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Perbedaan kadar kalium dan natrium pada saliva pasien periodontitis kronis dan tanpa periodontitis kronisDifferences in potassium and sodium levels in the saliva of patients with and without chronic periodontitis Mahardhika, Muhammad Haikal; Hendiani, Ina; Susanto, Agus
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 28, No 3 (2016): Desember
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Periodontitis kronis menyebabkan perbedaan kadar ion kalium dan natrium pada saliva karena terjadinya perpindahan ion- ion tersebut dari cairan intraseluler dan ekstraseluler sel dan jaringan yang mengalami peradangan menuju saliva. Tujuan penelitian ini bertujuan untuk Â mengetahui perbedaan kadar kalium dan natrium pada saliva pasien periodontitis kronis dan pasien tanpa periodontitis kronis. Metode: Penelitian deskriptif analitik, subjek penelitian sebanyak 30 pasien, terdiri dari 15 pasien periodontitis kronis dan 15 pasien tanpa periodontitis kronis. Pengukuran poket periodontal dan pengambilan saliva menggunakan spitting method serta pengukuran kadar kalium dan natrium saliva dalam satuan mmol/L menggunakan spektrofotometer AAS. Data diuji secara statistik menggunakan uji t independent sample test. Hasil: rata-rata kadar kalium dan natrium pada pasien periodontitis kronis (18,22 mmol/L dan 9,92 mmol/L), sedangkan pada pasien tanpa periodontitis kronis (16,54 mmol/L dan 6,95 mmol/L). Tidak terdapat perbedaan signifikan kadar kalium saliva pasien periodontitis kronis dan pasien tanpa periodontitis kronis (p=0,351), dan terdapat perbedaan signifikan kadar natrium pada saliva pasien periodontitis kronis dan pasien tanpa periodontitis kronis (p=0,004). Simpulan: Kadar natrium pada saliva pasien periodontitis kronis lebih tinggi dibandingkan pasien tanpa periodontitis.Â ABSTRACTIntroduction: Chronic periodontitis causes differences in potassium and sodium ion levels in saliva due to the transfer of these ions from intracellular and extracellular fluid cells and tissues that experience inflammation into saliva. The aim of this study was to determine differences in potassium and sodium levels in the saliva of chronic periodontitis patients and patients without chronic periodontitis. Methods: A descriptive analytic study conducted towards 30 patients, consisting of 15 chronic periodontitis patients and 15 patients without chronic periodontitis. Measurement of periodontal pockets and saliva retrieval using spitting method and measurement of salivary potassium and sodium levels in mmol / L using AAS spectrophotometer. Data were statistically tested using independent sample test t test. Results: The average potassium and sodium levels in chronic periodontitis patients (18.22 mmol / L and 9.92 mmol / L), whereas in patients without chronic periodontitis (16.54 mmol / L and 6.95 mmol / L) . There were no significant differences in potassium saliva levels of chronic periodontitis patients and patients without chronic periodontitis (p = 0.351), and there were significant differences in sodium levels in the saliva of chronic periodontitis patients and patients without chronic periodontitis (p = 0.004). Conclusion: Sodium levels in the saliva of chronic periodontitis patients are higher than patients without periodontitis.Keywords: Potassium, sodium, chronic periodontitis, saliva.

