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Rohadi
Department Of Neurosurgery, Faculty Of Medicine And Health Science, University Of Mataram, Mataram
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Relationship Between S100 Protein Expression and Grading Meningioma Lale Maulin Prihatina; Rohadi; Bambang Priyanto; Decky Aditya Zulkarnaen; Abdul Syukur
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11529

Abstract

Meningioma is the most common type of benign brain tumor in adults and mostly originates from the meningeal layer of the brain and spinal cord. The prevalence of meningioma in the world is estimated to be about 24-30% of intracranial primary brain tumors. This tumor is classified into three groups based on grade, grade I (benign), grade II (atypical), and grade III (anaplastic). The S100 protein is not specific to meningiomas but some studies have shown that the expression of S100 protein is stronger in grade I meningiomas than in grade II and III meningiomas. Based on these findings, the authors are interested in analyzing whether there is a relationship between S100 expression and meningioma grading. The determination of S100 protein expression is very necessary as a reference in determining the prognosis and selection of the best therapy for patients. This research was carried out in the period from January 2021 to December 2021. 9 samples were included in this study according to the inclusion and exclusion criteria. The data was analyzed using SPSS version 26. The results of this study: A normality test was carried out with the Shapiro Wilk test and a value of p=0.34 (CI 95%) was obtained using Spearman analysis.
Determinants of Executive Dysfunction: Serum NRF2 and Sociodemographic Profiles in Lombok Island’s Coastal Population Inayah Wulandari; Nurhidayati Nurhidayati; Ilsa Hunaifi; Arina Windri Rivarti; Herpan Syafii Harahap; Legis Octaviana Saputri; Dini Suryani; Fitriannisa Faradina Zubaidi; Rohadi Muhammad Rosyidi
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.74449

Abstract

Highlight: Coastal communities show high prevalence of cognitive decline. There is no correlation between NRF2 levels and executive function. Gender and education level were significantly associated with executive dysfunction.   ABSTRACT Introduction: Elderly people frequently suffer from neurodegenerative conditions that affect cognitive function. Redox homeostasis dysregulation plays a significant role in neurodegenerative diseases. Oxidative stress activates the transcription factor called nuclear factor erythroid 2-related factor 2 (NRF2), which is essential for regulating the expression of genes involved in cellular defense mechanisms. Objective: This study aimed to determine the relationship between serum NRF2 levels and executive function, as well as to identify other variables that may influence executive function among residents of coastal villages on Lombok Island. Methods: The study used a cross-sectional design with consecutive sampling. Data on sociodemographic characteristics, hypertension, diabetes mellitus, smoking status, and physical activity were collected. Statistical analyses employed Spearman's rank correlation test, Fisher's exact test, and logistic regression test. Results: A total of 39 participants were included, with an average age of 53.38 years. Most participants were female, had a low educational level, did not have hypertension or diabetes mellitus, had high physical activity levels, and were non-smokers. The average NRF2 level was 0.54 ng/mL. The correlation test showed no significant relationship between serum NRF2 levels and executive function. Fisher's exact test showed a significant relationship between gender and education with executive function. Furthermore, logistic regression analysis identified education level as a predictor of executive dysfunction. Conclusion: Serum NRF2 levels were not correlated with executive dysfunction. Educational level was identified as a predictive factor for executive dysfunction.
Studi Perbandingan Imunohistokimia NeuN dan NSE untuk Penilaian Neuroprotektif Kombinasi Centella asiatica, Kayu Manis, dan Spirulina pada Cedera Otak Traumatis Rohadi Rohadi; Bambang Priyanto; Januarman Januarman; Lale Maulin Prihatina
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 11 No. 3 (2025): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v11i3.968

