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All Journal Jurnal Kesehatan Hesti Wira Sakti MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Journal of Islamic Medicine Indonesian Journal of Cardiology Journal of Health Science and Prevention Journal of Nursing Care and Biomolecular
Achdiat Agoes
Departemen Saraf, Program Studi Pendidikan Dokter, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Islam Negeri Maulana Malik Ibrahim Malang
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Peran Elektro-Akupuntur terhadap Perbedaan Kadar IL-2 pada Tikus Putih (Rattus norvegicus) Galur Wistar yang Diinduksi DMBA Rahmah, Aliyah Adek; Agoes, Achdiat; Yuliatun, Laily
Majalah Kesehatan FKUB Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.897 KB)

Abstract

Kanker payudara adalah salah satu tumor yang bersifat ganas dan penyebab kematian utama pada wanita. Pada penderita kanker payudara, terjadi penurunan kadar interleukin-2 (IL-2) yang berfungsi sebagai antikanker. Terapi elektro-akupuntur (EA) adalah salah satu terapi komplementer yang dapat meningkatkan kadar interleukin-2 pada tubuh.  Penelitian ini bertujuan untuk mengetahui peran elektro-akupuntur terhadap perbedaan kadar interleukin-2 pada tikus yang diinduksi DMBA. Metode penelitian yang digunakan adalah true experimental in vivo, dengan sampel tikus Wistar berjumlah 25 ekor. Sampel dibagi menjadi 5 kelompok perlakuan yaitu (i) kontrol negatif (normal), (ii) kontrol positif (DMBA), (iii) perlakuan I (DMBA dan terapi EA selama 3 hari); (iv) perlakuan II (DMBA dan terapi EA selama 5 hari); (v) perlakuan III (DMBA dan terapi EA selama 10 hari). Kadar IL-2 diukur menggunakan metode ELISA sandwich dan datanya dianalisis dengan one way ANOVA. Hasil penelitian menunjukkan rata-rata kadar IL-2 terendah terdapat pada tikus kontrol positif dan rata-rata kadar IL-2 tertinggi pada tikus perlakuan EA 10 hari. Analisis statistik uji LSD  menunjukkan terdapat perbedaan yang bermakna diantara kelompok perlakuan terhadap rata-rata kadar IL-2 (p = 0.000). Kesimpulan yang diperoleh yaitu terapi elektro-akupuntur dapat meningkatkan kadar IL-2 pada tikus yang diinduksi DMBA. Kata kunci : DMBA, Interleukin-2, Kanker Payudara, Terapi elektro-akupuntur.
EFFECTS OF BRAIN AGE TO INCREASE COGNITIVE FUNCTION IN ELDERLY Agoes, Achdiat; Lestari, Retno; Alfaruqi, Saifullah
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.498 KB) | DOI: 10.21776/ub.mnj.2016.002.02.4

Abstract

Background. The concept of cognitive (from Latin cognosere, to know or to recognize) refers to the ability to process information, applying knowledge, and change the trend. cognitive function of the elderly can be optimized through a variety of ways, one of that way is the brain training game (Brain Age). The game was created specifically to train the cognitive function of elderly.Objective. To determine the effect of Brain Ag) to the improvement of cognitive function in the elderly in Malang. Methods. Quasi-experimental pretest-posttest approach, the treatment and control groups, and the sampling is done with purposive sampling to obtain the 20 respondents. Data collection instrument in this study are in general cognitive tests by using a measuring instrument MMSE. Then the data were analyzed by Mann-Whitney test showed p value 0.000 <α 0.05. Results. There is the effect of therapy brain training game (Brain Age) on increasing cognitive function of elderly in Malang.Conclusion. Therapy of brain training game (Brain Age) can be used as an alternative method of nursing actions that can be implemented in nursing geriatric and to consider inter-community cooperation between the elderly or nursing home.
ANALISIS FAKTOR – FAKTOR YANG MEMPENGARUHI KEMAUAN ORANG AWAM UNTUK MEMBERIKAN PERTOLONGAN PERTAMA PADA KORBAN KECELAKAAN LALU LINTAS DI KOTA MALANG Firdaus, Achmad Dafir; Agoes, Achdiat; Lestari, Retno
Journal Nursing Care and Biomolecular Vol 3, No 2 (2018)
Publisher : STIKes Maharani Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.664 KB) | DOI: 10.32700/jnc.v3i2.109

