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All Journal Journal of Biomedicine and Translational Research Jurnal Analis Kesehatan Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal Sehat Indonesia (JUSINDO)
Nuroh Najmi
Anatomy Pathology, Department Of Oral Biology Faculty Of Dentistry Universitas Padjadjaran, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Oral Candida Albicans Colonization In Denture Wearer: A Literature Review Febriane Balafif, Felisha; Rafisa, Anggun; Kuswandani, Faisal; Najmi, Nuroh
Jurnal EduHealth Vol. 15 No. 03 (2024): Jurnal EduHealt (September), Year 2024
Publisher : Sean Institute

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Abstract

Denture stomatitis is the most prevalent multifactorial, chronic inflammatory oral condition amongs denture wearers. One of the primary roles of dentures in denture stomatitis is their potential to cause irritation and inflammation of the oral tissues. This continuous irritation creates an environment where fungal infections, notably C. albicans. The traumatic factors such as mechanical trauma caused by loose prosthesis can increase the risk of tissue penetration and colonization of Candida species. This literature review aimed to explore the colonization of C. albicans in the denture wearer. The article was conducted of two databases and were limited to the period from 2019 to 2024 with a combination of the following keywords: “oral Candida albicans” "colonization" "denture wearer". The results obtained A total of 243 articles were initially identified through the designated keywords in PubMed and Google scholar. After meticulous removal of duplicate articles and application of the inclusion and exclusion criteria, 7 articles met the study’s eligibility criteria. C. albicans was the predominant species recovered from oral caviproty of both denture wearers and non-denture wearers. C. albicans can not only adhere to the oral mucosa but also can colonize the surface of the acrylic denture when it is poorly maintained. The presence of prosthetic appliances changes the microenvironment of the oral cavity through the facilitation of Candida colonization and proliferation. The biofilm on the denture can enhance its adhesion adding to its virulence. Wearing of a denture has been found to enhance adhesion of C. albicans.
Chemical And Physical Evaluation Of Herbal Artificial Saliva Formulations-Scoping Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Saliva plays an important role in physiological function. Alteration in saliva production results in serious health problems that affect patient oral health-related quality of life (OHRQiL). the purpose of the research was to investigate the chemical and physical evaluation of natural artificial saliva formulations. Methods, the data synthesis protocol for a rapid review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P). Electronic databases were searched on articles published in 2004- 2024. evaluating Chemical and physical properties of herbal artificial saliva formulations in preclinical study. Results, Identification from the Science Direct and PubMed databases obtained 332 scientific articles and 3 articles met inclusion criteria. Basella alba Linn. (Ceylon Spinach mucilage) shows non-Newtonian characteristic fluid, similar to normal human saliva. It has antioxidative activity, adhesion inhibition, and non-toxic. Propolis extract and Aloe vera extract showed minimal effect on viscoelastic properties but were still in the range of normal human saliva. Dioscorea batatas (Yam tuber mucilage) viscosity shows non-Newtonian characteristic fluid and antibacterial activity by influenced the enzymatic activity of lysozyme and peroxidase. Conclusion, Chemical and physiological evaluation shows that herbal plant extract has the potential to be used as an artificial saliva constituent. It had a viscosity in the range of normal human saliva with several advantages in terms of pharmacological activity.
Metabolic Disorders And Periodontal Disease: A Scoping Review Of Recent Studies Rafisa, Anggun; Febriane Balafif, Felisha; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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The bidirectional relationship between periodontal disease and metabolic disorders is of particular concern, as these conditions may exacerbate each other through shared inflammatory pathways and metabolic disturbances. This scoping review aims to comprehensively explore the current body of literature on the interconnection between metabolic disorders and periodontal disease. A comprehensive literature search was conducted across databases, such as PubMed and Scopus. This review included studies that focusing on the relationship between metabolic disorders and periodontal disease, as well as articles written in English and published between 2019 and 2024. Non-peer-reviewed articles, articles that were not available in full text, and animal studies were excluded. A total 186 studies met the inclusion and exclusion criteria and were included in the review. Only 2.2% of the studies employed an experimental design, while a substantial majority (77.4%) utilized observational methodologies The majority of the research (72.0%) focused on adults, with a relatively small proportion (16.1%) dedicated to children and adolescents. Research focusing on specific populations, such as women with obesity or gestational diabetes, was limited (7.5%). This review identified a significant gap in intervention studies specifically targeting metabolic disorders to improve periodontal outcomes. Furthermore, it underscores the need for more focused research on vulnerable populations such as children, adolescents, and pregnant women.
SIRT1 As A Novel Therapeutic Target For Periodontitis: A Rapid Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

