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All Journal VALENSI Bulletin of Chemical Reaction Engineering & Catalysis Biology, Medicine, & Natural Product Chemistry Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research Eksakta : Berkala Ilmiah Bidang MIPA PROFESSIONAL HEALTH JOURNAL Jurnal Akademika Kimia Jurnal Pengabdian Pada Masyarakat BIO-CONS: Jurnal Biologi dan Konservasi Bulletin of Chemical Reaction Engineering & Catalysis Pharmacon: Jurnal Farmasi Indonesia
Mohammad Rofik Usman
Bachelor In Pharmacy Program, Faculty Of Health Science, Universitas Dr. Soebandi, Jember, Jawa Timur
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Synthesis of Pentapeptide FWKVV (Phe-Trp-Lys-Val-Val) and Its Activity as Antioxidants Yanti, Eka Fitri; Nazareth, Eviyanti; Agustin, Yuana Dwi; Usman, Mohammad Rofik
Indonesian Journal of Chemical Research Vol 9 No 1 (2021): Edition for May 2021
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2021.9-eka

Abstract

Antioxidant pentapeptides are pentapeptide compounds that have antioxidant activity. One of the pentapeptide compounds that have antioxidant activity is FWKVV. FWKVV is a linear pentapeptide with the amino acid sequence phenylalanine-tryptophan-lysine-valine-valine, which was first isolated to hydrolyzate the muscle protein of Miiuy croaker (Miichthysmiiuy). In addition to isolation, FWKVV compounds can be produced by the peptide synthesis method because this method requires a shorter time than the isolation method from natural materials. Synthesis methods commonly used are solution-phase peptide synthesis and solid-phase peptide synthesis (SPPS). However, the SPSS method is more efficient because it does not require purification in every process. The purpose of this study was to synthesize FWKVV compounds using the SPPS method and test their antioxidant activity. FWKVV has been synthesized using the SPPS method with HBTU/HOBt coupling reagent and Fmoc protective group. The FWKVV crud produced was 148.8 mg and had antioxidant activity against DPPH radicals with an IC50 value of 4.2 mg/mL.
Pengolahan MBAH KOPI (liMBAH PAdat KOtoran saPI) sebagai Pupuk Kandang pada Kelompok Petani-Peternak Sejahtera di Desa Cangkring, Prajekan-Bondowoso Usman, Mohammad Rofik; Setyaningrum, Lindawati; Ivana, Nanda Letitia; Diana, Ilvid; Yanti, Eka Fitri
Jurnal Pengabdian Pada Masyarakat Vol 9 No 4 (2024): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v9i4.999

Abstract

Limbah kotoran sapi adalah sumberdaya peternak yang belum termanfaatkan. Peternak umumnya mengatasi limbah kotoran sapi dengan cara membuang ke sungai atau membakar limbah kotoran sapi. Dua hal tersebut dapat menimbulkan permasalahan lingkungan yang kompleks, dengan demikian diperlukan solusi untuk menangani hal tersebut yaitu dengan cara mengolah limbah kotoran sapi menjadi barang yang memiliki manfaat. Salah satu solusinya yaitu mengolah limbah kotoran sapi menjadi pupuk kandang menggunakan bahan Ni35 dimana bahan ini dapat mempercepat dekomposisi limbah padat kotoran sapi menjadi pupuk kandang. Metode yang digunakan dalam pengabdian ini dimulai dari penyuluhan, pelatihan, monitoring, dan evaluasi pelaksanaan produksi pupuk dan hasil uji pada tanaman kangkung dan cabai. Hasil pelaksanaan pengabdian menunjukkan bahwa peserta sangat antusias dalam mengikuti serangkaian kegiatan, serta dapat memproduksi pupuk kandang dengan kemampuan yang dapat bersaing dengan pupuk kandang konveksional/komersil. Cow manure is an underutilized resource among farmers. Generally, farmers address cow manure waste by discarding it into rivers or burning it. Both practices can lead to complex environmental problems. Thus, solutions are needed to manage this issue by transforming cow manure into valuable products. One solution involves processing cow manure into organic fertilizer using a substance called Ni35, which accelerates the decomposition of solid cow manure into usable compost. The method used in this community engagement project includes outreach, training, and monitoring, along with evaluating the production process and testing the fertilizer's effects on plants such as water spinach and chili. The results of this initiative show that participants were highly enthusiastic about the activities and successfully produced compost with competitive quality comparable to conventional commercial fertilizers.
Formulation and Evaluation of Hard Candy Preparation as an Innovative Internal Wound Medicine from Snakehead Fish (Channa striata) Albumin Extract Diana, Ilvid; Ardelia, Elfi Abidah; Nadriani, Nazilatun; Azizah, Dilna; Widhyati, Dea Nova; Usman, Mohammad Rofik
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.517-522

