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All Journal Jurnal Farmasi SYIFA Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Journal of Innovative and Creativity Compromise Journal : Community Proffesional
Widya Fitri
Universitas Sari Mutiara Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Effectiveness Test Of The Inhibition Power Of Ethanol Extract Of Salak Pondoh Fruit Skin (Salacca Zalacca (Gaertn.) Voss) Against Eschericia Coli Bacteria And Salmonella Typhi Bacteria Manahan Situmorang; Widya Fitri; Julia Susanti; Enjelina Br Sembiring Kembaren
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2058

Abstract

Diarrhea is the occurrence of defecation with a more liquid consistency than usual and may be accompanied by liquid mucus or blood with a frequency of three times or more within 24 hours. Salak pondoh contains chemical compounds consisting of flavonoids, saponins, phenols, tannins, alkaloids, chlorogenic acid, ferulic acid, and protocatechuic acid. The bacteria Escherichia coli and Salmonella typhi cause diarrhea and fever due to tissue damage. Based on the above description, this study will test the effectiveness of the inhibitory power of the ethanol extract of salak pondoh fruit skin (Salacca zalacca (Gaertn.) Voss) against Escherichia coli and Salmonella typhi bacteria. This research method uses an experimental agar diffusion method to test the antibacterial activity of salak pondoh fruit skin with concentrations of 20%, 40%, 60%, and 80%. The results of this study show that the concentrations of 20%, 40%, 60%, and 80%, and the positive control (chloramphenicol) of salak pondoh fruit skin have antibacterial inhibitory power against the growth of Escherichia coli bacteria, as indicated by inhibition diameters of 4.81 ± 22.74 mm, 7.81 ± 22.74 mm, 10.15 ± 06.65 mm, 15.07 ± 19.00 mm, and 27.56 ± 48.58 mm, respectively. For Salmonella typhi, the antibacterial inhibitory power was 2.22 ± 18.19 mm, 3.48 ± 23.30 mm, 7.32 ± 67.41 mm, 11.68 ± 112.07 mm, and 24.14 ± 77.77 mm, respectively. The conclusion from the results of this study is that the effectiveness test of the ethanol extract of salak pondoh fruit skin (Salacca zalacca (Gaertn.) Voss) can inhibit the growth of Escherichia coli and Salmonella typhi bacteria, and the concentration that can significantly affect bacterial growth inhibition is 80%.
Pemberdayaan Masyarakat Melalui Pelatihan Pembuatan Sediaan Gel Antijerawat Berbahan Herbal Lokal Suharyanisa Suharyanisa; Widya Fitri; Nuranti Rumela; Betharina br Tarigan
Compromise Journal Community Proffesional Service Journal Vol. 3 No. 1 (2025): Compromise Journal : Community Proffesional Service Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/compromisejournal.v3i1.562

Abstract

Acne is a common skin problem caused by excessive growth of Staphylococcus aureus on the skin due to increased sebum production. Dragon scale leaves (Drymoglossum piloselloides) contain active compounds such as saponins, phenols, tannins, and flavonoids, which have antibacterial and anti-inflammatory properties. This community service program aims to enhance public knowledge about the utilization of dragon scale leaf extract in acne gel formulations. The activities included education, a demonstration of gel preparation, and an evaluation of training effectiveness through pre-tests and post-tests. The evaluation results showed an increase in participant understanding from 20% to 75%, exceeding the targeted improvement. Active community participation indicates a strong interest in utilizing herbal plants as an alternative skincare solution, highlighting the potential for further development.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Antijerawat Ekstrak Etanol Daun Sisik Naga (Drymoglossum piloselloides (L.) Pressl.) terhadap Staphylococcus aureus Suharyanisa Suharyanisa; Widya Fitri; Nuranti Rumela; Betharina br Tarigan
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.560

