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All Journal Majalah Obstetri dan Ginekologi Journal of Maternal and Child Health Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas
Ratnasari, Affi Angelia
Faculty Of Medicine, Universitas Sebelas Maret / Department Of Obstetrics And Gynecology, Dr. Moewardi Hospital, Ir. Sutami 36 A, Kentingan Surakarta 57126 Telp. (0271) 662622
Education Health Professions Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Expression of Bax Protein as A Prognosis Factor of Radiotherapy Response to Decreased Tumor Size in Stage IIB-IIIB Cervical Cancer Fitriawan, Ahmad; Udiyanto, Hermawan; Respati, Supriyadi Hari; Ratnasari, Affi Angelia; Prabowo, Wisnu
Journal of Maternal and Child Health Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.074 KB) | DOI: 10.26911/thejmch.2022.07.03.07

Abstract

Background: Cervical cancer plays a role as the leading cause of cancer death for women in developing countries. Radiation therapy kills cancer cells through double strand breaks and the apoptotic process. Bax protein is one of the regulators of apoptosis. This study analyzed the role of Bax expression as a prognostic factor in radiation therapy response in reducing tumor size in patients with advanced cervical cancer (IIB-IIIB). Subjects and Method: This research is a retrospective cohort observational analytic study from January 2021 to April 2021 in the Department of Obstetrics and Gynecology in collaboration with the Department of Anatomical Pathology, Dr. Moewardi Hospital, Surakarta, Indonesia. This study involved 30 cervical cancer stage IIB-IIIB patients. The level of Bax expression was determined by immunohistochemical examination. ROC curve analysis was used to find cut-off points and evaluate the sensitivity and specificity of Bax in the prognosis of radiotherapy in patients with advanced cervical cancer (IIB-IIIB). Chi square test was used to determine the relationship between Bax expression and changes in tumor size in cervical cancer patients. Results: The ROC curve analysis showed that the AUC Bax score in prognosis of radiation therapy was 0.575 (CI 95%= 0.32 to 0.83) and the cutoff point was 62.5%. Based on the analysis of the ROC curve, the Bax expression of 62.5% shows a sensitivity of 56.5% and a specificity of 71.4%. Analysis of the relationship between Bax protein expression on changes in tumor size using the Chi Square test showed a P value of 0.390 (p> 0.05). Conclusion: The expression of Bax protein cannot play a role as a prognostic factor in the response of radiation therapy to the reduction in tumor size in stage IIB-IIIB uterine cervical cancer.
The success rate of intrauterine insemination in sperm preparation swim-up method at room temperature compared to the incubator temperature Eriana Melinawati; Uki Retno Budihastuti; Mulyoto Pangestu; Teguh Prakosa; Affi Angelia Ratnasari; Abdurahman Laqif; Darto; Cahyono Hadi; Lunardhi Susanto; Metanolia Sukmawati; Rakano Kautsar Dwiyana; Alfi Marita Tristiarti; Abida Zuhra Jatiningtyas
Majalah Obstetri & Ginekologi Vol. 31 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I12023.11-16

Abstract

HIGHLIGHTS There were no significant differences in TMSC, sperm motility, sperm morphology, and DFI in sperm preparation using the swim-up method at 27°C and 37°C. However, this study provided an overview of the average improvement of DFI at 27°C compared to 37°C. There was no significant difference in the pregnancy rate of IUI in sperm preparation using the swim-up method at 27°C and 37°C.   ABSTRACT Objective: This study aimed to determine the effect of temperature during sperm preparation on total sperm motile count (TMSC), sperm motility, sperm morphology, DNA fragmentation index (DFI), and pregnancy rate. Materials and Methods: A quasi-experimental laboratory study with pre- and post-test control group was conducted at Sekar Fertility Clinic, Dr. Moewardi General Hospital, Surakarta, Indonesia. A total of 20 sperm samples from infertile patients were prepared using the swim-up method at 27°C (group 1) and 37°C (group 2). TMSC, motility, morphology, and DFI examinations were performed. In addition, IUI was performed to confirm pregnancy rate. Sperm DNA fragmentation was determined using Sperm Chromatin Dispersion/SpermFunc DNAf test. Sperm DNA fragmentation was characterized by a halo <30% of the volume of the sperm head. Results: Group 1 had mean TMSC of 13.77 ± 9.30, while group 2 had 14.82 ± 8.82; p=0.218. Group 1 had a motility value 82.25+12.77 and group 2 had 82.55 ± 11.69; p=0.968. The morphological value for group 1 was 11.25 ± 5.15 and group 2 was 11.6 ± 5.34; p=0.626. The mean DFI for group 1 was 17.79 ± 10.88 and group 2 was 18.18 ± 12.95; p=0.765. Pregnancy rate in group 1 was 10% and group 2 was 20%; p=1.000. Conclusion: There were no significant differences in TMSC, sperm motility, sperm morphology, DFI, and pregnancy rate in sperm preparation using the swim-up method at 27°C and 37°C.
Kolaborasi Tenaga Medis dan Masyarakat dalam Mendukung Layanan Infertilitas Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Wijayanti, Agung Sari
Jurnal Abdidas Vol. 5 No. 6 (2024): Desember
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdidas.v5i6.1066

