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All Journal Journal of Biomedicine and Translational Research Jurnal Analis Kesehatan Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal Sehat Indonesia (JUSINDO)
Nuroh Najmi
Departemen Oral Biologi, Fakultas Kedokteran Gigi Universitas Padjadjaran Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Potential Protein Receptors in Enterococcus faecalis as Antibacterial and Anti-Biofilm Target Therapy in Endodontic treatment: A Review kuswandani, Faisal; Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Abstract

E. Faecalis  is responsible for 80−90% of hospital-acquired enterococcal infections and failed endodontic tretment. The emergence of E. Faecalis  multidrug resistance including to common endodontic medication and its ability to form biofilms have significantly complicated its clinical management. Thereby the development of novel antibacterial and antibiofilm agents is essential. Identifying and targeting key proteins is critical for drug discovery and development. This review aims to provide a brief information about potential protein receptors in E. Faecalis  that could serve as targets for antibacterial and antibiofilm therapies.
Non-Invasive Immunological Monitoring Using Saliva in Dental and Oral Health Research Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Febriane Balafif, Felisa
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Saliva plays vital roles in oral and systemic health and is emerging as a valuable tool in biomedical research. It contains bioactive components such as cytokines, enzymes, and immunoglobulins that reflect immune status, making it a promising non-invasive diagnostic fluid. A literature review was conducted using PubMed and Google Scholar Science Direct (2015–2025) with keywords related to saliva, immunological markers, and oral health. Studies included were original research on human subjects. Articles were screened following PRISMA guidelines. Salivary biomarkers such as IL-6, TNF-α, IL-17A/F, IFN-γ, CRP, calprotectin, IP-10, MCP-1, NT-proBNP, IL-1β, IL-2, IL-8, and sTNFRII have been linked to oral cancer, periodontitis, diabetes, autoimmune disorders, cardiovascular disease, and viral infections. Studies showed that these markers reflect both local inflammation and systemic immune responses. Saliva captures immune activity through pathways like Th17, TNF, and JAK/STAT signaling. Its non-invasive nature, molecular stability, and compatibility with modern analysis techniques (e.g., transcriptomics and proteomics) make it ideal for monitoring disease progression and immune function. The presence of stable biomarkers like cytokines, acute-phase proteins, and cardiovascular indicators in saliva supports its diagnostic relevance.Saliva offers a practical, non-invasive approach to immunological monitoring. With proven biomarkers for various diseases, it holds strong potential for future diagnostic and research applications.
DIABETES MELITUS GESTASIONAL DAN KESEHATAN RONGGA MULUT IBU DAN ANAK: TINJAUAN LITERATUR Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25042

Abstract

Diabetes melitus gestasional (DMG) merupakan kondisi hiperglikemia spontan selama kehamilan, didiagnosis pada trimester kedua atau ketiga pada individu yang tidak menunjukkan tanda-tanda diabetes sebelum kehamilan. Sejumlah penelitian telah menemukan implikasi DMG terhadap kesehatan ibu dan anak, termasuk terhadap kesehatan rongga mulut. Tinjauan ini bertujuan untuk mengkaji secara komprehensif literatur-literatur yang mengevaluasi mengenai hubungan antara diabetes gestasional dan kesehatan rongga mulut ibu-anak, menyoroti aspek penting dari perawatan prenatal dan potensi dampak jangka panjang terhadap kesehatan rongga mulut. Kondisi hiperglikemia pada penderita DMG berkontribusi terhadap berbagai perubahan pada rongga mulut, seperti perubahan mikrobiota dan peningkatan risiko penyakit periodontal pada ibu maupun anak. Periodontitis juga dapat berkontribusi terhadap kondisi DMG, dimana translokasi bakteri periodontitis maupun faktor virulensinya ke sirkulasi sistemik dapat membebani kinerja sel imun inflamasi secara terus menerus sehingga meningkatkan pelepasan mediator proinflamasi dan vesikel ekstraseluler. Tinjauan ini menggaris bawahi perlunya penelitian lebih lanjut untuk mengeksplorasi strategi pencegahan dan intervensi yang dapat diterapkan untuk meningkatkan kesejahteraan ibu dan anak.
EFEK PENGGUNAAN OBAT KUMUR PADA PENATALAKSANAAN DENTURE STOMATITIS Balafif, Felisha; Rafisa, Anggun; Kuswandani, Faisal; Najmi, Nuroh
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25059

