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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL FARMASIMED (JFM) Jurnal Buana Farma Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
ELVIE RIFKE RINDENGAN, ELVIE RIFKE
Poltekkes Kemenkes Manado
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Isolation And Characterization of Physicochemical Properties of Mucilago Gedi Leaf (Abelmoschus manihot L. Medik) Rindengan, Elvie Rifke; Abdassah, Marline; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.952 KB) | DOI: 10.15416/ijpst.v5i3.16744

Abstract

The aim of this research was to isolation of mucilage from gedi leaf (Abelmoschus manihot L. Medik) and characterized physicochemical properties. The isolation result was yellowish brown powder that swelling and dissolves slowly in water, but does not dissolve in ethanol, methanol, acetone and ether. The yield is 1.33%. Swelling index value 100% and viscosity 28 ± 2.65 mpas, pH 7.1. Proximate analysis showed 10.46% water content, 38.80% ash, 14.66% protein, 0.69% fat, 35.38% carbohydrate Water holding capacity (WHC) and  oil holding capacity (OHC) of musilago are respectively 4.23 ± 0.18 and 0.65 ± 0.14. Viscosity, Swelling index, WHC and OHC mucilage gedi leaf  may be considered as pharmaceutical excipients.Keywords: Mucilage, Abelmoschus manihot, swelling, viscosity
MUCILAGO OKRA : Variasi Ekstraksi Dan Potensinya Sebagai Eksipien Multifungsi Elvie Rifke Rindengan; Marline Abdassah; Anis Yohana Chaerunisaa
Farmaka Vol 15, No 2 (2017): Farmaka
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (428.086 KB) | DOI: 10.24198/jf.v15i2.12583

Abstract

Pembuatan bentuk sediaan farmasi memerlukan eksipien. Eksipien yang digunakan dalam suatu formula obat berasal dari bahan alam atau sintesis. Buah Okra (Abelmoschus esculentus) mempunyai kandungan mucilago yang dapat diperoleh melalui proses ekstrasi. Mucilago yang berasal dari tanaman dalam berbagai penelitian memiliki fungsi sebagai eksipien farmasi. Mucilago Okra dapat dimanfaatkan sebagai pengemulsi, pensuspensi, pengikat tablet, matrix tablet dalam pembuatan tablet lepas lambat.
Isolation And Characterization of Physicochemical Properties of Mucilago Gedi Leaf (Abelmoschus manihot L. Medik) Elvie Rifke Rindengan; Marline Abdassah; Anis Yohana Chaerunisaa
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.952 KB) | DOI: 10.24198/ijpst.v5i3.16744

Abstract

The aim of this research was to isolation of mucilage from gedi leaf (Abelmoschus manihot L. Medik) and characterized physicochemical properties. The isolation result was yellowish brown powder that swelling and dissolves slowly in water, but does not dissolve in ethanol, methanol, acetone and ether. The yield is 1.33%. Swelling index value 100% and viscosity 28 ± 2.65 mpas, pH 7.1. Proximate analysis showed 10.46% water content, 38.80% ash, 14.66% protein, 0.69% fat, 35.38% carbohydrate Water holding capacity (WHC) and  oil holding capacity (OHC) of musilago are respectively 4.23 ± 0.18 and 0.65 ± 0.14. Viscosity, Swelling index, WHC and OHC mucilage gedi leaf  may be considered as pharmaceutical excipients.Keywords: Mucilage, Abelmoschus manihot, swelling, viscosity
Pemberdayaan Masyarakat Melalui Pelatihan Pembuatan Sabun Berbahan Minyak Kelapa Produk Lokal Di Desa Utaurano Kec. Tabukan Utara, Kab. Kepulauan Sangihe Elisabeth Natalia Barung; Elvie Rifke Rindengan; Djois Sugiaty Rintjap; Donald Emilio Kalonio
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 6, No 4 (2023): Volume 6 No 4 April 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v6i4.8518

Abstract

ABSTRAK Masyarakat Desa Utaurano menghasilkan produk usaha mikro berupa minyak kelapa. Proses pembuatan minyak kelapa secara tradisional menghasilkan produk sampingan berupa ampas kelapa dengan nilai ekonomis rendah. Oleh karena itu perlu upaya untuk memanfaatkan sumber daya lokal. Kegiatan PkM ini bertujuan untuk meningkatkan pengetahun dan keterampilan masyarakat dalam menfaatkan sumber daya lokal untuk pembuatan sabun berbahan minyak dan ampas kelapa serta tata cara perijinan produksi dan pemasaran kosmetik produk usaha mikro. Solusi pemecahan permasalahan yang ditawarkan adalah participatory approach dengan metode penyuluhan dan pelatihan. Indikator target capaian dari kegiatan ini adalah peningkatan pengetahuan dan keterampilan masyarakat serta tersedianya produk sabun homemade. Hasil kegiatan ini bahwa melalui kegiatan pelatihan dapat meningkatkan pengetahun dan keterampilan masyarakat Desa Utaurano dalam menfaatkan sumber daya lokal untuk pembuatan sabun berbahan minyak dan ampas kelapa serta tata cara perijinan produksi dan pemasaran kosmetik produk usaha mikro. Kata Kunci: Sabun Dari Minyak dan Ampas Kelapa, Pelatihan, Sumber Daya Lokal, Desa Utaurano  ABSTRACT The Utaurano Village community produced coconut oil from micro-enterprise products. Coconut oil which was produced traditionally produces a by-product of coconut dregs with low economic value. Therefore it was necessary to make efforts to utilize local resources. This community service activity was aimed to increase the knowledge and skills of the community in utilizing local resources for the production of handmade soap made from oil and coconut dregs as well as procedures for licensing and marketing of cosmetics for micro-enterprise products. The problem-solving offered was a participatory approach with counselling and training methods. The target achievement indicators for this activity were increased community knowledge and skills as well as the availability of homemade soap products. The results of this activity are that through training, the knowledge and skills of the people of Utaurano Village could be increased in utilizing local resources for the production of soap made from oil and coconut dregs as well as procedures for license and marketing of cosmetics for micro-enterprise products   Keywords: Soap From Coconut Oil and Coconut Dregs, Training, Local Resources, Utaurano Village
EVALUASI TANAMAN DENGAN AKTIVITAS ANTIINFLAMASI YANG DIGUNAKAN MASYARAKAT KEPULAUAN SANGIHE DENGAN METODE STABILISASI MEMBRAN ERITROSIT: EVALUATION OF PLANTS WITH THE ANTI-INFLAMMATORY ACTIVITY USED BY THE SANGIHE ISLANDS COMMUNITY USING THE ERYTHROCYTE MEMBRANE STABILIZATION METHOD Donald Emilio Kalonio; Elvie Rifke Rindengan; Elisabeth Natalia Barung; Djois Sugiaty Rintjap
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.592

