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All Journal Damianus Journal of Medicine Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Cancer eJournal Kedokteran Indonesia Jurnal Penyakit Dalam Indonesia Jurnal Kedokteran Meditek
Profitasari Kusumaningrum
Departemen Ilmu Kesehatan Jiwa (Psikiatri), Fakultas Kedokteran Universitas Indonesia/ Rumah Sakit Umum Pusat Dr. Cipto MangunkusumoJakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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KOMORBIDITAS FISIK PADA GANGGUAN BIPOLAR DI RS. DR. H. MARZOEKI MAHDI BOGOR Tinambunan, Iriawan Rembak; Amir, Nurmiati; Budiman, Richard; Kusumaningrum, Profitasari
Majalah Kedokteran Indonesia Vol 68 No 8 (2018): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

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Abstract

Pendahuluan: Gangguan bipolar dikenal memiliki kaitan dengan berbagai komorbiditas klinis yang memengaruhi pekerjaan, kehidupan berkeluarga, dan fungsi interpersonal. Duapertiga pasien dengan gangguan bipolar memiliki komorbid yang akan memperburuk luaran gangguan bipolar dan dapat menganggu penatalaksanaan terhadap penyakitnya. Belum ada penelitian yang menggambarkan frekuensi komorbiditas fisik yang terjadi pada penderita bipolar di Indonesia. Rumah Sakit Dr. H. Marzoeki Mahdi sebagai rumah sakit jiwa tertua di Indonesia juga belum memiliki data mengenai jenis dan frekuensi komorbid fisik, mengingat bahwa rumah sakit ini juga menangani rawat inap umum di samping rawat inap psikiatri. Metode: Penelitian menggunakan rancangan potong lintang pada 100 orang dengan Gangguan Bipolar di Poliklinik Jiwa Dewasa dan Bangsal Psikiatri R.S. Dr. H. Marzoeki Mahdi Bogor. Penelitian ini menggunakan instrument Structured Clinical Interview For the DSM-IV Axis I Disorders untuk menentukan Gangguan Bipolar, dan kriteria diagnostik sepuluh komorbid fisik yang mengacu pada kriteria diagnostik masing-masing komorbid fisik. Hasil: Pada penelitian ini didapatkan adanya hubungan bermakna antara umur dengan terjadinya komorbid fisik yaitu p= 0.001(p di bawah 0.005). Pada analisis tambahan didapatkan adanya hubungan bermakna antara pemberian obat polifarmasi/monoterapi dengan terjadinya komobid fisik terbanyak yakni hipertensi (nilai p= 0,0001). Pada sepuluh komorbid fisik yang dinilai, migrain, hipertensi dan dermatitis merupakan yang paling banyak. Kesimpulan: Hipertensi, migrain dan dermatitis merupakan tiga besar komorbid fisik di R.S. Dr. Marzoeki Mahdi Bogor. Terdapat hubungan bermakna antara umur dengan terjadinya komorbid fisik. Pemberian obat polifarmasi/monoterapi juga bermakna dalam terjadinya hipertensi. Diperlukan kewaspadaan psikiater dalam mengawasi terjadinya komorbid fisik pada gangguan bipolar di layanan psikiatri. 
PENGGUNAAN ANTIPSIKOTIK PADA LANSIA DAN EFEK KARDIOVASKULAR: EVIDENCE BASED CASE REPORT Kasmianto Abadi; Natalia Widiasih; Profitasari Kusumaningrum; Martina W.Nasrun
Majalah Kedokteran Indonesia Vol 68 No 12 (2018): Journal of The Indonesian Medical Association Majalah Kedokteran Indonesia Volu
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v68i12.207