Abstract

Kolonisasi jamur Candida pada mukosa yang memakai gigi tiruan dan plat akrilik gigi tiruan, khususnya Candida albicans adalah faktor etiologi utama denture stomatitis.  Pemeliharaan kebersihan gigi dan mulut dan pemeriksaan rongga mulut secara berkala akan mencegah sebagian besar kasus kandidiasis oral. Penelitian ini bertujuan untuk menentukan efek penggunaan obat kumur pada penatalaksanaan denture stomatitis.  Desain penelitian ini adalah studi literatur (narrative review). Pencarian artikel menggunakan database jurnal penelitian PubMed pada bulan Oktober-November 2023. Kriteria inklusi penelitian meliputi artikel dalam bahasa Inggris, artikel publikasi pada 10 tahun terakhir, dan artikel uji klinis. Kriteria eksklusi penelitian meliputi uji hewan, penelitian in vitro, penelitian yang tidak diterbitkan. Nistatin pastiles lebih efektif dalam mengobati denture stomatitis. Obat kumur klorheksidin lebih efektif terhadap C. albicans. Indocyanine green mediated photodynamic therapy pada penggunaan obat kumur kombinasi nistatin. Obat kumur kitosan-kurkuminoid bebas alkohol dapat berfungsi sebagai alternatif terapi topikal yang aman dan potensial dalam mengobati denture stomatitis. Penggunaan obat kumur nistatin, klorheksidin, indocyanine green (ICG), kitosan-kurkuminoid bebas alcohol dapat menurunkan jumlah mikroorganisme pada gigi tiruan. Obat kumur dapat mencegah dan mengobati denture stomatitis.
HUBUNGAN KESEHATAN GIGI DAN MULUT DAN PRODUK SUSU Najmi, Nuroh; Kuswandani, Faisal; Rafisa, Anggun; Balafif, Felisa Febriane
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25062

Abstract

Susu mengandung latosa dan kalsium yang penting bagi tubuh serta tambahan nutrisi lainnya.  Produk susu juga dapat melindungi rongga mulut terhadap berbagai masalah gigi seperti karies dan penyakit periodontal. Perlindungan ini berkaitan dengan senyawa seperti fosfor, kalsium, dan protein. Pada beberapa kasus terdapat individu alergi produk susu dan individu dengan intoleransi laktosa. Sehingga asupan nutrisi yang terkandung di dalam susu akan berkurang. Penambahan bakteri probiotik menjadi salah satu cara untuk membantu dan menambah fungsi serta manfaat.  Menambahkan probiotik pada produk susu dapat menjadi strategi pendukung dalam pencegahan dan pengobatan penyakit mulut utama termasuk karies gigi, penyakit periodontal, dan kandidiasis
Vitamin Deficiencies among Adult Patients with Recurrent Aphthous Stomatitis: A Systematic Review Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Recurrent aphthous stomatitis (RAS) is a common inflammatory condition of the oral mucosa characterized by recurrent, painful ulcerations that significantly impair quality of life. Although its etiology is multifactorial, nutritional factors, particularly vitamin deficiencies, have been proposed as potential contributors through their roles in immune regulation, epithelial integrity, and wound healing. Evidence regarding vitamin status in adults with RAS, however, remains inconsistent. This systematic review aimed to synthesize and critically evaluate available evidence on vitamin levels in adult patients with recurrent aphthous stomatitis. A comprehensive literature search was conducted in PubMed and Scopus for studies published between January 2015 and December 2025, following PRISMA 2020 guidelines. Eligible studies included adult participants (≥18 years) diagnosed with RAS and reported serum or salivary vitamin levels. Observational and interventional studies were considered. Data were extracted on study characteristics, vitamin assessment methods, and key findings, and were analyzed descriptively. Seven studies met the inclusion criteria. Vitamin D was the most frequently investigated micronutrient, followed by vitamin B12 and other hematinic parameters. Several studies reported lower vitamin D levels in patients with RAS compared with controls, while others found similarly high rates of deficiency in both groups. Associations between vitamin levels and clinical severity of RAS were generally weak, although vitamin D deficiency was linked to increased ulcer multiplicity in one study. Vitamin B12 deficiency was primarily observed in populations with concomitant iron deficiency anemia rather than in otherwise healthy adults with RAS. Current evidence suggests that vitamin deficiencies, particularly vitamin D, may function as modifying or aggravating factors in adult RAS rather than direct causal agents. Further high-quality studies are required to clarify their clinical relevance and therapeutic implications.
Malnutrition and oral Health in Elderly: a Narrative Review Anggraini, Jamas Ari; Najmi, Nuroh; Rafisa, Anggun; Febriane Balafif, Felisa; Sari, Kartika Indah
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