Abstract

Snakehead fish (Channa striata) is another alternative source of albumin protein because it is known to contain important compounds for the human body including high protein, fat, water, and the mineral zinc (Zn). The albumin content in Snakehead fish is an important protein needed by the body and is useful for wound healing. This study aims to make preparations by modifying Snakehead fish albumin into hard candy while maintaining the albumin content. Thus, a more effective way to be consumed in accelerating wound healing was found. The treatment used is Snakehead fish albumin extract with concentrations including F1 (5%), F2 (10%), and F3 (15%). Tests were conducted physically (organoleptic test) and chemically (moisture content test, ash content test, and wound growth activity test). Formulation and evaluation of hard candy preparations of Snakehead fish albumin extract (Channa striata) can be declared successful, as evidenced by the formation of 5 successful formulations into hard candy preparations as evidenced by the results of organoleptic tests, water content tests and ash content tests that have met the standards.
The Effect of Banana Pell (Musa paradisiaca L) Ethanol Extract on The Blood Glucose Level of Diabetic Mice with Alloxan Induction Jazilah, Nur; Fifteen Aprila Fajrin; Hidayati, Sholihatil; Usman, Mohammad Rofik
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.6555

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion, insufficient insulin hormones, or the inability to use insulin effectively. One of the traditional medicine use with DM is to control their blood glucose levels using herbal plants, namely the banana peel plant (Musa paradisiaca L.) which is rich in flavonoids, alkaloids, and tannins. This study aims to determine the effect of ethanol extract banana peel EEBP on glucose levels in mice with alloxan induction. The design of this study was a laboratory experiment, using male white mice (Mus musculus L) Balb/c strain, which were induced with alloxan at a dose of 200 mg/kg.bw. The mice were divided into six groups, namely normal, negative (CMC Na 0.5%), positive (glibenclamide 5 mg/kg.bw), and three groups of EEBP at a dose of 100 mg/kg.bw, 200 mg/kg.bw, and 400 mg/kg.bw. Blood glucose levels were evaluated on day 3 after induction, as well as day 7 and 14 after treatment. Blood glucose level data were analyzed using one-way ANOVA, followed by LSD post hoc test with 95% confidence level. The 400 mg/kg.bw dose of banana peel ethanol extract showed the highest percentage reduction in blood glucose levels, namely 65.83% ± 0.800, compared to other doses. Based on LSD statistical test, doses of 200 mg/kg.bw and 400 mg/kg.bw of EEBP showed no significant difference compared to the positive control (p>0.05). The optimal dose for reducing blood glucose levels in DM mice induced by alloxan is the treatment of EEBP in doses of 200 mg/kg.bw and 400 mg/kg.bw
Uji Aktivitas dan Karakterisasi Senyawa Penurun Kolesterol dari Fraksi Etil Asetat Daun Bidara (Ziziphus mauritiana) Masyhuri, Aga Adi; Usman, Mohammad Rofik; Situmeang, Boima; Wibowo, Arianto
BIO-CONS : Jurnal Biologi dan Konservasi Vol. 6 No. 2 (2024): BIO-CONS: Jurnal Biologi dan Konservasi
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31537/biocons.v6i2.2114

