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All Journal Dental Journal (Majalah Kedokteran Gigi) Narra J Jurnal Natural
Basri A. Gani, Basri A.
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health

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Antioxidant and antiaging activity of Cinnamomum burmannii and Michelia champaca extract and combinations Qarani, Waisul; Husna, Fauzul; Yulia, Winda; Zulkarnain, Zulkarnain; Syahrizal, Dedy; Gani, Basri A.; Sary, Nirwana L.; Wardhani, Bantari WK.
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.111

Abstract

Aging is a natural skin process that occurs due to intrinsic and extrinsic factors, such as excessive exposure to ultraviolet light (photoaging). The mechanism of damage involves the production of excess free radicals that trigger oxidative stress in the skin. Determining the natural products that have high antioxidant activities as antiaging is up most important. Cinnamomum burmannii and Michelia champaca are typical Aceh plants that are believed to have high antioxidant effects. The aim of this study was to determining the contents of C. burmannii and M. champaca as well as to determine the antioxidant and antiaging activities of either individually or combinations. The qualitative phytochemical and semi-quantitative analysis of the extracts were conducted using gas chromatography and mass spectroscopy (GC-MS). The antioxidant activity was examined by radical scavenging using the DPPH radical while the antiaging activity was tested the tyrosinase enzyme inhibition test. The phenolic and flavonoid contents of C. burmannii were higher than M. champaca (66.34 vs 24.71 mg gallic acid equivalent/gr) and (80.52 vs 60.20 mg quercetin equivalent/gr). The inhibitory concentration (IC₅₀) of M. champaca extract in inhibiting DPPH indicated that M. champaca had a better antioxidant activity than C. burmannii. The combination of C. burmannii and M. champaca extracts had a lower IC₅₀ compared to M. champaca alone. C. burmannii and M. champaca extract had a weak potential to inhibit tyrosinase activity (IC₅₀ value ≥1000 µg/mL). In conclusion, this study indicates that M. champaca and C. burmannii have strong antioxidant activities and these might associate with polyphenol contents.
Effect of 17% ethylenediaminetetraacetic acid and silver citrate on sealer resin penetration in the apical third Kurmaena, Iceu Estu; Nurliza, Cut; Gani, Basri A.
Dental Journal Vol. 57 No. 3 (2024): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i3.p178-183

Abstract

Background: Endodontic sealers limit bacteria growth and clean the smear layer of the root canal. Biocompatible irrigants silver citrate and ethylenediaminetetraacetic acid (EDTA) have a chelating agent that increases sealer penetration in dentinal tubules. Purpose: This study aims to investigate the final irrigation difference in epoxy resin and bioceramic sealer penetration into dentinal tubules at the apical third. Methods: A total of 30 extracted mandibular premolars were split into six groups; three received epoxy resin sealer and three received bioceramic resin with aquadest, silver citrate (BioAKT) or EDTA 17% irrigation. A confocal laser scanning microscope estimated sealer penetration in dentinal tubules. For quantitative data analysis, Olympus Fluoview ver.4.2a was used. Results: Silver citrate final irrigation with bioceramic resin sealer had the highest dentinal tubular penetration (24%; 1,431 µm), followed by EDTA 17% (20%; 1,202 µm), aquadest (16.3%; 969 µm), EDTA 17% with epoxy resin (15.8%; 938 µm, 14%; 803 µm), and distilled water (10%; 584 µm). Significant differences existed in all groups (p = 0.001). Epoxy resin sealer penetration into dentinal tubules was similar between final irrigants (p = 0.257) and bioceramic resin groups (p = 0.658). Conclusion: Silver citrate (BioAKT), a bioceramic resin sealer-based final irrigation solution, penetrates dentinal tubules better for endodontic therapy.
Antibacterial assessment of Ziziphus mauritiana Lam on inhibition of the growth and biofilm of Streptococcus mutans Syafriza, Dharli; Hasanah, Uswatun; Hidayatullah, Taufiqi; Rifki, Ayudia; Gani, Basri A.
Dental Journal Vol. 57 No. 3 (2024): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i3.p189-194

