Garuda - Garba Rujukan Digital

Comparison of Phenolic Glycolipid 1 Antibody Levels in Household Contacts of Pausibasilary and Multibacilary Patients Febrina Andarini; Rusmawardiana; Soenarto Kartowigno; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.166

Abstract Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Distribution of leprosy cases in the world in 2015 was highest in the Southeast Asia region, with 156,118 cases. The increase in new cases and the high prevalence of leprosy requires action to break the chain of transmission. Household contact groups are easy to identify by the research group, because the group has good reasons for examining or getting chemoprophylaxis. Objectives: Our objective was to compare Phenolic Glycolipid 1 (PGL-1) antibody levels in household contacts of pausibasilary (PB) and multibacilary (MB) patients. Methods: This study was a analytic observational study with a cross-sectional design. ELISA examination will be conducted at the Leprosy Laboratory of the Institute of Tropical Diseases, Airlangga University, Surabaya. The study was conducted from 3 December 2019 to 31 January 2020, with a total sample of 60 samples. Resuls: PGL-1 antibodies in MB leprosy household contact were greater than PGL-1 antibodies in PB leprosy household contact, and the results showed statistically significant (p = 0.011). Conclusions: There are differences in the levels of PGL-1 antibodies between household contact PB leprosy patients and MB. The household contact PGL-1 antibody levels in MB leprosy are greater than PB leprosy.

Epidermal Proliferation and Differentiation in Ichthyosis Vulgaris Nopriyati; Deddy Deddy; Rusmawardiana; Mutia Devi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.214

A B S T R A C TEpidermal proliferation and differentiation is a physiological process which playscrucial role in protecting human body from external environment. Ichthyosisvulgaris is a disease caused by disruption of epidermal differentiation process.Disrupted of profilaggrin conversion to filaggrin caused by mutations from thefilaggrin gene (FLG) located on chromosome 1q21. Recently, caused of ichthyosisvulgaris is mutation of the CASP14 gene on chromosome 19p13.12 which producescaspase-14, is involved in the proteolytic degradation of filaggrin. Clinicalmanifestations of ichthyosis vulgaris are hyperlinear palmar and plantar, keratosispilaris, xerosis, and localized or generalized scaling of the skin. Application ofemollients, humectants and keratolytic agents are the main treatment of ichthyosisvulgaris. Further research on caspase-14 as a therapeutic target is needed in thetreatment of ichthyosis vulgaris.

Epidemiology of Leprosy in Childhood: A Retrospective Study Rusmawardiana; Fifa Argentina; Indri Widya Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.309

Background: Children are the group most susceptible to Mycobacterium leprae infection. The proportion of new leprosy cases in children is indicator of successful leprosy elimination program from World Health Organization (WHO), so this study would like to know the epidemiology of pediatric leprosy at Dermatology and Venereology Polyclinic, Dr. Mohammad Hoesin Palembang. Methods: Retrospective study of all new cases of leprosy in children (0-17 years) who came to Dermatology and Venereology Polyclinic, Dr. Mohammad Hoesin Palembang from January 2017 to December 2020. Results: There were 10 pediatric patients (7.58%) from 132 new leprosy cases. Most cases (40%) were in the 15-17 age group. There are more male than female. Most types of leprosy are BL (60%) followed by TT (20%). Manifestations of hyperpigmented skin patches and nervous disorders, grade 1 disability, and type 2 leprosy reactions are mostly found in type BL leprosy. The duration of illness 6-12 months has a grade 1 disability (30%). The history of positive contact came from same household in 3 cases (30%) with 7 people (70%) domiciled in Palembang. All cases received Multidrug Therapy (MDT) treatment according to WHO guidelines. Conclusion: Found 10 new cases of leprosy in children in Dermatology and Venereology Polyclinic Dr. Moh. Hoesin Palembang for four years, especially in the 15-17 age group, with the most cases being type BL leprosy. Household contact still plays an important role in leprosy transmission.

Black Dot Type Capitis Tinea Appreciates Bacterial Foliculitis Radema Maradong Ayu Pranata; Rusmawardiana; Fifa Argentina
Jurnal RSMH Palembang Vol. 1 No. 1 (2020): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Tinea capitis is a superficial fungal infection of the scalp and hair, which is seenpredominantly in children. In adults, it is usually related to immunocompromisedpatients and have an atypical features. In patients with end stage renal disease (ESRD),uremia is associated with immune suppression due to the impact of uremic milieu. Allspecimens of tinea capitis should be examined for microscopy, wood’s lamp andculture. Reported a case of 50–year-old male, animal husbandry, presented with itchypapules, pustules, patch alopecia and a hair loss for 6 months. Dermatologic featuresshowed papules, pustules, patch alopecia and black dot. The patient treated withketoconazole shampoo for 3 weeks without any improvement. He had an ESRD for 2years. Gram stain examination and culture showed no bacteri. Wood’s lampexamination showed no fluorescent. Potassium hydroxide (KOH) 10% from scalpscrapings and KOH 20% from hair showed a fungal elements, which support diagnosisof black dot tinea capitis. The patient treated with griseofulvin tablet 500 mg twice aday for 8 weeks, cetirizine tablet 10 mg once daily and 3x/week of ketoconazoleshampoo 2% showed improvement in clinical features and microscopic evaluation.