Perbandingan berkumur larutan ekstrak kulit buah manggis dan EnkasariÂ® terhadap penurunan indeks plakComparison of gargling solution of mangosteen pericarp extract and EnkasariÂ® in decreasing plaque index Pratiwi, Annisa Rizky; Hendiani, Ina; Pribadi, Indra Mustika Setia
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 28, No 3 (2016): Desember
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Plak terdiri dari berbagai macam bakteri. Plak dapat dikendalikan salah satunya dengan cara kimiawi, melalui penggunaan obat kumur. Salah satu obat kumur herbal yang sudah teruji klinis dan tersedia di pasaran adalah EnkasariÂ®. EnkasariÂ® memiliki kandungan utama daun sirih.Â Â Ekstrak kulit manggis telah teruji dapat berperan dalam menghambat pertumbuhan bakteri dan berpotensi dijadikan larutan kumur. Tujuan penelitian ini adalah membandingkan pengaruh dan perbedaan berkumur larutan ekstrak kulit buah manggis konsentrasi 50% dan EnkasariÂ® terhadap penurunan indeks plak. Metode: Penelitian yang digunakan adalah eksperimental semu dengan desain cross-over dan pengambilan sampel menggunakan purposive sampling. Penelitian dilakukan pada 32 orang mahasiswa Fakultas Kedokteran Gigi Universitas Padjadjaran angkatan 2010. Penelitian dilakukan di Rumah Sakit Gigi dan Mulut Universitas Padjadjaran. Pengukuran indeks plak gigi dilakukan sebelum dan sesudah berkumur larutan ekstrak kulit buah manggis dan EnkasariÂ® selama 2 hari tanpa oral hygiene. Pengolahan data menggunakan uji t berpasangan dan uji t independen. Hasil: Penelitian menunjukan bahwa kedua larutan sama-sama mempunyai pengaruh terhadap penurunan indeks plak. Subjek yang berkumur larutan ekstrak kulit buah manggis 50%, penurunan indeks plaknya lebih besar daripada subjek penelitian yang berkumur EnkasariÂ®. Hasil uji t independen menunjukan bahwa nilai signifikasi (0,045) dengan p<0,05. Simpulan: Terdapat pengaruh berkumur larutan ekstrak kulit buah manggis 50% dan EnkasariÂ® terhadap penurunan indeks plak serta terdapat perbedaan penurunan nilai indeks plak yang signifikan antara berkumur larutan ekstrak kulit buah manggis 50% dan EnkasariÂ®.Â ABSTRACTIntroduction: Plaque consists of various types of bacteria. Plaque can be controlled one of them by chemical means, through the use of mouthwash. One of the herbal mouthwashes that have been clinically tested and available on the market is EnkasariÂ®. EnkasariÂ® has the main content of betel leaf. Mangosteen peel extract has been tested to play a role in inhibiting bacterial growth and potentially being used as a mouth rinse. The purpose of this study was to compare the effects and differences of gargling solution of 50% mangosteen pericarp extract and EnkasariÂ® on the reduction of plaque index. Methods: The research used was quasi-experimental with cross-over design and sampling using purposive sampling. The study was conducted on 32 students of the Faculty of Dentistry, Padjadjaran University, class of 2010. The study was conducted at the Dental and Oral Hospital of Padjadjaran University. Measurement of dental plaque index was done before and after gargling the solution of mangosteen rind extract and EnkasariÂ® for 2 days without oral hygiene. Data processing uses paired t test and independent t test. Results: Research shows that both solutions have an effect on the decrease in plaque index. Subjects who rinsed the solution of mangosteen pericarp 50%, the decrease in plaque index was greater than the research subjects who rinsed EnkasariÂ®. The independent t test results showed that the significance value (0.045) with p < 0.05. Conclusion: There is an effect of gargling 50% mangosteen pericarp and EnkasariÂ® rind extract on decreasing plaque index and there is a significant difference in significant plaque index values between gargling 50% mangosteen pericarp extract and EnkasariÂ® rinse.Keywords: Mangosteen pericarp, dental plaque, dental plaque index.

Clinical evaluation of adjunctive topical therapy HCl 25 mg in surgical periodontal flap Sutamaya, Agus; Hendiani, Ina; Susanto, Agus
Padjadjaran Journal of Dentistry Vol 28, No 2 (2016): July 2016
Publisher : Faculty of Dentistry Universitas Padjadjaran

Introduction: HCl tetracycline has been used as adjunctive therapy in surgical flap for chronic periodontitis. The aim of this study was to investigate the effect of tetracycline HCl 25 mg as an adjunctive therapy in surgical flap to reduce pocket depth and gingival inflammation. Methods: Subjects are divided into 2 groups, surgical flap group with tetracycline HCl 25 mg and surgical flap only. Measurements of pocket depth and gingival inflammation were taken in first condition and 1 month after treatment. Result: flap surgical treatment with a tetracycline Hcl 25 mg given topically provides better results for pocket depth and gingival inflammation in patients with chronic periodontitis. Pocket measurements and gingival inflammation 1 month after surgery compared with early conditions showed significant differences (p = 0.00 and p = 0.00). Conclusion: Based on our study it was found that the use of tetracycline HCl 25 mg topically has a better influence in reducing pocket depth and gingival inflammation in chronic periodontitis.

