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All Journal Majalah Obstetri dan Ginekologi Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science
Manan, Heriyadi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Acquired uterine arteriovenous malformation after cesarean section Usman, Fatimah; Sutrisno, Muhammad Al Farisi; Effendi, Kemas Yusuf; Abadi, Adnan; Manan, Heriyadi; Amran, Rizani; Zulqarnain, Iskandar
Majalah Obstetri & Ginekologi Vol. 32 No. 2 (2024): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I22024.148-155

Abstract

HIGHLIGHTS 1. Acquired uterine arteriovenous malformation (AVM) is an uncommon sequela of cesarean section, warranting consideration in instances of persistent uterine bleeding in the puerperium.2. Embolization represents a viable and well-established treatment modality for AVM, providing a safe and efficacious intervention that serves as an alternative, less invasive modality for patients desiring fertility preservation.   ABSTRACT Objectives: To demonstrate that embolization is a viable and well-established treatment for acquired arteriovenous malformations (AVMs), offering a safe and effective, less invasive option for patients seeking to preserve fertility.Case Report: A 20-year-old female experiencing recurrent massive bleeding with a history of previous caesarean section and wound infection resuturing. The transvaginal color Doppler ultrasound showed a hypervascularity in the uterus around the surgical lesion, suggesting a uterine AVM and its confirmed by angiography. The patient underwent a series of uterine artery embolization interventions, which proved to be a successful therapeutic approach. As a result of this treatment modality, not only was the patient's condition effectively resolved, but her fertility was also preserved.Conclusion: Acquired uterine arteriovenous malformation (AVM) is an uncommon sequela of cesarean section, warranting consideration in instances of persistent uterine bleeding in the puerperium. Embolization represents a viable and well-established treatment modality for AVM, providing a safe and efficacious intervention that serves as an alternative, less invasive modality for patients desiring fertility preservation.
Effects of Combined Laparoscopic Cystectomy and Leuprolide Acetate Therapy on Anti-Mullerian Hormone Level and Antral Follicle Count Profile in Endometriosis Usman, Fatimah; Hilmawan, Bagus; Yusuf, Kemas; Manan, Heriyadi; Theodorus, Theodorus; Andrina, Hana
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.519

Abstract

Objective: This study examines the effectiveness of combined laparoscopic cystectomy and leuprolide acetate therapy on AMH level and AFC profile in endometriosis.Method: This study is a randomized controlled clinical trial with open label form. The subjects were divided into control and therapy groups, with the therapy group receiving leuprolide acetate injection following laparoscopic cystectomy. In both groups, the AMH levels and AFC were examined prior to the surgery and six weeks after before they were compared.Results: There were significant pre-post differences of AMH levels(p = 0.000) and AFC (p = 0.000) in the therapy group but not in the control group. In the therapy group, the mean increases of AMH level and AFC were 0.94 (95% CI: 0.63-1.25) and 9.53 (95% CI: 6.83-12.24), respectively. Linear regression model found that AFC level prior to intervention was a significant predictor of endometriosis ASRM grade (p = 0.001) with an R-value of 0.633, suggesting strong correlation.Conclusion: The combined therapy of laparoscopic cystectomy and leuprolide acetate injection for endometriosis provided better outcome concerning ovarian reserve, as opposed to the therapy with laparoscopic cystectomy alone. Peran Kombinasi Laparoskopi Kistektomi dan Terapi Leuprolide Asetat Terhadap Kadar Hormon Anti-Mullerian dan Profil Jumlah Folikel Antral pada Penderita EndometriosisAbstrakTujuan:Studi ini bertujuan menguji keefektifan kombinasi kistektomi laparoskopi dan terapi leuprolide acetate terhadap kadar AMH dan profil AFC pasien endometriosis.Metode: Penelitian ini merupakan uji klinis terkontrol acak dengan bentuk open label. Subjek dibagi menjadi kelompok kontrol dan terapi, dengan kelompok terapi menerima injeksi leuprolide acetate setelah kistektomi laparoskopi. Pada kedua kelompok, kadar AMH dan AFC diperiksa sebelum pembedahan dan enam minggu setelahnya sebelum kemudian dibandingkan.Hasil: Terdapat perbedaan bermakna kadar AMH (p = 0,000) dan AFC (p = 0,000) sebelum dan sesudah pada kelompok terapi tetapi tidak pada kelompok kontrol. Pada kelompok terapi, rata-rata peningkatan kadar AMH dan AFC adalah masing-masing 0,94 (95% CI: 0,63-1,25) dan 9,53 (95% CI: 6,83-12,24). Model regresi linier menemukan bahwa kadar AFC sebelum intervensi merupakan prediktor signifikan derajat endometriosis sesuai ASRM (p = 0,001) dengan nilai R sebesar 0,633 yang menunjukkan korelasi yang kuat.Kesimpulan: Terapi kombinasi kistektomi laparoskopi dan injeksi leuprolide acetate untuk endometriosis memberikan hasil yang lebih baik terhadap cadangan ovarium, dibandingkan dengan terapi dengan kistektomi laparoskopi saja.Kata kunci: endometriosis; leuprolide acetate; kistektomi; hormon anti-mullerian; jumlah folikel antral
Effectiveness of Vitamin D Therapy on the Lipid Profile of Patients with Polycystic Ovary Syndrome Usman, Fatimah; Abadi, Adnan; Effendi, Kms. Yusuf; Manan, Heriyadi; Andrina, Hana
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.522

