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All Journal Indonesian Journal of Cancer Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Maternal and Child Health Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas Indonesian Journal of Cancer Plexus Medical Journal

Hermawan Udiyanto

Faculty Of Medicine, Universitas Sebelas Maret / Department Of Obstetrics And Gynecology, Dr. Moewardi Hospital, Ir. Sutami 36 A, Kentingan Surakarta 57126 Telp. (0271) 662622

Author-ID : 407274

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Ekspresi Heat Shock Protein 70 (HSP70) dan Caspase-3 sebagai Prediktor terhadap Operabilitas Kanker Serviks Stadium IIB setelah Mendapat Kemoterapi Neoajuvant Paclitaxel-Carboplatin Udiyanto, Hermawan; Askandar, Brahmana; Fauziah, Dyah
Indonesian Journal of Cancer Vol 7, No 3 (2013): Jul - Sep 2013
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1074.677 KB)

Penelitian ini bertujuan untuk mengetahui peran ekspresi HSP70 dan Caspase-3 terhadap keberhasilan operabilitas kanker serviks stadium IIB setelah pemberian kemoterapi neoajuvant Paclitaxel-Carboplatin 3 seri. Metode: ekspresi HSP70 dan caspase-3 diperiksa dengan pengecatan imunohistokimia pada 40 potongan biopsi jaringan pasien kanker serviks IIB yang memenuhi kriteria inklusi, yang melakukan pengobatan di RSUD dr. Soetomo, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Airlangga, Surabaya, mulai Desember 2006 hingga Juli 2011. Kriteria inklusi meliputi penderita yang telah dilakukan evaluasi keberhasilan terapi (operabilitas) pasca-kemoterapi neoajuvant Paclitaxel-Carboplatin sebanyak 3 seri berturut-turut, dengan interval pemberian 3 minggu. Evaluasi keberhasilan terapi (operabilitas) tidak mengikuti kriteria respons terapi berdasarkan RECIST (Response Evaluation Criteria in Solid Tumours). Waktu pemeriksaan 3 â 4 minggu setelah pemberian kemoterapi yang terakhir. Operabilitas tumor, yaitu kondisi klinis kanker serviks di mana pada pemeriksaan dalam vagina (vaginal toucher/VT) dan pemeriksaan dalam rektum oleh tim ginekologi onkologi setelah penderita mendapatkan kemoterapi neoajuvant Paclitaxel-Carboplatin 3 seri dinyatakan bahwa pada parametrium secara klinis tidak didapatkan infiltrasi tumor. Jenis dan bentuk penelitian ini merupakan penelitian analitik observasional, studi case control pada penderita kanker serviks IIB yang mendapat kemoterapi neoajuvant Paclitaxel-Carboplatin sebanyak 3 kali dengan interval pemberian kemoterapi 3 minggu.Hubungan antara ekspresi HSP70 dan caspase-3 dengan operabilitas post-kemoterapi neoajuvant Paclitaxel-Carboplatin dianalisis dengan regresi logistik. Ekspresi HSP70 negatif dan HSP70 positif mempunyai jumlah total yang sama, yaitu 20 orang (50%), masing-masing 9 orang pada kelompok operabel dan 11 orang pada kelompok inoperabel. Tidak ada perbedaan yang bermakna hubungan antara HSP70 dengan operabilitas ( p = 1 ), dengan OR = 1,00 ( 95%CI : 0,28-3,47 ). Ekspresi caspase-3 positif sebanyak 24 orang (60,0%), masing-masing 13 orang pada kelompok operabel dan 11 orang pada kelompok inoperabel. Pada ekspresi Caspase-3 negatif, sebanyak 16 orang (40,0%), masing-masing 5 orang pada kelompok operabel dan 11 orang pada kelompok inoperabel. Tidak ada perbedaan yang bermakna hubungan antara ekspresi caspase-3 dengan operabilitas ( p = 0,154 ), dengan OR = 0,06 ( 95%CI : 0,69-9,81). Kombinasi antara ekspresi HSP70 (+) dan ekspresi caspase-3 (-), sebanyak 8 orang (20%), masing-masing 2 orang pada kelompok operabel dan 6 orang pada kelompok inoperabel. Sedangkan pada kelompok selain kombinasi antara ekspresi HSP70 (+) dan ekspresi caspase-3 (-) sebanyak 32 orang (80%), masing-masing 16 orang pada kelompok inoperabel dan 16 orang pada kelompok operabel. Tidak ada perbedaan yang bermakna hubungan antara kombinasi ekspresi HSP70 (+) dan ekspresi caspase-3 (-) dengan operabilitas ( p = 0,217 ), dengan OR = 3,0 ( 95 % CI : 0,525-17,159).Kesimpulan: ekspresi HSP70 dan caspase-3 tidak dapat dijadikan sebagai prediktor operabilitas pada kanker serviks stadium IIB yang mendapatkan neoajuvant kemoterapi Paclitaxel-Carboplatin.Kata kunci: Kanker serviks stadium IIB, kemoterapi neoajuvant Paclitaxel-Carboplatin, operabilitas pascakemoterapi neoajuvant.

