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All Journal Akta Kimia Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Pelayanan dan Pengabdian Masyarakat (Pamas) Amalee: Indonesian Journal of Community Research & Engagement Jurnal Sains dan Edukasi Sains Aptekmas : Jurnal Pengabdian Kepada Masyarakat JURNAL SIPISSANGNGI: Jurnal Pengabdian Kepada Masyarakat
Lodowik Landi Pote
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Kinetic and Optimization Study of Green Extraction of Bioactives from Anredera Cordifolia Leaves Latumakulita, Gertreda; Lodowik Landi Pote; Anggelinus Nadut; Juliano M.P. Umbu Jima Kadebu; Amandha V.D. Tukan
Amalee: Indonesian Journal of Community Research and Engagement Vol. 6 No. 2 (2025): Amalee: Indonesian Journal of Community Research and Engagement
Publisher : LP2M INSURI Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/amalee.v6i2.8119

Abstract

The sustainable extraction of bioactive compounds from medicinal plants supports environmentally responsible practices in the pharmaceutical and nutraceutical industries. This study investigates the extraction behavior of Anredera cordifolia leaves using green solvents, with a focus on process optimization and kinetic modeling. A factorial design was used to evaluate the effects of temperature (25–60°C), solvent type (ethanol, methanol, water), pH (4, 7, 9), and time (10–90 minutes). Total phenolic content (TPC) and antioxidant activity were measured via spectrophotometry. Kinetic analysis revealed that the pseudo-second-order model provided the best fit to the data (R² > 0.98), indicating chemisorption as the dominant mechanism. Response Surface Methodology (RSM) identified optimal conditions at 59°C, 70% ethanol, pH 7, and 65 minutes, yielding 213.2 mg GAE/g DW TPC and 91.8% antioxidant activity. Compared to conventional methods, this approach improved yield by 21% and reduced solvent use by 30%. These results demonstrate the value of combining kinetic modeling with statistical optimization to create efficient, scalable, and low-impact extraction protocols. Importantly, the findings offer practical relevance for advancing Indonesia’s herbal industry and supporting the development of sustainable biotechnology in tropical regions.
Co-Authors Amandha V.D. Tukan Angelinus Nadut Anggelinus Nadut Anggelinus Nadut Dwiputri Tukan, Amandha Victoria Gerardus Diri Tukan Gertreda Latumakulita Grace Rianti Latuheru Helena Hepa Lengari Juliano M.P. Umbu Jima Kadebu Kadebu, Juliano M. P. Umbu Jima Lalong, Paulus Risan F. Lasar, Maria Wilhelmina Latuheru, Grace Rianti Lengari, Helena Hapa Lengari, Helena Hepa Lusia Ina Dai Maximus M Taek Nadut, Angelinus Taek, Maximus M Taek, Maximus Markus Tukan, Amandha Victoria Dwiputri Wokal, Monika Woli Yakoba Koni Renda