Abstract

Latar Belakang Penggunaan Antipsikotik pada lanjut usia (lansia) berhubungan dengan efek samping kardiovaskular. Beberapa efek samping kardiovaskular dapat terjadi pada lansia baik ringan hingga dapat menyebabkan kematian mendadak. Jenis antipsikotik yang digunakan diduga berhubungan dengan kejadian mortalitas sistem kardiovaskular.Metode: Pencarian terstruktur dilakukan di Pubmed, EBSCO, dan Science Direct menggunakan kata kunci berdasarkan konsep Boolean operators yang sesuai dengan pertanyaan klinis. Populasi target yaitu pasien lanjut usia yang menggunakan antipsikotik dan efek terhadap sistem kardiovaskular.Hasil: Setelah menyaring 68 judul dan abstrak dengan menggunakan kriteria inklusi dan eksklusi, didapatkan 2 artikel. Selanjutnya dilakukan telaah kritis berdasarkan kesahihan, kepentingan hasil, dan aplikasi. Kedua artikel memperlihatkan adanya hubungan yang signifikan antara penggunaan antipsikotik dan kejadian mortalitas kardiovaskular.Kesimpulan: Penggunaan antipsikotik pada lansia dapat menyebabkan risiko mortalitas kardiovaskular, perlu untuk menilai profil keuntungan dan risiko penggunaan obat antipsikotik serta penyesuaian dosis dan evaluasi efek samping.
The Role of Cognitive Reserve as Measured by Cognitive Reserve Index Questionnaire Indonesia Version in Geriatric Delirium Cases Profitasari Kusumaningrum; Dewanto Andoko; Charles Evert Damping; Martina Wiwie Setiawan Nasrun
eJournal Kedokteran Indonesia Vol 9, No. 1 - April 2021
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.915 KB) | DOI: 10.23886/ejki.9.29.44

Abstract

Delirium is often associated with factors that worsen the condition and prognosis of a person's health. The Cognitive Reserve Index questionnaire Indonesia version (KICK) is a questionnaire that quantifies the cognitive reserve (CR) into a single index. This study aims to obtain an instrument to assess CR, namely KICK, and test its validity and reliability and finding the role of CR in geriatric delirium cases. The study was conducted in the integrated geriatric outpatient and acute geriatric inpatient of Cipto Mangunkusumo Hospital on June 2019 to September 2019, by validity testing and case control study in geriatric delirium cases to 33 subjects with delirium and 33 controls. Content validity test was carried out through a panel test with the conclusion that KICK is relevant for use as an instrument to examine CR. The construct validity of the three variables showed significant correlation with total score with p-value <0,001). Reliability test showed Cronbach’s Alpha of 0,688. Significant differences in CR score of delirium versus control (p<0,01) with OR 9 (95% CI 2.86 to 28.22).KICK is valid and reliable to measure CR of Indonesian elderly and patients with low CR score have a higher chance of developing delirium.
Factors Influencing Distress and Coping Strategies Among Patients with Metastatic Spinal Tumor at Cipto Mangunkusumo General Hospital Agiananda, Feranindhya; Nugraeni, Tiara; Diatri, Hervita; Aninditha, Tiara; Kusumaningrum, Profitasari
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.994