Abstract

Acne appears due to increased sebum production on the skin and the growth of Staphylococcus aureus bacteria. The antibacterial activity of ethanol extract of dragon scale leaves (EEDSL) against Staphylococcus aureus bacteria provides strong inhibitory power. Dragon scale leaves (Drymoglossum piloselloides(L.) Pressl.)) can act as an anti-acne and its use as a preparation has not been widely carried out. This study aims to determine that EEDSL can be formulated as a gel preparation that meets the physicochemical quality requirements and that EEDSL gel preparations have antibacterial activity against Staphylococcus aureus. This study was conducted using an experimental method, sampling using the purposive sampling method in Kidupen Village, Juhar District, Karo Regency. Dragon scale leaf extract was obtained using the maceration technique with an ethanol solvent. EEDSL was formulated into a gel and then subjected to physical evaluation tests and antibacterial tests on staphylococcus aureus bacteria by looking at the diameter of the inhibitory power formed. The results of the study showed that the formulation of the anti-acne gel preparation was colorless, clear, and odorless obtained at F0. At F1; F2; and F3, a brown gel preparation was obtained with a semi-solid form and a distinctive EEDSL smell. The antibacterial activity test of EEDSL against Staphylococcus aureus showed an average value ± SD of the inhibition zone in each formula, namely at F0: 0.00 ± 0.00 mm; F1: 6.86 ± 0.17 mm; F2: 8.46 ± 0.19 mm; F3: 9.17 ± 0.18 mm; and positive control: 14.09 ± 0.23 mm. Based on the results of the data obtained, it can be concluded that EEDSL can be formulated as a gel preparation that meets the physicochemical quality requirements. Each concentration of ethanol extract of dragon scale leaves (Drymoglossum piloselloides (L.) Pressl.) has antibacterial activity against Staphylococcus aureus with a medium category.
Jurnal Review: Aktivitas Biologis Jamu, Obat Herbal Terstandar, Dan Fitofarmaka Sebagai Antiinflamasi Fridelly Mairani; Jon Kenedy Marpaung; Rezza Fikrih Utama; Widya Fitri
Jurnal Farmasi SYIFA Vol 4 No 1 (2026): Jurnal Farmasi SYIFA
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jfs.v4i1.1007

Abstract

Jamu, obat herbal terstandar, dan fitofarmaka merupakan bagian penting dari sistem pengobatan berbasis bahan alam di Indonesia yang didukung oleh kekayaan keanekaragaman hayati. Berbagai tanaman obat diketahui mengandung senyawa bioaktif seperti flavonoid, tanin, saponin, kurkuminoid dan senyawa fenolik yang berperan dalam aktivitas biologis, khususnya sebagai agen antiinflamasi. Review ini bertujuan untuk mengidentifikasi dan menganalisis aktivitas biologis jamu, obat herbal terstandar, dan fitofarmaka sebagai antiinflamasi. Penelitian ini merupakan review literatur sistematis yang bersumber dari Google Scholar, PubMed, ScienceDirect, dan Portal Garuda. Artikel yang diseleksi merupakan penelitian eksperimental in vitro dan in vivo yang menguji aktivitas biologis sediaan jamu, obat herbal terstandar dan fitofarmaka yang dipublikasikan pada periode 2020–2025. Data dianalisis secara kualitatif dengan membandingkan jenis sediaan, senyawa bioaktif, metode uji, serta hasil aktivitas biologis. Hasil kajian menunjukkan bahwa jamu, obat herbal terstandar, dan fitofarmaka memiliki aktivitas antiinflamasi yang signifikan, ditandai dengan penurunan edema dan penghambatan mediator inflamasi. Formulasi terstandar seperti gel, minyak, sirup, serbuk dan stick herbal meningkatkan stabilitas serta konsistensi efek terapeutik. Kesimpulan yang didapat dari hasil identifikasi dan analisis yaitu jamu, obat herbal terstandar, dan fitofarmaka terbukti memiliki potensi antiinflamasi yang kuat melalui aktivitas senyawa bioaktif seperti flavonoid, tanin, saponin, kurkuminoid dan senyawa fenolik. Senyawa-senyawa ini berperan dalam menghambat mediator inflamasi, mengurangi edema, serta melindungi jaringan dari stres oksidatif. Jamu, obat herbal terstandar, dan fitofarmaka memiliki potensi besar sebagai agen antiinflamasi yang aman dan efektif. Standarisasi sediaan dan pendekatan ilmiah yang tepat mendukung integrasi obat tradisional ke dalam praktik kesehatan modern berbasis bukti ilmiah.
Co-Authors Betharina Br Tarigan Enjelina Br Sembiring Kembaren Fridelly Mairani Jon Kenedy Marpaung Julia Susanti Manahan Situmorang Nuranti Rumela Rezza Fikrih Utama Suharyanisa Suharyanisa