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All Journal Journal of Mathematical and Fundamental Sciences Jurnal Biologi Universitas Andalas JOPS (Journal Of Pharmacy and Science) Jurnal Kesehatan Saintika Meditory Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan GEMBIRA (Pengabdian Kepada Masyarakat)
Meiridha Mutiara Andania
Fakultas Kedokteran, Universitas Baiturrahmah
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines Meiridha Mutiara Andania; Friardi Ismed; Muhammad Taher; Solachuddin Jauhari Arief Ichwan; Amri Bakhtiar; Dayar Arbain
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 3 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.3.2

Abstract

In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-β-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-β-orcinol carboxylate (9) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.
PENGARUH EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUZ) DALAM MENGHAMBAT DEGRANULASI SEL MAST DAN MENCIT PUTIH JANTAN YANG TERSENSITISASI AKTIF Relin Yesika; Meiridha Mutiara A.
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

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Abstract

Type I hypersensitivity reactions, also known as allergic reactions or anaphylactic reactions. The mechanism of anaphylaxis involves the release of mediators from mediator cells. The degranulation of mast cells and basophils causes an exaggerated immune response and causes the signs and symptoms of anaphylaxis. Red dragon fruit peel contains secondary metabolites such as triterpenoid flavonoids and steroids. This study was an in vitro study of the ethanol extract of red dragon fruit peel (Hylocereus polyrhizuz) on the mast cells of male white mice induced by antigen. Five variations of the concentration used are 25; 50; 100; 200; 400 µg/mL. The percentage of mast cell degranulation by red dragon fruit peel extract at concentrations of 25; 50; 100; 200 dan 400 µg/mL is 75.27; 69.05; 64.04, 56.61; 45.17; dan 27.88%. There Red dragon fruit peel extract had a significant effect in inhibiting mast cell degranulation (p<0.05).
The Effect of Ethanol Extract of Cherry Tomato (Solanum lycopersicum L.) on Mast Cell Degranulation in Male White Mice Invitro Yesika, Relin; Andania, Meiridha Mutiara; Nurdi, Rahmi
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4678

Abstract

Cherry tomatoes (Solanum lycopersicum L.) belong to the Solanaceae family which contains antioxidant compounds such as carotenoid compounds, which come from the terpenoid group, for example lycopene, besides cherry tomatoes also have flavonoid compounds. Both of these compounds have many pharmacological activities, one of which is as an anti-inflammatory. Inflammation starts from the process of mast cell degranulation, which is the process of releasing mast cell granules containing inflammatory mediators such as histamine, leukotriene and prostaglandins that cause type I hypersensitivity (allergies). This study aims to determine the effect of cherry tomato ethanol extract on mast cell degranulation of male white mice in vitro. The experimental animals used were male white mice that were actively sensitized after being induced with 20% ovalbumin antigen 0.2 mL/20 g BW on the first day intraperitoneally and the 7th day subcutaneously. The results of the average percentage of mast cell degranulation by cherry tomato extract at concentrations of 25 μg/ml; 50 μg/ml; 100 μg/ml and 200 μg/ml were 54.70%; 51.71%; 46.73%; 42.65% and 38.92%. This study shows that cherry tomato extract (Solanum lycopersicum L.) can inhibit mast cell degranulation in male white mice
GAMBARAN TINGKAT PENGETAHUAN MAHASISWA NON KESEHATAN TENTANG SWAMEDIKASI DALAM PENANGANAN DEMAM DI UNIVERSITAS BAITURRAHMAH PADANG Ferilda, Siska; Andania, Meiridha Mutiara; Maidani, Ochi Srisepti; Fendri, Sandra Tri Juli; Fitriyasti, Betty
Jurnal Kesehatan Saintika Meditory Vol 7, No 2 (2024): November 2024
Publisher : STIKES Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v7i2.2895