Abstract

Background: Patients with metastatic spinal tumor are experiencing various symptoms, including neurological deficits that cause distress and affects their quality of life. The vulnerability to distress is influenced by coping strategies. Therefore, this study aimed to investigate factors associated with distress and coping strategies in patients with metastatic spinal tumors at Cipto Mangunkusumo General Hospital. Methods: In a cross-sectional study conducted at Cipto Mangunkusumo General Hospital from September 2021 to May 2022, factors associated with distress and coping strategies in patients with metastatic spinal tumors were investigated. The analysis included a total of 104 subjects from both outpatient and inpatient settings. Distress levels and areas of concern were assessed using the Distress Thermometer (DT) questionnaire while coping strategies were evaluated through the Coping Orientation to the Problem Experienced (COPE) instrument. Bivariate and multivariable analyses were carried out to assess the relationship between sociodemographic factors, spinal tumor characteristics, specific areas of concern, coping strategies, and distress.Results: The results showed that 57.7% of metastatic spinal tumor patients experienced distress. In the 18-59 age group, motor disorders, sensory disturbances, autonomic disorders, treatment status, problem-focused coping (PFC), emotion-focused coping (EFC), and avoidance coping had significant associations with distress. However, the multivariable analysis showed that EFC (OR = 1.156, 95% CI: 1.024–1.304, p=0.019), avoidance coping (OR = 1.154, 95% CI: 1.005–1.326, p=0.042), and sensory disturbance (OR = 16.001, 95% CI: 1.472–173.960, p=0.023) were identified as risk factors for distress.Conclusions: Patients with metastatic spinal tumors who used emotion-focused coping, avoidance coping, and sensory disturbance faced significant risk factors for distress
Faktor-Faktor yang Berhubungan dengan Gejala Depresi pada Pasien Insomnia Usia Lanjut di Rawat Jalan Pratiwi, Amalia Nur; Wahyudi, Edy Rizal; Kusumaningrum, Profitasari; Shatri, Hamzah; Rinaldi, Ikhwan; Gani, Rino Alvani; Wijaya, Ika Prasetya; Susilo, Adityo; Renaldi, Kaka
Jurnal Penyakit Dalam Indonesia Vol. 12, No. 3
Publisher : UI Scholars Hub

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Abstract

Introduction. The elderly population is increasing globally, including in Indonesia, where 10.7% of the population in 2020 were elderly. Insomnia is a common health issue among older adults and has been identified as a predictor of depression. This study aims to identify factors associated with depressive symptoms in elderly outpatients with insomnia. Methods. This cross-sectional study was conducted in 2024 on patients aged ≥60 years at the outpatient unit of Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia, using consecutive sampling to select participants. Elderly patients were screened using the Pittsburgh sleep quality index (PSQI), and those with a score >5 (indicating insomnia) were included as study subjects. Data were collected through interviews, covering sociodemographic characteristics, level of loneliness, duration of insomnia, depressive symptoms [Geriatric Depression Scale–15 (GDS-15) items], functional status [Barthel Activities of Daily Living (B-ADL)], cognitive status [Mini-Mental State Examination (MMSE)], nutritional status [Mini Nutritional Assessment (MNA)], and chronic diseases [Cumulative Illness Rating Scale for Geriatrics (CIRSG) score]. Results. The study included 209 elderly subjects with insomnia, with a mean age of 72.88 (SD 6.98) years, and a depression prevalence of 6.7%. Bivariate analysis showed significant associations between dependency (PR 5.24; 95% CI 1.50 – 18.29), malnutrition (PR 11.54; 95% CI 4.77 – 27.92), and chronic disease with a CIRSG score ≥9 (PR 4.15; 95% CI 1.18 – 14.50) and depressive symptoms in elderly patients with insomnia. No significant associations were found between sociodemographic factors, loneliness, duration of insomnia, or cognitive status and depression. Multivariate logistic regression analysis revealed a statistically significant association between malnutrition and depressive symptoms (p < 0.001). Conclusions. There is a significant association between malnutrition and depressive symptoms in elderly outpatients with insomnia. Further cohort studies are recommended to explore the causal relationship between malnutrition and depression in elderly patients with insomnia.
Hubungan Psikopatologi dan Mekanisme Koping dengan Internet Gaming Disorder (IGD) pada Populasi Dewasa di Indonesia Assandi, Pratiwi; Siste, Kristiana; Tobing, Heriani; Kusumaningrum, Profitasari
Jurnal Kedokteran Meditek Vol 31 No 4 (2025): JULI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i4.3728

