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All Journal Celebes Biodiversitas : Jurnal Sains dan Pendidikan Biologi Jurnal Analis Medika Biosains (JAMBS) Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Jurnal Abdi Insani Jurnal Inovasi Pendidikan dan Sains Jurnal Media Analis Kesehatan Jurnal Sains dan Kesehatan Bionature
Mukhtasyam Zuchrullah
Program Studi Farmasi, Fakultas Farmasi Universitas Megarezky, Kota Makassar, Sulawesi Selatan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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MEDIA ALTERNATIF EKSTRAK UBI JALAR SEBAGAI MEDIA TUMBUH JAMUR Aspergillus sp dan Candida sp PADA SERUMEN TELINGA PETANI DI KELURAHAN DORPEDU KOTA TERNATE Mukhtasyam Zuchrullah; Erpi Nurdin; Rahmawati Puni
CELEBES BIODIVERSITAS : Jurnal Sains dan Pendidikan Biologi Vol 6, No 1 (2023): Science Biology, Education, Conservation, Ecology
Publisher : Universitas Patompo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51336/cb.v6i1.390

Abstract

Fungal are plants that require habitat conditions and high humidity. So it is one of the causes of public health problems in Indonesia. Groups at high risk of fungal infection are farmers because one of them is in direct contact with warm and humid areas at work. Otomycosis is a fungal infection that often occurs in the outer ear. Predisposing factors that influence include high humidity, local trauma which is often caused by the habit of using cotton buds, iron hooks and hair strands, long-term use of steroids and a history of dermatomycosis. Otomycosis is one of the common symptoms that are often found in ENT clinics and its prevalence reaches 9% of all patients who show symptoms and signs of otitis externa with Candida Sp and Aspergillus as the fungal species obtained the most from the oscillates. This study aims to determine the presence of fungal growth in the ear serum of farmers in Dorpedu Village. The location of the sampling was conducted in the Dorpedu Village, Ternate City and the location of this research was carried out at the Integrated Laboratory of the Health Polytechnic of the Ministry of Health of Ternate, Department of Medical Laboratory Technology. The method used in this study is to examine the culture and followed by 10% KOH staining. This study used accidental sampling technique with a sample of 20 farmers' ear serumThe results obtained showed that from 20 samples of farmers' ear serum in Dorpedu Village examined, Candida albicans and Aspergillus sp.: Based on the results of the research conducted, it can be seen that from 20 samples of farmer ear serum in Dorpedu Village, it was found that in the sweet potato extract media there were 17 (85%) positive samples of C. albicans, 1 (5%)positive samples of Aspergillus sp. PDA 20 (100%) samples were positive for C. albicans, and 2 (10%) samples were negative on sweet potato extract media where no fungal colonies were found. Sweet potato extract media can be used as an alternative medium for fungal growth.Keywords: Fungal, ear cerumen swab, otomycosis
DETEKSI JAMUR DERMATOFIT DAN NON DERMATOFIT PADA TINEA UNGUIUM MENGGUNAKAN MEDIA ALTERNATIF SUKUN DEKSTROSA AGAR Erpi Nurdin; Mukhtasyam Zuchrullah; Nurul Izza M Achiruddin
JURNAL INOVASI PENDIDIKAN DAN SAINS Vol 4 No 1 (2023): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Nahdlatul Wathan Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51673/jips.v4i1.1451