Abstract

Swamedikasi (self medication) atau pengobatan sendiri dalam rangka meningkatkan kesehatan dirisendiri dan mengatasi/mengobati penyakit ringan tanpa pengawasan dokter. Pengobatan sendiridilatar belakangi oleh banyak alasan antara lain alasan keluarga, menghemat waktu, kepercayaanterhadap pengobatan tradisional, kekhawatiran akan kerahasiaan, biaya, jarak, dan kepuasandibandingkan dengan pengobatan sendiri sebelumnya. Hal yang penting untuk dipahami adalahpengobatan sendiri adalah tepat, aman dan masuk akal dan tidak melibatkan pengobatan tanpamencari informasi tentang pengobatan. Tujuan: penelitian ini bertujuan untuk mengetahuiGambaran Tingkat Pengetahuan Mahasiswa non Kesehatan tentang Swamedikasi dalam PenanganDemam di Universitas Baiturrahmah Padang. Metode: rancangan penelitian yang dilakukan denganobservasional dengan desain deskriptif. Hasil: dari 105 orang responden dengan pengetahuan baikyang mana terdiri dari 48 orang (45,7%), 54 orang mahasiswa berpengetahuan cukup (51,4%), dan3 orang mahasiswa berpengetahuan kurang (2.9%). Tidak terdapat pengaruh antara jenis kelaminterhadap tingkat pengetahuan dengan nilai Sig (0,078) > (0,05). Kesimpulan: tingakat pengetahuanmahasiswa non kesehatan cukup baik tentang swamedikasi penanganan demam.Kata kunci: Swamedikasi, Obat, pengetahuan, mahasiswa
PENINGKATAN PENGETAHUAN SANTRI TENTANG PENGGUNAAN OBAT YANG RASIONAL MELALUI EDUKASI DAGUSIBU DI PESANTREN PROF. DR. HAMKA II PADANG Elvionita, Cindy; Ferilda, Siska; Marsellinda, Elsa; Andania, Meiridha Mutiara; Arifa, Nurwahidatul; Putra, Rama Feriska
Jurnal Gembira: Pengabdian Kepada Masyarakat Vol 3 No 04 (2025): AGUSTUS 2025
Publisher : Media Inovasi Pendidikan dan Publikasi

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Abstract

Penggunaan obat yang tidak rasional merupakan salah satu permasalahan kesehatan yang masih sering terjadi di masyarakat, termasuk di lingkungan pesantren. Santri yang menjalani kehidupan secara mandiri rentan melakukan swamedikasi tanpa pengetahuan yang memadai. Edukasi DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) Obat dengan Benar merupakan salah satu pendekatan yang dapat digunakan untuk meningkatkan literasi penggunaan obat yang aman dan bertanggung jawab. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan santri kelas VII di Pondok Pesantren Prof. Dr. Hamka II Padang tentang penggunaan obat secara rasional melalui metode edukatif dan interaktif. Metode yang digunakan meliputi pemaparan materi, kuis interaktif, sesi tanya jawab, dan diskusi kasus sederhana. Hasil pelaksanaan menunjukkan tingginya partisipasi dan antusiasme santri, serta peningkatan pemahaman terkait klasifikasi obat, cara penyimpanan yang tepat, dan pentingnya membaca informasi pada kemasan obat. Edukasi ini juga mendorong terjadinya perubahan perilaku awal pada peserta, seperti keinginan untuk menyebarkan informasi yang diperoleh kepada teman sebaya. Kegiatan ini membuktikan bahwa pendekatan edukatif berbasis komunitas pesantren efektif dalam meningkatkan kesadaran dan pengetahuan remaja tentang penggunaan obat yang benar. Intervensi semacam ini diharapkan dapat direplikasi di pesantren lain sebagai upaya promotif dalam penguatan literasi kesehatan di kalangan remaja.
Studi Etnobotani Pemanfaatan Tumbuhan Obat Tradisional oleh Masyarakat Nagari Sijunjung Andania, Meiridha Mutiara; Yesika, Relin; ferdian, arif
Jurnal Biologi Universitas Andalas Vol 12 No 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jbioua.12.1.01-04.2024

Abstract

Minangkabau is one of the ethnics that uses plants as medicine. In this ethnobotanical study, the aim was to find out the use of plants as medicine by the people of Sijunjung. Data collection was carried out directly by interviewing native people. From the result known that there are about 42 types of plants used by the indigenous people of Sijunjung as medicine. Of the 42 types of plants used, sitawa (Costus speciosus) is the most widely used plant in the treatment of fever. Almost all plants used as medicine are taken orally.
Co-Authors Amri Bakhtiar Arifa, Nurwahidatul DAYAR ARBAIN Elsa Marsellinda Elvionita, Cindy Fendri, Sandra Tri Juli Ferdian, Arif Fitriyasti, Betty Friardi Ismed Maidani, Ochi Srisepti Muhammad Taher Nurdi, Rahmi Putra, Rama Feriska Relin Yesika Siska Ferilda Solachuddin Jauhari Arief Ichwan Yesika, Relin