Abstract

ABSTRAK                Kejadian kecelakan lalu lintas diprediksi cenderung semakin meningkat seiring dengan berjalannya waktu. Banyaknya orang yang menjadi korban kecelakaan tidak selalu ditunjang dengan banyaknya responder dan pelayanan kesehatan yang dapat memberikan pertolongan yang cepat serta tepat. Untuk mengatasi hal tersebut perlu pemberdayaan orang awam yang seringkali menjadi first responder. Namun orang awam saat ini juga tidak selalu mau untuk memberikan pertolongan dikarenakan beberapa faktor diantaranya faktor intrapersonal, psikososial dan situasional yang mempengaruhi. Tujuan dari penelitian ini adalah untuk menganalisis faktor – faktor tersebut sehingga dapat mengoptimal kemauan dan peran orang awam pada akhirnya. Penelitian ini merupakan penelitian observasional dengan metode pendekatan restrospektif menggunakan instrumen terstruktur yang telah dilakukan uji validitas dan reliabilitas. Analisis yang digunakan adalah analisis bivariat dengan uji Chi-Square dan Fisher sebagai alternatif. Sampel yang digunakan berjumlah 110 orang awam yang pernah menemui kejadian lalu lintas di Kota Malang. Hasil yang didapatkan adalah responden saat menemui kejadian kecelakaan lalu lintas (KLL) yang dipengaruhi faktor intrapersonal sebanyak 92,7%, faktor psikososial sebanyak 27,3%, dan faktor situasional sebanyak 60%. Sedangkan responden yang memberikan pertolongan adalah sebanyak 47,3%. Berdasarkan uji Chi-Square didapatkan hanya faktor situasional saja yang memiliki hubungan signifikan dengan kemauan orang awam untuk menolong korban kecelakaan lalu lintas dengan nilai p 0,002 (p&lt;0,005). Dengan demikian perlu pemberdayaan peran serta orang awam dengan cara – cara yang dapat meningkatkan pengetahuan, kemauan, serta kemampuan dalam memberikan pertolongan pertama pada korban kecelakaan lalu lintas. Kata Kunci : Kemauan, Pertolongan Pertama, Kecelakaan Lalu Lintas, Orang Awam ABSTRACTTraffic accidents predicted tend to increase over time. The number of people who become victims of accidents are not always supported by many responders and health care that can provide prompt and appropriate care. To overcome this problem, we need to give empowerment to laypeople who are often become the first responder. But, lay people nowadays are not always willing to provide assistance due to several factors including intrapersonal factors, psychosocial and situational influences. The purpose of this study was to analyze those factors so that we can optimize the willingness and the role of lay people in the end. This study is observational study with retrospective approach using structured instruments which have been validity and reliability tested. The analysis is bivariate analysis using Chi-Square and Fisher as an alternative. The samples are 110 lay people who had witnessed traffic accidents in Malang city. The results obtained are respondents who witnessing traffic accidents that are affected by intrapersonal factors is 92.7%, psychosocial factors is 27.3% and situational influences is 60%. While respondents who gave aid is 47.3%. Based on Chi-Square test is obtained only situational factors that have a significant relation with the willingness of lay people to help traffic accidents victim with a value p 0.002 (p&lt;0.005). Thus, we need to give empowerment to laypeople in ways that can improve kowledge, willingness, and ability to provide first aid to traffic accidents victims. Key Words: Willingness, First Aid, Traffic Accidents, Laypeople
ANALISIS FAKTOR YANG MEMPENGARUHI KETERLAMBATAN DALAM MENGATASI PASIEN STROKE SAAT MERUJUK KE RSUD JOMBANG Didik Saudin; Achdiat Agoes; Ika Setyo Rini
Jurnal Kesehatan Hesti Wira Sakti Vol. 4 No. 2 (2016)
Publisher : Institut Teknologi, Sains, dan Kesehatan RS dr. Soepraoen Malang

