Garuda - Garba Rujukan Digital

Effect of the ethanolic extract of red roselle calyx (Hibiscus sabdariffa L.) on hematocrit, platelets, and erythrocytes in healthy volunteers Setianingsih, Siti; Nurani, Laela Hayu; Rohman, Abdul
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kelopak bunga rosella (Hibiscus sabdariffaÂ L.) memiliki kandungan flavonoid terutama antosianin dan quersetin yang berpotensi sebagai antioksidan, hepatoprotektor, diuretik, antikolesterol serta imunostimulator. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian serta keamanan ekstrak etanol kelopak bunga rosella merah selama 30 hari dan selama 15 hari setelah tidak mengkonsumsi rosella terhadap nilai hematokrit, trombosit dan eritrosit. Penelitian ini menggunakan rancangan pre-post treatment design study. Dua puluh satu sukarelawan sehat digunakan dalam penelitian yang telah memenuhi kriteria inklusi dan eksklusi serta bersedia mengisi informed consent. Sukarelawan diberikan kapsul dengan dosis 500 mg sebanyak 1 kali sehari, 10-15 menit setelah makan pada malam hari selama 30 hari. Pemeriksaan hematologi dilakukan pada hari ke-0; 31; dan 45 yang meliputi parameter hematokrit, trombosit, dan eritrosit menggunakan hematology analyzer. Hasil yang diperoleh dibandingkan secara statistik menggunakan paired t testÂ dan wilcoxonÂ test. Hasil rerata hematokrit, trombosit, dan eritrosit pada sukarelawan laki-laki dan perempuan hari ke-0, hari ke-31 dan hari ke-45 masuk dalam rentang normal. Hasil penelitian menunjukkan tidak terdapat perbedaan bermakna (p>0,05) nilai hematokrit, trombosit dan eritrosit perbandingan hari ke-0 dengan hari ke-31, hari ke-31 dan hari ke-45, serta hari ke-0 dan hari ke-45. Pemberian kapsul ekstrak etanol rosella merah 500 mg selama 30 hari dan setelah 30 hari tidak mengkonsumsi kapsul ekstrak etanol rosella tidak mempengaruhi semua parameter hematologi pada sukarelawan sehat.

Effect of the ethanolic extract of red roselle calyx (Hibiscus sabdariffa L.) on hematocrit, platelets, and erythrocytes in healthy volunteers Siti Setianingsih; Laela Hayu Nurani; Abdul Rohman
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Roselle calyx (Hibiscus sabdariffa L) is widely used as an antioxidant, antihepatotoxic, diuretic, anti-cholesterol, and immunostimulant. Roselle contains anthocyanin and quercetin that have antioxidant activity. This study aimed to determine the effects of the ethanolic extract of roselle calyx on hematocrit, platelets, and erythrocytes in healthy volunteers during the 30-day administration and 15 days after it ceased. This study employed pre- and post-treatment design on 21 healthy volunteers, comprising 11 males and 10 females who fulfilled the inclusion criteria and filled out the informed consent form willingly. Volunteers were provided with roselle capsules for 30 days with a dosage of 500 mg a day taken 10-15 minutes after dinner. The hematologic examination was performed on Day 0, 31, and 45, including the measurement of hematocrit, platelet, and erythrocyte levels using a hematology analyzer. The obtained data were analyzed in SPSS with paired t-test and Wilcoxon test. The results showed that the hematocrit, platelets, and erythrocytes of all male and female volunteers on Day 0, 31, and 45 were within the normal range. The comparison analysis affirmed that there was no significant difference between these three parameters from Day 0 to 31, Day 31 to 45, and Day 0 to 45 (p>0.05). As a conclusion, the administration of the ethanolic extract of roselle calyx with a dosage of one 500mg capsule per day for 30 days did not affect the hematocrit, platelets, and erythrocytes in healthy volunteers. There was also no delayed effect on these three hematological parameters 15 days after the administration stopped.