Superficial mycosis profile in the Tertiary Hospital Dr. Moh. Hoesin Palembang: retrospective research Desi Harnis; Rusmawardiana; , Fifa Argentina
Jurnal RSMH Palembang Vol. 1 No. 1 (2020): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Background Superficial mycoses is a fungal infection of the skin, nails and hair thatcaused by dematophytes, yeast and mold. Superficial mycoses infections are commonlyfound in high temperature and humidity area such as Indonesia. Palembang is one ofregions in Indonesia has a high temperature and humidity, considered the incidenceof this disease is high. A retrospective study of new cases of superficial mycoses, datataken from medical records and register book at Policlinic of Dermatology andVenereology Dr. Moh. Hoesin Palembang during 5 years from January 2014-December2018. There were 1,236 (17.1%) new cases of superficial mycoses. Incidence ofsuperficial mycoses varies with range 6.9%-23%. The most common superficialmycoses is dermatophytes (38,3%). Microsporum canis, Trichophyton rubrum danTricophyton hmentagrophytes are frequent isolates in this study. The most age groupis 36-45 years (17.6%) with male more than female. Superficial mycoses are often foundin students (26.9%), followed by unskilled workers (20.8%). Of the 1,236 new cases,125 patients had comorbidities, such as malignancy 21 (16.8%) patients,cerebrovascular disease and diabetes mellitus each 16 patients (7.4%). Inguinal andabdomen are the most commonly infected regions. 656 (53.1%) patients was giventopical antifungal. The most common topical antifungal was ketoconazole 2% cream(62%) and systemic antifungal was itraconazole (55,3%).Conclusion: Cases ofsuperficial mycoses, especially dermatophytosis and Malassezia were still commonlyfound, especially in Palembang.

Ulceration of Corticosteroid-Induced StriaeDistensae in Children with Nephrotic Syndrome Indri Widya Sari; Rusmawardiana; Fifa Argentina
Jurnal RSMH Palembang Vol. 2 No. 1 (2021): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Striaedistensae(SD) is linear scar tissue in the epidermis and dermis due to excessive stretching of the skin.Striaedistensaeoccurs due to dysfunction of extracellular matrix components that play a role in skin elasticity increasing sensitivity to minor trauma and ulceration. One of the causes is the long-term use of corticosteroids. Systemic corticosteroids are the mainstay of treatment for nephrotic syndrome, so long-term prescribing of corticosteroids should be carried out with caution. It is reported case of a 15-year-old boy with nephrotic syndrome complains of red streaks appearing on his abdomen, back, buttocks, and lower limbs after 2 months of corticosteroid treatment. Pus-filled nodules develop which become ulcers on the red lines of the back. On physical examination found striaedistensae in the abdominal region, posterior trunk, gluteus, femoral and proximal 1/3 bilateral cruris posterior. Found 3 ulcers on the striaedistensae on the posterior trunk, oval to round shape, size 1x1x0,5 cm to 2x1,5x1 cm, base of necrotic tissue, pus contents, wall echoing, edges are not raised, surrounding tissue is erythematous-livid, tenderness, odor, and no induration. On examination of the ulcer swab with Gram stain found Gram-positive bacteria. The culture results showed Staphylococcus aureus. The patient was treated with topical 0.05% retinoic acid every night at SD, and ulcers were treatedsystemic antibiotics of 2 grams ceftriaxone per day for 1 week, as well as ulcer treatment by compressing 1%0 salicylic acid solution, hydrogel, and foam dressing. After 4 weeks of therapy, there was clinical improvement, thinning striae and reduced ulcer size.

Comparison of Phenolic Glycolipid 1 Antibody Levels in Household Contacts of Pausibasilary and Multibacilary Patients Febrina Andarini; Rusmawardiana; Soenarto Kartowigno; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.166

Abstract Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Distribution of leprosy cases in the world in 2015 was highest in the Southeast Asia region, with 156,118 cases. The increase in new cases and the high prevalence of leprosy requires action to break the chain of transmission. Household contact groups are easy to identify by the research group, because the group has good reasons for examining or getting chemoprophylaxis. Objectives: Our objective was to compare Phenolic Glycolipid 1 (PGL-1) antibody levels in household contacts of pausibasilary (PB) and multibacilary (MB) patients. Methods: This study was a analytic observational study with a cross-sectional design. ELISA examination will be conducted at the Leprosy Laboratory of the Institute of Tropical Diseases, Airlangga University, Surabaya. The study was conducted from 3 December 2019 to 31 January 2020, with a total sample of 60 samples. Resuls: PGL-1 antibodies in MB leprosy household contact were greater than PGL-1 antibodies in PB leprosy household contact, and the results showed statistically significant (p = 0.011). Conclusions: There are differences in the levels of PGL-1 antibodies between household contact PB leprosy patients and MB. The household contact PGL-1 antibody levels in MB leprosy are greater than PB leprosy.