Improved Understanding of IUD and Implant Family Planning Acceptors in Family Planning Services at Solo Peduli Clinic Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Darto, Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Prisasanti, Dympna Prameilita
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.944 KB)

Background: Family planning acceptor's understanding of intra uterine device (IUD) and implant contracep

Ekspresi Heat Shock Protein 70 (HSP70) dan Caspase-3 sebagai Prediktor terhadap Operabilitas Kanker Serviks Stadium IIB setelah Mendapat Kemoterapi Neoajuvant Paclitaxel-Carboplatin Hermawan Udiyanto; Brahmana Askandar; Dyah Fauziah
Indonesian Journal of Cancer Vol 7, No 3 (2013): Jul - Sep 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Penelitian ini bertujuan untuk mengetahui peran ekspresi HSP70 dan Caspase-3 terhadap keberhasilan operabilitas kanker serviks stadium IIB setelah pemberian kemoterapi neoajuvant Paclitaxel-Carboplatin 3 seri. Metode: ekspresi HSP70 dan caspase-3 diperiksa dengan pengecatan imunohistokimia pada 40 potongan biopsi jaringan pasien kanker serviks IIB yang memenuhi kriteria inklusi, yang melakukan pengobatan di RSUD dr. Soetomo, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Airlangga, Surabaya, mulai Desember 2006 hingga Juli 2011. Kriteria inklusi meliputi penderita yang telah dilakukan evaluasi keberhasilan terapi (operabilitas) pasca-kemoterapi neoajuvant Paclitaxel-Carboplatin sebanyak 3 seri berturut-turut, dengan interval pemberian 3 minggu. Evaluasi keberhasilan terapi (operabilitas) tidak mengikuti kriteria respons terapi berdasarkan RECIST (Response Evaluation Criteria in Solid Tumours). Waktu pemeriksaan 3 4 minggu setelah pemberian kemoterapi yang terakhir. Operabilitas tumor, yaitu kondisi klinis kanker serviks di mana pada pemeriksaan dalam vagina (vaginal toucher/VT) dan pemeriksaan dalam rektum oleh tim ginekologi onkologi setelah penderita mendapatkan kemoterapi neoajuvant Paclitaxel-Carboplatin 3 seri dinyatakan bahwa pada parametrium secara klinis tidak didapatkan infiltrasi tumor. Jenis dan bentuk penelitian ini merupakan penelitian analitik observasional, studi case control pada penderita kanker serviks IIB yang mendapat kemoterapi neoajuvant Paclitaxel-Carboplatin sebanyak 3 kali dengan interval pemberian kemoterapi 3 minggu.Hubungan antara ekspresi HSP70 dan caspase-3 dengan operabilitas post-kemoterapi neoajuvant Paclitaxel-Carboplatin dianalisis dengan regresi logistik. Ekspresi HSP70 negatif dan HSP70 positif mempunyai jumlah total yang sama, yaitu 20 orang (50%), masing-masing 9 orang pada kelompok operabel dan 11 orang pada kelompok inoperabel. Tidak ada perbedaan yang bermakna hubungan antara HSP70 dengan operabilitas ( p = 1 ), dengan OR = 1,00 ( 95%CI : 0,28-3,47 ). Ekspresi caspase-3 positif sebanyak 24 orang (60,0%), masing-masing 13 orang pada kelompok operabel dan 11 orang pada kelompok inoperabel. Pada ekspresi Caspase-3 negatif, sebanyak 16 orang (40,0%), masing-masing 5 orang pada kelompok operabel dan 11 orang pada kelompok inoperabel. Tidak ada perbedaan yang bermakna hubungan antara ekspresi caspase-3 dengan operabilitas ( p = 0,154 ), dengan OR = 0,06 ( 95%CI : 0,69-9,81). Kombinasi antara ekspresi HSP70 (+) dan ekspresi caspase-3 (-), sebanyak 8 orang (20%), masing-masing 2 orang pada kelompok operabel dan 6 orang pada kelompok inoperabel. Sedangkan pada kelompok selain kombinasi antara ekspresi HSP70 (+) dan ekspresi caspase-3 (-) sebanyak 32 orang (80%), masing-masing 16 orang pada kelompok inoperabel dan 16 orang pada kelompok operabel. Tidak ada perbedaan yang bermakna hubungan antara kombinasi ekspresi HSP70 (+) dan ekspresi caspase-3 (-) dengan operabilitas ( p = 0,217 ), dengan OR = 3,0 ( 95 % CI : 0,525-17,159).Kesimpulan: ekspresi HSP70 dan caspase-3 tidak dapat dijadikan sebagai prediktor operabilitas pada kanker serviks stadium IIB yang mendapatkan neoajuvant kemoterapi Paclitaxel-Carboplatin.Kata kunci: Kanker serviks stadium IIB, kemoterapi neoajuvant Paclitaxel-Carboplatin, operabilitas pascakemoterapi neoajuvant.