The aging process is generally defined as the accumulation of various changes that occur in cells and tissues as we age. According to the World Health Organization (WHO), an elderly individual is defined as a person who has reached or surpassed 60 years of age. Changes in conditions experienced by the elderly are not only physical changes, but also social and psychological changes. These changes influence each other and interact with other factors, which have an impact on the health conditions of the elderly, including appetite regulation which indirectly also has an impact on nutritional status in elderly. As we already know, nutrition is an important component for the elderly that affects the entire aging process and the general health condition of the elderly, including their oral health. Oral health and nutrition themselves have a multidirectional relationship. This relationship is manifested in the oral cavity, including plaque formation, dental caries, periodontal disease and other oral conditions. It is imperative for clinicians to comprehend the interplay between oral health and nutrition, as this knowledge is crucial for the effective management of elderly patients. This article focuses on the relationship between nutrition an oral health and its impact on older adults.
Soy Isoflavone Mediated Modulation of IL-1β Related Inflammatory Pathways in Oral Mucosal Cells: A Scoping Review of Experimental Studies Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Balafif, Felisha Febriane
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Background: Soy isoflavones, particularly genistein, have been widely studied for their anti-inflammatory properties. However, evidence regarding their modulatory effects on interleukin-1β (IL-1β)–related inflammatory pathways in oral mucosal tissues remains limited. Objective: This scoping review aimed to map the available experimental evidence on the effects of genistein on inflammatory responses associated with IL-1β in the oral cavity. Methods: A scoping review was conducted following a comprehensive literature search of PubMed and ScienceDirect databases. Articles published in English between 2016 and 2026 were screened using predefined keywords related to soy isoflavones, genistein, IL-1β, inflammation, and oral or periodontal tissues. Original experimental studies focusing on inflammatory modulation in oral or periodontal contexts were included. Results: From the literature search, only one experimental study met the inclusion criteria. The included study investigated a genistein-loaded folic acid–modified liposome-hydrogel composite for periodontitis treatment. The findings demonstrated that genistein exerted anti-inflammatory effects by modulating inflammatory cytokines, including IL-1β, and inhibiting the TLR4/MyD88/NF-κB signaling pathway. The study also reported improved inflammatory regulation through macrophage phenotype modulation and interaction with periodontal ligament stem cells. Conclusion: Current experimental evidence on the role of genistein in modulating IL-1β–related inflammation in the oral cavity is scarce. The limited findings suggest that genistein has potential anti-inflammatory effects in periodontal inflammation; however, further well-designed experimental studies focusing specifically on oral mucosal cells and inflammatory pathways are needed to support its therapeutic application.
Co-Authors Agus Rohmat Hidayat Anggraini, Jamas Ari Anggun Rafisa Anis Setyowati APRIANI Apriani Apriani Bahjah, Firda Hanan Balafif, Felisa Febriane Balafif, Felisha Balafif, Felisha Febriane Faisal Kuswandani Falisha Febriane Balafif Febriane Balafif, Felisa Febriane Balafif, Felisha Fifi Veronica Hanna Goenawan Kuswandani , Faisal Murti, Evivana Pranika Otih Yuningsih Ronny Lesmana Sari, Kartika Indah Setyawati, Rina