Abstract

Abstrak: Indonesia merupakan negara dengan cuaca lembab dan panas, menggambarkan daerah ideal untuk perkembangan aneka mikroorganisme antara lain jamur. Jamur merupakan tumbuhan yang memerlukan kondisi habitat dan kelembaban yang tinggi. Sehingga merupakan salah satu penyebab masalah kesehatan masyarakat di Indonesia. Kelompok yang berisiko tinggi terkena infeksi jamur yaitu para petani karena selalu berkontak langsung dengan daerah yang hangat dan lembab saat bekerja. Onikomikosis merupakan penyakit kuku yang paling umum dan menyebabkan hampir 50% dari seluruh kelainan kuku. Onikomikosis hanya digunakan untuk infeksi nondermatofita, sedangkan yang disebabkan jamur dermatofita disebut tinea ungunium. Untuk melihat pertumbuhan jamur pada infeksi kuku dengan menggunakan media alternatif sukun dekstrosa agar. Jenis penelitian ini menggunakan teknik accidental sampling. Identifikasi sampel menggunakan Metode KOH 10% dengan jumlah sampel 20 kuku kaki petani. Hasil yang diperoleh menunjukan bahwa dari 20 sampel kuku pada petani ditemukan jamur non dermatofit sebanyak 9 sampel (45%) Candida albicans, 4 sampel (20%) Aspergillus niger , dan jamur dermatofit 7 sampel (35%) Trichophyton rubrum. Berdasarkan hasil penelitian deteksi jamur dermatofit dan non dermatofit pada tinea unguium menggunakan media alternatif sukun dekstrosa agar ditemukan spesies jamur non dermatofit berupa Candida albicans dan Aspergillus niger , serta jamur dermatofit Trichophyton rubrum. Kata Kunci : Tinea unguium, jamur, media alternatif
Antibiotic Sensitivity Testing of Bacteria Isolated from Patients Suspected of Urinary Tract Infection: Uji Sensitivitas Antibiotik terhadap Bakteri yang Diisolasi dari Pasien Diduga Infeksi Saluran Kemih Erpi Nurdin; Suanbani, Dawika; Mukhtasyam Zuchrullah
Bionature Vol. 25 No. 1 (2024): April-Juni 2024
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v25i1.1883

Abstract

Urinary tract infections (UTIs) is a condition wherein inflammation occurs, caused by the proliferation of microorganisms in the human urinary tract. Antibiotics are the main choice in treating UTIs, the aim of giving antibiotics is to treat acute infections and prevent urosepsis. However, deviant use of antibiotics will reduce the sensitivity of antibiotics to bacteria. The aim of this study was to determine the sensitivity of bacteria to antibiotics from urine specimens of patients with suspected urinary tract infections (UTIs). The examination begins with the determination of the bacterial species and continues with the sensitivity test of the Kirby-Bauer diffusion method, looking at the barrier zone of each antibiotic. The observation results showed that there were 6 types of bacteria found from the urine culture results of patients with suspected urinary tract infections, with the most types of bacteria being gram positive S. aureus in 13 cases (40%), gram negative E. coli in 6 cases (18%), K. oxytoca and E. aerogenes were 5 cases (15%). According to the results of the antibiotic sensitivity test, each one shows the percentage of sensitive antibiotics. Ciprofloxacin is 100% against E. coli, K. oxytoca, P. mirabilis, 60% against E. aerogenes and 46% against S. aureus. Gentamicin is 100% against E. coli, K. oxytoca, P. mirabilis. Ampicillin is 83% against E. coli, 60% against S. epidermidis. Amoxicillin is 66% against E. coli. In conclusion, based on test results, Ciprofloxacin has better sensitivity, followed by gentamicin, ampicillin and amoxicillin. Keywords: antibiotics, sensitivity testing, urinary tract infection
Observation of Candida spp. in the urine of Female Teens : Observation of Candida spp. in the urine of Female Teens Nurdin, Erpi; Mukhtasyam Zuchrullah; Nofita Sari Djurumudi
Bionature Vol. 25 No. 2 (2024): Oktober-Desember 2024
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v25i2.4529

Abstract

Candida albicans is an opportunistic pathogenic fungus that most often causes urinary tract infections. The presence of C. albicans and NCA species in urine is known as candiduria, which can cause urinary tract infections. The presence of C. albicans in urine is caused because the female urethra is shorter than that of men. Research purposes to determine the frequency distribution and presentation of the presence of Candida spp. in the urine of female adolescents at the Hidayatullah Islamic Boarding School in Ternate City. Method this study uses a descriptive research type. This study describes the presence or absence of Candida spp. in the urine of female adolescents at the Hidayatullah Islamic Boarding School in Ternate City. Research results show obtained 40 urine samples of female adolescents examined, it was found that 14 samples (35%) were positive for C. albicans and 26 samples (65%) were negative for C. albicans. Results of this study concluded that 35% of the urine of female adolescents at the Hidayatullah Islamic Boarding School in Ternate City was infected with C. albicans. Keywords: Candida albicans, candiduria, urinary tract infection
Bacterial Resistance Test to Antibiotics Through Throat Swab Specimens of Children with Acute Respiratory Tract Infections (ARIs) Nurdin, Erpi; Zuchrullah, Mukhtasyam; Halik, Sofyanti Abdul
Jurnal Analis Medika Biosains (JAMBS) Vol 12, No 2 (2025): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jambs.v12i2.479