Biopsychosocial Analysis of Factors on COVID-19 Screening Awareness of Infertile Couples in Assisted Reproductive Technology Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru Priyanto; Darto, Darto; Rantasari, Affi Angelia; Wasyanto, Trisulo; Anggraeni, Asih; Wijayanti, Agung Sari
Journal of Maternal and Child Health Vol. 6 No. 5 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: The development of screening methods for infertility patients during the Coronavirus-2019 (COVID-19) pandemic provides new challenges in the adaptation of children's want programs in the era of the COVID-19pandemic. Several screening methods have been developed but various factors affect the awareness of couples to want to do COVID-19 screening. This study aimed to analyze biopsychosocial factors associated with awareness of COVID-19 screening in infertile couples. Subjects and Method: A cross-sectional study conducted at The Sekar Polyclinic of Dr. Moewardi Regional General Hospital during the COVID-19 pandemic. A number of 60 infertile couple of reproductive age who underwent the ART program was selected by random sampling. The dependent variable was awareness for COVID-19 screening. The independent variables were anxiety, knowledge, age, and length of infertility. The data were obtained from medical record and questionnaire and analyzed by a multiple logistic regression. Results: Anxiety (OR= 26; 95% CI; p<0.001) and above-average knowledge levels (OR=16; 95% CI; p<0.001) affected awareness for COVID-19 screening. While the age and length of infertility do not affect awareness for COVID-19 screening (p >0.05). Conclusion: Anxiety and above-average knowledge levels affect awareness for COVID-19 screening.