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Abstract

ABSTRAK Pendahuluan: Stroke adalah serangan otak yang timbul secara mendadak ditandai adanya gangguan aliran darah karena adanya sumbatan atau pecahnya pembuluh darah tertentu di otak. Keberhasilan penanganan stroke sangat tergantung dari kecepatan, kecermatan dan ketepatan terhadap penanganan awal atau waktu emas dalam penanganan stroke adalah ± 3 jam. Penelitian ini bertujuan untuk mengetahui beberapa faktor yang memepengaruhi keterlambatan dalam penanganan rujukan pasien stroke ke RSUD Jombang. Metode : Penelitian ini menggunakan methode Survey Cross Sectional merupakan suatu penelitian untuk mempelajari dinamika korelasi antara faktor-faktor resiko atau efek melalui observasi. Responden berjumlah 60 orang yang didapatkan dengan metode rule of thumb. Hasil dan Analisa : Hasil penelitian ini menunjukkan bahwa terdapat korelasi keterlambatan pasien stroke saat merujuk ke RSUD Jombang diantaranya jarak rujukan didapatkan signifikasi p value 0.021 dan pendampingan rujukan didapatkan p value 0.026. Berdasarkan uji regresi logistik disimpulkan bahwa ke 2 faktor mempunyai korelasi yang sama dengan keterlambatan pasien stroke dengan OR jarak rujukan sebesar 2.42 dan OR Pendampingan sebesar 2.27 serta diperkirakan keterlambatan pasien stroke sebesar 23.4%. Diskusi dan kesimpulan: Diantara variabel independen 6 faktor yang berpengaruh terhadap variabel dependen hanya ada dua variabel yang memiliki korelasi yaitu jarak rujukan dan pendampingan petugas saat melakukan rujukan ke RSUD Jombang. Kedua fakor memiliki kekuatan dan pengaruh yang sama saat melakukan rujukan pada kasus stroke ke RSUD Jombang. Kata Kunci: Stroke, Keterlambatan, Rujukan, Faktor yang mempengaruhi ABSTRACT Background: Stroke is a brain attack which occur suddenly marked by the interruption of blood flow due to blockage or rupture of blood vessels of the brain. The success of stroke treatment is highly dependent on the speed, accuracy and precision of the handling of the initial or the golden time in the treatment of stroke is ± 3 hours. This study aims to determine some of the factors that affect delays in the handling of a stroke patient referrals to hospitals Jombang. Method: This study uses a method Cross Sectional Survey is a research study to study the dynamics of the correlation between risk factors or the effects through observation. Respondents were 60 people who obtained the rule of thumb method. Result and Anlisys : The results of this study indicate that there is a correlation delay time stroke patients referred to hospitals Jombang include a reference distance obtained significance p value of 0.021 and referral assistance obtained p value 0.026. Based on logistic regression test concluded that to two factors have the same correlation with the delay of stroke patients with a referral by the distance OR OR 2:42 and 2:27 as well as the assistance of an estimated delay of 23.4% of stroke patients. Discussion and summary: Among the independent variables six factors that only two variables affect the dependent variable they are referral time and advocacy officer when making referrals to Jombang General Hospital. Both factor have the same power and influence when making reference to the Stroke case at Jombang General Hospital. Keywords : Stroke, Delay, Referral, Factors affecting
Kajian Rasio EPC dan Ce c Sebagai Prediktor Disfungsi Endotel pada Pasien dengan Kelompok Risiko Tinggi Berdasarkan Framingham Risk Score 10 Years Wiwit Nurwidyaningtyas; Djanggan Sargowo; Achdiat Agoes; Titin Andri W; S Satuman
Jurnal Kardiologi Indonesia Vol. 34, No. 1 Januari - Maret 2013
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v34i1.299

