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All Journal Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Prosiding University Research Colloquium Journal of Innovative and Creativity IJF (Indonesia Jurnal Farmasi) Jurnal Abdimas Indonesia Journal of Pharmascience
Eko Retnowati
Universitas Muhammadiyah Kudus
Religion Humanities Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Lumbricus Rubellus Earthworm Extract Hydrogel for Treatment of Diabetic Ulcer Wounds Diana Tri Lestari; Muhamad Jauhar; Eko Retnowati
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22880

Abstract

A diabetic ulcer is a complication that requires serious treatment because it is the highest cause of amputation. This condition has an impact on the morbidity, mortality, and socioeconomics of people with diabetes. Therefore, accuracy is needed in managing diabetic ulcers, one of which is natural ingredients that have potential as topical ulcer medicines, namely the Lumbricus rubellus earthworm. This study aims to find out the most effective formula for the treatment of diabetic ulcer wounds. The formula for this drug candidate is made using the hydrogel preparation formulation using an HPMC 940 base with variations in the active ingredient of lumbricus worm extract of 20%, 50%, and 80% to obtain the desired hydrogel preparation. The candidate drug will be tested, namely physical tests including organoleptic tests, homogeneity tests, pH tests, viscosity tests, spreadability tests, and adhesive tests. After that in vivo trial using Wistar rat experiments. The results of the organoleptic test showed that the three formulas were in gel form with a distinctive extract odor, but the three preparations showed different colors, namely brownish yellow, dark brown, and blackish brown. The three formulations appear homogeneous, having a pH between 4.36 and 4.44 and a viscosity between 5,376 cp and 5,894 cp. The spreading power in formulas 2 and 3 is good, and formula 2 has good adhesion. The results of this study demonstrate that the group treated with 50% L. rubellus topical extract experienced the most significant and rapid wound healing among all intervention groups. L. rubellus extract can be used as a topical gel preparation for wound care, with the best formulation at a concentration of 50%.
EDUCATION ON INITIAL HANDLING OF RESPIRATORY SYNCYTIAL VIRUS INFECTION IN MOTHERS OF KRAPYAK VILLAGE, TAHUNAN, JEPARA Anisah Nurussyifa; Eko Retnowati; Ulviani Yulia Husna
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 10 No. 2 (2026): JUNI
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v10i2.3451

Abstract

Respiratory Syncytial Virus (RSV) is one of the main causes of lower respiratory tract infections in children under five years old. Limited public knowledge regarding transmission, prevention, and early management of RSV increases the risk of severe complications, especially in rural areas such as Krapyak Village. This community service activity aimed to improve mothers’ knowledge regarding the early management of RSV infection through a health education program. The activity used a pre-experimental one-group pre-test post-test design involving 53 mothers with toddlers at Posyandu Mawar 6, Krapyak Village. The intervention included health education sessions, animated videos, interactive discussions, and leaflet distribution. Data were collected using a validated questionnaire and analyzed using the Wilcoxon signed-ranks test and N-Gain score. The results showed a significant increase in respondents’ knowledge after the intervention, with most participants achieving a good level of knowledge and an average N-Gain score in the moderate category. The program was effective in improving mothers’ understanding of early RSV management and is expected to support better preventive practices among toddlers in Krapyak Village.
ANALISIS INTERAKSI OBAT PADA PASIEN TB KOMORBID HIV DI RAWAT JALAN RSI SUNAN KUDUS Alifta Dwi Fara; Eko Retnowati; Ulviani Yulia Husna
Journal of Innovative and Creativity (Joecy) Vol. 6 No. 2 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i2.11962

