB 2%.
Antibacterial Activity of Zerumbone from Extract of Zingiber zerumbet (L.) Roscoe ex Smith Rhizomes Marliyana, Soerya Dewi; Handayani, Desi Suci; Hayati, Nida Nafisah; Ramadhani, Risna
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 1 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i1.94947

Abstract

The rhizome of Zingiber zerumbet, known as Lempuyang Gajah, is commonly used in the community for medicinal purposes due to its diverse biological activities, particularly its antibacterial compounds. Among these compounds, zerumbone is one of the major secondary metabolites found in Z. zerumbet rhizomes. This research focused on the isolation of zerumbone and the exploration of its antibacterial properties. The isolation process involved the use of the maceration method with acetone as the solvent, while various chromatographic techniques such as Liquid Vacuum Chromatography, Column Chromatography, and Thin Layer Chromatography were employed for fractionation and purification of zerumbone. The identification of zerumbone was accomplished through GC-MS data analysis. The antibacterial activity of zerumbone was tested against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa using the agar diffusion method. This compound exhibited moderate antibacterial activity against P. aeruginosa with an inhibition zone of 9.42 mm. The rhizome of Z. zerumbet can serve as an alternative source of zerumbone for further studies in the field of medicine.  
Peningkatan Rendemen Minyak Atsiri Melalui Maserasi Awal dengan Metode Ultrasonikasi di Rumah Atsiri Indonesia Firdaus, Maulidan; Suryanti, Venty; Kusumaningsih, Triana; Handayani, Desi Suci; Marliyana, Soerya Dewi; Wibowo, Fajar Rakhman; Wartono, Muhammad Widyo; Karimah, Qosrul; Darmawan, Dhea Afrisa
PRIMA: Journal of Community Empowering and Services Vol 9, No 1 (2025): June
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/prima.v9i1.86385

Abstract

Enhancing Essential Oils Yield through Initial Maceration using Ultrasonication Method at Rumah Atsiri Indonesia. Metode ekstraksi minyak atsiri yang paling umum digunakan adalah destilasi uap. Pada umumnya, metode destilasi uap banyak digunakan oleh industri kecil termasuk di Rumah Atsiri Indonesia (RAI), karena memiliki beberapa keuntungan, diantaranya pengoperasian yang mudah serta peralatan yang sederhana. Akan tetapi, metode ini juga memiliki beberapa kelemahan, seperti membutuhkan waktu yang cukup lama dan hasil produksi yang kurang optimal. Untuk mengatasi kelemahan tersebut, solusi yang dapat dilakukan adalah melakukan proses destilasi minyak atsiri yang didahului maserasi dengan bantuan ultrasonik. Bekerja sama dengan RAI, Tim Riset Group Natural Products and Synthetic Organic Chemistry Prodi Kimia FMIPA UNS telah melaksanakan Program Pengabdian kepada Masyarakat (PkM). PkM bertujuan memberikan penyuluhan sekaligus praktik mengenai cara destilasi minyak atsiri dengan memulai proses maserasi dan menerapkan teknik ultrasonikasi di RAI. Pendekatan ini bertujuan untuk meningkatkan efisiensi dan hasil proses destilasi dengan menggunakan gelombang ultrasonik untuk membantu memecah bahan tanaman sebelum destilasi. Hal ini memudahkan untuk mengekstrak lebih banyak minyak dan meningkatkan kualitas minyak atsiri secara keseluruhan. Kegiatan dimulai dengan diskusi tentang teori dan aplikasi maserasi awal dengan metode ultrasonikasi. Sesi selanjutnya adalah praktik maserasi awal dengan metode ultrasonikasi sebelum dilakukan destilasi. Luaran dari pelatihan ini adalah adanya peningkatan performa metode destilasi minyak atsiri. Hasil perlakuan ekstraksi awal dengan teknik ultrasonikasi bisa meningkatkan rendemen minyak sereh wangi dari 0,86% menjadi 1,86% atau meningkat 2,2 kali lebih banyak dibandingkan tanpa maserasi awal.
Usaha Peningkatan Standar Mutu UMKM Jamu Herbal Ratu Botani Solo di Surakarta Azhari, Fauziyah; Rakhmawati, Rita; Mudyantini, Widya; Marliyana, Soerya Dewi; Handayani, Nestri; Wahyuni, Titi; Suryani, Esti; Handayani, Desi Suci; Islah, Siti Baroroh Zakiyatul; Zikri, Fahrul; Ermaningsih, Yeni; Lestari, Witri Wahyu
SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Vol 14, No 2 (2025): November
Publisher : LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/semar.v14i2.105220

