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All Journal JURNAL BIOMEDIK JSME MIPA UNIMA Paediatrica Indonesiana Jurnal Kedokteran Klinik Jurnal Ilmiah Wahana Pendidikan INTERNATIONAL JOURNAL OF EDUCATION, INFORMATION TECHNOLOGY, AND OTHERS

Julius H. Lolombulan, Julius H.

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Author-ID : 531191

Religion Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Social Sciences Other

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Articles

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Melatonin level and sleep disorders in adolescents Andre Inigo; Hesti Lestari; Nurhayati Masloman; Julius Lolombulan
Paediatrica Indonesiana Vol 55 No 4 (2015): July 2015
Publisher : Indonesian Pediatric Society

Background Sleep disorder is defined as a disturbance in the quality and time of sleep. Decreased melatonin levels have been noted in people with sleep disorders. Melatonin is a neurohormone, produced mainly by the pineal gland, as well as a small part of the retina. Its function is to maintain normal circadian rhythms and it is related to sleep regulation in humans.Objective To assess for a relationship between melatonin levels and sleep disorders in adolescents.Methods We conducted a cross-sectional study on students of two secondary schools in Tuminting, Manado, North Sulawesi, from May to June 2013. Subjects were obtained by consecutive sampling for a total of 44 adolescents aged 12-15 years. Subjects filled questionnaires, underwent wrist actigraphy, and provided blood specimens for examination of melatonin levels. We used descriptive and logistic regression analyses to assess for relationships between variables.Results Thirty (68.2%) subjects experienced sleep disorders. There was a significant association between decreased melatonin levels and the higher incidence of sleep disturbances (P = 0.02).Conclusion There is a correlation between melatonin levels in adolescents with sleep disorders. Decreased melatonin levels are associated with sleep disorders.

Blood pH and urinary uric acid-creatinine ratio in newborns with asphyxia Sally Palit; Rocky Wilar; Ari Runtunuwu; Julius Lolombulan
Paediatrica Indonesiana Vol 55 No 6 (2015): November 2015
Publisher : Indonesian Pediatric Society

Background Asphyxia is one of the leading causes of death in the world. Prematurity (28%), sepsis (26%), and asphyxia (23%) are the most common causes of death in newborns. In Indonesia, the newborn mortality incidence is 82 per 1,000 live births. Blood pH is a routine laboratory examination to diagnose newborn asphyxia, but it is preferrable to avoid such invasive procedures in newborns. An examination of urinary uric acid-creatinine (UA/ Cr) ratio may be useful as an alternative method for diagnosis of asphyxia. Hypoxia causes anaerobic metabolism which will increase the blood acidity, while creatinine will decline as a result of incomplete renal function in newborns. Objective To assess for a possible correlation between blood pH and urinary UA/Cr ratio in newborn asphyxia. MethodsWe conducted an observational, cross-sectional study in Prof. Dr. R. D. Kandou Hospital, Manado, North Sulawesi, from November 2013 to April 2014. Subjects were full term newborns with asphyxia. Blood pH and urinary UA/Cr ratio were compared with Pearsonâ€™s correlation test. Data was analyzed with SPSS version 22 software and P values <0.05 were considered to be statistically significant. Results Forty subjects met the inclusion criteria. Their predominant risk factor for asphyxia was fetal distress. Subjectsâ€™ mean blood pH was 7.1 (SD 0.1) and mean urinary UA/Cr ratio was 3.7 (SD 1.9). There was a moderate negative correlation between blood pH and urinary UA/Cr ratio (r= -0.55; P<0.001). Conclusion In newborns with asphyxia, lower blood pH is correlated with higher urinary UA/Cr ratio.

Correlation between tumor necrosis factor-alpha and septic shock in children Khrisanti Dinata; Ari L. Runtunuwu; Jose M. Mandei; Julius H. Lolombulan
Paediatrica Indonesiana Vol 53 No 1 (2013): January 2013
Publisher : Indonesian Pediatric Society

Background The crucial role cytokines play in the pathophysiologyof sepsis is widely accepted. Infection stimulates the productionof cytokines in various cell types. Tumor necrosis factor-alpha(TNF-a) is one of the most extensively investigated cytokines inexperimental and clinical sepsis. Tumor necrosis factor-alpha hasbeen shown to mediate lethality in experimental sepsis.Objective To evaluate for a possible correlation between TNF-alevel and septic shock in children.Methods This cross-sectional study was conducted in Manadofrom June to September 2011. A total of 40 patients with arecent diagnosis of sepsis or septic shock were included. Plasmaspecimens were collected from subjects for measurement ofTNF-a concentration. Logistic regression analysis was used toassess the correlation between TNF-a level and sepsis, as well asthe probability of shock in children with sepsis, with P<0.05 asstatistically significant.Results There was a strong positive correlation betweenTNF-a level and the probability of shock in children with sepsis(regression coefficient = 0. 78, P = 0.002).Conclusions There is a strong positive correlation betweenTNF-a level with the probability of shock in children with sepsis.Higher plasma level ofTNF-a is associated with higher probabilityof septic shock.