Abstract

Research background. Circulating Endothelial Cells (CEC) is a reflection of endothelial damage or endothelial stress, increasing of CEC amount depend on endothelial mechanism, edothelial adhesivity damage and cellular apoptosis as a result of decreasing sitoskleleton function. If higher exposure affects the increasing of CEC amount,VEGF other growth factor mediators will be reflected as endothelial stress manifestation which roles in the increasing of re-population and Endothelial Progenitor Cells (EPC) differentiation. Endothelial Progenitor Cells is a mononuclear cell (a part of stem cell) that could change to be mature endothel and roles in re-edothelialisation and neovascularisation. This research aimed to investigate the ratio of EPC : CEC in risk group through Framingham Risk Score (FRS) 10 years approach as endothelial dysfunction predictor.Research method and result. There were 55 research subjects whom taken by FRS scoring and devided into some risk groups and two control groups. They were control group I (health) and control group II (sick). Base blood was taken to every each of them to analyze their EPC and CEC with Flowcytometry. EPC was analyzed by CD34 Per CP Santa Cruz SC-19621 and CD 133 FITC (fluorescein isothiocyanate) Bioss bs-0395R-FITCmarker.WhileCEC was analyzed CD45 FITC Biolegend 202205 dan CD 146 PE Biolegend 134704 marker. Result showed, there was significant ratio differences of EPC : CEC in those six groups which was proven by p-value 0.032< ? (0.05). The higher ratio was in high risk group (139.06).Conclusion. Research showed that EPC amount was increase related to the increasing of high risk level according to FRS 10 years, but its increasing did not followed by its ability to homing in injury area as role part in re-endothelialisation process. It found that EPC amount was higher in high risk group than in low risk group.
Polimorfisme Gen UCP2 Dan Kadar H2O2 Terhadap Variasi CEC Sebagai Prediktor Aktivasi Endotel Pada Pasien Stroke M.Nur FAFA; Djanggan Sargowo; Achdiat Agoes; Wiwit Nurwidyaningtyas
Jurnal Kardiologi Indonesia Vol. 35, No. 4 Oktober - Desember 2014
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v35i4.492

Abstract

Research Background. Stroke as brain vascular disorder that can be ruptured vascular commonly referred to as a bleeding stroke or ischemic stroke may be due to cerebral arterial thrombosis as a final impact the progression of atherosclerosis, especially in the area of branching blood vessels. Atherogenesis related to endothelial dysfunction as a consequence shear stress exposure leads endothelial cells undergo premature senescence and activation of endothelial than occur endothelial detachment from the basement membrane as a circulating endothelial cells (CEC). Mechanism shears stress on endothelial activation can not be separated from the increased production of hydrogen peroxidase (H2O2), which will activate the PPAR-? then increase levels of free fatty acids are capable of modulating the uncoupling protein 2 (UCP 2) gene as a compensation for lowering of free fatty acids.Reseach Methods and Results. Researchers used 40 subjects were classified into two categories on a range of healthy and sick, who then performed blood sampling edge for lipid profile analysis, CEC using flowcytometry, H2O2 measurement with ELISA techniques and DNA isolation followed by PCR procedures with the Genomic DNA that has been extracted from blood samples amplified with the 5’-GCT GCT CAC AGG TCT GCC AC-3’sebagai forward primer and 5’-AGG CGT CAG GAG ATG GAC CG-3’sebagai reverse primer (Sesti et al, 2003; Oktavianthi et al, 2012). Genotype (-866) AA is characterized by fragments of 363 bp cutting results Mlu1 sites, whereas genotypes (-866) GG marked on fragments of 295 bp and 68 bp. The equipment used was a thermal cycler (Gene Amp® PCR System 9700 [Applied Biosystems, Foster City, CA, USA]). Results showed thatConclusion. CEC in the group sick 3 times higher than the healthy group as well as the levels of H2O2, but the two groups are not found polymorfism in both groups. Similarly, from the analysis of UCP2 gene allele frequencies between groups of stroke was not significantly different from the control group, this means yet certain UCP2 gene predispose and contribute to the pathogenesis of stroke.
Hypertension Associated with Poor Sleep Quality in The Elderly Population in Batu City Siti Roziah Ria Famuji; Abdul Malik Setiawan; Achdiat Agoes
Journal of Health Science and Prevention Vol. 5 No. 2 (2021): JHSP Vol 5 No 2 - 2021
Publisher : State Islamic University of Sunan Ampel

