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All Journal Biology, Medicine, & Natural Product Chemistry Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Biomedika dan Kesehatan Indonesian Community Empowerment Journal
Mgs. Irsan Saleh, Mgs. Irsan
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Religion Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences

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GLUT4 as A Protein Target for T2DM Therapy with Natural Compounds Sutandar, Vivi Hendra; Saleh, Mgs. Irsan; Maritska, Ziske
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.289-293

Abstract

WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance. Medication for T2DM mainly focuses on lowering blood glucose and treating affected organs. Current medications are still lacking, thus research is needed in finding novel medications to accommodate T2DM. This paper aims to present the current research on potential plant extract in increasing GLUT4 translocation in diabetes conditions. insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels.
Hubungan Polimorfisme Panjang Pengulangan CAG pada Gen Reseptor Androgen dengan Sindrom Ovarium Polikistik di RSUP dr. Mohammad Hoesin Palembang Silvana, Rista; Wahyu Pranata, Wahyu Pranata; Manan, Heriyadi; Usman, Fatimah; Theodorus, Theodorus; Saleh, Mgs. Irsan
Syifa'Medika Vol 15, No 2 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v15i2.9474

Abstract

Latar Belakang: Sindrom Ovarium Polikistik (SOPK) merupakan suatu kondisi anovulatori umum yang mempengaruhi 6–8% perempuan premenopause. Terdapat hubungan antara panjang pengulangan CAG pada pasien anovulatoar dengan kadar androgen serum rendah. Tujuan: Untuk menginvestigasi polimorfisme CAG pada gen RA pada perempuan dengan SOPK.Metode: Penelitian observasional dengan desain kasus kontrol pada perempuan normal dan SOPK pada November – Desember 2021. Sampel diambil dari sampel darah perifer atau serum perempuan normal (kontrol) dan terdiagnosis SOPK (kasus) di RSMH Palembang. Kemudian, dilakukan pemeriksaan DNA di Biologi Molekuler Fakultas Kedokteran Universitas Sriwijaya Palembang.Hasil: Terdapat 50 wanita SOPK sebagai kasus dan 50 wanita normal sebagai kontrol yang memenuhi kriteria inklusi penelitian. Panjang pengulangan gen CAG-RA yang memiliki sensitivitas dan spesifisitas paling baik adalah pada nilai 22,5 dengan AUC 0,50 (IK95% 0,386–0,616). Sampel dengan panjang pengulangan CAG pada gen RA ? 22,5 memiliki risiko sama besar mengalami SOPK dengan sampel yang memiliki panjang pengulangan CAG pada gen RA < 22,5 (OR = 1,084 (IK95% 0,493–3.384); p  = 1,000). Titik potong kadar testosteron, yaitu 44,64, SHBG sebesar 26,295, dan FTI sebesar 5,73. Terdapat hubungan yang tidak bermakna antara testosteron (OR = 1,625 (IK95% 0,530–4,984);p  = 0,570); SHBG (OR = 1,040 (IK95% 0,339–3,190); p  = 1,000), dan FTI (OR = 1,244  (IK95% 0,402–3,853); p  = 0,927) dan panjang pengulangan CAG pada gen RA.Simpulan: Tidak terdapat hubungan antara panjang pengulangan CAG gen reseptor androgen dan penderita SOPK.
Counseling of the Use of Herbal Medicines for Health Care to the Community Parisa, Nita; Kamaluddin, M. T.; Theodorus; Saleh, Mgs. Irsan; Lusiana, Evi; Tamzil, Nia Savitri; Wicaksono, Bonanza Abi; Nashif, Arkan Abdullah
Indonesian Community Empowerment Journal Vol. 2 No. 2 (2022): Indonesian Community Empowerment Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/icejournal.v2i2.21

Abstract

Herbal medicine is growing quite rapidly, especially in every area that has traditional medicine using natural ingredients that are believed to treat disease. In addition, the use of herbal medicines is believed to have fewer side effects compared to conventional medicine. WHO also recommends the use of traditional and herbal medicines in efforts to maintain health, as well as prevent and treat diseases ranging from mild to chronic diseases. Based on the various problems faced, the purpose of implementing community service is to increase public knowledge and understanding of medicinal plants, independent health screening, and self-medication, and the role of supplements (vitamins and herbs) in health care and disease prevention efforts.
Pengaruh Estradiol Terhadap Sepsis Haloho, Agustina Br.; Amin, Ramzi; Saleh, Mgs. Irsan; Murti, Krisna
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.104-112

Abstract

Sepsis is an emergency condition as a result of host dysregulation systemic immune response to infection that is related to the end stage of organ dysfunction. Both sepsis and septic shock conditions are the main problems in ICU especially, those that affect millions of people in the whole world every year. Studies in line with immune-neuroendocrine related to sepsis get high attention about factors that play roles in sepsis pathogenesis and prognosis, like correlation to gender, hormones, and other factors. In this case, lots of experimental studies and clinical studies showed that sepsis has significant sexual dysmorphic. The female gender has proven protective against sepsis, meanwhile, males could have worse sepsis because of decreasing immunologic response that mediates cell and cardiovascular function. Estrogen is a hormone in women that plays important roles in not only reproductive function but also non-reproductive function. Physiological estrogen in women is divided into three forms: estrone (E1), estradiol (E2 or 17β- estradiol), and estriol (E3). Several experimental studies in animals showed that estradiol has a protective response when infection occurs. Estrogen generally stimulates cytokine release, induction of HO-1, and restoration of organ function due to sepsis. Potential pathogenesis for this condition is a specific expression of cytokine pro and anti-inflammation. This pathological inflammatory condition is related to gender that is found in surgical patients at the molecular level.
Co-Authors Evi Lusiana Haloho, Agustina Br. Krisna Murti M. T. Kamaluddin Manan, Heriyadi Nashif, Arkan Abdullah Nita Parisa Ramzi Amin, Ramzi Silvana, Rista Sutandar, Vivi Hendra Theodorus Theodorus Theodorus Usman, Fatimah Wahyu Pranata, Wahyu Pranata Wicaksono, Bonanza Abi Ziske Maritska