Abstract

Tuberkulosis (TB) dan Human Immunodeficiency Virus (HIV) adalah dua penyakit menular yang kerap muncul bersamaan dan menjadi tantangan kesehatan di tingkat global, termasuk di Indonesia. Koinfeksi TB dan HIV memerlukan pengobatan kombinasi antara Obat Anti Tuberkulosis (OAT) dan Antiretroviral (ARV), yang dapat menyebabkan interaksi obat. Interaksi ini dapat memengaruhi efektivitas pengobatan serta meningkatkan kemungkinan munculnya efek samping, sehingga perlunya analisis lebih mendalam. Tujuan penelitian ini adalah untuk menilai kemungkinan terjadinya interaksi obat, jenis interaksi, serta tingkat keparahan interaksi antara OAT dan ARV pada pasien TB yang juga mengidap HIV di instalasi rawat jalan RSI Sunan Kudus. Penelitian ini mengadopsi metode kuantitatif dengan desain observasional analitik pendekatan cross sectional. Sampel penelitian melibatkan 45 responden yang diambil melalui teknik total sampling dengan berdasarkan data rekam medis pasien TB-HIV. Pengumpulan data dilakukan secara retrospektif menggunakan rekam medis pasien selama bulan Januari – Oktober 2025. Analisis data dilakukan baik secara univariat maupun bivariat. Penelitian menunjukkan bahwa karakteristik responden didominasi oleh laki - laki sebanyak 55,6% dan perempuan 44,4%. Dari segi usia, mayoritas berada pada kisaran usia 41-60 tahun sebesar 40,0%. Dari pendidikan, sebagian besar memiliki latar belakang pendidikan tidak sekolah dan smp masing-masing dengan persentase 26,7%. Sekitar 95,6% pasien memiliki riwayat terapi lebih dari enam bulan. Sebelum analisis interaksi obat dilakukan. Berdasarkan tingkat keparahan, interaksi obat dengan kategori moderete adalah yang paling umum ditemukan, mencapai 82,8%, diikuti oleh interaksi mayor yang tercatat sebesar 17,2%. Dari segi mekanisme, interaksi yang bersifat farmakokinetik minimal/ tidak bermakna klinis lebih mendominasi dengan persentase sebesar 53,3%, sementara farmakokinetik mencakup 46,7%. Analisis perbandingan sebelum dan sesudah menunjukkan adanya peningkatan signifikan dalam identifikasi interaksi obat yang sebelumnya tidak terdeteksi menjadi terdeteksi pada sebagian besar pasien. Kesimpulan dari studi ini menunjukkan bahwa mayoritas pasien TB-HIV menghadapi potensi interaksi obat, dengan interaksi pada tingkat moderete serta mekanisme farmakokinetik minimal/ tidak bermakna klinis yang paling sering terjadi. Oleh karena itu, sangat penting untuk melakukan pemantauan terapi secara ketat guna menghindari efek samping dan meningkatkan efektivitas pengobatan.
Analisis Pengaruh Efek Samping Kemoterapi terhadap Quality of Life Pasien Kanker di RSUD R.A. Kartini Yahya Adi Alfatih; Eko Retnowati; Intan Adevia Rosnarita
Journal of Innovative and Creativity (Joecy) Vol. 6 No. 2 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i2.12677

Abstract

The increasing global cancer incidence has positioned it as a major public health challenge, particularly in Indonesia where chemotherapy remains the primary treatment modality, frequently accompanied by significant side effects that can potentially reduce patient quality of life. This study aimed to analyze the influence of chemotherapy side effects on quality of life among cancer patients at RSUD R.A. Kartini Jepara. An observational analytic study with a cross-sectional design was conducted on 120 cancer patients undergoing chemotherapy in 2025 using purposive sampling. Side effects were measured using the CTCAE v5.0 questionnaire (Cronbach Alpha = 0.882) and quality of life was assessed using the EORTC QLQ-C30 (Cronbach Alpha = 0.994). Chi-Square analysis revealed no statistically significant relationship between chemotherapy side effects and patient quality of life (p = 0.510). The majority of respondents experienced mild side effects (53.9%) with adequate quality of life (75.7%). The most frequently reported side effects were nausea (84.3%), vomiting (77.4%), and diarrhea (59.1%). Patients receiving imatinib mesylate therapy showed the highest proportion of mild side effects. (60.0%), while all cisplatin patients experienced severe effects. These findings suggest that cancer quality of life is influenced by multiple factors beyond chemotherapy toxicity alone, including social support, therapy type, and patient adaptability, necessitating a holistic, patient-centered oncology care approach.
Co-Authors Adisti Maulina Firdaus Alifta Dwi Fara Anisah Nurussyifa Bintari Tri Sukoharjanti Devi Ayu Alami Devi Renha Lestari Diana Tri Lestari Endang Setyowati Fahrudin Arif Hardiyani Presticasari Intan Adevia Rosnarita Latifah Dikdayani Latifah Dikdayani Muhamad Jauhar Munawaroh Munawaroh N Nirmala Nisa Indah Setyani Noor Elvina Lailatul Fitria Nur Farida Ulfa Nurul Huda Septiana Dwi Astuti Sitta Hasanatin Sholihah Sitta Hasanatin Solikah Teguh Asrroyo Ulviani Yulia Husna Yahya Adi Alfatih Yayuk Mundriyastutik Yulis Trinovita