Abstract

Acute Respiratory Infections (ARIs) are contagious diseases that affect the respiratory tract and remain a leading cause of morbidity and mortality, particularly among children. The use of antibiotics without proper sensitivity testing can lead to bacterial resistance; therefore, research is needed to determine the effectiveness of commonly prescribed antibiotics. ARIs is one of the primary causes of morbidity and mortality, especially in children in developing countries. The irrational use of antibiotics or the absence of adequate sensitivity testing is one of the main factors contributing to the rise in bacterial resistance, which may reduce the effectiveness of treatment and increase the public health burden. Objective to determine the sensitivity levels of several types of antibiotics against bacteria that cause ARIs, obtained from throat swab specimens of children with ARIs in several community health centers (Puskesmas) under the Ternate City Health Office. This study is a descriptive research using a laboratory approach, applying the Kirby-Bauer method for antibiotic sensitivity testing against bacteria using Mueller Hinton Agar (MHA) media. Bacterial identification showed a predominance of Staphylococcus epidermidis (45%), followed by Streptococcus pneumoniae (35%), and Streptococcus pyogenes (20%). Sensitivity testing revealed that Streptococcus pneumoniae was most sensitive to gentamicin (100%), while Staphylococcus epidermidis showed high sensitivity to ciprofloxacin (100%). On the other hand, cefixime exhibited the highest level of resistance. Sensitivity testing is crucial before administering antibiotics to prevent resistance and ensure appropriate treatment for children with ARIs.
PEMANFAATAN MEDIA ALTERNATIF DALAM ISOLASI BAKTERI PADA URINE PENDERITA DIABETES MELLITUS DI WILAYAH DAERAH BINAAN KELURAHAN DUFA-DUFA KOTA TERNATE Nurdin, Erpi; Mukhtasyam Zuchrullah; Lewa, Irma B. Hi
Jurnal Abdi Insani Vol 12 No 9 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i9.2811

Abstract

Background: Bacteriological examination, particularly bacterial culture, is a standard method for diagnosing infectious diseases, including in patients with Diabetes Mellitus (DM). However, the limited availability and high cost of semi-synthetic culture media pose significant challenges, especially in regions such as North Maluku, including Ternate City. These constraints have encouraged the exploration of alternative culture media, one of which utilizes tuna-based ingredients. This alternative is expected to be applicable for urine culture tests in DM patients and to enhance the technical competencies of laboratory personnel. Nevertheless, the utilization of tuna as a component of alternative media for microbiological diagnostic purposes remains suboptimal. Methods: The activity was conducted in the form of community outreach in Dufa-Dufa Subdistrict through lectures, presentations, discussions, and evaluations using pre-tests and post-tests. The materials delivered focused on diabetes mellitus and the use of alternative media in microbiological examinations. Results: The results indicated a significant improvement in participants understanding. Initially, 51% of participants had no knowledge of DM and laboratory testing, which decreased to 0% after the educational session. The percentage of participants with moderate understanding declined from 44% to 0%, while those with good understanding increased from 5% to 49%, and those with excellent understanding rose from 0% to 51%. Additionally, the results of urine culture tests on patients with diabetes mellitus using tuna-based media showed that 90% of participants showed bacterial growth and 10% showed no bacterial growth. Conclusion: This initiative demonstrates that locally sourced alternative media hold promise as a feasible solution for laboratory diagnostics. Furthermore, the activity effectively raised community awareness regarding the importance of early detection of potential infections in patients with diabetes mellitus. Keywords: Diabetes mellitus, Urine culture, Alternative media, Laboratory diagnostics
Studi Tuberkulosis Kontak Serumah pada Masyarakat Pesisir di Wilayah Kerja Puskesmas Siko Kota Ternate Erpi Nurdin; Irma B. Hi. Lewa; Mukhtasyam Zuchrullah
Bionature Vol. 23 No. 2 (2022): Oktober 2022
Publisher : Jurusan Biologi Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pulmonary tuberculosis is still the main cause of death in the world, accounting for 2 million people die every year. WHO states that around 1.9 billion people, one third of the world's population, have been infected with tuberculosis germs, every second one person is infected with tuberculosis in the world. Pulmonary tuberculosis is transmitted through droplet spread with the source of infection being patients who are coughing with household contacts as a high risk group for transmission. To find out the results of the examination and see the percentage of positive or negative acid-fast bacilli (AFB) in a sample of clients who have a history of household contact with patients with pulmonary tuberculosis. This study uses a with correlation approach research method with an observational approach. The sampling technique is purposive sampling, namely sampling based on the considerations of the researcher. The examination method used was the Zielh Nelseen method of 30 sputum samples examined. From 30 respondents, 4 respondents were found positive for microscopic acid-fast bacilli (AFB). 2 positive family members, have the characteristics of dense housing (not eligible), humidity and ventilation do not meet the requirements, but the type of floor still meets the requirements. Based on the research that has been carried out, it is concluded that 4 (13%) respondents were identified as positive for scanty with the presence of tuberculosis in 3 places of tuberculosis in household contacts, with factors that influence the occurrence of tuberculosis in household contacts. There is no significant relationship between the results of AFB examination and gender (p value = 0.407> 0.05). There is no significant relationship between the results of AFB examination and age (p value = 0.272> 0.05).
Analisis Leukosit Urine Dipstik dan Kultur Bakteri Pada Pasien Diabetes Mellitus di Kota Ternate Nurdin, Erpi; Zuchrullah, Mukhtasyam; Nasarudin, Sandi
Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Vol 8 No 1 (2024): Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health)
Publisher : Poltekkes Kemenkes Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35910/jbkm.v8i1.735

