Garuda - Garba Rujukan Digital

PENGARUH PENGGUNAAN ANTIBIOTIK ERITROMISIN DENGAN TERAPI CALCIUM-CHANNEL BLOCKER TERHADAP GAGAL GINJAL AKUT Vinci Mizranita; Dea Sarra Pramudhita
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Calsium-Channel Blocker (CCB) seperti amlodipin, felodipin, nifedipin, diltiazem, dan verapamil dimetabolisme oleh enzim CYP3A4. Kadar CCB dalam darah dapat meningkat ke level yang berbahaya jika enzim tersebut dihambat. Eritromisin (antibiotik makrolida) merupakan inhibitor CYP3A4, penggunaan bersamaan CCB dan makrolida diasosiasikan dengan peningkatan risiko rawat inap akibat gagal ginjal akut. Tujuan penelitian ini untuk mengetahui pengaruh yang ditimbulkan oleh penggunaan CCB dan eritromisin terhadap fungsi ginjal pada pasien rawat inap poliklinik penyakit dalam RS Dr. Moewardi. Penelitian dilakukan secara deskriptif dengan pendekatan pengambilan data secara retrospektif. Data diperoleh dari hasil observasi catatan rekam medik pasien selama menjalani perawatan di rumah sakit (rawat inap). Hasil dari 4 pasien diketahui masing-masing pasien mengalami peningkatan kadar kreatinin dan ureum dengan rata-rata kenaikan kreatinin 34,8% dan ureum 36,6%. Hal ini kemungkinan disebabkan adanya interaksi makrolida dan CCB yang mengakibatkan kenaikan kadar CCB dalam darah sehingga menyebabkan hipotensi. Keadaan hipotensi dapat menyebabkan hipoperfusi ginjal yang berpotensi terjadinya gagal ginjal akut, dimana ditandai dengan meningkatnya kadar ureum dan kreatinin. Kata kunci :Antibiotik makrolida, CCB, interaksi obat, ureum, kreatinin

Penyuluhan tentang Keamanan Sediaan Obat Sirup pada Warga Dusun Randusari, Mojosongo, Jebres, Surakarta Inayatush Sholihah; Nestri Handayani; Novita Dhewi Ikakusumawati; Vinci Mizranita
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 6, No 10 (2023): Volume 6 No 10 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v6i10.11066

ABSTRAK Kasus gagal ginjal akut telah menimpa ratusan anak di Indonesia dalam beberapa waktu terakhir. Kejadian ini dikaitkan dengan penggunaan obat sirup yang mengandung cemaran etilen glikol dan dietilen glikol. Penyuluhan ini bertujuan untuk meningkatkan pengetahuan warga Dusun Randusari, Kelurahan Mojosongo, Kecamatan Jebres, Kota Surakarta mengenai keamanan obat sirup. Minimnya pengetahuan warga tentang keamanan obat sirup disebabkan mayoritas warga tidak memperoleh pendidikan yang cukup tinggi dan mayoritas warga hanya bekerja sebagai pemulung. Kegiatan penyuluhan ini dilakukan secara tatap muka dengan warga. Kegiatan diawali dengan pengenalan tentang penggolongan obat dan Dagusibu Obat Sediaan Cair. Dilanjutkan dengan edukasi tentang Keamanan Obat Sirup dan dan Mengenali Gejala Klinis Gagal Ginjal Akut pada Anak. Media pembelajaran yang digunakan adalah video edukasi, leaflet, dan buletin. Evaluasi keberhasilan program dilakukan dengan membandingkan antara hasil pretest dan postest. Kegiatan penyuluhan dihadiri oleh 25 warga. Dari pretest diperoleh hasil rerata 79,73. Hasil postest diperoleh peningkatan pengetahuan dari peserta dengan hasil rerata nilai 89,60. Dengan terlaksananya kegiatan pengabdian kepada masyarakat di wilayah Dusun Randusari, Kelurahan Mojosongo, Kecamatan Jebres, Kota Surakarta ini, mampu meningkatkan pengetahuan peserta yang terlihat dari antusias peserta yang bertanya, berdisukusi dan berbagi pengalaman seputar obat-obatan, serta peningkatan nilai postest. Kata Kunci: Penyuluhan, Keamanan Obat Sirup, Randusari ABSTRACT Cases of acute kidney failure have befallen hundreds of children in Indonesia in recent times. This incident was associated with the use of drug syrup containing ethylene glycol and diethylene glycol contamination. This community service aimed to increase the knowledge of the residents of Randusari Hamlet, Mojosongo Village, Jebres District, Surakarta City regarding the safety of syrup medicine. The lack of knowledge of residents about the safety of syrup medicine was caused by the majority of residents not obtaining a high enough education and the majority of residents only working as scavengers. This community service activity was carried out face to face with residents. The activity began with an introduction to drug classification and Dagusibu Liquid Medicine. Followed by education about the Safety of Syrup Medicine and and Recognizing Clinical Symptoms of Acute Kidney Failure in Children. The learning media used were educational videos, leaflets, and bulletins. Evaluation of the success of the program was done by comparing the results of the pretest and posttest. The counseling activity was attended by 25 participants. From the pretest, the average result was 79.73. The posttest results obtained increased knowledge from the participants with a mean score of 89.60. The implementation of community service activities in the Randusari Hamlet area, Mojosongo Village, Jebres District, Surakarta City, was able to increase the participants' knowledge as seen from the enthusiasm of the participants who asked questions, discussed and shared experiences about drugs, as well as increased posttest scores. Keywords: Counseling, Safety of Syrup Medicine, Randusari

