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Efek Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Binahong Terhadap Penyembuhan Luka Fase Proliferasi Pada Mencit Diabetik Eka Sakti Wahyuningtyas; N Nasruddin; Heni Setyowati Esti Rahayu; Heni Lutfiyati; Isabella Meliawati Sikumbang; Laela Hayu Nurani; Arum Kartikadewi; Nia Salsabila; Gela Setya Ayu Putri; Putri Kurniasiwi; Devi Kemala Dewi
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Plasma medicine is a relatively new and multidisciplinary studyinvolving the study of plasma science, biomedicine, pharmacy, andother health sciences to utilizing plasma for medical therapy. Plasmais the fourth substance, after solids, liquids, and gases. Plasma canproduce biological molecules of Reactive Oxygen and NitrogenSpecies (RON) which, if controlled in the right dose, can bebeneficial for health. This animal study examines the effect ofcombinative treatment of medicine plasma and binahong leaf extracton proliferation phase wound healing in a diabetic test model. Thestudy used Balb mice 7-8 years old which were induced by STZ withacute wounds which were divided into 4 groups, namely the woundgroup of diabetic mice without treatment (C), the group of diabeticmice with the treatment of binahong leaf extract (B), the group ofcombined treatment wounds plasma jet (P) and the wound group ofdiabetic mice treated with a combination of plasma and, binahongleaf extract (PB). Binahong leaf extract concentration 1% in DMSOsolvent. The jet type medicine plasma treatment was carried outevery day from day 0 to day 6. Macroscopic observation of thewound was carried out every day from day 0 to day 7. On day 7 itappears that the size of the wound area for P is much smaller thanfor C, B, and PB. The size of area B and PB is relatively the same,but smaller than C. The results of this study indicate that thebinahong leaf extract tends to inhibit the performance of medicineplasma in accelerating the healing of the proliferation phase.

Gambaran Hasil Pemeriksaan Aktivitas Enzim Alanine Aminotransferase (ALT) pada Serum Setelah Disimpan Selama 14 Hari: Overview of Alanine Aminotransferase (ALT) Enzyme Activity Assay Result in Serum After Storage for 14 Days Putri Kurniasiwi; Roosmarinto Roosmarinto; Narendra Yoga Hendarta
Borneo Journal of Medical Laboratory Technology Vol. 5 No. 2 (2023): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v5i2.4866

Storage of serum at 4°C over three days causes a 10% decrease in the enzyme Alanine Aminotransferase (ALT) activity. However, several laboratories store remaining serum samples for one week or even one month after examination, which is not under Good Laboratory Practice (GLP). The serum storage is used to anticipate if there is an examination error. This study aims to describe the results of examining ALT enzyme activity in serum that was immediately checked and stored for 14 days. This type of research is descriptive quantitative using the Pretest-Posttest Design. The sample in this study was human blood serum, with a total sample of 10 patients. Data were analyzed descriptively for all data obtained and presented in tabular form. The average yield of ALT enzyme activity examination before storage and storage on day seven and day 14 was 50.7 U/L, 46.1 U/L, and 40.5 U/L. This study concluded that there was a decrease in the results of examining the activity of the ALT enzyme by 9% on the 7th day and 20% on the 14th day. Therefore, it is suggested that laboratory staff check the sample as soon as possible. If there is a need to repeat the analysis, verify the results or add laboratory tests, samples should be frozen to ensure stability.

PEMBERDAYAAN MASYARAKAT MELALUI PENDAMPINGAN PROGRAM HEALTH PROMOTION MODEL (HPM) DAN PELATIHAN ETIKA BERSIN YANG BENAR SEBAGAI UPAYA PENCEGAHAN KASUS TUBERKULOSIS (TBC) Fitriani Kahar; Anung Sugihantono; - Irnawati; Muh. Yusuf; Ririh Jatmi Wikandari; Putri Kurniasiwi; Abdul Salam; Abdul Wadood
Prosiding Seminar Nasional Unimus Vol 6 (2023): Membangun Tatanan Sosial di Era Revolusi Industri 4.0 dalam Menunjang Pencapaian Susta
Publisher : Universitas Muhammadiyah Semarang