Abstract

Introduction: Psychopathology and maladaptive coping can contribute to Internet Gaming Disorder (IGD) in adults, threatening productivity and life. Purpose: This study aimed to explore the associations between psychopathology and coping mechanisms with IGD in Indonesian  adults. Methods: This cross-sectional study included 358 adults aged 18 to 59 who engaged in online gaming through consecutive sampling. Data were collected online using Symptoms Check List-90, Brief COPE, Ten-Item Internet Gaming Disorder Test, and sociodemographic questionnaire and were analyzed using chi-square, Kolmogorov Smirnov, Mann-Whitney, and logistic regression tests. Results: The IGD proportion was 16,5%. Psychopathology (somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobia, paranoia, and psychotic), coping mechanisms (active-coping, use of instrumental support, humor, use of emotional support, positive reframing, self-distraction, denial, substance use, behavioral disengagement, venting, and self-blame), age, marital status, gaming duration, and Multiplayer Online Battle Arena games were significantly associated with IGD (p<0,05). Gaming duration exceeding three hours per day (OR=3,220, CI=1,574-6,588), dysfunctional coping (OR=1,154, CI=1,067-1,248), and hostility (OR=7,231, CI=3,038-17,213) identified as risk factors, while venting (OR=0,727, CI=0,533-0,991) served as protective factor. Conclusion: Psychopathology and dysfunctional coping are associated with IGD. Education on related factors, early detection of psychopathology, and identification of coping mechanisms support comprehensive IGD management.
Komorbiditas Fisik pada Gangguan Bipolar di RS. Dr. H. Marzoeki Mahdi Bogor Iriawan Rembak Tinambunan; Nurmiati Amir; Richard Budiman; Profitasari Kusumaningrum
Majalah Kedokteran Indonesia Vol 68 No 8 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.8-2018-45

Abstract

Introduction: Bipolar disorders are known to cause various clinical comorbidity that may affect work, family and interpersonal function. Two third of bipolar disorder have comorbidities that may worsen the outcome of bipolar itself and interfere with it’s therapy. There has not been sufficient study about physical comorbidities in bipolar in Indonesia. As the oldest psychiatric hospital in Indonesia that treats physical and psychiatric inpatients, Dr. H. Marzoeki Mahdi hospital still lacks data concerning types and frequencies of physical comorbidities. Method: This research uses cross-sectional design from 100 people with bipolar disorder at Psychiatric Clinic and Psychiatric Ward at Dr. H. Marzoeki Mahdi Bogor Hospital. This research also uses the Structured Clinical Interview For the DSM-IV Axis I Disorders to ensure the bipolar diagnosis, and criteria diagnostic for ten physical comorbidities from each of their field. Result: There is a significant relationship in this research between age and physical comorbidities p=0.001 (p less-than 0,005). In the additional analysis, there are significant relationship in this research between polypharmacy / monotherapy and hypertension (p=0,0001). Migraine, hypertension, and dermatitis were the top three physical comorbidities in this research. Conclusion: Hypertension, migraine and dermatitis are the top three in our physical comorbidities in Dr. H. Marzoeki Mahdi hospital. Age has a significant relationship with physical comorbidities. Polipharmacy and monotherapy also has significances in hypertension. Therefore psychiatrist must be aware about the possibility of physical comorbidity in the psychiatric care.
Penggunaan Antipsikotik pada Lansia dan Efek Kardiovaskular: Evidence Based Case Report Kasmianto Abadi; Natalia Widiasih; Profitasari Kusumaningrum; Martina W.Nasrun
Majalah Kedokteran Indonesia Vol 68 No 12 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.12-2018-207

