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All Journal Jurnal Gizi dan Pangan Sari Pediatri Paediatrica Indonesiana Trends in Infection and Global Health
Sudung O. Pardede, Sudung O.
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Delayed growth rate based on bone age in children with idiopathic nephrotic syndrome at a general hospital in Banda Aceh, Indonesia Haris, Syafruddin; Dimiati, Herlina; Hasballah, Kartini; Pardede, Sudung O.
Trends in Infection and Global Health Vol 4, No 2 (2024): December 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i2.42807

Abstract

Paediatric nephrotic syndrome is the most common kidney disease in children, with corticosteroids as the primary treatment. While effective, corticosteroid therapy may decrease bone mineral density. Concurrent vitamin D and calcium supplementation can mitigate bone loss but does not entirely prevent it and may introduce side effects. This study assessed growth delay based on bone age in children with idiopathic nephrotic syndrome receiving long-term steroid therapy at Dr. Zainoel Abidin Public Hospital in Banda Aceh, Indonesia. This observational analytic study used a retrospective cohort design, with data collected from the hospitals Paediatric Polyclinic over one month. Paediatric patients diagnosed with INS who met inclusion criteria were included, and data were extracted from electronic medical records. Statistical analysis was conducted using the Mann-Whitney test. Among the 50 children included, 32 (64%) were male and 18 (36%) were female. The median corticosteroid therapy duration was 24 months (range: 284 months). No significant association was found between corticosteroid therapy duration and growth delay, as measured by BA (p=0.363). INS was more common in boys, particularly in the six to 10-year age group. Most participants had normal nutritional status and stature, with steroid-resistant nephrotic syndrome being the most prevalent type. The findings suggest no relationship between corticosteroid therapy duration and growth delay based on bone age, providing reassurance about the treatments impact on growth outcomes.
An Additional Adequate Water Intake Increases the Amniotic Fluid Index in Pregnant Women with Oligohydramnios: A Systematic Review Rosemiarti, Tria; Siregar, Parlindungan; Hardinsyah, Hardinsyah; Pardede, Sudung O.; Santoso, Budi Iman; Riza, Ras Adiba; Tjahjono, Erinna
Jurnal Gizi dan Pangan Vol. 17 No. 1 (2022)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.281 KB) | DOI: 10.25182/jgp.2022.17.1.47-56

Abstract

This systematic review aimed to answer whether an additional amount of water intake can increase the Amniotic Fluid Index (AFI) in pregnant women with oligohydramnios. Article searches were conducted and data was obtained from “SCOPUS”, “EBSCO”, “PUBMED”, “COCHRANE” and “Google Search” databases using the following keywords: “hypovolemic”, “dehydration” “pregnancy” “outcome”, “hydration”. “water intake”, “oligohydramnios”, and “amniotic fluid index”. We used MeSH headings (hydration pregnancy) for search keyword, Inclusion criteria were subjects who were pregnant women with oligohydramnios (without any pathological disorder in the mother and fetus), the outcomes include AFI of <5 cm, study design was prospective cohorts and clinical trials, consumption of plain water (non-calorie beverages) and language restriction applied for articles published in English. Out of 391 articles, eight articles that met these criteria for anaylsis. Result showed that additional amount of water intake for pregnant women with oligohydramnios without maternal/fetal abnormalities in the third trimester (28−37 weeks) can increase AFI. Oral maternal hydration gave a better effect than intravenous maternal hydration on AFI. The additional amount of water intake per day required by pregnant women with oligohydramnios to increase AFI to normal ranges from 1,500 to 2,500 ml depending on the condition of each pregnant woman. Additional water intake via oral can be a strategy for oligohydramnios therapy in pregnant women.
Risk factors of drug-resistant epilepsy in children under three-year-old Sukmono, Suryawati; Mangunatmadja, Irawan; Pardede, Sudung O.
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.42-7