Abstract

Background: Traumatic brain injury (TBI) is a major cause of morbidity and mortality globally, often resulting in cognitive and functional impairment. Effective neuroprotective strategies are needed to mitigate secondary injuries following TBI. This study evaluated the neuroprotective effects of combined Centella asiatica, cinnamon, and spirulina using NeuN and neuron-specific enolase (NSE) immunohistochemical staining in a rat model of TBI. Methods: Ten male Sprague-Dawley rats (200–400 g, 10–12 weeks) were subjected to TBI using the modified Marmarou model and treated orally with a combination extract of Centella asiatica, cinnamon, and spirulina for 10 days. On day 11, brain tissues were collected for histopathological examination and immunohistochemical staining using NeuN and NSE markers to evaluate neurogenesis and neuronal survival. Results: Immunohistochemical analysis revealed a mean positive expression of 71.66% in the NeuN group, indicating increased neuronal survival and neurogenesis, while the NSE group consistently showed 0% positive staining across all samples. The NeuN staining provided a clear depiction of neuronal preservation in the brain tissue, whereas NSE did not demonstrate detectable neurogenesis or neuronal protection in this model. Conclusion: The administration of a combined extract of Centella asiatica, cinnamon, and spirulina demonstrated neuroprotective effects in a rat model of subacute traumatic brain injury, as indicated by increased NeuN immunohistochemical expression, reflecting enhanced neurogenesis and neuronal survival. NeuN staining provided a clearer and more sensitive depiction than NSE, supporting its reliability as an immunohistochemical marker for evaluating neuroprotection and neurogenesis during the subacute phase of TBI in models treated with herbal-based interventions.
Strategi Produk Hospital At Home Sebagai Inovasi Layanan Masa Depan Rohadi Rohadi; Wachyu Sulistiadi
Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI) Vol 10, No 2 (2026): Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI)
Publisher : LPPM Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/marsi.v10i2.8759

Abstract

Introduction: Overcrowding in hospital inpatient facilities has become a major challenge that can reduce service quality, operational efficiency, and patient safety. Advances in healthcare technology, along with the growing demand for more personalized care, have encouraged the emergence of the Hospital at Home (HaH) concept as an alternative home-based inpatient care model. This study aims to analyze the product development strategy of Hospital at Home through the integration of homecare services and remote monitoring technology. Methods: This study employed a qualitative approach using a literature review method. Data were collected from scientific articles, academic journals, and other relevant literature related to the implementation of Hospital at Home. Results: The findings indicate that Hospital at Home is effective for patients with stable acute conditions who meet specific clinical criteria. This model can reduce hospital inpatient burdens, improve patient comfort, and lower healthcare service costs. Its successful implementation depends on the readiness of multidisciplinary teams, integrated homecare systems, and reliable remote monitoring technologies. Conclusion: Hospital at Home represents an innovative healthcare service model with the potential to enhance service quality, hospital efficiency, and patient satisfaction in a sustainable manner.Keywords: Hospital at Home; Overcrowding; Integrated homecare; Remote monitoring; Service innovation.
Co-Authors Abdul Syukur Achmad Evin Kafrawi Ahmad Taufik S Akbar Dwi juliardi NR Andari, Marie Yuni Annisa Diyanabila Indrasari Arina Windri Rivarti Bambang Priyanto Bambang Priyanto Bambang Priyanto Bambang Priyanto Bayu Putra Wibowo Bayu Tirta Dirja Bq. Dina Ayuni A Decky Aditya Zulkarnaen Decky Aditya Zulkarnaen Dini Suryani Fitriannisa Faradina Zubaidi Gibran Ihza Sukma Herpan Syafii Harahap I. MD. Arya Wiradana Ilsa Hunaifi Ilsa Hunaifi Inayah Wulandari Januarman Januarman Januarman Januarman Johan Trinanda Hermawan Kamariatul Kibtiah Lale Maulin Prihatina Lale Maulin Prihatina Lale Maulin Prihatina Lalu Wahyu Alfian Muharzami Legis Octaviana Saputri Listia Putri Meylia Arifathiyah Muzakki Hasnan Ali Muzzaki Hasnan Ali Nurhidayati Nurhidayati Puji Widyastuti Talitha Syahla Thania Olang Tassya Vanessa Essianda Wachyu Sulistiadi Widya Rahayu Wira Risky Amanda Zikrul Haikal