The effectiveness of mangosteen rind extract as additional therapy on chronic periodontitis (Clinical trials) Hendiani, Ina; Hadidjah, Dede; Susanto, Agus; Setia Pribadi, Indra Mustika
Padjadjaran Journal of Dentistry Vol 29, No 1 (2017): March 2017
Publisher : Faculty of Dentistry Universitas Padjadjaran

Introduction: Periodontitis is an inflammatory disease that attacks the periodontal tissue comprises the gingiva, periodontal ligament, cementum and alveolar bone caused mainly by plaque bacteriophage or other specific dominant type of bacteria. The purpose of this study was to determine the therapeutic effect of clinical application of mangosteen peel extract gel as adjunctive therapy scaling and root planing in patients with chronic periodontitis. This research was expected to developed new treatment in the field of dentistry, particularly in periodontics, which can be used as supporting material for the treatment of chronic periodontitis. Methods: Quasi-experimental research, split mouth, with as many as 14 chronic periodontitis patients. Mangosteen rind was prepared to be formed into extract gel, dried at room temperature, then the dried samples were macerated by using ethanol, then evaporated and decanted for 3 days until obtained condensed extract. The samples were patients with chronic periodontitis in at least 2 teeth with pockets ≥ 5 mm. Clinical parameters of pocket depth, gingival bleeding, and clinical epithelial attachment level were measured at baseline and 1 month after treatment. Analysis of data using the t-test. Results: The comparison of average gap ratio of pockets depth, gingival index, gingival bleeding and epithelium attachment levels, before and after treatment showed significant differences, such as in the test and control sides. Conclusion: The mangosteen rind gel as adjunctive therapy for scaling and root planing is able to reduce pockets depth, gingival index, and gingival bleeding, and improve clinical epithelial attachment.

Inhibitory and bactericidal power of mangosteen rind extract towards Porphyromonas Gingivalis and Actinobacillus Actinomycetemcomitans (Laboratory test) Hendiani, Ina; Hadidjah, Dede; Susanto, Agus; Mustika SP, Indra
Padjadjaran Journal of Dentistry Vol 28, No 2 (2016): July 2016
Publisher : Faculty of Dentistry Universitas Padjadjaran

Introduction: The bacteria that cause the occurrence of pathogens of periodontal disease are gram negative anaerobes. These bacteria include Pophyromonas Gingivalis and Actinobacillus Actinomycetemcomitans. Mangosteen skin extract is known to have anti-inflammatory, anti microbial, and anti oxidant properties. The extract of the mangosteen peel is altered in gel preparation in order to streamline its clinical application in periodontal disease. The purpose of this study was to examine the antibacterial power of the ginger mangosteen tree extract gel against Pophyromonas gingivalis and Actinobacillus Actinomycetemcomitans (Aggregatibacter Actinomycetemcomitans). Methods: This research was conducted by experimental laboratory. Mangosteen fruit extract gel with concentration of 100%, 50%, 25%, 12,5%, 6,25%, 3,125% and 0,78% were tested against Pophyromonas Gingivalis and Aggregatibacter Actinomycetemcomitans with agar diffusion method. Results: The results of this study indicate that for Actinobacilus Aggregatibacter bacteria minimal inhibitory concentration at a concentration of 6.25% with a diameter of 13,5mm inhibition. Minimal bactericidal concentration at 12,5% concentration with 14,7mm inhibitory diameter. In the test of Pophyromonas Gingivalis bacteria, minimal inhibitory concentrations were obtained at a concentration of 1.56% and a minimum bactericidal concentration was obtained at a concentration of 3.125%. Conclusion: The conclusion that mangosteen peel skin gel extract can inhibit bacterial growth and is bactericidal against Pophyromonas Gingivalis and Actinobacillus Actinomycetemcomitans (Aggregatibacter Actinomycetecomitans).

