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All Journal Medical Journal of Indonesia Sari Pediatri Paediatrica Indonesiana eJournal Kedokteran Indonesia
Wirahmadi, Angga
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia Rumah Sakit Cipto Mangunkusumo
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Growth and developmental delay risk factors among under-five children in an inner-city slum area Hartono Gunardi; Resyana P. Nugraheni; Annisa R. Yulman; Soedjatmiko Soedjatmiko; Rini Sekartini; Bernie E. Medise; Angga Wirahmadi; Elizabeth Melina
Paediatrica Indonesiana Vol 59 No 5 (2019): September 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.872 KB) | DOI: 10.14238/pi59.5.2019.276-83

Abstract

Background Growth and developmental delays are common among children under the age of five years (under-five children), especially in slum areas. Early detection and intervention may give better prognoses. Objective To detect growth and developmental delays and related risk factors among under-five children living in an inner-city slum area of the Indonesian capital. Methods This cross-sectional study was conducted from October to November 2018 in Tanah Tinggi, Johar Baru District, an inner-city slum area in Central Jakarta. Subjects were healthy children aged 3–60 months. Socioeconomic profile was obtained through questionnaires, anthropometric data through measurements, and developmental status through the Kuesioner Pra Skrining Perkembangan (KPSP) instrument. Development was considered to be delayed for KPSP scores <9. Data were analyzed using Chi-square test. Results Of 211 subjects, prevalence of underweight, stunting, and wasting were 35.1%, 28.0%, and 20.9%, respectively, meanwhile low maternal education, and low family income were 57.9% and 75%. The prevalence of developmental delay was 10%, while suspected developmental delay was 26.1%. The prevalence increased from age 21 months and peaked at 36 months. Associated risk factors were low maternal education, low family income, underweight weight-for-age, stunted height-for-age, and microcephalic head circumference-for-age. Conclusion Low education and low income were significant risk factors for growth and developmental delay.
Pengetahuan dan Kepatuhan Remaja Terhadap Implementasi Protokol Kesehatan pada Tahun Kedua Pandemi COVID-19 Bernie Endyarni Medise; Sreshta Mukhi; Angga Wirahmadi; Hartono Gunardi; Soedjatmiko Soedjatmiko
Sari Pediatri Vol 24, No 6 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp24.6.2023.370-6

Abstract

Latar belakang. Kasus pertama pasien COVID-19 di Indonesia dilaporkan pada bulan Maret 2020. Pemerintah memberlakukan Pembatasan Sosial Berskala Besar termasuk penutupan sekolah tatap muka serta mengeluarkan protokol kesehatan untuk diterapkan oleh masyarakat. Pandemi menyebabkan perubahan besar dalam tatanan kehidupan, kebiasaan dan pola hidup remaja. Tujuan. Penelitian ini ingin melihat pengetahuan dan kepatuhan remaja terhadap implementasi protokol kesehatan pada tahun ke dua pandemi COVID-19.Metode. Penelitian ini menggunakan metode potong lintang menggunakan kuesioner yang diisi secara daring dan dilakukan pada tahun ke dua pandemi COVID-19 dari bulan April hingga Juli 2021. Subjek merupakan remaja usia 10-18 tahun di DKI Jakarta. Pemilihan sekolah dilakukan secara cluster sampling. Hasil. Sebanyak 406 responden dari 20 sekolah mengikuti penelitian. Hanya sekitar 5,42% responden yang menjawab dengan benar cara transmisi SARS-CoV-2 dan hanya 43,84% responden yang menjawab dengan tepat 6 langkah cuci tangan. Sebanyak 45,81% responden memiliki nilai total pengetahuan yang baik (nilai >7). Terdapat tren yang menunjukkan persentase remaja yang mendapatkan skor pengetahuan di atas tujuh lebih banyak pada kelompok remaja dengan nilai kepatuhan yang lebih tinggi.Kesimpulan. Pada tahun ke dua pandemi COVID-19 masih banyak remaja yang kurang pengetahuannya mengenai COVID-19 dan belum menerapkan protokol kesehatan dengan baik.
Evaluation of Safety and Anti-RBD IgG Sars Cov-2 after Indovac Administration in Depok Kuntjoro Harimurti; Harningtyas Jasmin; Rini Sekartini; Muhammad Aini; Irene Yuniar; Wahyuni Indawati; Angga Wirahmadi
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.393.118-25