Epidermal Proliferation and Differentiation in Ichthyosis Vulgaris Nopriyati; Deddy Deddy; Rusmawardiana; Mutia Devi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.214

A B S T R A C TEpidermal proliferation and differentiation is a physiological process which playscrucial role in protecting human body from external environment. Ichthyosisvulgaris is a disease caused by disruption of epidermal differentiation process.Disrupted of profilaggrin conversion to filaggrin caused by mutations from thefilaggrin gene (FLG) located on chromosome 1q21. Recently, caused of ichthyosisvulgaris is mutation of the CASP14 gene on chromosome 19p13.12 which producescaspase-14, is involved in the proteolytic degradation of filaggrin. Clinicalmanifestations of ichthyosis vulgaris are hyperlinear palmar and plantar, keratosispilaris, xerosis, and localized or generalized scaling of the skin. Application ofemollients, humectants and keratolytic agents are the main treatment of ichthyosisvulgaris. Further research on caspase-14 as a therapeutic target is needed in thetreatment of ichthyosis vulgaris.

Epidemiology of Leprosy in Childhood: A Retrospective Study Rusmawardiana; Fifa Argentina; Indri Widya Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.309

Background: Children are the group most susceptible to Mycobacterium leprae infection. The proportion of new leprosy cases in children is indicator of successful leprosy elimination program from World Health Organization (WHO), so this study would like to know the epidemiology of pediatric leprosy at Dermatology and Venereology Polyclinic, Dr. Mohammad Hoesin Palembang. Methods: Retrospective study of all new cases of leprosy in children (0-17 years) who came to Dermatology and Venereology Polyclinic, Dr. Mohammad Hoesin Palembang from January 2017 to December 2020. Results: There were 10 pediatric patients (7.58%) from 132 new leprosy cases. Most cases (40%) were in the 15-17 age group. There are more male than female. Most types of leprosy are BL (60%) followed by TT (20%). Manifestations of hyperpigmented skin patches and nervous disorders, grade 1 disability, and type 2 leprosy reactions are mostly found in type BL leprosy. The duration of illness 6-12 months has a grade 1 disability (30%). The history of positive contact came from same household in 3 cases (30%) with 7 people (70%) domiciled in Palembang. All cases received Multidrug Therapy (MDT) treatment according to WHO guidelines. Conclusion: Found 10 new cases of leprosy in children in Dermatology and Venereology Polyclinic Dr. Moh. Hoesin Palembang for four years, especially in the 15-17 age group, with the most cases being type BL leprosy. Household contact still plays an important role in leprosy transmission.

Diagnosis Eksantema Akibat Infeksi Hari Darmawan; Rusmawardiana -
Cermin Dunia Kedokteran Vol 47, No 3 (2020): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i3.366

Eksantema merupakan manifestasi erupsi kulit makulopapular eritem difus disebabkan virus atau bakteri. Erupsi kulit terjadi karena kerusakan sel akibat mikroorganisme, toksin, dan respon imun pejamu. Morbili, rubela, roseola, demam skarlatina, dan hand-foot and mouth disease (HFMD) adalah lima penyakit eksantema terbanyak. Kelainan ini sering sulit dibedakan satu sama lain dan dengan erupsi obat tipe makulopapular. Diagnosis berdasarkan anamnesis, gejala prodromal, gambaran erupsi kulit, dan manifestasi klinis khas. Pemeriksaan laboratorik dan serologik membantu diagnosis. Sebagian besar eksantema bersifat self-limiting sehingga terapi hanya suportif. Exanthema is maculopapular skin eruption of diffuse erythematous caused by viral or bacteria. Skin eruptions occur due to cell damage caused by microorganisms, toxin, and host immune response. Morbili, rubella, roseola, scarlet fever, and hand-foot and mouth disease (HFMD) are the five most common exanthema diseases. The disease is difficult to distinguish from each other and with drug eruption. Diagnosis is based on history, prodromal symptoms, skin eruption, and typical clinical manifestation. Laboratory and serologic examinations help establish diagnosis. Most exanthemas are self-limiting and only need supportive therapy.

Title

Found 23 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 23 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 23 Documents
Search