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Tuberkulosis (TBC) ialah salah satu penyakit menular yang disebabkan oleh kuman dari kelompokMycobacterium yaitu Mycobacterium tuberculosis. Penyakit ini masih banyak ditemukan di Jawa Tengahkhususnya di Kota Semarang. Usaha mengurangi kasus TBC bahkan menghilangkan harus dilakukan untukmendukung program pemerintah yaitu eliminasi TBC tahun 2030. Salah satunya dengan Program HealthPromotion Model (HPM). Program HPM adalah pendekatan dengan tujuan perubahan sikap dan perilakuyang ditandai dengan meningkatnya pengetahuan tentang informasi Kesehatan pada seseorang. Pengabdimelakukan kegiatan pengabdian masyarakat ini menggunakan metode ceramah dengan bantuan mediapower point dan video edukasi sebagai metode sosialisasi dan pendampingan pada masyarakat. Sasarandari kegiatan ini adalah masyarakat Kelurahan Bangetayu Wetan Kecamatan Genuk yang berjumlahsebanyak 66 orang. Metode yang digunakan dalam kegiatan ini adalah perencanaan, persiapan kegiatan,pelaksanaan dan monitoring evaluasi kegiatan. Hasil dari kegiatan pengabdian kepada masyarakat iniadalah kegiatan PKM dapat menambah wawasan dan ilmu pengetahuan masyarakat terkait Penyakit TBCsehingga dapat mencegah penularan penyakit TBC pada masyarakat. Masyarakat telah mengetahui terkaitpenyakit TBC seperti pengertian, faktor risiko, cara penularan, cara pencegahan dan pengobatan penyakitTBC serta penerapan etika batuk dan bersin yang benar. Masyarakat mampu menerapkan perilakupencegahan TBC dan menerapkan etika batuk dan bersin yang benar pada kehidupan sehari-hari. Hal inimenunjukkan bahwa program pendampingan masyarakat melalui Health Promotion Model (HPM) efektifuntuk meningkatkan pengetahuan masyarakat sebagai upaya pencegahan kasus TBC. Kata Kunci: Pendampingan Masyarakat, Health Promotion Model (HPM), Tuberkulosis Paru

Training on Early Detection of Breast Cancer Through Sadari (Breast Self Examination) as Control of Non-Communicable Diseases (NCDs) Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Kurniasiwi, Putri
AURELIA: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Vol 3, No 2 (2024): July 2024
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/aurelia.v3i2.2746

Breast cancer is the most common type of cancer in women in Indonesia. Early detection through SADARI can help identify changes in the breast that may be early signs of cancer. The aim of this activity is to increase the knowledge and skills of women in carrying out SADARI as an effort to detect breast cancer early. The method used is counseling and practical training on SADARI. The training participants were 40 women of productive age who lived in the Sendang mulyo sub-district. The results of this activity showed an increase in participants' knowledge and skills in carrying out SADARI as measured through pre-test and post-test. Before the training, only 5% of participants understood the correct way to SADARI. After training, this figure increased to 97.5%. The conclusion of this activity is that SADARI training is effective in increasing the knowledge and skills of women in the Sendang mulyo sub-district.

THE EFFECT OF BOILED WATER CONCENTRATION OF RED BETEL LEAF (Piper crocatum) ON THE KIDNEY AND PANCREAS HISTOPATHOLOGY OF DIABETIC MICE (Mus musculus) Kurniasiwi, Putri; Surati, Surati; Armalia, Desi; Farizal, Jon
Journal Of Health Science (Jurnal Ilmu Kesehatan) Vol 8 No 2 (2023): JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN)
Publisher : Fakultas Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24929/jik.v8i2.2880

Red betel leaves contain flavonoid compounds that can reduce blood sugar levels and minimize tissue damage by reducing lipid peroxide. This study aims to determine the effect of red betel leaf boiled water with a concentration of 25%, 50%, 75% and 100% on the histopathology of the kidneys and pancreas of diabetic mice and to determine the most effective concentration. This experimental research was a completely randomized design with 2 control groups, K+ and K-, and 4 treatment groups, P1, P2, P3 and P4, with a sample population of 18 mice. Experimental animals were treated by giving red betel leaf boiled water with a concentration of 25%, 50%, 75% and 100%, 50 mg and a sonde dose of 0.13 ml for 7 days. Then the kidneys and pancreas were taken, processed histologically and observed with a 400x magnification microscope in 3 fields of view. The results of pancreatic histopathological observations were statistical tests using the Kruskal Wallis followed by the Mann Whitney test showing sig. 0.015 means that the histopathological picture of the pancreas of mice P3, P4 has a significant difference compared to mice in the K (+) group. Concentrations of 75% and 100% resulted in enlargement of kidney cell size approaching the size of healthy kidney cells and there was the best improvement in the pancreas organ. The conclusion is that concentrations of 25%, 50%, 75% and 100% of red betel leaf boiled water affect the histopathology of the kidneys and pancreas of diabetic mice.