Abstract

Kolaborasi antara tenaga medis dan masyarakat memiliki peran penting dalam mendukung penanganan infertilitas, sebuah kondisi yang sering menyebabkan kecemasan, stres, dan dampak negatif lainnya pada kesehatan mental. Tenaga medis berperan dalam diagnosis, perencanaan pengobatan, dan mendukung pasien mencapai tujuan mereka untuk memiliki anak, sementara masyarakat dapat memberikan dukungan emosional yang membantu mengurangi isolasi dan depresi pasien. Kegiatan pengabdian ini berfokus pada edukasi dan pemberdayaan tenaga medis serta masyarakat untuk meningkatkan pemahaman dan kapasitas mereka dalam mendukung individu dengan infertilitas. Evaluasi menggunakan pre-test dan post-test menunjukkan bahwa 25% peserta mengalami peningkatan pengetahuan setelah kegiatan, sementara 72% telah memiliki pemahaman yang memadai sebelumnya. Hasil ini menggambarkan efektivitas program dalam meningkatkan pemahaman terkait infertilitas. Selain itu, kegiatan ini berhasil menyebarkan informasi akurat dan memerangi mitos yang beredar di komunitas, sehingga meningkatkan kesadaran dan mengurangi stigma terhadap individu dengan infertilitas. Kesimpulannya, program ini efektif dalam meningkatkan dukungan sosial dan kapasitas tenaga medis untuk memberikan perawatan holistik yang lebih baik bagi pasien infertilitas, serta berkontribusi pada pengurangan dampak psikologis dan sosial yang dialami pasien.
Peningkatan Kesadaran dan Deteksi Dini Kanker Serviks dan Kanker Payudara melalui Edukasi dan Skrining bagi Tenaga Kesehatan dan Masyarakat Budihastuti, Uki Retno; Melinawati, Eriana; Priyanto, Heru; Ratnasari, Affi Angelia; Susilawati, Tri Nugraha; Prastyoningsih, Aris; Septiana, Yesika Cahya; Mufidah, Amatullah
Jurnal Abdidas Vol. 6 No. 4 (2025): Agustus 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdidas.v6i4.1171

Abstract

Kanker serviks dan kanker payudara merupakan dua jenis kanker yang paling umum menyerang wanita di seluruh dunia. Kanker serviks disebabkan oleh infeksi human papillomavirus (HPV), sedangkan kanker payudara disebabkan oleh pertumbuhan sel abnormal pada jaringan payudara. Deteksi dini dan pengobatan yang tepat dapat meningkatkan kemungkinan kesembuhan dan mengurangi angka kematian. Oleh karena itu, edukasi dan deteksi dini kanker serviks dan kanker payudara sangat penting untuk meningkatkan kesadaran dan kesehatan masyarakat. Dalam pengabdian masyarakat ini, kami melakukan edukasi dan deteksi dini kanker serviks dan kanker payudara pada tenaga kesehatan dan masyarakat wanita yang berdomisili di area Solo Raya. Hasilnya menunjukkan bahwa edukasi dan deteksi dini dapat mengingatkan kembali kesadaran dan pengetahuan masyarakat tentang kanker serviks dan kanker payudara, serta meningkatkan kemungkinan deteksi dini dan pengobatan yang tepat.
Education on Assisted Reproductive Technology Program with Low Cost Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Wijayanti, Agung Sari
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 1 (2023): February
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i1.64796

Abstract

Background: Assisted reproductive technology (ART) programs have proven to be a solution to help infertility couples to conceive. However, most couples face a financial crisis related to the relatively expensive cost of ART treatment. This service aims to educate about ART's meaning, direction, and procedures. Thus, couples want children to be able to understand the ART program at an affordable cost (low-cost) and undergo the ART program without any concerns about costs.Method: Seminar participants be given socialization in person and online through zoom software by the service provider. It is in two stages, in-person and online, so participants who cannot attend in person can follow this service program. In addition, participants are given a pre-test and post-test questions to assess their understanding of the ART program at an affordable cost.Result: The pre-test and post-test results were analyzed using Wilcoxon, which showed that after providing education about the ART program, the post-test results were significantly better than the pre-test results. Down value: 5.5%, fixed value: 15.2%, value rise: 79.3% with significance p<0.001.Conclusion: There are significant differences in the pre-test and post-test scores, which means that the participants understood the explanation the servicer gave.
Efforts to Increase Understanding of COVID-19 Screening in Assisted Reproductive Technology Services Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 2 (2023): August
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i2.74618

Abstract

Background: The assisted reproductive technology (ART) program for examining infertile couples requires face-to-face with a doctor. This face-to-face examination for the ART program has a risk for the transmission of COVID-19 to all medical personnel and infertile couples who want to undergo the ART program. This study aims to understand pre- and post-test education about COVID-19 screening on ART services.Methods: A total of 50 infertile couples in the ART program are given education online. The use of online methods using the Zoom application due to the COVID-19 pandemic. Evaluation of the level of understanding using pre and post-test providing education. Data analysis was carried out using the SPSS 23 application.Results: Analysis of the level of understanding of pre-test and post-test education using the Wilcoxon test. Pre-test results were 69.90±12.05, post-test 73.00±10.83 with significance values p<0.001. Chi-Square test analysis results obtained p<0.001 and OR = 15.68.Conclusion: There was a significant increase in understanding of COVID-19 screening in the post-test education ART service via the Zoom application compared to pre-test education.
Co-Authors ., Darto Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Alfi Marita Tristiarti Anggraeni, Asih Asih Anggraeni Bambang Sutrisna Cahyono Hadi Darto Darto - Eriana Melinawati Fitriawan, Ahmad Hariyono Winarto Hermawan Udiyanto Heru Priyanto Heru Priyanto Laqif, Abdurahman Lunardhi Susanto Metanolia Sukmawati Mufidah, Amatullah Mulyoto Pangestu Prastyoningsih, Aris Rakano Kautsar Dwiyana Septiana, Yesika Cahya Sigit Purbadi Sri M. Sekarutami Supriyadi Hari Respati Teguh Prakosa, Teguh Tri Nugraha Susilawati Uki Retno Budihastuti Wijayanti, Agung Sari WISNU PRABOWO