Abstract

Background Repeated seizures may result in chronic injury to the brain, triggering the neuroplasticity process that can cause or augment existing pathological processes. High neuroplasticity during first 3 year of life may influence the clinical course and outcome of children with epilepsy. Objective To evaluate initial risk factors and evolution risk factors during treatment to predict drug-resistant epilepsy in children under 3 years old. Initial risk factors consist of initial seizure frequency, seizure type, imaging result, history of febrile convulsion, neurodevelopmental status and initial electroencephalography (EEG) result. Evolution risk factors evaluate changes in initial risk factors and seizure control after treatment. Evolution risk factors consist of early response to therapy (seizure control during the first 6 months of treatment), evolution of seizure type and frequency, changes in EEG (background rhythm and epileptiform discharges) during treatment and neurodevelopmental evolution. Methods This retrospective cohort study used medical record data of pediatric patients 1 month to 3 years old with drug-resistant epilepsy seeking treatment at Cipto Mangunkusumo Hospital, Anakku Clinic Pondok Pinang, and National Brain Center Hospital, Jakarta, from 2015 to 2020. Results Thirty-three subjects met drug-resistant epilepsy criteria. Abnormal EEG was the only initial risk factor significantly associated with drug-resistant epilepsy (OR 4.48; 95%CI 1.82 to 11.03; P=0.001). Increased seizure frequency (aOR 7.0; 95%CI 1.0 to 49.7; P=0.048) and seizure persistence during the first six months of treatment (aOR 10.92; 95%CI 2.6 to 45.87; P=0.01) were significantly related with drug-resistant epilepsy. Conclusion Abnormal initial EEG result was the only initial risk factor associated with drug-resistant epilepsy. Evolution risk factors associated with drug-resistant epilepsy were increased seizure frequency and seizure persistence in the first six months of treatment.
Nilai Diagnostik Neutrophil Gelatinase-Associated Lipocalin Urin, Kelainan Urinalisis, dan Kombinasi Keduanya pada Infeksi Saluran Kemih Anak Usia 2–5 Tahun Estetika, Citra; Pardede, Sudung O.; Munasir, Zakiudin; Supriyatno, Bambang; Prawitasari, Titis; Yanuarso, Piprim Basarah
Sari Pediatri Vol 26, No 3 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.3.2024.137-45

Abstract

Latar belakang. Infeksi saluran kemih (ISK) pada anak memiliki manifestasi klinis yang tidak khas sehingga sulit untuk diagnosis dini. Biakan urin memerlukan waktu hingga lima hari sehingga dapat menyebabkan keterlambatan terapi serta tingginya komplikasi ISK. Kelainan urinalisis yang saat ini digunakan masih memiliki spesifisitas yang rendah. Tujuan. Mengetahui nilai diagnostik Neutrophil gelatinase-associated lipocalin (NGAL) urin, kelainan urinalisis, dan kombinasi keduanya untuk mendiagnosis dini ISK pada anak usia 2-5 tahun.Metode. Uji diagnostik menggunakan biakan urin sebagai baku emas dengan desain potong lintang pada anak berusia 2-5 tahun dengan tersangka ISK dan dirawat di Rumah Sakit Dr. Cipto Mangunkusumo.Hasil. Pemeriksaan NGAL urin diketahui memiliki sensitivitas 85,7% (IK95%: 63,6-96,9%), spesifisitas 74,3% (IK95%: 57,8-86,9%), positive predictive value 64,3% (IK95%: 50,6–75,9%), dan negative predictive value 90,6% (IK95%: 76,9-96,5%) pada anak dengan minimal satu kelainan urinalisis. Pemeriksaan NGAL urin hanya meningkatkan spesifisitas kelainan urinalisis berupa leukosituria saja dan tidak meningkatkan spesifisitas pada yang telah memiliki tiga kelainan urinalisis. Kesimpulan. Neutrophil gelatinase-associated lipocalin urin tidak dianjurkan untuk meningkatkan spesifisitas urinalisis dalam diagnosis ISK pada anak usia 2–5 tahun. Gabungan tiga kelainan urinalisis tanpa NGAL urin sudah memiliki spesifisitas yang baik. Perlu dilakukan penelitian biomarker lain untuk mendiagnosis dini ISK dengan lebih baik.
Co-Authors Bambang Supriyatno Budi Iman Santoso Citra Estetika Hardinsyah Herlina Dimiati, Herlina Irawan Mangunatmadja Kartini Hasballah Parlindungan Siregar Piprim Basarah Yanuarso, Piprim Basarah Riza, Ras Adiba Rosemiarti, Tria Sukmono, Suryawati Syafruddin Haris, Syafruddin Titis Prawitasari, Titis Tjahjono, Erinna Zakiudin Munasir