Abstract

Background: Diabetes mellitus sufferers with poor diabetes control will generally develop urinary tract infections. Methods: This is a descriptive study, namely to obtain a dipstick urine leukocyte picture and bacterial culture in diabetes mellitus patients in Ternate City. Results: The research results showed that there were 21 female respondents (66%) and 11 male respondents (34%), and the frequency of age in the late elderly category was more dominant, namely 13 people (41%). Based on the length of time they have suffered from diabetes mellitus, with >10 years, there are 20 people (63%). The frequency of blood glucose increasing based on Point of Care Testing (POCT) examination was 23 people (72%). The urine culture results of diabetes mellitus patients showed that the average urine bacteria number was 6,3.103 CFU/mL with the interpretation of possible urinary tract infection (UTI), namely 11 people (34%), and 6,0.101 CFU/mL with the interpretation of no UTI, being 21 people (66%). Conclusion: Based on the research results, it was concluded that 3 respondents (9%) had positive leukocyte values despite the possibility of an UTI, and 8 respondents (25%) had negative leukocyte values despite the possibility of an UTI. There were 11 respondents (34%) with increased blood glucose accompanied by the possibility of UTI, and 3 respondents (9%) with increased blood glucose accompanied by positive leukocyte values.
Deteksi Gen Resistensi Karbapenemase Dan Metallo-Β-Lactamase Pada Acinetobacter Baumannii Zuchrullah, Mukhtasyam; Nurdin, Erpi
Jurnal Media Analis Kesehatan Vol 15 No 1 (2024): JURNAL MEDIA ANALIS KESEHATAN
Publisher : Potekkes Kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/jmak.v15i1.631

Abstract

Peningkatan resistensi terhadap antibiotik golongan karbapenem merupakan salah satu fenomena yang harus diwaspadai. Acinetobacter baumannii merupakan salah satu bakteri penyebab infeksi berat yang didapatkan di rumah sakit. Penelitian ini bertujuan untuk mendeteksi gen intrinsik dan gen yang membawa resistensi obat golongan karbapenem terhadap A. baumannii. Penelitian ini dilaksanakan di Laboratorium HUM-RC RSPTN Universitas Hasanuddin Makassar. Desain penelitian ini adalah deskriptif eksperimental laboratorium dengan jumlah sampel 50 isolat yang didapatkan dengan cara total sampling yang dikumpulkan dari RSUP Wahidin Sudirohusodo Makassar. Data yang dianalisis adalah hasil karakteristik isolat, uji sensitivitas dengan menggunakan Vitek-2, uji genotipe gen intrinsik OXA-51 dan blaIMP-1 dengan menggunakan Polymerase Chain Reaction. Hasil penelitian menunjukkan bahwa dari total 50 isolat A. baumannii, ditemukan paling banyak pada sampel sputum sejumlah 30 isolat (60%). Dari total 50 sampel uji sensitivitas antibiotik, isolat A. baumanni paling banyak resisten terhadap meropenem 14 isolat (28%) kemudian imipenem 9 isolat (18%), dan Doripenem 9 isolat (18%). Gen intrinsik OXA-51 ditemukan pada semua isolat sampel sedangkan hanya satu isolat dari A. baumannii yang mampu memproduksi enzim metallo-β-Lactamase (MBL) dan membawa gen blaIMP-1 yaitu pada sampel urine yang seluruhnya resisten terhadap ketiga golongan obat karbapenem. Kata Kunci : Acinetobacter baumannii, Karbapenem, MBL, Polymerase Chain Reaction
Evaluasi dan Hubungan Ketepatan Penggunaan Obat Anti Tuberkulosis Lini 1 terhadap Karakteristik Pasien Rawat Jalan di Rumah Sakit Umum Daerah X: Evaluation and Correlation of the Appropriateness of the Use of First-Line Anti-Tuberculosis Drugs to the Characteristics of Outpatients at X Regional General Hospital Musdar, Tamzil Azizi; Hasmar, Wahyu Nuraini; Azis, Muhammad Israwan; Zuchrullah, Mukhtasyam; Saputro, Syaifullah; Kurniati, Kurniati; Ihsan, Mifta Khaerati; Supardi, Nurjannah; Santi, Elvira; Asjur, Asti Vebriyanti
Jurnal Sains dan Kesehatan Vol. 7 No. 6 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i6.2552