Abstract

Polycystic ovary syndrome (PCOS) is characterized by chronic hyperandrogenism and anovulation that is also associated with various clinical and biochemical features. Vitamin D deficiency is a common problem that affects up to half of the adult population worldwide, including patients with PCOS. Based on these considerations, we are interested in further exploring the effectiveness of vitamin D in improving lipid profiles in PCOS.Efektivitas Terapi Vitamin D pada Profil Lipid Penderita Sindrom Ovarium PolikistikAbstrakSindrom Ovarium Polikistik (PCOS) ditandai dengan hiperandrogenisme kronis dan anovulasi yang juga berhubungan dengan berbagai gambaran klinis dan biokimia. Kekurangan vitamin D adalah masalah umum yang mempengaruhi setengah populasi orang dewasa di seluruh dunia, termasuk pasien PCOS. Tinjauan literatur ini dilakukan untuk mencari artikel asli dan review mengenai pertanyaan spesifik mengenai efektivitas terapi vitamin D terhadap profil lipid pasien PCOS.Kata kunci: PCOS, Lipid, Vitamin D
Hubungan Polimorfisme Panjang Pengulangan CAG pada Gen Reseptor Androgen dengan Sindrom Ovarium Polikistik di RSUP dr. Mohammad Hoesin Palembang Silvana, Rista; Wahyu Pranata, Wahyu Pranata; Manan, Heriyadi; Usman, Fatimah; Theodorus, Theodorus; Saleh, Mgs. Irsan
Syifa'Medika Vol 15, No 2 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v15i2.9474

Abstract

Latar Belakang: Sindrom Ovarium Polikistik (SOPK) merupakan suatu kondisi anovulatori umum yang mempengaruhi 6–8% perempuan premenopause. Terdapat hubungan antara panjang pengulangan CAG pada pasien anovulatoar dengan kadar androgen serum rendah. Tujuan: Untuk menginvestigasi polimorfisme CAG pada gen RA pada perempuan dengan SOPK.Metode: Penelitian observasional dengan desain kasus kontrol pada perempuan normal dan SOPK pada November – Desember 2021. Sampel diambil dari sampel darah perifer atau serum perempuan normal (kontrol) dan terdiagnosis SOPK (kasus) di RSMH Palembang. Kemudian, dilakukan pemeriksaan DNA di Biologi Molekuler Fakultas Kedokteran Universitas Sriwijaya Palembang.Hasil: Terdapat 50 wanita SOPK sebagai kasus dan 50 wanita normal sebagai kontrol yang memenuhi kriteria inklusi penelitian. Panjang pengulangan gen CAG-RA yang memiliki sensitivitas dan spesifisitas paling baik adalah pada nilai 22,5 dengan AUC 0,50 (IK95% 0,386–0,616). Sampel dengan panjang pengulangan CAG pada gen RA ? 22,5 memiliki risiko sama besar mengalami SOPK dengan sampel yang memiliki panjang pengulangan CAG pada gen RA < 22,5 (OR = 1,084 (IK95% 0,493–3.384); p  = 1,000). Titik potong kadar testosteron, yaitu 44,64, SHBG sebesar 26,295, dan FTI sebesar 5,73. Terdapat hubungan yang tidak bermakna antara testosteron (OR = 1,625 (IK95% 0,530–4,984);p  = 0,570); SHBG (OR = 1,040 (IK95% 0,339–3,190); p  = 1,000), dan FTI (OR = 1,244  (IK95% 0,402–3,853); p  = 0,927) dan panjang pengulangan CAG pada gen RA.Simpulan: Tidak terdapat hubungan antara panjang pengulangan CAG gen reseptor androgen dan penderita SOPK.
Co-Authors Adnan Abadi, Adnan Andrina, Hana Effendi, Kemas Yusuf Effendi, Kms. Yusuf Hilmawan, Bagus Mgs. Irsan Saleh, Mgs. Irsan Rizani Amran Silvana, Rista Sutrisno, Muhammad Al Farisi Theodorus Theodorus Usman, Fatimah Wahyu Pranata, Wahyu Pranata Yusuf, Kemas Zulqarnain, Iskandar