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All Journal Teknosains: Media Informasi Sains dan Teknologi Celebes Biodiversitas : Jurnal Sains dan Pendidikan Biologi Jurnal Analis Medika Biosains (JAMBS) Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Jurnal Abdi Insani Jurnal Inovasi Pendidikan dan Sains Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Jurnal Media Analis Kesehatan Jurnal Sains dan Kesehatan Bionature
Mukhtasyam Zuchrullah
Program Studi Farmasi, Fakultas Farmasi Universitas Megarezky, Kota Makassar, Sulawesi Selatan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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A REVIEW OF THE USE OF RESTRICTIVE ANTIBIOTICS IN ONE OF THE TEACHING HOSPITALS IN INDONESIA Munawir; Rakhmat Muzakkir; Riska Ropika; Mukhtasyam Zuchrullah
Jurnal Endurance Vol. 10 No. 1 (2025): Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jen.v10i1.3300

Abstract

The irrational use of antibiotics in hospitals can increase bacterial resistance, necessitating monitoring of their usage patterns. This study aims to describe the clinical characteristics of patients and the usage patterns of meropenem and vancomycin antibiotics at Universitas Hasanuddin Hospital. The study employed a retrospective analytical method using secondary data from electronic medical records and antibiotic request forms. The results showed that the majority of meropenem users were adults (61.25%) and the elderly (28.75%), while vancomycin was predominantly used by adult patients. Among meropenem patients, the primary diagnoses were CKD (13.75%) and sepsis (7.5%), whereas vancomycin was mainly prescribed for phlebitis and thrombophlebitis (20%). Therapeutic outcomes indicated that 50% of meropenem patients improved, but 41.25% died, while 60% of vancomycin patients showed improvement. Meropenem was primarily used for empirical therapy (53.75%) for 1–14 days, while vancomycin was mostly used for definitive therapy (80%) with more varied durations, including >14 days (20%). Adverse effects were minimal, with 1 case reported for meropenem (1.25%) and none for vancomycin. This study highlights the importance of rational antibiotic use monitoring to prevent resistance and improve therapeutic effectiveness in hospitals. Keywords: antibiotics, meropenem, vancomycin, bacterial resistance, teaching hospital.
Evaluasi sediaan clay mask stick kombinasi ekstrak bengkuang (Pachyrhizus erosus L.) dan madu (Genus: Apis) sebagai antioksidan Adri, Tenri Ayu; Ramadani, Lisa; Zuchrullah, Mukhtasyam
Teknosains Vol 20 No 2 (2026): Mei-Agustus
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v20i2.60814

Abstract

Clay mask stick yang mengandung ekstrak bengkuang (Pachyrhizus erosus L.) dan madu (Genus Apis) dikembangkan sebagai alternatif perawatan wajah alami yang aman untuk jangka panjang. Kandungan antioksidan dari kedua bahan ini bermanfaat untuk mencerahkan kulit dan melindungi dari radikal bebas. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan sediaan menggunakan metode DPPH yang dianalisis dengan spektrofotometer UV-Vis. Metode yang digunakan adalah eksperimental, dengan variasi konsentrasi ekstrak bengkuang (4%, 5%, 6%) dan madu (2%, 3%, 4%). Parameter yang diuji meliputi aktivitas antioksidan (IC₅₀), serta karakteristik fisik seperti organoleptik, pH, homogenitas, daya lekat, daya sebar, waktu kering, dan potensi iritasi. Hasil menunjukkan bahwa sediaan memiliki bentuk, warna, dan bau yang stabil; homogenitas, daya sebar, dan waktu kering baik; namun pH, daya lekat kurang stabil dan tidak ditemukan iritasi kulit pada uji yang dilakukan. Berdasarkan uji statistik, variasi konsentrasi memberikan pengaruh yang signifikan terhadap aktivitas antioksidan (nilai p<0,05), di mana sediaan tersebut termasuk dalam kategori aktivitas antioksidan sangat kuat.
Studi Tuberkulosis Kontak Serumah pada Masyarakat Pesisir di Wilayah Kerja Puskesmas Siko Kota Ternate Erpi Nurdin; Irma B. Hi. Lewa; Mukhtasyam Zuchrullah
Bionature Vol. 23 No. 2 (2022): Oktober 2022
Publisher : Jurusan Biologi FMIPA Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pulmonary tuberculosis is still the main cause of death in the world, accounting for 2 million people die every year. WHO states that around 1.9 billion people, one third of the world's population, have been infected with tuberculosis germs, every second one person is infected with tuberculosis in the world. Pulmonary tuberculosis is transmitted through droplet spread with the source of infection being patients who are coughing with household contacts as a high risk group for transmission. To find out the results of the examination and see the percentage of positive or negative acid-fast bacilli (AFB) in a sample of clients who have a history of household contact with patients with pulmonary tuberculosis. This study uses a with correlation approach research method with an observational approach. The sampling technique is purposive sampling, namely sampling based on the considerations of the researcher. The examination method used was the Zielh Nelseen method of 30 sputum samples examined. From 30 respondents, 4 respondents were found positive for microscopic acid-fast bacilli (AFB). 2 positive family members, have the characteristics of dense housing (not eligible), humidity and ventilation do not meet the requirements, but the type of floor still meets the requirements. Based on the research that has been carried out, it is concluded that 4 (13%) respondents were identified as positive for scanty with the presence of tuberculosis in 3 places of tuberculosis in household contacts, with factors that influence the occurrence of tuberculosis in household contacts. There is no significant relationship between the results of AFB examination and gender (p value = 0.407> 0.05). There is no significant relationship between the results of AFB examination and age (p value = 0.272> 0.05).
Antibiotic Sensitivity Testing of Bacteria Isolated from Patients Suspected of Urinary Tract Infection: Uji Sensitivitas Antibiotik terhadap Bakteri yang Diisolasi dari Pasien Diduga Infeksi Saluran Kemih Erpi Nurdin; Dawika Suanbani; Mukhtasyam Zuchrullah
Bionature Vol. 25 No. 1 (2024): April-Juni 2024
Publisher : Jurusan Biologi FMIPA Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v25i1.1883