The effect of carbonate apatite membrane gelatin application on IL-1β level gingival crevicular fluid in chronic periodontitis patients Pribadi, Indra Mustika Setia; Hendiani, Ina; Sartiono, Reynaldy
Padjadjaran Journal of Dentistry Vol 31, No 3 (2019): November 2019
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol31no3.23930

Introduction: Apatite carbonate material plays an important role in bone tissue regeneration. The use of this membrane is expected to achieve better treatment success than those without additional therapy. The antimicrobial content in the apatite carbonate membrane can be used to support periodontal treatment of chronic periodontitis after scaling and root planing. The purpose of this research was to analyse the effect of carbonate apatite membrane gelatin application on the IL-1β level of the gingival crevicular fluid in chronic periodontitis patients. Methods: This research was a double-blind, randomised controlled trial method, with purposive sampling, and split-mouth design. The parameter was the IL-1β level in the gingival crevicular fluid before and after scaling and root planing. Carbonate apatite membrane gelatin was applied to the periodontal pocket on the test group after scaling and root planing. Data were analysed by the Wilcoxon test with a p-value < 0.05. Results: The reduction of IL-1β level gingival crevicular fluid on day-0 and day-30 on both groups showed significant value (p < 0.001). However, it showed no significant differences statistically, between the test group and the control group. Conclusion: Carbonate apatite membrane gelatin application might reduce the IL-1β level of the gingival crevicular fluid, but not showing a better reduction from the control group.Keyword: Carbonate apatite membrane gelatin, IL-1β, periodontal therapy

Dietary habit of chronic periodontitis patients based on Balanced Nutrition Guidelines from the Ministry of Health of the Republic of Indonesia Kono, Ghinda Nevithya; Hendiani, Ina; Komara, Ira
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.15404

Introduction: Prevalence of the periodontal disease in Indonesia is 73.1%; one of them is periodontitis. Periodontitis is an inflammation of the tooth-supporting tissue caused by specific microorganisms or a specific group of microorganisms, destroying the periodontal ligament and alveolar bone with increased of clinical attachment loss. Chronic periodontitis patients generally have a poor dietary habit. This study was aimed to describe the dietary habit of chronic periodontitis patients at Universitas Padjadjaran Dental Hospital. Methods: The research method used was descriptive survey research. This study's population was diagnosed with chronic periodontitis based on medical records at the Clinics of Periodontics Specialist Program of Universitas Padjadjaran Dental Hospital. The research sample was taken by purposive sampling. The number of samples in this study was taken through the Lemeshow formula A total of 43 research respondents who met the inclusion and exclusion criteria. Respondents were asked to fill out a questionnaire regarding their diet. Results: This study showed that the study respondents were averagely consumed three portions of staple food, two portions of side dishes, one portion of vegetables, and one portion of fruits. Conclusion: Dietary habit of chronic periodontitis patients are mostly not following the Balanced Nutrition Guidelines from the Ministry of Health of the Republic of Indonesia regarding the types of staple foods, side dishes, vegetables, and fruits.

Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of mangosteen (Garcinia mangostana Linn.) rind extract against Aggregatibacter actinomycetemcomitans Hendiani, Ina; Susanto, Agus; Carolina, Dyah Nindita; Ibrahim, Rahmat; Balafif, Felisha Febriane
Padjadjaran Journal of Dentistry Vol 32, No 2 (2020): July 2020
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no2.27366

Introduction: The main contents of mangosteen (Garcinia mangostana Linn.) is xanthone with antibacterial activity. Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) was a gram-negative, facultative anaerobic bacillus that causes periodontal diseases such as localised aggressive periodontitis (LAP). Mangosteen rind extract could inhibit the growth of Porphyromonas gingivalis and A. actinomycetemcomitans. This study was aimed to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of mangosteen rind extract against A. actinomycetemcomitans. Methods: This study was an experimental and in-vitro study of antimicrobial properties of mangosteen (Garcinia mangostana Linn.).The extract of mangosteen was made by the maceration method using 70% ethanol solvent. A. actinomycetemcomitans (ATCC 43718) obtained from Laboratorium of Microbiology Airlangga University Surabaya. This study used a microdilution method and analysed using the Enzyme Linked Immune Sorbent Assay (ELISA). The determination of the MIC was measured using the formula for cell inhibition percentage. Three concentrations higher than the MIC standard were cultured on the Mueller Hinton agar. The lowest concentration on agar which was not found any growth of the bacterial colonies was determined as the MBC. Results: The results of this study indicated that the MIC and MBC of mangosteen rind extract against A. actinomycetemcomitans were 195.3 ppm and 1562.5 ppm, respectively. Conclusion: Mangosteen rind extract can inhibit and bactericide the growth of A. actinomycetemcomitans.

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