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All Journal Sari Pediatri Paediatrica Indonesiana Jurnal Respirologi Indonesia
Jasin, Madeleine Ramdhani
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia/ Rumah Sakit Dr. Cipto Mangunkusumo
Health Professions Medicine & Pharmacology

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Efficacy of sputum induction from lower respiratory tract in children Madeleine Ramdhani Jasin; Darmawan Budi Setyanto; Sri Rezeki Hadinegoro; Lisnawati Lisnawati; Pramita Gayatri; Nia Kurniati
Paediatrica Indonesiana Vol 55 No 2 (2015): March 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.119 KB) | DOI: 10.14238/pi55.2.2015.101-8

Abstract

Background Although sputum is a good specimen for variousexaminations, such as cytology and microbiological culture,sputum induction (SI) is not a routine procedure in children.Objective To identify the efficacy of SI to obtain specimen fromlower respiratory tract in children, identify side effects of SI, andthe results of microbiological examination.Methods A cross sectional study was performed in children (aged1 month to 18 years) who underwent SI. Sputum induction wasperformed by inhalation with hypertonic solution, consisted ofsalbutamol for 15 minutes continued with NaCl 3% solutionfor another 15 minutes. Sputum specimens were examined fornumber of alveolar macrophage cell, surfactant protein A (SP-A)concentration, also acid-fast bacili smear, and M. tuberculosisculture, or aerobic microbial culture.Results Forty subjects with lower respiratory tract infectionparticipated in this study, and SI was succesfully performed inall subjects. Youngest subject was 2 month old, the eldest was 16year 7 month old. Median duration of SI was 45 minutes, andmajority of volume was 3 or 4 mL. Side effects were nosebleeds(40%) and vomiting (2.5%). Macrophage alveolar more than 5cells in one specimen was found in 97.5% subjects. Surfactantprotein A examination was performed in 30 specimens, and SP-Awas detected in all specimens (median concentration 264.528 pg/mL). Culture for M. tuberculosis was positive in 1 of 27 subjects,while acid fast bacili smear was negative in all examined subjects.Aerobic microbial culture was positive in 5 of 13 subjects.Conclusions Sputum induction has good efficacy in obtaininglower respiratory tract specimen and it is safe to perform inchildren. Specimen from sputum induction yields good positiveresult for aerobic microbial cultures.
Infeksi Tuberkulosis Laten pada Anak: Diagnosis dan Tatalaksana Nastiti Kaswandani; Madeleine Ramdhani Jasin; Gufron Nugroho
Sari Pediatri Vol 24, No 2 (2022)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp24.2.2022.134-40

Abstract

Infeksi laten tuberkulosis (ILTB) adalah keadaan respons imun persisten terhadap antigen Mycobacterium tuberculosis tanpa bukti manifestasi klinis tuberkulosis aktif. Anak-anak lebih mudah terinfeksi dan menjadi penderita tuberkulosis (TB) aktif dibandingkan orang dewasa setelah kontak erat dengan pasien TB aktif. Masa inkubasi TB bervariasi selama 2-12 minggu, biasanya 4-8 minggu. Investigasi kontak dan penegakan diagnosis ILTB harus dilakukan pada anak yang memiliki risiko tinggi terinfeksi, yaitu memiliki kontak erat dengan penderita TB aktif, dengan HIV, serta dengan kondisi imunokompromais lainnya. Pengobatan pencegahan ILTB bertujuan mencegah anak yang terinfeksi M.tuberculosis berkembang menjadi tuberkulosis aktif. Pedoman WHO yang kemudian diadopsi oleh Petunjuk Teknis Penanganan Infeksi Laten Tuberkulosis Kementerian Kesehatan Republik Indonesia tahun 2020 memberikan rekomendasi pemberian terapi pencegahan tuberkulosis yang terdiri dari beberapa pilihan obat dan durasi pemberian, antara lain isoniazid selama 6 bulan, isoniazid – rifampisin selama 3 bulan, isoniazid -  rifapentin sekali sepekan dalam 3 bulan, atau rifampisin selama 4 bulan. Diagnosis dini dan pemberian terapi pencegahan yang cepat penting untuk menurunkan kejadian TB aktif sehingga visi pemberantasan TB dunia pada tahun 2050 bisa tercapai.
Nebulisasi Salin Hipertonik pada Anak dengan Bronkiolitis Madeleine Ramdhani Jasin; Citra Estetika
Sari Pediatri Vol 25, No 2 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.2.2023.123-9

Abstract

Latar belakang. Bronkiolitis sering tering terjadi pada anak hingga usia dua tahun, dengan penyebab terbanyak adalah respiratory syncytial virus (RSV). Terapi bronkiolitis bersifat suportif, namun beberapa terapi tambahan lain sering digunakan walaupun laporan mengenai efektivitas masih kontroversial, salah satunya adalah pemberian nebulisasi salin hipertonik.Tujuan. Menelaah lebih lanjut manfaat klinik nebulisasi salin hipertonik pada anak dengan bronkiolitis.Metode. Penelusuran pustaka database elektronik, yaitu Pubmed dan Cochrane dengan kata kunci bronchiolitis, child atau infant, hypertonic, saline atau NaCl, nebulization atau nebulized atau inhalation, dan length of stay atau LOS atau length of hospitalization.Hasil. Terpilih tiga artikel untuk telaah kritis. Meta-analisis oleh Yu dkk mendapatkan hasil nebulisasi salin hipertonik lebih superior dari isotonik dalam menurunkan lama perawatan (mean difference MD:-0,6 hari), perbaikan skor keparahan penyakit (MD:-0,79), angka perawatan (odd ratio OR:0,74), dan distres napas (MD:-0,6). Hasil serupa juga diperoleh oleh studi Bashir dkk mengenai lama rawat, walaupun studi Alatwani dkk mendapatkan hasil yang berbeda. Kesimpulan. Nebulisasi salin hipertonik dapat mengurangi lama perawatan rumah sakit serta skor tingkat keparahan pada anak dengan bronkiolitis. Namun, belum banyak bukti mengenai manfaat dan risiko nebulisasi salin hipertonik pada kasus bronkiolitis berat.
Co-Infection of Tuberculosis and COVID-19 in Children: A Case Report Madeleine Ramdhani Jasin; Talitha Rahma Ayuningtyas; Achmad Rafli; Irawan Mangunatmadja; Wahyuni Indawati; Nastiti Kaswandani
Jurnal Respirologi Indonesia Vol 44, No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.323

