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All Journal Jambura Journal of Health Sciences and Research JURNAL FARMASIMED (JFM) Jurnal Kepengawasan, Supervisi dan Manajerial (JKSM) Jurnal Indah Sains dan Klinis
Ika Julianti Tambunan
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Other

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Journal : JURNAL FARMASIMED (JFM)

 1 
Formulation and Antioxidant Activity Test Of Body Lotion Preparation of Ethanol Extract of Sky Mustard Leaves (Cyanthillium cinereum (L) H.Rob) As A Moisturizer Ika Julianti Tambunan; Siti Muliani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2441

Abstract

The skin is the first protection to ward off free radicals. Cosmetics used on the skin throughout the body are body lotions. The content of the sky mustard leaves (Cyanthillium cinereum (L) H. Rob) are alkaloid compounds, phenols, saponins, steroids, tannins, and flavonoids that function as antioxidants. This study aims to determine the antioxidant activity of the formulation of body lotion preparations of ethanol extract of sky mustard leaves. This study was conducted using an experimental method. The method of maceration of sky mustard leaves (Cyanthillium cinereum (L) H. Rob) using 96% ethanol. The methods used include selecting a standard formula, making body lotion preparations in concentrations of 1%, 1.5%, 2% and blanks, as well as evaluating the physical quality of the preparations and testing antioxidant activity using the DPPH method. The results showed that the leaves of the sky mustard (Cyanthillium cinereum (L) H. Rob) can be formulated into a body lotion preparation. The preparation obtained was stable and homogeneous, an oil-in-water emulsion type, pH immediately after being made 5.6 - 6.0 and after the cycling test 6.0 - 6.05, with a viscosity value of 2,300-4750 mPa's. The body lotion preparation of the sky mustard leaves with a concentration of 2% was the best preparation with a recovery percentage of 57.53% and an IC50 value of 61.38 ppm, including the "strong" category. The extract of the sky mustard leaves had an IC50 value of 14.75 ppm, which was categorized as "very strong". The blank preparation had an IC50 value of 156.91 ppm, including the "moderate" category.
Antidiarrheal Activity Test of a Combination of Guava Leaf Extract (Psidium guajava  L.) and Kencur Rhizome (Kaempferia galanga) on Male Mice (Mus musculus) Salmah Handayani Lubis; Muharni Saputri; Ika Julianti Tambunan; Adilla Apriliani; Della Aisyah Syah Fitri
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/m2vf9674

Abstract

Background Diarrhea is the leading cause of high morbidity and mortality in children in developing countries such as Indonesia. Diarrhea can be caused by bacterial infections. Guava leaves and kencur have astringent properties that can help reduce the frequency of bowel movements and stop diarrhea. Aim: The study aims to determine the most effective dose concentration of a combination of guava leaf ethanol extract (PGEE) and kencur rhizome ethanol extract (KGEE) as an antidiarrheal medicine. Methods: The study used an experimental method with stages of simplisia preparation, extract preparation by maceration, simplisia characteristics, phytochemical screening, and antidiarrheal efficacy testing using 25 male mice divided into 5 groups, namely F1 = negative control (NaCMC); F2 = positive control (Loperamide); F3, F4, and F5 were combinations (PGEE:KGEE) with 3 different dose concentrations, namely (25%:75%); (50%:50%), and (75%:25%), where the base doses used were (PGEE=400mg/kg/BW) and (KGEE=27.5mg/kgBW). Results: The parameters observed included the onset time of diarrhea, duration, frequency of bowel movements, and stool consistency. Statistical data analysis was performed using ANOVA and Tukey's post hoc test with the help of SPSS software. Statistical analysis with Tukey's post hoc test showed that there was a significant difference (p < 0.05) in fecal weight between the treatment group and the negative control group. Conclusion: The dose concentration (50%:50%) showed the most significant effect in reducing fecal weight comparable to loperamide, so that the combination of PGEE and KGEE at that dose concentration proved to be the most effective in reducing fecal weight and overcoming diarrhea, both visually (graph) and based on statistical analysis results.
Co-Authors Adilla Apriliani Ayuning Putri Julian Bunga Rimta Barus Della Aisyah Syah Fitri Fanny Rizky Sembiring Kanne Dachi Kanne Dachi Mariany Razali Muharni Saputri Nilsya Febrika Zebua, Nilsya Febrika Nurmala Sari Nurul Afwa Yustika Sari Pravil Mistryanto Tambunan Salmah Handayani Lubis Salman Samran, Samran Siti Muliani Siti Muliani Julianty Siti Salmiyah Sudewi Sudewi Sumardi Supran Hidayat Sihotang