Impact of mRNA COVID-19 Vaccines on Blood Pressure in Hypertensive Patients: A Retrospective Observational Study Raysyifa, Mugi Rahma; Khamdiyah Indah Kurniasih; Siti Setianingsih
Archives of The Medicine and Case Reports Vol. 5 No. 4 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i4.628

The COVID-19 pandemic necessitated rapid vaccine development, with mRNA vaccines (Moderna or Pfizer) emerging as frontrunners. While effective, concerns arose regarding their impact on blood pressure (BP), particularly in hypertensive individuals, a population already at increased cardiovascular risk. The study aimed to investigate the effects of mRNA COVID-19 vaccines on BP in hypertensive patients. A retrospective observational study was conducted at the Mrebet Community Health Center. Data from hypertensive patients receiving the second dose of either Moderna or Pfizer vaccine were analyzed. Pre- and post-vaccination BP readings, patient demographics, medication profiles, and hypertension severity were assessed. Statistical analysis was performed to evaluate changes in BP and identify potential associations. The study included 33 hypertensive patients (mean age: 55.2 years, 84.8% female). The majority (84.8%) received the Moderna vaccine. Pre- and post-vaccination BP readings showed a slight increase in systolic BP (133 mmHg to 137 mmHg) and a minor decrease in diastolic BP (85 mmHg to 84 mmHg). Statistical analysis revealed a significant association between vaccination and changes in diastolic BP (p < 0.05), but not systolic BP (p > 0.05). In conclusion, mRNA COVID-19 vaccines may have a modest impact on BP in hypertensive patients, particularly on diastolic BP. The clinical significance of these changes warrants further investigation. Close monitoring of BP in hypertensive individuals post-vaccination is recommended.

Analisis Pengaruh Vaksin Covid-19 Terhadap Nilai HbA1c Pasien DM Tipe-2 Di Puskesmas: Studi Retrospektive Setyaningsih, Intan Wiji; Kurniasih, Khamdiyah Indah; Setianingsih, Siti
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5666

Coronavirus Disease 2019 (Covid-19) is a dangerous type of infection that causes death and is at risk in DM patients, so the selection of vaccines is very selective, especially moderna or pfizer vaccines that will know the increase in blood glucose. The purpose of this study was to determine the description and relationship of HbA1c values in type 2 DM patients after the 2nd dose of moderna or pfizer Covid-19 vaccine at Mrebet Health Center. The method used was analytical research with a retrospective observational approach conducted by conducting interviews with DM patients in the form of compliance with drug use, remaining drug use in 1 month, and sugar diet. Measurement of HbA1c values obtained from 3 months before and 3 months after the 2nd dose of moderna or pfizer vaccine. The results of the study obtained 32 DM prolanis patients, where the most patients were aged 45 - 65 years as many as 28 (87.5%), and female gender 27 (84.4%). The type of vaccine obtained was 25 (78.1%) moderna vaccine and 7 (21.9%) pfizer vaccine. The average pre-vaccine and post-vaccine HbA1c values increased by 0.3% from 8.0% to 8.3% and a standard deviation of 0.10. Based on the analysis, the p-value of 0.000 <0.050 was obtained, so statistically there was a slight increase with almost the same value between HbA1c values in type 2 DM patients after the Covid-19 moderna vaccine or the 2nd dose of pfizer. Conclusion There is an increase between pre-vaccine and post-vaccine HbA1c values and there is a relationship between HbA1c values in patients with type 2 DM after the Covid-19 moderna or pfizer 2nd dose vaccine.

Effect of the ethanolic extract of red roselle calyx (Hibiscus sabdariffa L.) on hematocrit, platelets, and erythrocytes in healthy volunteers Setianingsih, Siti; Nurani, Laela Hayu; Rohman, Abdul
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.8738

Roselle calyx (Hibiscus sabdariffa L) is widely used as an antioxidant, antihepatotoxic, diuretic, anti-cholesterol, and immunostimulant. Roselle contains anthocyanin and quercetin that have antioxidant activity. This study aimed to determine the effects of the ethanolic extract of roselle calyx on hematocrit, platelets, and erythrocytes in healthy volunteers during the 30-day administration and 15 days after it ceased. This study employed pre- and post-treatment design on 21 healthy volunteers, comprising 11 males and 10 females who fulfilled the inclusion criteria and filled out the informed consent form willingly. Volunteers were provided with roselle capsules for 30 days with a dosage of 500 mg a day taken 10-15 minutes after dinner. The hematologic examination was performed on Day 0, 31, and 45, including the measurement of hematocrit, platelet, and erythrocyte levels using a hematology analyzer. The obtained data were analyzed in SPSS with paired t-test and Wilcoxon test. The results showed that the hematocrit, platelets, and erythrocytes of all male and female volunteers on Day 0, 31, and 45 were within the normal range. The comparison analysis affirmed that there was no significant difference between these three parameters from Day 0 to 31, Day 31 to 45, and Day 0 to 45 (p>0.05). As a conclusion, the administration of the ethanolic extract of roselle calyx with a dosage of one 500mg capsule per day for 30 days did not affect the hematocrit, platelets, and erythrocytes in healthy volunteers. There was also no delayed effect on these three hematological parameters 15 days after the administration stopped.