PROFESSIONAL PRACTICES AND PERCEPTIONS OF COMMUNITY PHARMACISTS AND PHARMACY TECHNICIANS TOWARDS THE USE OF HERBAL MEDICINES IN INDONESIA Mizranita, Vinci; Sakinatun Nisa, Fauziyyah
Jurnal Jamu Kusuma Vol. 4 No. 1 (2024): JURNAL JAMU KUSUMA
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jurnaljamukusuma.v4i1.100

This study examines the perceptions of community pharmacists and pharmacy technicians regarding the use of herbal medicines practice in Indonesia. Given the rich biodiversity and traditional medicinal practices in Indonesia, herbal medicines play a significant role in healthcare. This study aims to examine the role of pharmacists and pharmacy technicians in advising patients on herbal medicines, focusing on their knowledge, scope, and practices. A cross-sectional survey was conducted among pharmacists and pharmacy technicians in Surakarta, Indonesia, who attended Indonesian Pharmacists Association (IAI) and Indonesian Pharmacy Technicians Association (PAFI) seminars. A total of 123 pharmacists and 121 pharmacy technicians participated in the study. The results indicate that pharmacy technicians are more involved in managing simple common ailments such as acne (93.4%) and cough and cold symptoms (90.1%) compared to pharmacists, who are more involved in treating conditions like acute pain (72.4%) and diarrhoea (58.5%). This study also show a significant shift in referral patterns when symptoms do not improve, with pharmacy technicians referring patients to pharmacists 89.3% of the time. This study highlights the critical role of pharmacy technicians in the initial management of symptoms and underscores the importance of collaboration between pharmacists and pharmacy technicians to ensure optimal patient outcomes. The findings suggest areas for further training and protocol development to enhance the efficiency and effectiveness of pharmacy services in Indonesia.

Upaya Edukasi Swamedikasi dan Perilaku Hidup Sehat Pada Warga Dusun Randusari, Kelurahan Mojosongo, Kecamatan Jebres, Kota Surakarta Mizranita, Vinci; Astuti, Rini Budi; Ikakusumawati, Novita Dhewi; Sholihah, Inayatush; Pratama, Tiara Dewi Salindri; Manurung, Devi Yanthre Sari; Nugraha, Akbar Eka
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 9 (2025): Volume 8 No 9 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i9.21803