Abstract

Background: Streptococcus mutans (S. mutans) causes dental caries. S. mutans biofilms are inhibited by the antibacterial properties of Ziziphus mauritiana Lam (Z. mauritiana Lam). Purpose: Evaluating the potential of Z. mauritiana Lam in inhibiting the growth and biofilm formation of S. mutans ATCC 25175 in vitro. Methods: This study used the ethanolic extract of Z. mauritiana Lam as the test material and S. mutans as the research subject. Spectrophotometry (620 nm) was used to assess the growth of S. mutans, the inhibition of S. mutans biofilm using a 1% crystal violet staining was measured by spectrophotometry (520 nm), and the visualization of the biofilm mass was conducted with an electric microscope (200x). Results: At all concentrations, Z. mauritiana Lam displayed excellent growth inhibition of S. mutans 0.04–0.09 (< 300 CFU/mL) and was able to inhibit the formation of S. mutans biofilm with a strong scale of optical density (OD) 0.4 at 24 hours incubation time. At the same time, the incubation time of 48 and 72 hours tended to have moderate-scale biofilm inhibition (OD 0.2–3.9). At a concentration of 25%, the biofilm mass decreased by a relatively small size, the same as the positive control group. At 50%, 12.5%, and 6.25%, it was seen that the S. mutans biofilm mass experienced a dominant loss. Conclusion: Z. mauritiana Lam can be bacteriostatic against the growth of S. mutans and can inhibit the formation of biofilms by degrading the structure and mass of S. mutans biofilms.
Study of mathematical models of type 2 diabetes mellitus and its complications MAGHFIRAH, AFIATUN; GANI, BASRI A.; RAMLI, MARWAN; IKHWAN, MUHAMMAD
Jurnal Natural Volume 24 Number 3, October 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i3.33482

Abstract

The rapid increase in type 2 diabetes mellitus (DM) cases in Indonesia, driven by hereditary factors and unhealthy lifestyles, poses significant health challenges. This study develops a compartmental model to analyze the progression of type 2 DM and the onset of complications, classifying individuals into susceptible, patients without complications, patients with complications, and those disabled due to complications. The model examines the influence of two key factors on the recovery from complications: habitual factors, including medication adherence, physical activity, dietary habits, smoking history, and environmental factors, such as stress levels, environmental support, patient trust, and compliance. The results indicate that habitual factors have a more substantial impact on mitigating complications compared to environmental factors, suggesting that lifestyle interventions are crucial in improving patient outcomes. The model also shows that an increase in behavioral interactions leading to disease progression results in instability, emphasizing the need for early and consistent behavioral interventions. This research offers valuable insights for healthcare providers and policymakers. By identifying the most influential factors in managing complications, the model can guide the development of targeted interventions that prioritize habitual changes, such as medication adherence and physical activity. Public health strategies can be tailored to emphasize the importance of these habitual factors, potentially reducing the burden of type 2 DM complications. Overall, this study highlights the critical role of personalized, behavior-focused interventions in the management and prevention of complications in patients with type 2 DM, offering a practical framework for improving patient care.
Fungistatic effect of Gracilaria verrucosa on phospholipase enzymes and the cell surface hydrophobicity of Candida albicans Gani, Basri A.; Andayani, Ridha; Batubara, Fitri Yunita; Ifwandi, Ifwandi; Syafriza, Dharli; Herlambang, Muhammad Mas'ud; Fathirah, Shiti Alya; Rifki, Ayudia
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 1 (2025): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i1.p66-73

Abstract

Background: Candida albicans (C. albicans) was reported as a primary cause of oral candidiasis. Phospholipase enzymes and cell surface hydrophobicity (CSH) are involved in the pathogenesis of its infection. Gracilaria verrucosa (G. verrucosa) is reported to contain flavonoids, tannins, and phenolic compounds, which can inhibit the development of C. albicans. Purpose: The study analyzed the effect of the ethanol extract of G. verrucosa on the inhibition of the phospholipase enzyme and CSH of C. albicans. Methods: The G. verrucosa chemical compounds were examined by phytochemical tests and phospholipase enzyme-inhibiting egg yolk media, and a CSH assay was conducted using xylene. Results: Gracilaria verrucosa contains steroids, terpenoids, tannins/phenolics, and flavonoids. The 25%–100% concentrations inhibit the phospholipase enzyme of C. albicans more strongly at 48 hours than at 12 hours and 24 hours (p < 0.05). Furthermore, the 100% and 75% concentrations substantially affect the inhibition of CSH of C. albicans, with a strong relationship. Conclusion: Gracilaria verrucosa has a more substantial inhibitory effect in suppressing the phospholipase enzyme and CSH of C. albicans.
Co-Authors Cut Nurliza, Cut Dedy Syahrizal Fathirah, Shiti Alya Fitri Yunita Batubara, Fitri Yunita Herlambang, Muhammad Mas'ud Hidayatullah, Taufiqi Husna, Fauzul Ifwandi Ifwandi, Ifwandi Kurmaena, Iceu Estu MAGHFIRAH, AFIATUN Marwan Ramli Muhammad Ikhwan Qarani, Waisul Ridha Andayani Rifki, Ayudia Sary, Nirwana L. Syafriza, Dharli Uswatun Hasanah Wardhani, Bantari WK. Winda Yulia Zulkarnain Zulkarnain