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All Journal Journal of Community Service Pharmaceutical Sciences and Research (PSR)
Takhwifa, Famila
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Humanities Economics, Econometrics & Finance Education Industrial & Manufacturing Engineering Social Sciences

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The Effect of Heparinoid as Systemic Prophylactic Anticoagulants on COVID-19 Patient Mortality and Its Safety Profiles: A Systematic Review and Meta-Analysis Anggarany, Ariska Deffy; Sauriasari, Rani; Alkaff, Muhammad; Takhwifa, Famila; Nufus, Hayatun; Paramita, Diana
Pharmaceutical Sciences and Research Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Coagulopathy is one of the complications of COVID-19 and is associated with a higher risk of mortality. However, evidence regarding the effectiveness and safety of anticoagulant therapy in various doses among COVID-19 patients is limited. This systematic review and meta-analysis aims to review and explore the effect of using heparinoids as a systemic anticoagulant at prophylactic doses on mortality in COVID-19 patients. Systematic searches were conducted of various databases (Pubmed, ScienceDirect, SpringerLink, Scopus, and ProQuest) covering the period 2019-2021. We assessed the quality of the articles using the STROBE checklist. Studies with a high risk of bias were excluded before pooled effect size was synthesized with 95% confidence intervals (CI) using random-effects models. From the 12 identified studies (N=8,968), six observational studies (N=7,176) were involved in the meta-analysis. The studies reviewed in the paper used a retrospective cohort design in various settings. The pooled effect size of mortality comparing prophylactic anticoagulant and no anticoagulant in three studies showed that there was an association between using prophylactic anticoagulant and a lower risk of in-hospital mortality (pooled OR= 0.47; 95% CI 0.19-0.76). A prophylactic dose of heparinoid anticoagulant was also associated with lower mortality (pooled OR= 0.51; 95% CI 0.21-0.82) and with lower bleeding events compared to intermediate-to-therapeutic dose anticoagulants. Administration of heparinoid anticoagulants at prophylactic doses was associated with reduced mortality risk in hospitalized COVID-19 patients. Due to the increased risk of bleeding with therapeutic doses, the use of prophylaxis anticoagulant is suggested in COVID-19 patients who are not critically ill.
EMPOWERING INDONESIAN MIGRANT WORKERS’ FAMILIES IN MALAYSIA THROUGH USED COOKING OIL-BASED SOAP MAKING TRAINING AND LITERACY ENHANCEMENT FOR PARENTS AND CHILDREN Zulys, Agustino; Bintari, Dini Rahma; Maulana, Ary; Yani, Sela Vivi; Takhwifa, Famila
Journal of Community Service Vol 8 No 1 (2026): JCS, June 2026
Publisher : Ikatan Dosen Menulis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56670/jcs.v8i1.420

Abstract

Indonesian Migrant Workers (PMI) families in Malaysia face layered challenges such as limited access to formal education services for their children and economic vulnerability for the parents. This community service aims to enhance the economic capacity of households through the utilization of used cooking oil waste and the optimization of the learning and literacy quality of PMI children at the Sanggar Bimbingan (SB) Meru, Klang, Selangor. The implementation method consists of stages of problem identification, data collection, data analysis, intervention priority setting, goal setting, program execution, evaluation, and adjustment. Implementation of a multidimensional program that includes training in making bar soap from used cooking oil, children’s literacy classes, sensorimotor stimulation, teacher training, and psychoeducational parenting. The program is implemented in collaboration with Universiti Teknologi Malaysia (UTM) and the Biman Foundation to ensure the program’s reliability. The impact measurement results are assessed qualitatively and quantitatively. Quantitative evaluation using pre-test and post-test instruments shows a significant increase in knowledge across all target groups. Parents’ understanding of soap making increased by 51,19%, teacher’s understanding after attending the literacy class improved by 31,04%. Beneficiary satisfaction evaluation scored an average of 4.49 out 5.00. Long-term sustainability is supported by the provision of modulus and self-education kits, backed by regular online monitoring. Through the framework of community empowerment, this program has successfully strengthened the economic, social, and educational dimensions for marginalized PMI communities.
Co-Authors Agustino Zulys Ariska Deffy Anggarany, Ariska Deffy Ary Maulana Dini Rahma Bintari Hayatun Nufus Muhammad Alkaff Paramita, Diana Rani Sauriasari, Rani Yani, Sela Vivi