ABSTRAK Sampah merupakan bahan yang berasal dari aktivitas manusia dan hewan yang dibuang karena dianggap tidak memiliki manfaat lagi. Pengelolaan sampah yang tidak baik dapat menyebabkan berbagai dampak negatif, salah satunya masalah kesehatan seperti infeksi saluran pernapasan, penyakit kulit, dan diare. Tempat Pembuangan Akhir (TPA) Putri Cempo merupakan salah satu TPA di Kota Surakarta. Jumlah sampah di TPA Putri Cempo meningkat seiring dengan bertambahnya penduduk. Peningkatan timbunan sampah ini menimbulkan gangguan kesehatan, utamanya pernapasan, pencernaan, dan kulit. Dusun Randusari menjadi salah satu tempat yang terdampak akibat timbunan sampah tersebut. Salah satu cara yang dapat dilakukan oleh masyarakat yaitu pengobatan secara mandiri atau swamedikasi. Program sosialisasi ini diharapkan mampu meningkatkan pengetahuan masyarakat Dusun Randusari dalam upaya untuk mengurangi dan mencegah terjadinya masalah kesehatan akibat sampah. Kegiatan sosialisasi ini dihadiri oleh 24 warga. Kegiatan diawali dengan pre-test, pemaparan materi swamedikasi dan pola hidup sehat, post-test, praktik swamedikasi penyakit kulit (panu), dan diakhiri dengan evaluasi keberhasilan program. Hasil nilai rata-rata pre-test dan post-test berturut-turut adalah 76,25 dan 88,3. Dari hasil tersebut, menandakan bahwa terdapat peningkatan pemahaman mengenai swamedikasi dan pola hidup sehat. Kata Kunci: Sosialisasi, Pola Hidup Sehat, Swamedikasi, Infeksi, Panu, Pernapasan ABSTRACT Waste is material that comes from human and animal activities that is discarded because it is considered to have no more benefits. Poor waste management can cause various negative impacts, one of which is health problems such as respiratory tract infections, skin diseases, and diarrhea. Putri Cempo Final Disposal Site (TPA) is one of the TPAs in Surakarta City. The amount of waste in Putri Cempo TPA increases along with the population growth. The increase in waste piles causes health problems, especially respiratory, digestive, and skin. Randusari Hamlet is one of the places affected by the pile of waste. One way that can be done by the community is self-medication. This socialization program is expected to be able to increase the knowledge of the Randusari Hamlet community to reduce and prevent health problems caused by waste. This socialization activity was attended by 24 residents. The activity began with a pre-test, presentation of self-medication material and healthy lifestyles, post-test, self-medication practice for skin diseases (tinea versicolor), and ended with an evaluation of the success of the program. The average pre-test and post-test scores were 76.25 and 88.3, respectively. These results indicate that there is an increase in understanding of self-medication and healthy lifestyles. Keywords: Socialization, Healthy Lifestyle, Self-medication, Infection, Tinea Versicolor, Respiratory

Perceptions of Practice Towards Management of Common Ailments In Indonesian Community Pharmacies: A Cross-Sectional Study Mizranita, Vinci; Sakinatun Nisa, Fauziyyah
Devotion : Journal of Research and Community Service Vol. 5 No. 9 (2024): Devotion: Journal of Community Research
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v5i9.799

Managing common ailments is a growing service in developing countries. Community pharmacists and pharmacy technicians managing common ailments are essential for improving treatment outcomes. While common ailment services have been successfully implemented in developed countries, Indonesia needs more documentation of these practices. This study aimed to document the scopes of community pharmacists and pharmacy technicians in managing common ailments, their practices, and the perceived experience in providing these services. These cross-sectional surveys were conducted from May to June 2023 in separate pharmacists’ and pharmacy technicians’ seminars in Surakarta, Indonesia. Binary logistic regression compared the pharmacists' and pharmacy technicians' perceptions of managing ailments. A total of 180 pharmacists and 140 pharmacy technicians participated. Among 13 common ailments listed in the survey, acute pain (P<0.001) was an ailment that was perceived as limited to a pharmacist's scope. Ailments such as dandruff, constipation and mild headache were perceived to be within the scope of a pharmacy technician (P<0.001). Given the differing approaches by pharmacists and pharmacy technicians, there is a need to ensure that each professional practices within their area of scope.

