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All Journal Jurnal Kedokteran Syiah Kuala Majalah Kedokteran Bandung Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Global Medical and Health Communication Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia
Pati Aji Achdiat
Departemen Ilmu Kesehatan Kulit Dan Kelamin, Fakultas Kedokteran Universitas Padjadjaran/RSUP Dr. Hasan Sadikin, Bandung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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KUTIL ANOGENITAL YANG MENYERUPAI LESI KARSINOMA SEL SKUAMOSA DAN BERESPONS DENGAN KRIM PODOFILOKS 0,5% Rivanzah, Yovan; Achdiat, Pati Aji; Maharani, Retno Hesty
Media Dermato-Venereologica Indonesiana Vol 50 No 4 (2023): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i4.433

Abstract

Kutil anogenital (KAG) merupakan salah satu infeksi menular seksual berupa lesi proliferatif jinak yang disebabkan oleh Human papillomavirus (HPV). Karsinoma sel skuamosa (KSS) ad regio anogenital sering menjadi diagnosis banding dari KAG. Krim podofiloks menjadi salah satu terapi pilihan untuk pengobatan KAG. Dilaporkan satu kasus KAG ad regio penis dan perianal pada pasien Human Immunodeficiency Virus (HIV), seorang laki-laki berusia 31 tahun. Pada pemeriksaan fisis ditemukan lesi papul sewarna kulit dengan permukaan papilomatosa dan verukosa pada penis dan perianal. Pemeriksaan penunjang acetowhitedidapatkan hasil positif. Gambaran histopatologis menunjukkan gambaran hiperplastis, hiperkeratosis, akantosis, dan papilomatosa. Berdasarkan hasil polymerase chain reaction (PCR) HPV tipe 6, 11, 16, dan 18 didapatkan hasil negatif. Pasien mendapatkan terapi krim podofiloks 0,5% selama tiga siklus dengan hasil yang signifikan. Diagnosis KAG ditegakkan berdasarkan anamnesis, pemeriksaan fisis, histopatologis, dan PCR. Sampai saat ini belum ada terapi yang ideal dan spesifik untuk pengobatan KAG. Podofiloks merupakan salah satu pilihan pengobatan topikal yang diaplikasikan sendiri oleh pasien dua kali sehari selama tiga hari diikuti dengan empat hari tanpa terapi diulang sebanyak empat siklus. Diperlukan pemeriksaan yang komprehensif untuk dapat menegakkan KAG dan menyingkirkan diagnosis banding dengan KSS. Terapi podofiloks dapat menjadi pilihan yang dapat dipertimbangkan untuk terapi pada KAG.
Histopathological Progression and Clinicopathologic Factors Associated with Anogenital Condyloma Acuminata: A Pathological Perspective From a Tertiary Hospital in Indonesia Husnayain, Karimah Ihda; Usman, Hermin Aminah; Etis Primastari; Pati Aji Achdiat
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 38 No. 1 (2026): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V38.1.2026.27-38

Abstract

Background: Anogenital condyloma acuminata (CA) is a benign lesion caused by low-risk human papillomavirus (HPV). Although typically benign and non-dysplastic, a subset may undergo histopathological progression. Histopathology is essential not only for diagnosis but also for early detection of malignant transformation. In people living with HIV (PLHIV), immunosuppression may further modify the course of CA. Purpose: To analyze clinicopathologic and sexual behavioral factors associated with HIV status in patients with CA and to evaluate histopathological progression from a pathological perspective. Methods: A retrospective cross-sectional study included 224 patients with histopathologically confirmed CA at Dr. Hasan Sadikin General Hospital, Bandung, between 2023 and 2024. Sociodemographic, clinicopathologic, and sexual behavioral data were retrieved from medical records. Associations with HIV status were analyzed using chi-square or Fisher’s exact tests and multivariate logistic regression. Result: Among 224 patients, 87 (38.8%) were HIV-positive. Bisexual orientation (aOR: 12.52; 95% CI: 1.03–151.98), lesion duration >6 months (aOR: 6.14; 95% CI: 1.74–21.72), and internal lesion location (aOR: 0.17; 95% CI: 0.03–0.88) were independent predictors of HIV positivity. Histopathological progression was identified in 13 patients (5.8%), comprising eight low-grade squamous intraepithelial lesions, three high-grade squamous intraepithelial lesions, and two squamous cell carcinomas. It occured in both HIV-positive (n=3) and HIV-negative (n=10). Conclusion: HIV is highly prevalent among CA patients, with sexual and clinicopathologic factors as significant predictors. The identification of histopathological progression, including malignant transformation, highlights the crucial role of pathology and emphasizes the necessity for routine histopathological evaluation to detect malignant potential.
Co-Authors Cahyawari, Dartri Dina Fatmasari Effendi, Rendy Ariezal Etis Primastari Febrina, Dia Feriza, Vina Gynaecia Lamsu Hendra Gunawan Hermin Aminah Usman Husnayain, Karimah Ihda Iriani, July Jayawarsa, A.A. Ketut Laila Tsaqilah Maharani, Retno Hesty Nugrahaini, Pramita Kusuma Catur Oki Suwarsa Rachel Marsella Rahardjo Rachmatdinata Rachmatdinata Rachmatdinata Rachmatdinata, Rachmatdinata Rasmia Rowawi Reiva Farah Dwiyana Reyshiani Johan Rivanzah, Yovan Roslina, Nina Rowawi, Rosmia Siswahyudianto Tony S Djajakusumah, Tony S Tony S. Djajakusumah Tsaqilah, Laila