Abstract

The WHO declared the COVID-19 pandemic on March 11, 2020, then several centres developed Covid-19 vaccines. The Indovac vaccine contains SARS-CoV-2 RBD antigen adjuvanted with Alum and CpG1018. This article reported Jakarta Centre Phase 1 trial results of the safety and immunogenicity of Indovac in Kota Depok. This study is a randomised, observer-blinded, active-control (Sinovac) clinical trial. The study included 175 healthy adults aged 18–70 and 75 participants were enrolled by the Jakarta centre. Two vaccine doses were given 28 days apart. Four vaccine formulas were tested. Safety evaluations included solicited and unsolicited adverse events (AE) up to 28 days post-injection. SARS-CoV-2 anti-RBD IgG was tested before, 14, and 28 days after second injection to determine immunogenicity. Most solicited AEs were injection site pain. Local pain was highest in the RLCL group after the first dose (38.62%) and RHCH after the second dose (23.08%). 13.33% and 6.67% of control group subjects experienced local pain after the first and second injections, respectively. RHCL has the highest seroconversion (100%) after two injections. Anti-RBD IgG responses increased (p<0.005) in all groups and plateaued 28 days after the second dose injection. In conclusion, Indovac was safe and immunogenic in Jakarta.
Mental health problems in children with chronic disease at the pediatric inpatient ward of Dr. Cipto Mangunkusumo Hospital Wangke, Lydia; Medise, Bernie Endyarni; Wirahmadi, Angga; Sekartini, Rini; Gunardi, Hartono; Soedjatmiko, Soedjatmiko
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.37-41

Abstract

Background Since the survival of a patient with chronic physical illness has improved, major concerns arise about their quality of life and functioning. Childhood and adolescence are critical periods for promoting mental health because more than half of mental health problems begin at this stage, and many of those mental health problems will persist into adult life. Objective To analyze the risk of mental health problems among children hospitalized with chronic disease. Method An analytic observational study with a cross-sectional design was conducted using secondary data of 754 children aged 4-18 years admitted to the pediatric inpatient ward of Cipto Mangunkusumo Hospital, Jakarta between June 2021 and August 2022. We collected the results of subjects’ mental health screening conducted by the Growth, Development, and Social Pediatrics Division, Department of Child Health, Cipto Mangunkusumo Hospital during the subjects’ admission. Mental health problems evaluated in this study included psychosocial dysfunction screened using the Pediatric Symptom Checklist 17 (PSC-17) and depression screened using the Children’s Depression Inventory (CDI). Results Of the 754 subjects included, 520 (69.0%) were classified as having a chronic disease. The prevalence of psychosocial dysfunction and depression in children with chronic diseases was 19.6% and 6.3%, respectively. Gender, nutritional status, and height had no significant association with psychosocial dysfunction and depression in children. Children with chronic disease were more likely to develop psychosocial dysfunction (OR 2.13; 95%CI 1.31 to 3.59; P<0.001) and depression (OR 2.57; 95%CI 1.04 to 7.62; P<0.03) compared with those who did not have chronic disease. Conclusion Children with chronic disease were more likely to develop psychosocial dysfunction and depression compared to those without a chronic disease. These results highlight the importance of mental health support in pediatric patients with chronic disease.
Safety and immunogenicity of the CoV2-Bio in a healthy population aged 18 years and older in Indonesia Maria, Suzy; Olfriani, Ciho; Koesnoe, Sukamto; Sekartini, Rini; Soedjatmiko; Medise, Bernie Endyarni; Yuniar, Irene; Indawati, Wahyuni; Wirahmadi, Angga; Sari, Rini Mulia; Adi, Nuri Purwito; Retnaningdyah, Windri
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247476