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/jhsp.v5i2.458

Abstract

Hypertension affects approximately 26% of the adult population and it is a leading cause of death in up to 13.5% worldwide. Hypertension is a disease with the highest prevalence in Indonesia, so good treatment and prevention are needed. Several studies suggest that there is a correlation between hypertension risk factors and the disturbance of sleep quality. Therefore, it is necessary to develop preventive and promotive efforts to obtain optimum blood pressure in patients with hypertension to avoid complications or even death. This study aims to find out the correlation between sleep quality and the value of blood pressure in the elderly ?60 years old in Batu City. A cross-sectional study was conducted in Batu City in 2020. Stratified random sampling was performed to select the respondents. A validated PSQI questionnaire and sphygmomanometer were used to assess sleep quality and blood pressure, respectively. A Chi-Square test was used to test the hypothesis. There were 391 respondents involved in this study. Most of the respondents have poor sleep quality, 205 respondents (52,43%) of which 41 respondents (20%) have normal blood pressure, and 164 respondents (80%) have high blood pressure. The statistical analysis shows a significant correlation (p=0,000) between sleep quality and blood pressure. In conclusion, hypertension is associated with poor sleep quality in the geriatric population in Batu City.
Hubungan antara Durasi Tidur dengan Asupan Makan, Aktivitas Fisik dan Kejadian Obesitas Pada Mahasiswa Program Studi Pendidikan Dokter UIN Maulana Malik Ibrahim Malang Ermin Rachmawati; Nimas Eka Firdaningrum; Achdiat Agoes
Journal of Islamic Medicine Vol 5, No 1 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i1.11674

Abstract

Durasi tidur yang pendek merupakan masalah yang kerap dihadapi oleh mahasiswa kedokteran. Disisi lain, obesitas merupakan salah satu masalah gizi utama di dunia termasuk Indonesia, dengan salah satu faktor resiko yaitu gangguan fungsi tidur. Penelitian ini bertujuan untuk meneliti hubungan antara durasi tidur dengan asupan makan, aktivitas fisik dan kejadian obesitas pada mahasiswa PSPD UIN Maulana Malik Ibrahim Malang. Penelitian ini merupakan studi cross sectional dengan teknik cluster sampling. Sebanyak 78 mahasiswa PSPD UIN Maulana Malik Ibrahim Malang berpartisipasi sebagai responden penelitian ini. Durasi tidur diukur dengan menggunakan kuisioner Rerata Durasi Tidur dalam 1 minggu, asupan makan diukur dengan kuisioner 24 Hours Food Recall, aktivitas fisik diukur dengan kuisioner GPAQ (Global Physical Activity Questionnaire) dan kejadian obesitas dinilai dari BMI (Body Mass Index), BMI diukur dengan menggunakan timbangan berat badan dan tinggi badan SMIC ZT-120. Data yang diperoleh diolah mengggunakan statistik deskriptif dan inferensial, dengan uji analisis chi-square. Dari total 78 responden, didapatkan bahwa sebagian besar mahasiswa memiliki durasi tidur yang buruk (6 jam; 53,8%), sedangkan mahasiswa yang memiliki durasi tidur cukup (6 jam) sebesar 28,2% dan durasi tidur baik (7-9 jam) sebesar 17,9%. Hasil analisis chi-square menunjukkan bahwa durasi tidur memiliki hubungan yang signifikan dengan asupan makan (p-value= 0,000) dan kejadian obeistas (p-value= 0,000), tetapi durasi tidur tidak memiliki hubungan yang signifikan dengan aktivitas fisik (p-value= 0,171). Durasi tidur yang buruk memiliki hubungan dengan kejadian obesitas melalui asupan makan, tapi tidak dengan aktivitas fisik.Kata kunci : Kata kunci : Body Mass Index, Asupan Makan, Kejadian Obesitas, Aktivitas Fisik, Durasi Tidur
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Malik Setiawan Aliyah Adek Rahmah, Aliyah Adek Didik Saudin Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Ermin Rachmawati Firdaus, Achmad Dafir Ika Setyo Rini Laily Yuliatun M.Nur FAFA Nimas Eka Firdaningrum S Satuman Saifullah Alfaruqi, Saifullah Satuman Satuman Siti Roziah Ria Famuji Teuku Heriansyah, Teuku Titin A Wihastuti, Titin A Titin Andri W Wiwit Nurwidyaningtyas