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Silma Kaaffah
Universitas Harapan Bangsa
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Journal : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia

 1 
Uji Toksisitas Akut Ekstrak Etanol Daun Manggis (Garcinia Mangostana L.) dengan Melihat Fungsi Hati Tikus Putih Jantan Galur Wistar Agustina, Inayah Dwi; Setianingsih, Siti; Kaaffah, Silma
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8322

Abstract

Mangosteen (Garcinia mangostana L.) is known to contain various bioactive compounds such as xanthones, flavonoids, and tannins which have great potential as herbal medicine, although its safety aspect still requires further research. This study aims to determine the LD₅₀ value and assess the effect of administering ethanol extract of mangosteen leaves on liver function of male white rats of the Wistar strain using SGOT and SGPT enzyme parameters. Acute toxicity tests were conducted based on the Acute Toxic Class (OECD 423) method by administering the extract orally to two dose groups, namely 300 mg/kgBW and 2000 mg/kgBW, as well as a control group using 1% Na-CMC. The test results showed that at a dose of 300 mg/kgBW no mortality was found in the experimental animals (0%), while at a dose of 2000 mg/kgBW mortality was recorded at 60% (2 out of 3 test animals). The LD₅₀ value cannot be determined precisely due to limited dose variation, but it can be estimated to be in the range of 300–2000 mg/kgBW, in accordance with OECD guidelines that allow reporting of LD₅₀ values ​​in interval form if data are incomplete. Furthermore, liver function tests showed an increase in liver enzyme levels in the 2000 mg/kgBW dose group, where SGOT increased from 42.25 U/L to 74.25 U/L, while SGPT increased from 35.25 U/L to 52.25 U/L, although these values ​​are still within the normal physiological range. Thus, mangosteen leaf extract shows potential toxicity at high doses, so its use as a herbal medicine still requires further study.
Pengaruh Intervensi Pill Box dan Medication Chart Terhadap Kepatuhan Dan Luaran Klinis Pasien Diabetes Mellitus Tipe 2 di Puskesmas Susukan Nurul Izha Arisqa; Siti Setianingsih; Silma Kaaffah
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8327

Abstract

Type 2 Diabetes Mellitus (T2DM) is a major non-communicable disease in Indonesia with high morbidity and mortality. Poor adherence to antidiabetic medication is a key factor contributing to inadequate glycemic control. Practical tools such as pill boxes and medication charts have been developed to support patients in following prescribed therapy. This study aimed to evaluate the effectiveness of pill boxes and medication charts in improving medication adherence and clinical outcomes, specifically fasting blood glucose (GDP) and random blood glucose (GDS), among T2DM patients at Susukan Public Health Center. A quasi-experimental pre-test and post-test design with a control group was applied. Ninety respondents were recruited using total sampling and divided equally into pill box, medication chart, and control groups. Medication adherence was assessed using the Medication Adherence Rating Scale-10 (MARS-10), while GDP and GDS levels were measured using a glucometer. Data were analyzed with paired t-tests, Wilcoxon tests, and intergroup comparisons at a 5% significance level. Results showed significant improvement in adherence in both intervention groups compared to the control (p<0.05). In the pill box group, mean GDP decreased from 157.23 ± 53.21 mg/dL to 126.76 ± 14.82 mg/dL (p=0.000), while in the medication chart group it decreased from 162.66 ± 24.89 mg/dL to 145.66 ± 26.54 mg/dL (p=0.006). No significant change was seen in the control group (p=0.741). For GDS, a significant reduction was found only in the pill box group (p=0.005). In conclusion, both pill boxes and medication charts improved adherence among T2DM patients, with pill boxes providing greater benefit for glycemic control. These low-cost, practical strategies are recommended for routine use in primary healthcare to enhance diabetes management.are recommended for integration into primary healthcare services to optimize diabetes management.
Co-Authors Afifah, Zalfa Ifri Nur Agustina, Inayah Dwi Delmayana, Mikna Fauziah Fera Indriyana Galih Samodra Indah Kurniasih, Khamdiyah Khamdiyah Indah Kurniasih Khisan, Gita Fitriatul Lia erfika, Linda Linda Lia erfika Nurraya Lukitasari Nurul Izha Arisqa Prabandari, Rani Riyadi, Hidayat Sugeng Siti Setianingsih Sunarti Sunarti Sunarti Sunarti Yulinda Eka Pratiwi Yulinda Eka Pratiwi