Abstract

Urinary tract infections (UTIs) is a condition wherein inflammation occurs, caused by the proliferation of microorganisms in the human urinary tract. Antibiotics are the main choice in treating UTIs, the aim of giving antibiotics is to treat acute infections and prevent urosepsis. However, deviant use of antibiotics will reduce the sensitivity of antibiotics to bacteria. The aim of this study was to determine the sensitivity of bacteria to antibiotics from urine specimens of patients with suspected urinary tract infections (UTIs). The examination begins with the determination of the bacterial species and continues with the sensitivity test of the Kirby-Bauer diffusion method, looking at the barrier zone of each antibiotic. The observation results showed that there were 6 types of bacteria found from the urine culture results of patients with suspected urinary tract infections, with the most types of bacteria being gram positive S. aureus in 13 cases (40%), gram negative E. coli in 6 cases (18%), K. oxytoca and E. aerogenes were 5 cases (15%). According to the results of the antibiotic sensitivity test, each one shows the percentage of sensitive antibiotics. Ciprofloxacin is 100% against E. coli, K. oxytoca, P. mirabilis, 60% against E. aerogenes and 46% against S. aureus. Gentamicin is 100% against E. coli, K. oxytoca, P. mirabilis. Ampicillin is 83% against E. coli, 60% against S. epidermidis. Amoxicillin is 66% against E. coli. In conclusion, based on test results, Ciprofloxacin has better sensitivity, followed by gentamicin, ampicillin and amoxicillin. Keywords: antibiotics, sensitivity testing, urinary tract infection
Observation of Candida spp. in the urine of Female Teens : Observation of Candida spp. in the urine of Female Teens Erpi Nurdin; Mukhtasyam Zuchrullah; Nofita Sari Djurumudi
Bionature Vol. 25 No. 2 (2024): Oktober-Desember 2024
Publisher : Jurusan Biologi FMIPA Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/bionature.v25i2.4529

Abstract

Candida albicans is an opportunistic pathogenic fungus that most often causes urinary tract infections. The presence of C. albicans and NCA species in urine is known as candiduria, which can cause urinary tract infections. The presence of C. albicans in urine is caused because the female urethra is shorter than that of men. Research purposes to determine the frequency distribution and presentation of the presence of Candida spp. in the urine of female adolescents at the Hidayatullah Islamic Boarding School in Ternate City. Method this study uses a descriptive research type. This study describes the presence or absence of Candida spp. in the urine of female adolescents at the Hidayatullah Islamic Boarding School in Ternate City. Research results show obtained 40 urine samples of female adolescents examined, it was found that 14 samples (35%) were positive for C. albicans and 26 samples (65%) were negative for C. albicans. Results of this study concluded that 35% of the urine of female adolescents at the Hidayatullah Islamic Boarding School in Ternate City was infected with C. albicans. Keywords: Candida albicans, candiduria, urinary tract infection
Co-Authors Adetya Ardheva Septyana Asjur, Asti Vebriyanti Azis, Muhammad Israwan Dawika Suanbani Erpi Nurdin Erpi Nurdin Erpi Nurdin Erpi Nurdin Erpi Nurdin Erpi Nurdin Fifi B Umagapi Gevanda Adnilla Rizkika Putri Halik, Sofyanti Abdul Hasmar, Wahyu Nuraini Ihsan, Mifta Khaerati Irma B. Hi. Lewa Kurniati Kurniati Lewa, Irma B. Hi Miranda A. Abd Karim Munawir Musdar, Tamzil Azizi Nasarudin, Sandi Nofita Sari Djurumudi Nurul Izza M Achiruddin Rahmawati Puni Rakhmat Muzakkir Ramadani, Lisa Riska Ropika Santi, Elvira Saputro, Syaifullah Supardi, Nurjannah Tenri Ayu Adri Windi Alicya Samantha