Abstract

Background: Coinfection of TB and COVID-19 might occur, yet few evidence has been reported. Current COVID-19 pandemic also results in disruption at TB management in the community.Case: A 5-month-old boy came with recurrent seizure, with history of persistent cough and fever for 1 month prior, also positive possible TB contact. He was diagnosed with disseminated TB, involving miliary appearance in chest Xray also meningitis, coinfected with COVID-19.Discussion: During COVID-19 pandemic, TB service in the community is disrupted, resulting in delay in TB diagnosis, as observed in this patient, leading to severe manifestation. Coinfection of TB and COVID-19 can occur and may lead to more severe symptoms in either both diseases. Management of TB COVID-19 coinfected children is similar to those without COVID-19. Our patient received treatment consisting of 2 RHZE then 10 RH. Monitoring of symptoms and possible sequelae is necessary.Conclusion: Coinfection TB and COVID-19 may occur in children, and both can lead to more severe manifestation of each condition, particularly if diagnosis is delayed. Strengthening TB care in the community is essential so that there will be no delay in diagnosis, also no disruption in treatment and monitoring.
Scrofuloderma in a 1-year-old girl with severe malnutrition: a case report Jasin, Madeleine Ramdhani; Neldy, Fahreza Aditya; Setyanto, Darmawan Budi; Nugroho, Gufron; Sunhaji, Valerie; Ham, Maria Francisca
Paediatrica Indonesiana Vol. 63 No. 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.511-6

Abstract

Tuberculosis (TB) remains a global burden and a leading cause of mortality due to infectious diseases worldwide. In 2020, 845,000 new TB cases (312 per 100,000 population) were diagnosed, with 96,000 deaths, including 4,700 deaths of TB with HIV. Tuberculosis typically affects the lungs, but it can also affect other organs, a condition termed extrapulmonary TB. In 2020, 16% of all TB cases had extrapulmonary manifestations.1 The first case of TB affecting the skin was reported in 1826.2,3 There are many types of cutaneous TB; one of the most common is scrofuloderma, more often found in children and young adults.4 Scrofuloderma starts with a lesion in a lymph node, bone, muscle, or tendon that spreads to the skin.5 The lesion progresses very slowly and is usually not painful. Therefore, many patients wait to seek treatment until an advanced stage, leading to poor prognosis.3 In this report, we present a case of a severely malnourished one-year-old girl with scrofuloderma.
Co-Infection of Tuberculosis and COVID-19 in Children: A Case Report Jasin, Madeleine Ramdhani; Ayuningtyas, Talitha Rahma; Rafli, Achmad; Mangunatmadja, Irawan; Indawati, Wahyuni; Kaswandani, Nastiti
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.323

Abstract

Background:Coinfection TB and COVID-19 might occur, yet few evidence has been reported. Current COVID-19 pandemic also results in disruption at TB management in the community. Case: A 5-month-old boy came with recurrent seizure, with history of persistent cough and fever for 1 month prior, also positive possible TB contact. The diagnosis was disseminated TB (miliary and meningitis), coinfected with COVID-19.Discussion: During COVID-19 pandemic, TB service in the community is disrupted resulting in delay in TB diagnosis, as observed in this patient, leading to severe manifestation. Coinfection of TB and COVID-19 can occur and may lead to more severe symptoms in either both diseases. Management of TB COVID-19 coinfected children is similar to those without COVID-19. Our patient received treatment consisting of 2 RHZE then 10 RH. Monitoring of symptoms and possible sequelae is necessary.Conclusion: Coinfection TB and COVID-19 may occur in children, and both can lead to more severe manifestation of each condition, particularly if diagnosis is delayed. Strengthening TB care in the community is essential so that there will be no delay in diagnosis, also no disruption in treatment and monitoring.Keywords COVID-19, tuberculosis, coinfection, children
Co-Authors Araysi, Leo Alfath Ayuningtyas, Talitha Rahma Citra Estetika Gufron Nugroho Ham, Maria Francisca Hartono Gunardi Irawan Mangunatmadja Irawan Mangunatmadja Lisnawati Lisnawati Nastiti Kaswandani Neldy, Fahreza Aditya Nia Kurniati Nugroho, Gufron Pramita Gayatri Rafli, Achmad Saharso, Ersal Rasyid Setyanto, Darmawan Budi Sri Rezeki Hadinegoro Sunhaji, Valerie Talitha Rahma Ayuningtyas Ufairah, Kamilia Rifani Wahyuni Indawati Wahyuni Indawati, Wahyuni Wirahmadi, Angga