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Kanti Yunika, Kanti
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Journal : Medica Hospitalia

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FAKTOR RISIKO OBSTRUCTIVE SLEEP APNEA PADA PASIEN DIABETES MELLITUS : FAKTOR RISIKO OBSTRUCTIVE SLEEP APNEA PADA PASIEN DIABETES MELLITUS Patria, Dimas Adi; Budiarti, Rery; Ayu Ruspita, Dian; Yunika, Kanti; Tedjo Minuljo, Tania; Farokah, Farokah
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.824

Abstract

LATAR BELAKANG : Sleep Disordered Breathing(SDB) memiliki hubungan dua arah dengan sindrom metabolik seperti Diabetes Mellitus (DM) dan hipertensi, komponen sindrom metabolik meningkatkan risiko terjadinya SDB. IMT >30 kg/m2, aktivitas fisik, lingkar leher >40 cm dan hipertensi berisiko tinggi terhadap kejadian SDB. SDB telah terbukti meningkatkan risiko dan keparahan DM, sehingga penanganan SDB dibutuhkan untuk tindakan preventif  DM. TUJUAN : Mengetahui bahwa obesitas, lingkar leher besar, hipertrofi konka inferior, deviasi septum hidung, hipertrofi tonsila palatina, makroglosia, obstruksi saluran nafas atas dan hipertensi merupakan faktor resiko yang mempengaruhi kejadian SDB pada penderita DM. METODE : Penelitian observasional analitik dengan desain cross sectional melibatkan subyek sebanyak 57 penderita DM rawat jalan di Poli Penyakit Dalam RSUP Kariadi Semarang yang memenuhi kriteria inklusi pada bulan Januari 2022 - Maret 2022. Data diperoleh dari rekam medik, kuesioner ESS, pemeriksaan fisik THT dan pemeriksaan Laryngoscopy Flexible. Analisis menggunakan uji chi-square dan uji regresi multivariat. HASIL : Rerata usia 51.87 tahun, dengan SD 9.094, termuda usia 27 tahun, tertua usia  63 tahun. Laki-laki sebanyak 28(49.1%) dan perempuan 29 (50.9%). Obesitas (p= 0,036), lingkar leher besar(p=0.017), hipertrofi konka inferior(p=0,020), makroglossia(p=0,012), hipertrofi tonsila palatina(p=0,017), hipertensi (p=0,001), dan obstruksi saluran nafas atas(p=0,020) merupakan faktor risiko SDB pada penderita DM. Analisis regresi multivariat didapatkan obesitas (p=0,043 RP=13,387.CI 95%:1,083-165,475)dan hipertropi tonsil palatina(p=0,019 RP=9,703.CI 95%=1,446-65,121) merupakan faktor risiko yang paling dominan. SIMPULAN : Obesitas, lingkar leher besar, hipertrofi konka inferior, makroglossia, hipertrofi tonsila palatina, hipertensi, dan obstruksi saluran nafas atas merupakan faktor resiko SDB pada penderita DM. Obesitas dan hipertropi tonsil palatina merupakan faktor risiko yang paling dominan KATA KUNCI: SDB, DM, faktor risiko, hipertrofi tonsil, makroglosia
OSA FAKTOR RISIKO KEJADIAN OBSTRUCTIVE SLEEP APNEA PADA PASIEN STROKE ISKEMIK: - Rosyidah, Nurul Uly; Mailasari Kusuma Dewi, Anna; Marliyawati, Dwi; Yunika, Kanti; Suryawati, Herlina; Budiarti, Rery
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.826

Abstract

LATAR BELAKANG: Sleep Disordered Breathing (SDB)  memiliki hubungan dua arah dengan stroke iskemik. SDB yang tidak diobati dapat menyebabkan stroke berulang. Penanganan SDB adalah kunci untuk preventif pada pasien stroke. TUJUAN: Menganalisis IMT, lingkar leher besar, deviasi septum, hipertrofi konka, hipertrofi tonsila palatina, makroglosia, dan obstruksi saluran nafas atas sebagai faktor risiko SDB pasien stroke iskemik. METODE: Penelitian observasional dengan desain cross sectional, pada 86 pasien stroke iskemik di Poli Neurologi dan THT-KL RSUP Kariadi Semarang bulan Desember 2021-Juli 2022. Data diperoleh melalui kuesioner, pemeriksaan fisik dan pemeriksaan nasolaringoskopi fleksibel. Analisis menggunakan uji chi-square dan uji regresi multivariat. HASIL: Didapatkan 86 subjek terdiri dari 42 laki-laki(48,8%) dan perempuan 44 (51,2%), usia rerata 54 th, dan 61 subjek (70,9%) stroke iskemik pertama. Septum deviasi (p= 0,020), hipertrofi konka inferior (p= 0,021), makroglosia (p= 0,012), hipertrofi tonsila palatina (p= 0,013), dan obstruksi saluran nafas atas (p= 0,035) merupakan faktor risiko SDB pada pasien stroke iskemik. Septum deviasi berisiko 6,1x, konka inferior hipertrofi berisiko 4,1x, dan hipertrofi tonsila palatina  berisiko 8,8x terhadap SDB pada pasien stroke iskemik. SIMPULAN: Septum deviasi, konka inferior hipertrofi, makroglossia, hipertrofi tonsila palatina, makroglosia, dan obstruksi saluran nafas atas merupakan faktor resiko terhadap SDB pasien stroke iskemik. Hipertrofi tonsila palatina merupakan faktor risiko yang paling dominan terhadap SDB pasien stroke iskemik. KATA KUNCI: SDB, faktor risiko, stroke iskemik, hipertrofi tonsila palatina, septum deviasi
Comparison Of Clinical Response Between Combine Chemotherapy 5 Fluorourasil - Platinum Based And Ifosfamid - Taxane - Platinum Based In Recurrent Nasopharyngeal Carcinoma Sanjaya, Rio; Yusmawan, Willy; Antono, Dwi; Marliyawati, Dwi; Yunika, Kanti
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.926