SIRT1 plays a pivotal role in regulating a multitude of biological processes, including cellular metabolism, aging, DNA repair, inflammation, and oxidative stress. evidence suggesting a potential association between SIRT1 activity and periodontal health including periodontitis. This article aims to explore the immunobiological functions of SIRT1 in the initiation and progression of periodontitis. This comprehensive review utilized the PubMed and Cochrane Library databases to collate studies from December 2024 to December 2024. Arround 53 studies were screened and 5 studies were deemed suitable for analyses. Evidence based revealed that, SIRT1 levels elevated after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. Conclussion, clinical studies shows that SIRT1's potential as a biomarker and therapeutic target. Elevated SIRT1 levels after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. However, Prospective studies are necessary to deepen our understanding of their role in the pathophysiology of periodontitis and their potential clinical applications.
A Review Of IL-17 Relation With Microbiome In Metabolic Disorder Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Falisha Febriane Balafif
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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The relationship between IL-17 and the microbiome remains an area requiring extensive research. IL-17, a pro-inflammatory cytokine, plays a crucial role in immune function, particularly in its interactions with the microbiome, especially within the intestinal digestive system. In metabolic diseases linked to inflammation, this connection underscores the importance of understanding cytokine activity and the microbiome's response within the body. In this literature review, three articles were retrieved from a single database, exploring the relationship between IL-17, metabolic diseases, and the microbiome.
Dietary Vitamin D in Periodontal Diseases: A Scoping Review of Interventions and Assessments Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Vitamin D has gained significant attention for its potential role in periodontal health. This scoping review investigates the evidence on dietary vitamin D interventions and assessments in periodontal diseases, examining their impact on periodontal outcomes and identifying research gaps. Using the PRISMA for Scoping Reviews protocols, data were sourced from PubMed and Scopus, including studies focused on dietary vitamin D interventions in periodontal diseases. Exclusions were non-peer-reviewed articles, reviews, animal studies, and inaccessible full-text articles. A total of 22 studies were included: 11 experimental and 11 observational. Among experimental studies, vitamin D supplementation (n=7) was the most common intervention. Observational studies employed various dietary assessment methods, including 24-hour dietary recall (n=2), food frequency questionnaires (FFQ) (n=3), dietary supplement intake (n=3), and combined methods (n=3). Experimental findings suggest that vitamin D supplementation may enhance periodontal health, particularly when paired with non-surgical treatments. Mixed findings from observational studies and limited research on surgical contexts underscore the complexity of establishing definitive conclusions. These findings emphasize the need for standardized methodologies and further investigation to better understand the role of vitamin D in periodontal health.
Potential Protein Receptors in Enterococcus faecalis as Antibacterial and Anti-Biofilm Target Therapy in Endodontic treatment: A Review kuswandani, Faisal; Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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E. Faecalis  is responsible for 80−90% of hospital-acquired enterococcal infections and failed endodontic tretment. The emergence of E. Faecalis  multidrug resistance including to common endodontic medication and its ability to form biofilms have significantly complicated its clinical management. Thereby the development of novel antibacterial and antibiofilm agents is essential. Identifying and targeting key proteins is critical for drug discovery and development. This review aims to provide a brief information about potential protein receptors in E. Faecalis  that could serve as targets for antibacterial and antibiofilm therapies.
Dental Biofilm Formation: A Scoping Review Febriane Balafif, Felisha; Anggun Rafisa; Faisal Kuswandani; Nuroh Najmi
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Abstract