Efek Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Binahong Terhadap Penyembuhan Luka Fase Proliferasi Pada Mencit Diabetik Wahyuningtyas, Eka Sakti; Nasruddin, N; Rahayu, Heni Setyowati Esti; Lutfiyati, Heni; Sikumbang, Isabella Meliawati; Nurani, Laela Hayu; Kartikadewi, Arum; Salsabila, Nia; Putri, Gela Setya Ayu; Kurniasiwi, Putri; Dewi, Devi Kemala
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Plasma medicine is a relatively new and multidisciplinary studyinvolving the study of plasma science, biomedicine, pharmacy, andother health sciences to utilizing plasma for medical therapy. Plasmais the fourth substance, after solids, liquids, and gases. Plasma canproduce biological molecules of Reactive Oxygen and NitrogenSpecies (RON) which, if controlled in the right dose, can bebeneficial for health. This animal study examines the effect ofcombinative treatment of medicine plasma and binahong leaf extracton proliferation phase wound healing in a diabetic test model. Thestudy used Balb mice 7-8 years old which were induced by STZ withacute wounds which were divided into 4 groups, namely the woundgroup of diabetic mice without treatment (C), the group of diabeticmice with the treatment of binahong leaf extract (B), the group ofcombined treatment wounds plasma jet (P) and the wound group ofdiabetic mice treated with a combination of plasma and, binahongleaf extract (PB). Binahong leaf extract concentration 1% in DMSOsolvent. The jet type medicine plasma treatment was carried outevery day from day 0 to day 6. Macroscopic observation of thewound was carried out every day from day 0 to day 7. On day 7 itappears that the size of the wound area for P is much smaller thanfor C, B, and PB. The size of area B and PB is relatively the same,but smaller than C. The results of this study indicate that thebinahong leaf extract tends to inhibit the performance of medicineplasma in accelerating the healing of the proliferation phase.

Gambaran Kadar Glukosa Darah Pada Tikus Wistar Sebagai Pendahuluan Uji Terapi Ektrak Daun Bandotan: Description of Blood Glucose Levels In Wistar Rats as an Introduction to The Therapy Test of Bandotan Leaf Extract Kurniasiwi, Putri; Rosa, Hilari Rio; Nastiti, Nastiti; Maulana, Mochamad Rizal
Borneo Journal of Medical Laboratory Technology Vol. 6 No. 2 (2024): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v6i2.7094

Diabetes Melitus (DM) termasuk salah satu penyakit tidak menular yang telah menjadi masalah serius bagi kesehatan masyarakat di Indonesia maupun di dunia. Indonesia menduduki peringkat ke 7 di dunia dengan penderita diabetes sebanyak 10,7 juta pada tahun 2019 dan jumlah tersebut diperkirakan akan meningkat menjadi 13,7 juta pada tahun 2030 dan 16,6 juta pada tahun 2045 (1,2). Komplikasi yang terjadi pada penderita DM adalah karena kerusakan dan kematian sel yang disebabkan peningkatan stress oksidatif dan aktivitas mediator inflamasi temasuk interleukin-6 (Il-6). Pemberian obat hipoglikemi oral pada pasien DM tidak menunjukkan perbaikan pada stress oksidatif. Oleh karena itu, diperlukan terapi tambahan untuk pasien DM yang dapat menurunkan stress oksidatif dan mediator inflamasi serta mendukung kerja antioksidan endogen. Daun bandotan merupakan tanaman yang mengandung antioksidan dan digunakan sebagai obat tradisional untuk pasien DM. Tujuan dari penelitian ini adalah untuk mengetahui kadar guloksa darah sebetlum terapi ekstrak daun bandotan. Penelitian ini menggunakan tikus wistar jantan yang diinduksi dengan streptozotocin (stz) untuk menjadi DM tipe 2. Kemudian diperiksa kadar glukosa darah pada hari ke lima setelah induksi stz. Hasil menunjukkan secara keseluruhan kadar glukosa darah telah mencapai lebih dari 200 mg/dl. Hal tersebut menunjukkan bahwa tikus telah mengalami hiperglikemi dan bisa dilanjutkan untuk perlakuan terapi.

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