Abstract

BACKGROUND : Recurrence of Nasopharyngeal Carcinoma (NPC) is the emergence of a tumor remission after administration of chemoradiation based on symptoms and several examinations. The combination of chemotherapy in recurrent NPC still gives good results. The combine of regimens used is still varied and not much study has been done to assess the clinical response. OBJECTIVE : To compare the clinical response between administration of combination 5 Fluorouracil-Platinum based (5-FU) and Ifosfamide-taxan-platinum based (IFO) in recurrent NPC. METHOD :. This observational study used electronic medical record (ERM) data at the ENT oncology clinic at Dr. Kariadi General Hospital for the period January 2020-January 2022. The number of samples that suited to the inclusion and exclusion criteria was 44 subjects divided into two groups of 22 subjects respectively. The chi-square test was used to assess differences in alteration of clinical symptoms, tumor mass size, neck lymph node enlargement, tumours stage reduction, and the effect of confounding factors on response to therapy in both groups. RESULTS : The highest number of patients with recurrent NPC were aged ≥45 Years old and male (75%). WHO type 3 is the most common (95.5%) and ECOG status 1 (95.5%). There was no significant difference administration of the combination of 5-FU with IFO in alteration of clinical symptoms (p=0.500), shrink tumor size (p=0.347), reduction of neck lymph node size (p=0.164), and reduction tumor staging (p=0.347). There was no relationship from confounding factors to clinical response between the administration of the two groups. CONCLUSION : Administration of 5 Fluorouracil-platinum based combination chemotherapy did not provide a better clinical response in terms of clinical symptoms, changes in primary tumor size, neck lymph node size, and decreased tumor stage compared to the Ifosfamide-taxane-platinum based combination based on recurrent NPC.
Risk Factors for Peripheral Vertigo Sekarwangi, Yuni Retno; Marliyawati, Dwi; Yunika, Kanti; Naftali, Zulfikar
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.977

Abstract

Background: Several risk factors influence the occurrence of peripheral vertigo, including advanced age, gender, and chronic metabolic diseases. This disease is not widely recorded in primary care due to the need for detection with simple examinations. Research on the association of several risk factors has yet to be reported. Objectives: To examine the relationship between age, gender, type 2 diabetes mellitus (DM2), and hypertension as risk factors for peripheral vertigo. Methods: This study is a case-control study that used consecutive sampling. The study sample consisted of 39 people: 19 in the case group and 20 in the control group. Data were obtained from 2 health centers and Diponegoro National Hospital, Semarang City. The data were obtained from history taking and physical examinations such as the Gans Sensory Organization Performance Test (SOP), past pointing test, and dysdiadokokinesia test. DM2 disease and hypertension were gathered from medical records. Data analysis used univariate analysis, bivariate analysis with chi-square, and logistic regression multivariate analysis. Results:  Statistical test results concluded that hypertension is a risk factor for peripheral vertigo (p = 0.008; OR = 6.964; 95%CI = 1.657 - 29.263). Whereas age, gender, and DM2 were not risk factors, with p-values of 0.187, 0.378, and 0.417, respectively. Conclusion: The significant risk factor associated with the occurrence of peripheral vertigo was hypertension by 6.964 times.
Co-Authors Antono, Dwi Astika, Ismiar Ayu Ruspita, Dian Budiarti, Rery Dana, Indra Pratama Dewi, Anna Mailasari Kusuma Farokah, Farokah Juneson, Albert Kuntjoro, RR Lydia Purna Widyastuti Setjadiningrat Mailasari Kusuma Dewi, Anna Marliyawati, Dwi Patria, Dimas Adi Rio Sanjaya Rosyidah, Nurul Uly Sekarwangi, Yuni Retno Suryawati, Herlina Tedjo Minuljo, Tania Willy Yusmawan, Willy Zulfikar Naftali, Zulfikar