Dental biofilm is a structured microbial community that adheres to the tooth surface and becomes embedded within a self-produced extracellular matrix. This matrix, rich in polysaccharides, proteins, and nucleic acids, enables microorganisms to survive environmental stresses and contributes to the onset of oral diseases such as caries and periodontitis. The purpose of this scoping review is to determine current knowledge the dental biofilm formation. The articles published from 2020 until 2025 were searched for using the keywords: "dental and biofilm and formation" in the PubMed, ScienceDirect, and Google scholar databases. Using PRISMA-Scr, existing articles were chosen based on inclusion and exclusion criteria. There were five articles found that were suitable for review. The data presented in the article vary according to the study's location, purpose, method, and samples. The major classes of extracellular polymeric substances that form the matrix are common to most biofilms and comprise carbohydrates, proteins, nucleic acids, and cell wall polymers, such as peptidoglycans and lipids. Several unique resistance mechanisms make biofilms particularly tough to manage. Biofilm bacteria employ multiple defense mechanisms, such as capsule protection, efflux pumps, membrane modifications, genetic adaptations, quorum sensing, metabolic dormancy, and stress responses, making them highly resistant to treatment and contributing to persistent infections.
Non-Invasive Immunological Monitoring Using Saliva in Dental and Oral Health Research Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Febriane Balafif, Felisa
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Saliva plays vital roles in oral and systemic health and is emerging as a valuable tool in biomedical research. It contains bioactive components such as cytokines, enzymes, and immunoglobulins that reflect immune status, making it a promising non-invasive diagnostic fluid. A literature review was conducted using PubMed and Google Scholar Science Direct (2015–2025) with keywords related to saliva, immunological markers, and oral health. Studies included were original research on human subjects. Articles were screened following PRISMA guidelines. Salivary biomarkers such as IL-6, TNF-α, IL-17A/F, IFN-γ, CRP, calprotectin, IP-10, MCP-1, NT-proBNP, IL-1β, IL-2, IL-8, and sTNFRII have been linked to oral cancer, periodontitis, diabetes, autoimmune disorders, cardiovascular disease, and viral infections. Studies showed that these markers reflect both local inflammation and systemic immune responses. Saliva captures immune activity through pathways like Th17, TNF, and JAK/STAT signaling. Its non-invasive nature, molecular stability, and compatibility with modern analysis techniques (e.g., transcriptomics and proteomics) make it ideal for monitoring disease progression and immune function. The presence of stable biomarkers like cytokines, acute-phase proteins, and cardiovascular indicators in saliva supports its diagnostic relevance.Saliva offers a practical, non-invasive approach to immunological monitoring. With proven biomarkers for various diseases, it holds strong potential for future diagnostic and research applications.
DIABETES MELITUS GESTASIONAL DAN KESEHATAN RONGGA MULUT IBU DAN ANAK: TINJAUAN LITERATUR Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25042

Abstract

Diabetes melitus gestasional (DMG) merupakan kondisi hiperglikemia spontan selama kehamilan, didiagnosis pada trimester kedua atau ketiga pada individu yang tidak menunjukkan tanda-tanda diabetes sebelum kehamilan. Sejumlah penelitian telah menemukan implikasi DMG terhadap kesehatan ibu dan anak, termasuk terhadap kesehatan rongga mulut. Tinjauan ini bertujuan untuk mengkaji secara komprehensif literatur-literatur yang mengevaluasi mengenai hubungan antara diabetes gestasional dan kesehatan rongga mulut ibu-anak, menyoroti aspek penting dari perawatan prenatal dan potensi dampak jangka panjang terhadap kesehatan rongga mulut. Kondisi hiperglikemia pada penderita DMG berkontribusi terhadap berbagai perubahan pada rongga mulut, seperti perubahan mikrobiota dan peningkatan risiko penyakit periodontal pada ibu maupun anak. Periodontitis juga dapat berkontribusi terhadap kondisi DMG, dimana translokasi bakteri periodontitis maupun faktor virulensinya ke sirkulasi sistemik dapat membebani kinerja sel imun inflamasi secara terus menerus sehingga meningkatkan pelepasan mediator proinflamasi dan vesikel ekstraseluler. Tinjauan ini menggaris bawahi perlunya penelitian lebih lanjut untuk mengeksplorasi strategi pencegahan dan intervensi yang dapat diterapkan untuk meningkatkan kesejahteraan ibu dan anak.
Co-Authors Achmad Syawqie Agus Rohmat Hidayat Anggraini, Jamas Ari Anggun Rafisa Anis Setyowati APRIANI Apriani Apriani Bahjah, Firda Hanan Balafif, Felisa Febriane Balafif, Felisha Faisal Kuswandani Faisal Kuswandani Falisha Febriane Balafif Febriane Balafif, Felisa Felisha Febriane Balafif Fifi Veronica Hanna Goenawan Ina Hendiani Jennifer Putri Kuswandani , Faisal Murti, Evivana Pranika Nurwijayanti Otih Yuningsih Rizky Farida Berlian Ronny Lesmana Sari, Kartika Indah Setyawati, Rina Stephanie Yessica