Abstract

 Industri jamu Indonesia memiliki potensi ekonomi besar dengan pasar domestik Rp 20 triliun, ekspor Rp 16 triliun. Namun, UMKM jamu masih menghadapi tantangan signifikan terkait standarisasi mutu, keamanan produk, dan kepatuhan terhadap regulasi. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kapasitas UMKM Jamu Ratu Botani Solo (RBS), Surakarta melalui penguatan standar mutu produk, khususnya dalam aspek uji mutu produk dan pengemasan. Metode pelaksanaan meliputi tiga tahap: (1) Pra-kegiatan dilakukan dengan FGD untuk identifikasi kebutuhan dan tantangan mitra; (2) Pelatihan penyuluhan empat materi yaitu pemilihan bahan herbal, metode ekstraksi, implementasi teknik ekstraksi skala industri, penandaan obat bahan alam. Kegiatan ini disertai pemberian bantuan alat pengemasan dan analisis mutu produk di laboratorium (3) Evaluasi keberlanjutan untuk mengukur dampak dan keberlanjutan implementasi oleh mitra. Hasil kegiatan menunjukkan peningkatan signifikan pemahaman peserta (80–100%) pada seluruh materi pelatihan, terutama terkait penandaan produk sesuai ketentuan BPOM. Mitra kini mampu mengimplementasikan teknik ekstraksi yang sesuai standar, seperti remaserasi dan digesti, dalam proses produksi jamu. Mitra juga telah memiliki akses terhadap layanan uji mutu (logam berat, kadar air, dan mikrobiologi) di laboratorium UPT UNS. Kegiatan ini berhasil memberdayakan RBS dalam memproduksi jamu berstandar nasional, meningkatkan daya saing, dan mendukung keberlanjutan usaha berbasis herbal. 
Co-Authors Abu Masykur Amin, Zainal Arifin Almaqqomul Atmira Sariwati Azhari, Fauziyah Chairil Anwar Darmawan, Dhea Afrisa Dewi Marliyana, Soerya Dewi, Anita Kusuma Dian Endah Kusuma Astuti, Dian Endah Dwi Siswanta Edi Pramono edi pramono Ermaningsih, Yeni Esti Suryani Fajar Rakhman Wibowo Fita Sari Hayati, Nida Nafisah I.F. Nurcahyo I.F. Nurcahyo Ichiro Kamei Islah, Siti Baroroh Zakiyatul Jumina Jumina Karimah, Qosrul Laksono Trisnantoro Lestari, Witri Wahyu Maulidan Firdaus Muhamad Widyo Wartono Mustofa Mustofa Nestri Handayani, Nestri Ninis Yuliati Pranoto Pranoto Qurotul Aini Rakhman Wibowo, Fajar Ramadhani, Risna Respati ., Respati Riska Azizawati Sholikh, Riska Azizawati Rita Rakhmawati, Rita Soerya Dewi Marliyana Suwaji, Bagus Indra Tahara, Alfia Uke Triana Kusumaningsih Venty Suryanti Venty Suryanti Wahyuni, Titi WIDYA MUDYANTINI Windrawati Windrawati, Windrawati Witri Wahyu Lestari Yuni Lestari Yuniawan Hidayat Zainal Arifin Almaqqomul Amin, Zainal Arifin Zikri, Fahrul