Abstract

Background: Effects of antipsychotics in the elderly (elderly) is associated with cardiovascular side effects. Some cardiovascular side effects can occur in the elderly and can cause sudden death. The type of antipsychotics used is thought to be related to the incidence of cardiovascular mortality.Methods: A structured search was conducted at Pubmed, EBSCO, and Science Direct using keywords based on the Boolean operators concept that was suitable for clinical questions. The target population is elderly patients who use antipsychotics and effects on the cardiovascular system.Results: After filtering 68 titles and abstracts using inclusion and exclusion criteria, 2 articles were obtained. Furthermore, a critical review is based on validity, importance of results, and application. Both articles showed a significant association between the use of antipsychotics and the incidence of cardiovascular mortalityConclusions: The use of antipsychotics in the elderly can lead to cardiovascular mortality risk, it is necessary to assess the profile of the benefits and risks of using antipsychotic drugs as well as dose adjustments and evaluation of side effects.
Gangguan Fungsi Kognitif pada Pasien HIV / AIDS di Layanan Rawat Jalan RSCM dan Faktor yang Memengaruhinya Gabriela Ellenzy; Kristiana Siste Kurniasanti; Profitasari Kusumaningrum; Gina Anindyajati
Bahasa Indonesia Vol 24 No 3 (2025): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v24i3.6647

Abstract

Pendahuluan: Kemajuan teknologi medis dan akses yang lebih luas terhadap terapi antiretroviral (ART) telah meningkatkan angka harapan hidup orang dengan HIV. Namun, gangguan neurokognitif masih sering ditemukan dan dapat berdampak negatif terhadap kualitas hidup. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang berhubungan dengan penurunan fungsi kognitif pada pasien HIV/AIDS di Rumah Sakit Cipto Mangunkusumo (RSCM). Metode: Penelitian potong lintang dilakukan pada Mei 2022 hingga Januari 2024 di RSCM. Subjek penelitian adalah pasien HIV berusia 18–59 tahun, berbahasa Indonesia, dan sedang menjalani ART. Pasien dengan gangguan fisik atau mental berat dikecualikan. Sebanyak 121 subjek direkrut menggunakan metode pengambilan sampel acak sederhana. Data yang dikumpulkan meliputi karakteristik demografis, komorbiditas fisik, kondisi kesehatan mental, penggunaan zat, waktu inisiasi ART, durasi infeksi HIV, durasi penggunaan ART, kepatuhan pengobatan, dan dukungan sosial. Fungsi kognitif dinilai menggunakan Montreal Cognitive Assessment versi Indonesia (MoCA-INA). Analisis regresi linear dilakukan untuk mengidentifikasi faktor yang berhubungan dengan gangguan kognitif. Hasil: Rerata usia subjek adalah 40,25 ± 8,42 tahun dan mayoritas berjenis kelamin laki-laki. Prevalensi gangguan kognitif sebesar 55,4%. Pada analisis multivariat, keterlambatan inisiasi ART dan riwayat meningitis berhubungan secara signifikan dengan penurunan skor MoCA-INA. Setiap keterlambatan satu tahun inisiasi ART berhubungan dengan penurunan skor MoCA-INA sebesar 0,3 poin (p<0,05), sedangkan riwayat meningitis berhubungan dengan penurunan skor sebesar 2,63 poin (p<0,05). Simpulan: Keterlambatan inisiasi ART dan riwayat meningitis berhubungan dengan penurunan fungsi kognitif pada pasien HIV. Inisiasi ART sedini mungkin dan penapisan kognitif secara berkala perlu ditekankan untuk meningkatkan luaran jangka panjang.
Co-Authors Adityo Susilo, Adityo Agiananda, Feranindhya Charles Evert Damping Dewanto Andoko E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edy Rizal Wahyudi Gabriela Ellenzy Gina Anindyajati Hervita Diatri Ika Prasetya Wijaya Ikhwan Rinaldi Iriawan Rembak Tinambunan Kaka Renaldi Kasmianto Abadi Kasmianto Abadi Kurniasanti, Kristiana Siste Martina W.Nasrun Martina W.Nasrun Martina Wiwie Setiawan Nasrun Nugraeni, Tiara Nurmiati Amir Nurmiati Amir Pratiwi Assandi Pratiwi, Amalia Nur Raharjanti, Natalia Widiasih Richard Budiman Richard Budiman Rino A Gani Siste, Kristiana Tiara Aninditha Tiara Aninditha Tinambunan, Iriawan Rembak Tobing, Heriani