Abstract

Salah satu bahan alam yang dapat digunakan untuk menurunkan aktivitas kolesterol dalam tubuh adalah tanaman bidara, (Ziziphus mauritiana). Penelitian sebelumnya menunjukkan bahwa daun bidara positif mengandung alkaloid, flavonoid, saponin, dan tannin. Penelitian ini bertujuan untuk mengetahui karakter dan aktivitas senyawa penurun kolesterol pada daun bidara. Ekstraksi dilakukan dengan metode maserasi dengan pelarut metanol. Fraksinasi dilakukan dengan metode kromatografi kolom cair-cair dengan pelarut n-heksana dan etil asetat. Hasil skrining fitokimia pada fraksi etil asetat bidara menunjukkan bahwa fraksi mengandung senyawa golongan alkaloid, fenolik, flavonoid, terpenoid dan steroid. Hasil uji aktivitas penurun kolesterol mengungkapkan bahwa fraksi etil asetat memiliki aktivitas dan kemampuan menurunkan kolesterol yang cukup kuat. Hasil analisis dengan FTIR menunjukkan kandungan senyawa metabolit sekunder pada fraksi etil asetat adalah senyawa golongan  triterpenoid.
Identification of Gamma-Aminobutyricacid (GABA) of Tempeh Made from Koro Kratok (Phaseolus lunatus) Bean and Beluntas (Plunchea indica) Leaves as Glucose Stabilizer Istiqomah, Istiqomah; Rini, Dina Mustika; Tania, Larisa; Hidayati, Sholihatil; Usman, Mohammad Rofik
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.645-654

Abstract

The tempeh available on the market is predominantly made from imported soybeans, but alternative formulations using locally sourced legumes, such as koro kratok (Phaseolus lunatus), have been explored. This study investigates the potential of koro kratok tempeh enriched with Plunchea indica (beluntas) leaves to improve its functionality. The study will evaluate gamma-aminobutyric acid (GABA) levels and physicochemical changes during fermentation. Tempeh was produced using different koro kratok-to-P. indica leaf ratios (100:0, 75:25, and 50:50). Key parameters observed included mycelium development and the content of fat, moisture, ash, protein, carbohydrates, and pH. Adding P. indica increased the fat content by 0.66–2.28%, the moisture content by 68.81–78.42%, and the ash content by 0.36–1.09%. Meanwhile, the protein content ranged from 6.62–8.87%, the carbohydrate content from 12.07–21.31%, and the pH between 4.21–4.25. The inclusion of P. indica also altered the profile of dominant volatile compounds. GABA was detected in all samples, and in vivo studies showed improved blood glucose levels and glucose tolerance in prediabetic rats. These results suggest that koro kratok tempeh enriched with P. indica leaves could be a promising functional food for regulating blood glucose.
Co-Authors Ade Nisa’ Kartika Azzahra Aditya F. Ardinsyah Alfian Nur Firdaus Alfian Nur Firdaus Aliyah Purwanti Ardelia, Elfi Abidah Atiek Rostika Noviyanti Ayik Rosita Puspaningtyas1 Ayu Wanda Marita Ayu Wanda Marita Azizah, Dilna Azmi Prasasti Azmi Prasasti Diana Rakhmawaty Eddy Diana Rakhmawaty Eddy Diana, Ilvid Dwiki Yudistira Dyah Purwaningtyas Dyan Wigati Eka Fitri Yanti Eka Fitri Yanti, Eka Fitri Erma Pujiawati Fathor Rosi Fifteen Aprila Fajrin Frida Oktavia Putri Hermanto Haikal Alhamdi Sirojul Alam Hakiki, Lutfiah Nurul Hidayati, Sholihatil Ikfira Agustina Putri Ima F. Lestari Ima Fitria Lestari Istiqomah Hariyanto Ivana, Nanda Letitia Lindawati Setyaningrum lindawati setyaningrum Maasyitoh Sari Latifah Masyhuri, Aga Adi Mega T. Wulandari Muhamad D. Permana Nabila, Rifka Nadriani, Nazilatun Nazareth, Eviyanti Nur Jazilah, Nur Reno Kurnia Ramadhan Reza Zarkasih Adytia Ridho Anil Shohibul Falah Rini, Dina Mustika Rosita Dina Dwi Ayunliana Setyaningrum, Lindawati Situmeang, Boima Sovia Islamiah Sovia Islamiah Stephanie D. Artemisia Syamsiyatul Fajriyah Syamsiyatul Fajriyah Tania, Larisa Wibowo, Arianto Widhyati, Dea Nova Wima Anggitasari Yuana Dwi Agustin, Yuana Dwi