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All Journal Journal of Maternal and Child Health Maghza: Jurnal Ilmu al-Qur'an and Tafsir
Fitriawan, Ahmad
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Religion Medicine & Pharmacology Public Health Social Sciences

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Expression of Bax Protein as A Prognosis Factor of Radiotherapy Response to Decreased Tumor Size in Stage IIB-IIIB Cervical Cancer Fitriawan, Ahmad; Udiyanto, Hermawan; Respati, Supriyadi Hari; Ratnasari, Affi Angelia; Prabowo, Wisnu
Journal of Maternal and Child Health Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.074 KB) | DOI: 10.26911/thejmch.2022.07.03.07

Abstract

Background: Cervical cancer plays a role as the leading cause of cancer death for women in developing countries. Radiation therapy kills cancer cells through double strand breaks and the apoptotic process. Bax protein is one of the regulators of apoptosis. This study analyzed the role of Bax expression as a prognostic factor in radiation therapy response in reducing tumor size in patients with advanced cervical cancer (IIB-IIIB). Subjects and Method: This research is a retrospective cohort observational analytic study from January 2021 to April 2021 in the Department of Obstetrics and Gynecology in collaboration with the Department of Anatomical Pathology, Dr. Moewardi Hospital, Surakarta, Indonesia. This study involved 30 cervical cancer stage IIB-IIIB patients. The level of Bax expression was determined by immunohistochemical examination. ROC curve analysis was used to find cut-off points and evaluate the sensitivity and specificity of Bax in the prognosis of radiotherapy in patients with advanced cervical cancer (IIB-IIIB). Chi square test was used to determine the relationship between Bax expression and changes in tumor size in cervical cancer patients. Results: The ROC curve analysis showed that the AUC Bax score in prognosis of radiation therapy was 0.575 (CI 95%= 0.32 to 0.83) and the cutoff point was 62.5%. Based on the analysis of the ROC curve, the Bax expression of 62.5% shows a sensitivity of 56.5% and a specificity of 71.4%. Analysis of the relationship between Bax protein expression on changes in tumor size using the Chi Square test showed a P value of 0.390 (p> 0.05). Conclusion: The expression of Bax protein cannot play a role as a prognostic factor in the response of radiation therapy to the reduction in tumor size in stage IIB-IIIB uterine cervical cancer.
Problematika Penafsiran Ayat-ayat Jihad di Era Modern (Analisis Penafsiran Ayat-ayat Jihad dalam Perspektif Tafsir Nusantara) Fitriawan, Ahmad; Zen, Abdul Muhaimin
MAGHZA Vol 8 No 2 (2023): Juli-Desember 2023
Publisher : Fakultas Ushuluddin Adab dan Humaniora (FUAH), Universitas Islam Negeri Profesor Kiai Haji Saifuddin Zuhri Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24090/maghza.v8i2.7726

Abstract

Penerapan konsep jihad perang di negeri-negeri yang hidup damai tidaklah relevan dengan konsep jihad dalam Islam. Dalam kondisi normal seperti di negara Indonesia, jihad lebih ditekankan dalam bentuk dakwah untuk menjaga serta memperbaiki mentalitas dan moralitas warga negara khususnya umat Islam. Namun demikian bukan berarti kemudian wawasan tentang jihad perang ditinggalkan secara total, karena bagaimanapun ia adalah bagian dari syariat yang memiliki kedudukan yang tinggi dan harus dipahami dengan benar. Penelitian ini dilakukan untuk mengangkat penafsiran-penafsiran problematis terhadap ayat-ayat jihad dalam beberapa karya tafsir Nusantara. Dengan pendekatan sosio-historis dan fenomenologi, penulis mengelaborasi pemahaman beberapa mufassir Nusantara dan menemukan bahwa terdapat beberapa problem dalam penafsiran ayat-ayat jihad baik yang terkesan mendukung paham jihadis radikalis maupun melemahkan kedudukan jihad itu sendiri.
Co-Authors Hermawan Udiyanto Ratnasari, Affi Angelia Supriyadi Hari Respati WISNU PRABOWO Zen, Abdul Muhaimin