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All Journal Farmaka Jurnal Surya Medika JMM (Jurnal Masyarakat Mandiri) Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Journal of Experimental and Clinical Pharmacy (JECP) IICSDGs Jurnal Katalisator

PRISCA SAFRIANI WICITA

Poltekkes Kemenkes Gorontalo

Author-ID : 5295172

Religion Agriculture, Biological Sciences & Forestry Arts Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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UJI AKTIVITAS ANTIBAKTERI SEDIAAN PEEL OFF MASK EKSTRAK ETANOL DAUN KELOR Pratiwi Ishak; Fihrina Mohamad; Prisca Safriani Wicita; Nangsih Sulastri Slamet; Arlan K. Imran
JURNAL KATALISATOR Vol. 7 No. 1 (2022): Jurnal Katalisator Volume 7 Nomor 1, April 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Propionibacterium acnes is one of the bacteria that trigger acne. A popular face mask preparation today for acne skin care is the peel off Mask. The purpose of this study was to formulate ethanol extract of moringa leaves (Moringa oleifera L.) become a Peel Off mask preparation and see the antibacterial activity of the preparation against Propionibacterium acnes. This research method is quasi experimental, formulated Peel Off Mask preparation with variation of ethanol extract of moringa leaves F1 (10%), F2 (15%) and F3 (20%), then physical test (organoleptic test with hedonic scale 1-5, pH test, irritation test, spreadability test, dry time test) and antibacterial activity test with diffusion method. Data analysis of antibacterial activity test results using one way ANOVA test. The results showed organoleptic test, pH test, irritation test and drying time test F1-F3 all meet the standard. Antibacterial activity test has the greatest power is F1 17.17 mm. The result of one way anova test between F3 treatment with positive control 2 (peel Off mask Brand x®) obtained significance value (0.01) <(0.05), which means F3 has a significant difference to KP2. Conclusion; preparation peel Off Mask ethanol extract of Moringa leaves F3 is the best formula physically and has the greatest antibacterial activity of 17.17 mm (strong) against Propionibacterium acnes.

SUPLEMENTASI SARI DAUN KELOR (Moringa oleifera L.) MENURUNKAN BILANGAN PEROKSIDA DAN ASAM LEMAK BEBAS VCO Nangsih Sulastri Slamet; Ghaitsa Zahira Sopha Yusuf; Fadli Husain; Fihrina Mohamad; Prisca Safriani Wicita; Zulfiayu; Fitriah Ayu Maghfirah Yunus
JURNAL KATALISATOR Vol. 8 No. 1 (2023): Jurnal Katalisator Volume 8 No. 1, April 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Syarat VCO menurut SNI 7381:2008 yaitu memiliki nilai bilangan peroksida dan kadar asam lemak bebas yang rendah. Permasalahan VCO yang beredar saat ini yaitu pada parameter organoleptik khususnya pada aroma bau tengik yang mempengaruhi kualitas dan penyimpanan. Sehingga untuk mengatasi hal tersebut diperlukan antioksidan alami. Daun kelor merupakan tanaman yang berpotensi sebagai antioksidan alami, sehingga berpotensi dalam menurunkan bilangan peroksida dan asal lemak bebas pada VCO.Penelitian ini bertujuan mengetahui nilai bilangan peroksida dan asam lemak bebas pada VCO yang disuplementasi dengan sari daun kelor (Moringa oleifera L.) menggunakan metode fermentasi.Penelitian ini merupakan penelitian quasi eksperimen mengunakan rancangan acak lengkap (RAL) dengan 4 formulasi dengan variasi volume penambahan sari daun kelor F1 (0 mL); F2 (50 mL); F3 (100 mL) dan F4 (150 mL). Bilangan peroksida dan asam lemak bebas dianalisis menggunakan metode titrimetri. Analisis data menggunakan uji Kruskal Wallis dan dilanjutkan dengan uji Mann Whitney.Hasil Penelitian: penambahan sari daun kelor dapat menurunkan bilangan peroksida dan asam lemak bebas pada VCO yang dihasilkan. Bilangan peroksida terukur pada F1, F2, F3 dan F4 berturut-turut adalah 5,76; 3,33; 2,42 dan 1,82 meq/kg, sedangkan kadar asam lemak bebas terukur berturut-turut sebesar 0,4; 0,36; 0,31 dan 0,2 %.Kesimpulan: Semakin besar volume sari daun kelor yang ditambahkan maka nilai bilangan peroksida dan kadar asam lemak bebas pada VCO semakin rendah.

PENINGKATAN KELARUTAN SIMVASTATIN MELALUI PENAMBAHAN BAHAN PENGOMPLEKS SULFANILAMID Arlan Imran; Prisca Safriani Wicita; Zulfiayu Sapiun
JURNAL KATALISATOR Vol. 8 No. 1 (2023): Jurnal Katalisator Volume 8 No. 1, April 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Simvastatin is a drug used to lower cholesterol levels in the blood. The mechanism of action of simvastatin is by inhibiting the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which competitively inhibits the cholesterol biosynthesis process in the body. Simvastatin is included in the class II BCS (Biopharmaceutics Classification System) drug, which has low water solubility and high permeability. The low solubility of simvastatin in water will affect its bioavailability in the body, which result in a therapeutic effect that is not achieved. Drug complexation is a method used to determine the solubility of a compound by adding a complexing agent. Complexing materials that are often used in other research are materials that do not have therapeutic activity such as cyclodextrin, but ini this study used complexing material from anti-microbial drug class by utilizing the reaction of glucoronide formation in the glucoronic acid structure of sulfanilamide. This research is a quantitative research with a laboratory experimental trial method which aims to see the effect of adding sulfanilamide complexing agents at various concentrations (25 ppm, 50 ppm, 75 ppm, and 100 ppm) on the solubility level of simvastatin using the acid-base titration method. The dissolved simvastatin concentration values for F1, F2, F3, F4, and F5 were 0.261 ± 0.087, respectively; 0.348 ± 0.151; 0.416 ± 0.195; 0.444 ± 0.163; 0.539 ± 0.118. The results obtained showed that the higher concentration of the sulfanilamide complexing agent added, the greater solubility of simvastatin.

Co-Authors Basri, Insyira Fadliana Basri, Rakhmadhana Fitraeni Daud, Rizka Puji Astuti Denny Indra Setiawan Fadli Husain Fihrina Mohamad Fitriah Ayu Magfirah Yunus Fitriah Ayu Maghfirah Yunus Ghaitsa Zahira Sopha Yusuf Hartati Hartati Husain, Fadli Imran, Arlan K Insyira Fadliana Basri Nangsih Sulastri Slamet Nur, Mohamad Usman Pratiwi Ishak Pratiwi Y Ishak Putri, Nurwigya Mohamad Sapiun, Zulfiayu Vyani Kamba Wantaa, Nurunnisa Yahya, Cindy Ysrafil, Ysrafil Yunus, Fitriah Ayu Magfirah

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