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All Journal IJEEM - Indonesian Journal of Environmental Education and Management Bioscientia Medicina : Journal of Biomedicine and Translational Research
Najla Khairunnisa
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience

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Analisis Manajemen Risiko Usaha (Studi Kasus Burgerchill) Anugerah Tirta Kenanga Unggul Mitra Mandiri; Muhammad Mufti Abdullah; Arya Budi Saputra; Nahda Nabilaturrahma; Najla Khairunnisa; Rian Ardiansah; Syti Sarah Maesaroh
IJEEM - Indonesian Journal of Environmental Education and Management Vol 7 No 1 (2022): IJEEM: Indonesian Journal of Environmental Education and Management Volume 7 Nomo
Publisher : Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/ijeem.v7i1.31676

Abstract

Burgechill merupakan Salah satu UMKM di Kota Bandung, di didirikan oleh Dzaky Muhammad Abdullah Rahim dan Naufal Muhammad Abdullah Rahim. Burgerchill sendiri menjual makanan home made burger dan berkonsep burger yang berukuran mini. Sesuai dengan namanya, yaitu Burgerchill atau Burger kecil untuk chill, dengan taglinenya adalah “Gak cukup satu”. Esensi dari penelitian ini untuk mengetahui sumber risiko yang ada pada perusahaan Burgerchill dan menganalisis penyebab dan cara penanggulangan risiko yang terjadi. Metode penelitian yang digunakan adalah metode analisis kualitatif deskriptif dan identifikasi risiko menggunakan metode cause effect analysist (fishbone).
The Effect of Activated Growth Factor (AGF) from Platelets on Alpha-SMA Levels in Osteoarthritis: Invivo Study Ziske Maritska; Hidayat, Rachmat; Septi Purnamasari; Muhammad Rizky Hidayatullah; Sarah; Najla Khairunnisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 5 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i5.980

Abstract

Background: The most prevalent joint condition and leading contributor to disability is osteoarthritis (OA), resulting in a significant socio-economic impact. It occurs due to an imbalance of pro-inflammatory and anti-inflammatory mediators, influencing anabolic and catabolic activities. This study aims to determine the effect of activated growth factor (AGF) on alpha-SMA levels. Methods: This research is an in vivo post-test-only control group experimental study conducted at the Eureka Research Laboratory. Thirty male Wistar rats were divided into five treatment groups: normal control group, negative control group, AGF I group (TGF-β 100 pg/mL), AGF II group (TGF-β 1000 pg/mL), and AGF III group (TGF-β 10,000 pg/mL). AGF was obtained from rat blood intravenously and centrifuged at a predetermined speed. Growth factor activation was performed by adding 10% CaCl2, and then TGF-β levels were measured. All groups of rats were acclimatized for 7 days. After that, osteoarthritis was induced with intra-articular injection of monoiodoacetate (MIA) 4.8 mg/60μL in all groups of rats except the normal control group. Next, rats were given treatment according to the group for 21 days. On the 21st day, rats were euthanized, and alpha-SMA levels were measured using the sandwich method ELISA kit. Results: Sequentially, the mean Alpha-SMA levels for each group in pg/mL were: 91.495 ± 2.36; 10.682 ± 1.09; 30.502 ± 2.00; 52.892 ± 1.29; and 76.180 ± 2.65. In the AGF group, there was an increase in alpha-SMA levels directly proportional to the dose of TGF-β injected. Conclusion: AGF has an effect on increasing alpha-SMA levels in the joints of rats with a model of osteoarthritis.
Co-Authors Anugerah Tirta Kenanga Unggul Mitra Mandiri Arya Budi Saputra Maesaroh, Syti Sarah Muhammad Mufti Abdullah Muhammad Rizky Hidayatullah Nahda Nabilaturrahma RACHMAT HIDAYAT Rian Ardiansah Sarah Septi Purnamasari Ziske Maritska