Edukasi Penggunaan Obat melalui Penyuluhan Dagusibu Antibiotik Kepada Warga Dusun Randusari Surakarta Handayani, Nestri; Ikakusumawati, Novita Dhewi; Sholihah, Inayatush; Mizranita, Vinci
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 12 (2025): Volume 8 No 12 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i12.18269

ABSTRAK Kurangnya pengetahuan masyarakat mengenai dapatkan, gunakan, simpan, dan buang (DAGUSIBU) serta penggunaan antibiotik yang bijak menjadi permasalahan yang perlu diperhatikan. Penggunaan antibiotik yang bijak merujuk pada penggunaan antibiotik secara rasional, dengan mempertimbangkan dampak munculnya dan penyebaran bakteri resisten. Kegiatan penyuluhan ini bertujuan untuk meningkatkan pengetahuan warga Dusun Randusari, Kelurahan Mojosongo, Kecamatan Jebres, Kota Surakarta mengenai pentingnya pemahaman DAGUSIBU obat khususnya antibiotik dengan baik dan benar. Kegiatan penyuluhan diawali dengan pengenalan mengenai DAGUSIBU obat secara umum dan dilanjutkan secara khusus mengenai antibiotik. Media penyuluhan yang digunakan diantaranya berupa leaflet, Microsoft Powerpoint, dan buku saku. Sebelum penyampaian materi, dilakukan pre-test dan setelahnya, dilakukan post-test untuk mengetahui tingkat pemahaman warga. Kegiatan penyuluhan dihadiri oleh 29 warga. Pengetahuan warga sebelum diberikan penyuluhan dan sesudahnya menunjukkan adanya peningkatan, dari nilai rata-rata yang hanya 59,3 menjadi 87,8. Dalam kegiatan penyuluhan, warga terlihat sangat antusias dengan aktif bertanya dan berdiskusi selama acara berlangsung. Kata Kunci: Penyuluhan, DAGUSIBU, Antibiotik, Randusari ABSTRACT The lack of public awareness regarding the proper handling of antibiotics, including their storage, disposal, and use (DAGUSIBU), represents a significant challenge that requires urgent attention. The term "wise use of antibiotics" refers to the rational use of antibiotics, which entails considering the impact of the emergence and spread of resistant bacteria. The objective of this counselling is to enhance the knowledge of residents of Randusari Hamlet, Mojosongo Village, Jebres District, Surakarta City, regarding the significance of comprehending DAGUSIBU drugs, particularly antibiotics, in an accurate and effective manner. This counselling initiative commenced with an introduction to DAGUSIBU drugs in general and proceeded to a specific focus on antibiotics. The counselling medium employed included leaflets, Microsoft PowerPoint, and pocket books. Before the delivery of the material, a pre-test was conducted, followed by a post-test to ascertain the level of comprehension among the residents. The counselling activity was attended by 29 residents. The knowledge of residents before and after the counselling demonstrated a notable improvement, with an average score of 59.3 increasing to 87.8. During the counselling activities, residents demonstrated a high level of engagement, with active questioning and discussion occurring throughout the event. Keywords: Counseling, DAGUSIBU, Antibiotic, Randusari

Rasionalitas dan Potensi Drug-Related Problems pada Penggunaan Antibiotik pada Pasien Rawat Inap dengan Ulkus Diabetes Mellitus Tipe II Vinci Mizranita; Inayatush Sholihah; Novita Dhewi Ikakusumawati; Tiara Dewi Salindri Pratama; Rini Budi Astuti; Devi Yanthre Sari Manurung; Akbar Eka Nugraha
Generics: Journal of Research in Pharmacy Vol 6, No 1 (2026): Generics : Journal of Research in Pharmacy
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v6i1.28510

Ulkus diabetes melitus (DM) tipe II merupakan komplikasi kronis yang sering menimbulkan infeksi serius, memerlukan terapi antibiotik, dan berisiko tinggi terhadap kejadian drug-related problems. Penelitian ini bertujuan untuk mengevaluasi rasionalitas dan penggunaan antibiotik, serta identifikasi drug-related problems pada pasien ulkus diabetes mellitus tipe II. Penelitian deskriptif ini dilakukan pada 44 pasien ulkus diabetes mellitus tipe II di Instalasi Rawat Inap Rumah Sakit Universitas Sebelas Maret. Data dikumpulkan melalui rekam medis dan dianalisis menggunakan klasifikasi PCNE V9.1 untuk mengidentifikasi drug-related problems. Sebagian besar pasien berusia 60–74 tahun (52%), memiliki komplikasi terbesar makrovaskuler (91%), khususnya hipertensi (43,75%) dan amputasi (34,38%). Antibiotik yang paling sering digunakan adalah seftriakson (27%) dan metronidazol (20%), dengan rute pemberian secara parenteral (66,94%) sebagai rute pemberian utama. Sebanyak 113 kasus kejadian drug-related problems yang teridentifikasi, didominasi oleh kombinasi penggunaan obat yang tidak sesuai (51,3%), dosis tidak tepat, dan terapi tidak sesuai dengan formularium atau guideline. Penggunaan antibiotik pada pasien ulkus diabetes mellitus sebagian besar sesuai rekomendasi, namun tetap memiliki risiko tinggi. Diperlukan pemantauan terapi, medication review, dan intervensi terapi berbasis guideline untuk meningkatkan efektivitas pengobatan.