Expression of Bax Protein as A Prognosis Factor of Radiotherapy Response to Decreased Tumor Size in Stage IIB-IIIB Cervical Cancer Fitriawan, Ahmad; Udiyanto, Hermawan; Respati, Supriyadi Hari; Ratnasari, Affi Angelia; Prabowo, Wisnu
Journal of Maternal and Child Health Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: Cervical cancer plays a role as the leading cause of cancer death for women in developing countries. Radiation therapy kills cancer cells through double strand breaks and the apoptotic process. Bax protein is one of the regulators of apoptosis. This study analyzed the role of Bax expression as a prognostic factor in radiation therapy response in reducing tumor size in patients with advanced cervical cancer (IIB-IIIB). Subjects and Method: This research is a retrospective cohort observational analytic study from January 2021 to April 2021 in the Department of Obstetrics and Gynecology in collaboration with the Department of Anatomical Pathology, Dr. Moewardi Hospital, Surakarta, Indonesia. This study involved 30 cervical cancer stage IIB-IIIB patients. The level of Bax expression was determined by immunohistochemical examination. ROC curve analysis was used to find cut-off points and evaluate the sensitivity and specificity of Bax in the prognosis of radiotherapy in patients with advanced cervical cancer (IIB-IIIB). Chi square test was used to determine the relationship between Bax expression and changes in tumor size in cervical cancer patients. Results: The ROC curve analysis showed that the AUC Bax score in prognosis of radiation therapy was 0.575 (CI 95%= 0.32 to 0.83) and the cutoff point was 62.5%. Based on the analysis of the ROC curve, the Bax expression of 62.5% shows a sensitivity of 56.5% and a specificity of 71.4%. Analysis of the relationship between Bax protein expression on changes in tumor size using the Chi Square test showed a P value of 0.390 (p> 0.05). Conclusion: The expression of Bax protein cannot play a role as a prognostic factor in the response of radiation therapy to the reduction in tumor size in stage IIB-IIIB uterine cervical cancer.

Edukasi Skrining COVID-19 pada Program Teknologi Reproduksi Berbantu di Era Pandemi COVID-19 Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Darto, Darto; Ratnasari, Affi Angelia; Anggraeni, Asih
Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Vol 5, No 2 (2023): Juli-Desember
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/baktiku.v5i2.7064

In the era of the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 screening education is essential for the general public, especially for those who undergo assisted reproductive technology (ART) programs. Understanding the preventive measures and precautions of COVID-19 during the treatment process is necessary. Health care staff must also understand the importance of proper COVID-19 screening and control measures. This educational activity is in the form of a YouTube live streaming program that can be followed by the general public, including infertile couples who want to know about infertility, examination procedures, COVID-19 screening guidelines, and the TRB program. Education about COVID-19 screening can minimize stigma and enhance public confidence in the screening procedures. The results of this educational delivery make the general public, especially couples who will undergo the ART program, ready and have the ability to undergo COVID-19 testing, services, and screening. In addition, by providing education and implementing effective screening, we can work together to combat the COVID-19 pandemic and ensure that people receive quality and safe health services.

Kolaborasi Tenaga Medis dan Masyarakat dalam Mendukung Layanan Infertilitas Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Wijayanti, Agung Sari
Jurnal Abdidas Vol. 5 No. 6 (2024): Desember
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdidas.v5i6.1066

Kolaborasi antara tenaga medis dan masyarakat memiliki peran penting dalam mendukung penanganan infertilitas, sebuah kondisi yang sering menyebabkan kecemasan, stres, dan dampak negatif lainnya pada kesehatan mental. Tenaga medis berperan dalam diagnosis, perencanaan pengobatan, dan mendukung pasien mencapai tujuan mereka untuk memiliki anak, sementara masyarakat dapat memberikan dukungan emosional yang membantu mengurangi isolasi dan depresi pasien. Kegiatan pengabdian ini berfokus pada edukasi dan pemberdayaan tenaga medis serta masyarakat untuk meningkatkan pemahaman dan kapasitas mereka dalam mendukung individu dengan infertilitas. Evaluasi menggunakan pre-test dan post-test menunjukkan bahwa 25% peserta mengalami peningkatan pengetahuan setelah kegiatan, sementara 72% telah memiliki pemahaman yang memadai sebelumnya. Hasil ini menggambarkan efektivitas program dalam meningkatkan pemahaman terkait infertilitas. Selain itu, kegiatan ini berhasil menyebarkan informasi akurat dan memerangi mitos yang beredar di komunitas, sehingga meningkatkan kesadaran dan mengurangi stigma terhadap individu dengan infertilitas. Kesimpulannya, program ini efektif dalam meningkatkan dukungan sosial dan kapasitas tenaga medis untuk memberikan perawatan holistik yang lebih baik bagi pasien infertilitas, serta berkontribusi pada pengurangan dampak psikologis dan sosial yang dialami pasien.