Abstract

Tuberculosis is an infectious disease that attacks the respiratory organs (lungs). This study aims to determine the characteristics of the use of first-line anti-tuberculosis drugs (OAT) and evaluate the use of OAT based on the 2019 Tuberculosis Management Guidelines and analysis of the relationship between patient characteristics and treatment outcomes. Data collection was retrospective, with a sample size of 91 Patient Medical Records. The results showed that the most common patient characteristics were male (57.1%), age 46-55 years (24.2%), weight 38-54 kg (53.8%), with working status (52.7%), without comorbidities (89%), new patient type (92.3%), type of OAT category 1 (100%), unsuccessful treatment results (54.9%). Evaluation of OAT use was 100% correct indication, correct patient, and correct drug. While the correct dose (97.8%), correct duration of treatment (41.8%). The relationship analysis obtained age factors (p = 0.04), duration of treatment (p = 0.001) have a significant relationship to treatment outcomes, while gender (p = 0.301) and the number of P.PK (p = 0.733) both do not have a significant relationship to treatment outcomes. Keywords:          TB, Evaluation of OAT Use, X Hospital   Abstrak Penyakit Tuberculosis merupakan penyakit infeksi menular yang menyerang organ pernafasan (paru-paru). Penelitian ini bertujuan untuk mengetahui karakteristik penggunaan obat anti tuberkulosis (OAT) lini 1 dan mengevaluasi penggunaan OAT berdasarkan Pedoman Tatalaksana Tuberkulosis tahun 2019 serta analisis hubungan antara karakteristik pasien terhadap hasil pengobatan. Pengumpulan data secara retrospektif, jumlah sampel sebanyak 91 Rekam Medik Pasien. Hasil penelitian menunjukkan karakteristik pasien terbanyak yaitu berjenis kelamin laki-laki (57,1%), usia 46-55 tahun (24,2%), berat badan 38-54 kg (53,8%), dengan status bekerja (52,7%), tanpa penyakit penyerta penyerta (89%), tipe pasien baru (92,3%), jenis OAT kategori 1 (100%), hasil pengobatan tidak berhasil (54,9%). Evaluasi penggunaan OAT 100 % tepat indikasi, tepat pasien, dan tepat obat. Sedangkan tepat dosis (97,8%), tepat lama pengobatan (41,8%). Analisis hubungan diperoleh faktor usia (p=0,04), lama pengobatan (p=0,001) memiliki hubungan yang signifikan terhadap hasil pengobatan, sedangkan jenis kelamin (p=0,301) dan banyaknya penyakit penyerta kronis (P.PK) (p=0,733) keduanya tidak memiliki hubungan signifikan terhadap hasil pengobatan. Kata Kunci:         TBC, Evaluasi Penggunaan OAT, RSUD X
Co-Authors Adetya Ardheva Septyana Asjur, Asti Vebriyanti Azis, Muhammad Israwan Erpi Nurdin Erpi Nurdin Erpi Nurdin Erpi Nurdin Fifi B Umagapi Gevanda Adnilla Rizkika Putri Halik, Sofyanti Abdul Hasmar, Wahyu Nuraini Ihsan, Mifta Khaerati Irma B. Hi. Lewa Kurniati Kurniati Lewa, Irma B. Hi Miranda A. Abd Karim Musdar, Tamzil Azizi Nasarudin, Sandi Nofita Sari Djurumudi Nurul Izza M Achiruddin Rahmawati Puni Santi, Elvira Saputro, Syaifullah Suanbani, Dawika Supardi, Nurjannah Windi Alicya Samantha