Correlation between interleukin-6 and septic shock in children Stephanie Yulianto; Ari Runtunuwu; Vivekenanda Pateda; Jose Mandei; Julius Lolombulan
Paediatrica Indonesiana Vol 52 No 6 (2012): November 2012
Publisher : Indonesian Pediatric Society

Background Sepsis is a lifeô€†threatening condition and the mostcommon cause of death in intensive care units in developingcountries, such as Indonesia. The first clinical signs of sepsis areusually nonô€†spedfic. More specific signs and laboratory parametersoften occur late and are associated 'With organ dysfunction andhigh mortality rates. Interleukinô€†6 (IL--6) is a biomarker reported tobe superior to clinical signs and conventional tests for sepsis. IL--6levels may indicate microorganism invasion, as well as progressionof infection into sepsis, severe sepsis, and septic shock.Objective To evaluate a correlation between interleukin (IL)ô€†6and septic shock in childrenMethods This crossô€†sectional study was conducted in the pediatricintensive care unit of Prof. Dr. R.D. Kandou Hospital, Manado,between June to September 2011. Subjects were children withsepsis or septic shock aged 1 month to 13 years, v.ith diagnosesbased on the International Pediatric Sepsis Consensus ConferenceCriteria 2005. A oneô€†time measurement of IL--6 plasma levelswas done at the time of diagnosis. Data was analyzed by logisticregression test using SPSS version 17 software. A P value of <0.05indicated statistical significance.Results The mean IL--6 plasma level in the septic group was 1.68(95%CI 1.45 to 1.91) pg/mL and that of the septic shock groupwas 2.33 (95%CI 1.79 to 2.86) pg/mL. Our results showed astrong positive correlation between ILô€†6 plasma levels v.ith theprobability of septic shock in children v.ith sepsis (regressioncoefficientô€‡1.3lO, Pô€‡O.024).Conclusion Higher plasma IL--6 levels were associated v.ith ahigher risk of septic shock in children with sepsis. [Paediatrrndones.2012;52:352-5].

Lactate clearance and mortality in pediatric sepsis Dedi K. Saputra; Ari L. Runtunuwu; Suryadi N. N. Tatura; Jeanette I. Ch. Manoppo; Julius H. Lolombulan
Paediatrica Indonesiana Vol 56 No 4 (2016): July 2016
Publisher : Indonesian Pediatric Society

Background Sepsis is a life-threatening condition often encountered in the pediatric intensive care unit. In the last five decades, despite the use of aggressive antibiotics and advances in intensive care medicine, the mortality rate of sepsis remains high. In 2005, the World Health Organization (WHO) estimated that 11 million children die annually due to sepsis, of these, 30,000 children under five years of age die daily. Serum lactate concentration is useful to evaluate the progression of sepsis in children. Lactate clearance can be used to evaluate the outcomes in sepsis management in children.Objective To evaluate the relationship between lactate clearance and patient mortality. We also attempted to assess the usefulness of lactate clearance as an early prognostic marker in pediatric sepsis.Methods This prospective cohort study was conducted at the Pediatrics Department of Prof Kandou General Hospital from November 2013 to April 2014. Consecutive sampling was undertaken on 45 children aged 1 month to 15 years who were diagnosed with sepsis according to the inclusion criteria. First lactate serum was measured immediately following patient admission to the PICU. The next serum lactate measurement was six hours after initial treatment in the PICU.Results The mean lactate clearance was higher in the survivorsâ€™ than in the non-survivorsâ€™ group (58.48%vs. 18.20%, respectively). Logistic regression analysis revealed a lactate clearance cutoff point of 34.7%, with sensitivity 87.50%, specificity 96.55%, positive predictive value 93.33%, and negative predictive value 93.33%. The formula used was y=1/{1+exp-(4.135-0.119 lactate clearance)}. Chi-square analysis of lactate clearance and mortality revealed an odds ratio (OR) of 196.0 (95%CI 16.34 to 2,351.53; P<0.001).Conclusion Higher lactate clearances significantly associate with lower mortality in children with sepsis.

