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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Penelitian Pendidikan IPA (JPPIPA) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Odonto dental journal
Indra Bramanti
Department Of Pediatric Dentistry, Faculty Of Dentistry, Universitas Gajah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics

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Datura metel SEED NANO CHITOSAN EXTRACT GEL’S EFFECT ON ANGIOGENESIS WOUND HEALING OF WISTAR RAT Asriningrum, Vika; Bramanti, Indra; Ardhani, Retno
Odonto : Dental Journal Vol 12, No 3 (2025): December 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.3.269-279

Abstract

Background: Datura metel possesses anti-inflammatory properties useful for treating oral mucosal injuries common in children, where healing relies on angiogenesis. Nano chitosan technology addresses herbal bioavailability issues. This study investigated the effect of 1% Datura metel seed nano chitosan extract gel on angiogenesis in Wistar rats. Methods: Eighteen Wistar rats were divided into three groups: 1% Datura metel seed chitosan extract, 1% nano chitosan extract, and a control group. Gels were applied to mandibular gingival wounds with assessments on days 3 and 5. Histological angiogenesis counts were analyzed using two-way ANOVA (p<0.05). Results: Significant differences in angiogenesis counts were found among the chitosan extract, nano chitosan extract, and positive control groups. Furthermore, variations in angiogenesis counts were observed between day 3 and day 5 across all groups. Conclusion: The 1% Datura metel seed chitosan extract gel demonstrated a greater effect in triggering angiogenesis compared to the 1% nano chitosan extract and the positive control.
Co-Authors Amalia, Rahmi Ayu Budi Asriningrum, Vika Gamasita, Natasha Ismianti Iwa Sutardjo RS Muhammad Isa Navilatul Ula Ngatidjan Ngatidjan Prathiwi, Caecilia Dewi Ratna Putri Kusuma Wardani Mahendra Retno Ardhani Rifani, Rifani Rinaldi Budi Utomo Rizki, Faisal Rus Sudarso, Iwa Sutardjo Santoso, Aloysia Supartinah Setyo Purwono Sri Budi Barunawati Suryono Titien Soeprihati, Indah Wardani, Sito Resmi Hayuning William Susanto, William Wulandari, Veronica Veronica Yunirahmilia, Yunirahmilia