Pelatihan Pemanfaatan Limbah Minyak Jelantah Menjadi Lilin Aromaterapi Di Desa Windujaya Kurniasih, Khamdiyah Indah; Samodra, Galih; Setianingsih, Siti; Nurkholis, Fiqih; Hakim, Lukman
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 4, No 1 (2025)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v4i1.31247

Minyak jelantah adalah minyak yang telah digunakan secara berulang-ulang hingga 3-4 kali penggorengan. Dampak negative dari minyak goreng bekas jika dibuang begitu sajatanpapengolahanakanmenjadilimbahdanakanmerusaklingkungansekitar.Salahsatubentuk produk hasil pengolahan minyak goreng bekas adalah lilin aromaterapi. Sasaranmitra pengabdian ini adalah masyarakat ekonomi non produktif di desaWindujaya yang bekerja bekerja sebagai Ibu Rumah Tangga dan tidak memiliki penghasilan. UrgensiPemberdayaan Masyarakat Pemula ini meningkatkan keterampilan Kelompok Kader DesaWindujaya dalam Pelatihan Pembuatan lilin aromaterapi yang berbahan dasar limbah minyak jelantah. Tujuan kegiatan ini yaitu, meminimalisasipembuangan minyak jelantah, berubahnya pola hidup masyarakat untuk mengolah limbahminyak jelantah berbasis zero waste industry, berkurangnya pembuangan minyak jelantahdisembarang tempat dapat mengurangi resiko pencemaran air tanah, dan erciptanya produklilinaromaterapidansabunbernilaiekonomis. Kegiatan ini telah terlaksana pada tanggal 18 agustus 2024 dengan peserta ibu rumah tangga yang ada di Desa Winduajaya, Banyumas. Metode Kegiatan ini menggunakan metode difusi ilmu pengetahuan dan teknologi (ipteks) dengan tahapan berupa tahapan persiapan dan koordinasi terkait dengan pengetahuan Masyarakat terhadap lombah minyak jelantah ,Pemberdayaan Masyarakat, monitoring dan evaluasi serta sasaran pelatihan. Hasil pengabdian didapat bahwa terdapat peningkatan pengetahuan terkait pemanfaatan limbah minyak jelantah dalam bentuk lilin aromaterapi.

Uji Keamanan Ekstrak Etanol Daun Manggis (Garcinia Mangostana L.) Terhadap Tikus Jantan Galur Wistar Dengan Pendekatan Efek Toksisitas Akut: Up and Down Procedure Delmayana, Mikna; Kaaffah, Silma; Setianingsih, Siti
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 7 (2025): Agustus 2025
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.17043371

The use of mangosteen leaves (Garcinia mangostana L.) as traditional medicine is becoming increasingly widespread due to their content of bioactive compounds such as xanthones, flavonoids, and tannins, which are known to have various pharmacological potentials. However, information regarding their safety aspects is still limited, necessitating further research. This study aims to determine the LD50 dose of mangosteen leaf ethanol extract that causes acute toxicity in male wistar rats using the Up and Down Procedure method based on OECD Guideline 425. The study was conducted at the limit test stage using five test animals with a single dose of 2000 mg/kgBW the extract was administered orally to one rat and observed for 24 hours. The results showed that two of the five rats died, but the mortality rate was still below 50%, so the study did not proceed to the main test stage. Based on OECD guideline 425, the LD?? value is estimated to be greater than 2000 mg/kgBW and is classified as mildly toxic according to the GHS (Globally Harmonized System) classification. The conclusion of this study is that the ethanol extract of mangosteen leaves at a dose of 2000 mg/kgBW exhibits low toxicity and has the potential to be safe as a candidate herbal medicine ingredient.