Rasionalitas dan Potensi Drug-Related Problems pada Penggunaan Antibiotik pada Pasien Rawat Inap dengan Ulkus Diabetes Mellitus Tipe II Vinci Mizranita; Inayatush Sholihah; Novita Dhewi Ikakusumawati; Tiara Dewi Salindri Pratama; Rini Budi Astuti; Devi Yanthre Sari Manurung; Akbar Eka Nugraha
Generics: Journal of Research in Pharmacy Vol 6, No 1 (2026): Generics : Journal of Research in Pharmacy
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v6i1.28510

Ulkus diabetes melitus (DM) tipe II merupakan komplikasi kronis yang sering menimbulkan infeksi serius, memerlukan terapi antibiotik, dan berisiko tinggi terhadap kejadian drug-related problems. Penelitian ini bertujuan untuk mengevaluasi rasionalitas dan penggunaan antibiotik, serta identifikasi drug-related problems pada pasien ulkus diabetes mellitus tipe II. Penelitian deskriptif ini dilakukan pada 44 pasien ulkus diabetes mellitus tipe II di Instalasi Rawat Inap Rumah Sakit Universitas Sebelas Maret. Data dikumpulkan melalui rekam medis dan dianalisis menggunakan klasifikasi PCNE V9.1 untuk mengidentifikasi drug-related problems. Sebagian besar pasien berusia 60–74 tahun (52%), memiliki komplikasi terbesar makrovaskuler (91%), khususnya hipertensi (43,75%) dan amputasi (34,38%). Antibiotik yang paling sering digunakan adalah seftriakson (27%) dan metronidazol (20%), dengan rute pemberian secara parenteral (66,94%) sebagai rute pemberian utama. Sebanyak 113 kasus kejadian drug-related problems yang teridentifikasi, didominasi oleh kombinasi penggunaan obat yang tidak sesuai (51,3%), dosis tidak tepat, dan terapi tidak sesuai dengan formularium atau guideline. Penggunaan antibiotik pada pasien ulkus diabetes mellitus sebagian besar sesuai rekomendasi, namun tetap memiliki risiko tinggi. Diperlukan pemantauan terapi, medication review, dan intervensi terapi berbasis guideline untuk meningkatkan efektivitas pengobatan.

Overview of Indonesian Community Pharmacy: Understanding Practice Changes Mizranita, Vinci; Ponto, Thellie; Sipana, Beulah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.80498

Community pharmacy practice in Indonesia has shifted to a patient-centered model, offering a range of services that include treatment advice, chronic disease management, and public health promotion. This shift benefits consumers who visit community pharmacies as their initial healthcare point. The Indonesian healthcare system, a mix of public and private providers, is governed by a decentralized structure, fostering significant investment in private healthcare despite access limitations due to financial capacity. Medicines distribution, managed by the District Health Office, ensures supply to primary healthcare facilities, with community pharmacies regulated by the Ministry of Health and the Indonesian National Food and Drug Agency. Despite stringent regulations mandating comprehensive services, most pharmacists are not remunerated for their services. Pharmacy staff, including formally qualified pharmacists and pharmacy technicians, are registered professionals, with recent trends indicating a shift towards employing pharmacy technicians to enable pharmacists to focus on clinical roles. Economic factors and innovative service delivery modes, such as telepharmacy and online purchasing, are expected to influence future practices, enhancing the pharmacist's role in chronic disease management and other health conditions. The evolving community pharmacy practice in Indonesia reflects broader changes in the healthcare system and professional roles, with continued progression anticipated.

Title

Found 9 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 9 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 9 Documents
Search