Blood count to determine chronic inflammation severity in obese adolescents Martini Wongkar; Handoko Lowis; Sarah M. Warouw; Julius Lolombulan; Stefanus Gunawan
Paediatrica Indonesiana Vol 60 No 1 (2020): January 2020
Publisher : Indonesian Pediatric Society

Background Obesity is a growing public health problem of rapidly increasing prevalence in developing countries. Chronic low-grade inflammation plays a key role in the pathophysiology of obesity. Blood count values and ratios have been used as markers of inflammatory diseases. These parameters may be useful to determine the severity of chronic inflammation in obese children. Objective To determine if red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet distribution width (PDW), and platelet-to-lymphocyte ratio (PLR) can be useful for determining the severity of chronic inflammation in obese children. Methods This observational, analytic study was conducted in obese adolescents aged 14-18 years at senior high schools in Manado, North Sulawesi, from July to September 2018. Students with congenital anomalies, autoimmune diseases, history of asthma, or malignancy were excluded. Pearsonâ€™s correlation was used to analyze for potential relationships between obesity and red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet distribution width (PDW), and platelet-to-lymphocyte ratio (PLR). Results There was a negative relationship between obesity and MPV, but it was not statistically significant (r=-0.006; P=0.485). There were positive, but not significant relationships between obesity and RDW (r=0.139; P=0.192), NLR (r=0.155; P=0.166), PDW (r=0.02; P=0.45), and PLR (r=0.146; P=0.181). Conclusion The RDW, NLR, MPV, PDW, and PLR values are not significantly associated with severity of obesity in adolescents.

Platelet-lymphocyte ratio and sepsis outcome in children Ferry Kurniawan; Jeanette I. Ch. Manoppo; Ari Lukas Runtunuwu; Novie Homenta Rampengan; Julius Lolombulan
Paediatrica Indonesiana Vol 61 No 6 (2021): November 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.6.2021.322-7

Background Sepsis is the most common cause of death in infants and children worldwide. Identification of patients with a high risk of death and accurately anticipating outcomes in the early phase is very important in order to provide adequate intervention to the patient. Predictors and scoring systems have been used to determine the prognosis of sepsis n children. The platelet-lymphocyte ratio (PLR), a newly-used marker for inflammation, has received recent attention, as it can act as an indicator in a variety of diseases, including sepsis. Objective o investigate the relationship between PLR and clinical outcomes in pediatric patients with sepsis. Methods This study was conducted using an analytic, observational method with a prospective cohort approach in children with sepsis in the Pediatric Intensive Care Unit (PICU) of Prof. Dr. R. D. Kandou Central General Hospital, Manado, North Sulawesi, from February to August 2020. We analyzed patientsâ€™ platelet-lymphocyteratio (PLR), mortality rate, and length of stay using SPSS software. The PLR were recorded once within the first 24 hours of PICU admission. Results Of 96 PICU patients, 87 patients were eligible for this study. In total, 50 patients (57.47%) died. Mean PLR was 77.53 among sepsis survivors and 157.2 among non-survivors (rpb=0.566, P<0.0001) indicating a strong relationship between PLR and mortality. We also found a strong positive linear relationship between PLR and PICU length of stay. Conclusion Platelet-lymphocyte ratio is a predictor of sepsis outcomes that can be easily and inexpensively checked. Thus, it can be used in regions with limited health facilities.

Co-Authors Andre Inigo Angliadi, L S Ari L. Runtunuwu Ari L. Runtunuwu Ari Lukas Runtunuwu Ari Runtunuwu Ari Runtunuwu Baideng, Novdian H.S. Bawala, Arter Dedi K. Saputra Deflita R.N. Lumi Febilia Melanie Kasiuhe Ferry Kurniawan Gesal, Joudy Handoko Lowis Heber B. Sapan, Heber B. Hesti Lestari I Wayan Damai Ismail, Frans F D Jeanette I. Ch. Manoppo Jeanette I. Ch. Manoppo Jose M. Mandei Jose Mandei Khrisanti Dinata Kodir, Emilia Laurens T. B. Kalesaran, Laurens T. B. Leo Rendy Lidwina S. Sengkey Lumintang, Seila Martini Wongkar Novie Homenta Rampengan Nurhayati Masloman Paulina E. Wowiling, Paulina E. Repi, Johanis C. F. Rocky Wilar Sally Palit Santoso, Yuliati Sarah M. Warouw Selfie L. Kumesan Senduk, Meifira M. Stefanus Gunawan Stephanie Yulianto Sukmonowati, Kurnia Suryadi N. N. Tatura Vivekenanda Pateda Wolter Weol Yunita Sumakul

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