Abstract

BACKGROUND According to the WHO Target Product Profiles for COVID-19 Vaccines, vaccine development should be indicated for active immunization in all populations, in conjunction with other control measures to curtail the pandemic. Several RBD-based COVID-19 vaccines are being evaluated and have shown advantages. CoV2-Bio was developed based on the wild-type SARS-CoV-2 RBD amino acid sequence, representing residues of the spike protein of the Wuhan-Hu-1 isolate. This study aimed to evaluate the safety and immunogenicity of CoV2-Bio when compared to CoronaVac. METHODS This was an observer-blinded, randomized controlled prospective study of safety and immunogenicity of the CoV2-Bio in healthy adult population. A total of 54 healthy participants were randomized to receive either 3 doses of CoV2-Bio or 2 doses of CoronaVac, and 1 dose of placebo, administered 28 days apart. Participants were followed up for safety and immunogenicity. IgG antibody titers (ELISA) and neutralization assay against Wuhan and Delta strains were evaluated at baseline, Days 28, 56, and 84. We assessed seropositive rate, seroconversion, and GMT as parameters. RESULTS Both vaccines were well tolerated and induced good antibody response. The incidence rate and intensity of local and systemic adverse events did not differ between vaccine and control groups. The vaccine group showed a larger proportion of seroconversion (4-fold increase antibody) (87.5% versus 46.2%, p = 0.001) and higher GMT (305.9 AU/ml versus 102.4 AU/ml, p<0.001) when compared to control group. CONCLUSIONS 3 doses of the CoV2-Bio are safe and immunogenic in healthy adult population. 3 doses of the CoV2-Bio COVID-19 vaccine produce a better immunogenicity profile compared to CoronaVac.
Parental knowledge, attitude, and practice towards COVID-19 vaccination for children aged 6 to 11 years Ufairah, Kamilia Rifani; Gunardi, Hartono; Araysi, Leo Alfath; Saharso, Ersal Rasyid; Wirahmadi, Angga; Jasin, Madeleine Ramdhani
Paediatrica Indonesiana Vol. 65 No. 3 (2025): May 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.3.2025.197-206

Abstract

Background The COVID-19 pandemic significantly impacted the well-being of both adults and children, leading to a high number of cases and fatalities among the younger population. Acknowledging the effectiveness of vaccination in preventing COVID-19, parents have shown keen interest in the vaccination campaign for children aged 6 to 11 years. Objective To evaluate parents’ knowledge, attitude, and practices towards COVID-19 vaccination for children aged 6 to 11 years. Methods This descriptive, cross-sectional study included 262 parents of children aged 6 to 11 years, conducted via an online self-reported survey from February to May 2023. Parents' knowledge, attitudes, and practices towards COVID-19 vaccination were assessed using a questionnaire with 14 true/false knowledge items (maximum score: 14), a 10-item Likert scale for attitudes (maximum score: 50), and nine practice questions (maximum score: 9). Results Good knowledge was shown by 30.2% of participants, while good attitude was demonstrated by only 15.6%. The majority of participants demonstrated good practice at 62.2%. Most participants had a moderate level of knowledge and attitude, at 46.2% and 76.3%, respectively. Knowledge was moderately correlated with practice (r=0.333; P=0.001), as was attitude and practice (r=0.432; P=0.001). Good knowledge was significantly associated with higher income (OR 2.2; 95%CI 1.08 to 4.61; P=0.03) and higher education (OR 3.2; 95%CI 1.47 to 7.07; P=0.003). Conclusion The majority of participants demonstrated good practice, while their knowledge and attitude levels were moderate. Education emerged as a significant factor influencing good knowledge.
Co-Authors Annisa R. Yulman Araysi, Leo Alfath Bernie E. Medise Bernie Endyarni Medise Elizabeth Melina Harningtyas Jasmin Hartono Gunardi Hartono Gunardi Hartono Gunardi Irene Yuniar, Irene Jasin, Madeleine Ramdhani Kuntjoro Harimurti Maria, Suzy Muhammad Aini Nuri Purwito Adi Olfriani, Ciho Resyana P. Nugraheni Retnaningdyah, Windri Rini Mulia Sari Rini Sekartini Rini Sekartini Rini Sekartini Saharso, Ersal Rasyid Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Sreshta Mukhi Sukamto Koesnoe Ufairah, Kamilia Rifani Wahyuni Indawati Wahyuni Indawati, Wahyuni Wangke, Lydia