Unraveling Of Urinary Disorders to Adenomyosis and Dysmenorrhea darto, darto; Anggraeni, Asih; Ngudi Insan Ksyatria, Yudhistira; Alifa, Rosita; Farras Wahdan, Arib; Retno Budihastuti, Uki; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Angelia Ratnasari, Affi
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2203

Objective : This study aims to explore the relationship between micturition disorders and adenomyosis and dysmenorrhea and provide insight into the factors associated with the severity of LUTS symptoms in these conditions. Methods : This study was a descriptive qualitative study. We retrospectively collected medical record data from the Obstetrics Gynecology Outpatient Ward of Dr. Moewardi Surakarta General Hospital in the period January 2021 to May 2023. The results of this study analyzed using Pearson correlation analysis if normally distributed and using Mann-Whitney if not normally distributed, thus, statistically analyzed. Results: There is a significant relationship between adenomyosis and dysmenorrhea on urinary disorders (p value of 0.016) where urinary disorders are found to be more severe in adenomyosis patients with dysmenorrhea. Conclusion : Lower urinary tract symptoms are common in symptomatic adenomyosis patients and greatly affect the patient's quality of life. Dysmenorrhea can be a potential risk factor that increases the occurrence of moderate to severe LUTS. Keywords: adenomyosis; dysmenorrhea; urinary disturbance.

Education on Assisted Reproductive Technology Program with Low Cost Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Wijayanti, Agung Sari
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 1 (2023): February
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i1.64796

Background: Assisted reproductive technology (ART) programs have proven to be a solution to help infertility couples to conceive. However, most couples face a financial crisis related to the relatively expensive cost of ART treatment. This service aims to educate about ART's meaning, direction, and procedures. Thus, couples want children to be able to understand the ART program at an affordable cost (low-cost) and undergo the ART program without any concerns about costs.Method: Seminar participants be given socialization in person and online through zoom software by the service provider. It is in two stages, in-person and online, so participants who cannot attend in person can follow this service program. In addition, participants are given a pre-test and post-test questions to assess their understanding of the ART program at an affordable cost.Result: The pre-test and post-test results were analyzed using Wilcoxon, which showed that after providing education about the ART program, the post-test results were significantly better than the pre-test results. Down value: 5.5%, fixed value: 15.2%, value rise: 79.3% with significance p<0.001.Conclusion: There are significant differences in the pre-test and post-test scores, which means that the participants understood the explanation the servicer gave.

Efforts to Increase Understanding of COVID-19 Screening in Assisted Reproductive Technology Services Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 2 (2023): August
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i2.74618

Background: The assisted reproductive technology (ART) program for examining infertile couples requires face-to-face with a doctor. This face-to-face examination for the ART program has a risk for the transmission of COVID-19 to all medical personnel and infertile couples who want to undergo the ART program. This study aims to understand pre- and post-test education about COVID-19 screening on ART services.Methods: A total of 50 infertile couples in the ART program are given education online. The use of online methods using the Zoom application due to the COVID-19 pandemic. Evaluation of the level of understanding using pre and post-test providing education. Data analysis was carried out using the SPSS 23 application.Results: Analysis of the level of understanding of pre-test and post-test education using the Wilcoxon test. Pre-test results were 69.90±12.05, post-test 73.00±10.83 with significance values p<0.001. Chi-Square test analysis results obtained p<0.001 and OR = 15.68.Conclusion: There was a significant increase in understanding of COVID-19 screening in the post-test education ART service via the Zoom application compared to pre-test education.

Co-Authors ., Darto Abdurahman Laqif Alifa, Rosita Angelia Ratnasari, Affi Anggraeni, Asih Asih Anggraeni Askandar Tjokroprawiro Bagus Wicaksono Bagus Wicaksono Darto - Darto Darto Dihade, Ajeng DYAH FAUZIAH, DYAH Eriana Melinawati Eric Edwin Yuliantara Farras Wahdan, Arib Fitriawan, Ahmad Garwita Anindya Restisa Heru Priyanto Heru Priyanto Laqif, Abdurahman Ngudi Insan Ksyatria, Yudhistira Prisasanti, Dympna Prameilita Rantasari, Affi Angelia Ratnasari, Affi Angelia Rika Ernawati Rika Ernawati Supriyadi Hari Respati Teguh Prakosa, Teguh Uki Retno Budihastuti Wasyanto, Trisulo Wijayanti, Agung Sari WISNU PRABOWO

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