EVALUASI PENGGUNAAN ANTIHIPERTENSI DI PUSKESMAS BULUSPESANTREN II KEBUMEN MENGGUNAKAN METODE ATC/DDD Afifah, Zalfa Ifri Nur; Setianingsih, Siti; Kaaffah, Silma
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 3 (2025): DESEMBER 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i3.50055

Introduction: Hypertension is one of the major health problems and remains the leading cause of cardiovascular morbidity and mortality worldwide. Although many management strategies have been implemented, including the administration of antihypertensive drugs according to indication, most patients still fail to achieve target blood pressure control. This situation highlights the need for evaluating the rational use of antihypertensive drugs in primary healthcare facilities.Objective: This study aimed to evaluate the use of antihypertensive drugs at Buluspesantren II Public Health Center, Kebumen, in 2023 using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) method. Methods: This descriptive study used a retrospective design with data obtained from medical records of patients receiving antihypertensive drugs during January–December 2023. Sampling was conducted using total sampling of all outpatient medical records. Drugs were classified based on the ATC code, and the quantity of drug use was calculated in DDD units and DDD/1000 outpatients per month. Results: The findings showed that the highest use of antihypertensive drugs was amlodipine, amounting to 7768 DDD/1000 outpatients per year, with monthly distribution around 647 DDD/1000 outpatients. Other drugs used included captopril (63 DDD/1000 outpatients), furosemide (20 DDD/1000 outpatients), nifedipine (6 DDD/1000 outpatients), and hydrochlorothiazide (3 DDD/1000 outpatients). Conclusion: Amlodipine was the most widely used antihypertensive drug at Buluspesantren II Public Health Center. Evaluation using the ATC/DDD method provides a quantitative overview of drug utilization, which can serve as a basis for decision-making in achieving more effective and rational antihypertensive therapy management.

FORMULASI SEDIAAN HANDWASH EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) Amanda, Yusi Lusiana; Nawangsari, Desy; Setianingsih, Siti
Jurnal Keperawatan dan Kesehatan Vol 16 No 2 (2025): Jurnal Keperawatan dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Keperawatan Muhammadiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54630/jk2.v16i2.454

Hands are a medium that can spread bacteria, this spread can be prevented by washing hands. Synthetic antibacterial ingredients such as triclosan in soap can damage the skin's normal flora. Starfruit leaves (Averrhoa bilimbi L.) are known to contain flavonoids, tannins, saponins and alkaloids. The aim of this research is to determine the physical properties and stability of handwash from the ethanol extract of starfruit leaves (Averrhoa bilimbi L.). This research uses experimental methods in making handwash with variations in the concentration of starfruit extract ethanol FI (10%), FII (12.5%) , and FIII (15%), the dosage for which physical properties were evaluated included organoleptic, homogeneity, pH, viscosity and foam height and stability tests were carried out using the cycling test method. Research shows that handwash preparations of ethanol extract of starfruit leaves have criteria according to soap standards set by SNI. The handwash preparation is homogeneous and the addition of the extract causes the preparation to be light brown in color, pH 8.2-9.7; viscosity 1,928-10,094 cPs; and foam height 1.53-1.93 cm. Has stable handwash preparation properties seen from the sig value. 2 tails > 0.05. Thus, the ethanol extract handwash from starfruit leaves has physical properties that comply with SNI including organoleptic, homogeneity, pH, viscosity and high foam and has stable properties.

Pengetahuan, Kesadaran, dan Praktik Orang Tua tentang Resistensi Antibiotik Pada Anak di Sampang, Kabupaten Cilacap Wijayanti, Pepi Nur; Kaafah, Silma; Setianingsih, Siti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i2.18235

Inappropriate use of antibiotics in children contributes to antibiotic resistance. Parents in Cilacap have limited knowledge and awareness of it. This study aimed to describe the knowledge, awareness, and practices of parents regarding antibiotic resistance in 0-11 years old children in Cilacap, as well as to explore the relationship of those aspects and the respondents’ characteristics. The research used a descriptive cross-sectional approach in Sampang District, Cilacap Regency, conducted in May 2024 with 96 respondents selected through cluster random sampling with inclusion criteria. The respondents were parents of 0-11 years old children, with or without antibiotic treatment history, and willing to participate by completing questionnaires. Results showed that 63.5% respondents had high knowledge, 66.7% respondents had high awareness, and 65.6% respondents had good practices. The results indicated that age and education significantly influenced knowledge, awareness, and practices, with p-values <0.05. Meanwhile, gender and occupation showed no significant effect, as evidenced by p-values >0.05. The findings indicate that parents in Sampang District generally demonstrate high knowledge and awareness, as well as good practices concerning antibiotic resistance in children. However, certain demographic factors, particularly age and education, remain influential in shaping these outcomes.

Title

Found 14 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 14 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 14 Documents
Search