Abstract

Keanekaragaman flora dan fauna endemik serta kearifan lokal masyarakat Kepulauan Sangihe dalam pemanfaatan tanaman untuk pengobatan, khususnya sebagai antiinflamasi dapat dijadikan dasar penemuan dan pengembangan obat baru. Akan tetapi, untuk menyediakan bukti ilmiah, perlu dilakukan uji farmakologi untuk mengetahui mekanisme kerjanya. Penelitian bertujuan untuk mengevaluasi aktivitas antiinflamasi tanaman yang digunakan oleh masyarakat Kepulauan Sangihe dengan metode stabilisasi membran eritrosit. Metode penelitian yang digunakan adalah survei eksploratif dan eksperimen. Penelitian dilakukan di wilayah Kepulauan Sangihe. Informan pada penelitian ini adalah pengobat tradisional atau sesepuh masyarakat yang menggunakan tanaman sebagai antiinflamasi. Data yang diperoleh adalah persentasi aktivitas stabilisasi membran dianalisis menggunakan regresi linear untuk menentukan nilai IC50. Hasil penelitian menunjukkan bahwa terdapat sembilan tanaman obat yang dimanfaatkan secara tradisional sebagai antiinflamasi oleh masyarakat Kepulauan Sangihe. Tanaman tersebut adalah daun Limpa Dalreng, kulit batang Nonang, daun Bunalre, daun Duku Bunalre, duri Pasa, daun Bakeng, herba Malrunto dan herba Dumarela memperlihatkan aktivitas antiinflamasi yang diduga melalui mekanisme stabilisasi membran eritrosit dari hemolisis yang diinduksi panas, sedangkan kulit batang Pempararaeng bukan melalui melalui mekanisme tersebut.   Kata kunci : Tanaman dengan aktivitas antiinflamasi, Kepulauan Sangihe, stabilisasi membran eritrosit
EVALUASI TANAMAN DENGAN AKTIVITAS ANTIINFLAMASI YANG DIGUNAKAN MASYARAKAT KEPULAUAN SANGIHE DENGAN METODE STABILISASI MEMBRAN ERITROSIT: EVALUATION OF PLANTS WITH THE ANTI-INFLAMMATORY ACTIVITY USED BY THE SANGIHE ISLANDS COMMUNITY USING THE ERYTHROCYTE MEMBRANE STABILIZATION METHOD Donald Emilio Kalonio; Elvie Rifke Rindengan; Elisabeth Natalia Barung; Djois Sugiaty Rintjap
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.592

Abstract

Keanekaragaman flora dan fauna endemik serta kearifan lokal masyarakat Kepulauan Sangihe dalam pemanfaatan tanaman untuk pengobatan, khususnya sebagai antiinflamasi dapat dijadikan dasar penemuan dan pengembangan obat baru. Akan tetapi, untuk menyediakan bukti ilmiah, perlu dilakukan uji farmakologi untuk mengetahui mekanisme kerjanya. Penelitian bertujuan untuk mengevaluasi aktivitas antiinflamasi tanaman yang digunakan oleh masyarakat Kepulauan Sangihe dengan metode stabilisasi membran eritrosit. Metode penelitian yang digunakan adalah survei eksploratif dan eksperimen. Penelitian dilakukan di wilayah Kepulauan Sangihe. Informan pada penelitian ini adalah pengobat tradisional atau sesepuh masyarakat yang menggunakan tanaman sebagai antiinflamasi. Data yang diperoleh adalah persentasi aktivitas stabilisasi membran dianalisis menggunakan regresi linear untuk menentukan nilai IC50. Hasil penelitian menunjukkan bahwa terdapat sembilan tanaman obat yang dimanfaatkan secara tradisional sebagai antiinflamasi oleh masyarakat Kepulauan Sangihe. Tanaman tersebut adalah daun Limpa Dalreng, kulit batang Nonang, daun Bunalre, daun Duku Bunalre, duri Pasa, daun Bakeng, herba Malrunto dan herba Dumarela memperlihatkan aktivitas antiinflamasi yang diduga melalui mekanisme stabilisasi membran eritrosit dari hemolisis yang diinduksi panas, sedangkan kulit batang Pempararaeng bukan melalui melalui mekanisme tersebut.   Kata kunci : Tanaman dengan aktivitas antiinflamasi, Kepulauan Sangihe, stabilisasi membran eritrosit
Comparison of Different Extraction Methods on Sorghum Seeds (Shorgum bicolor (L). Moench) on Extract Yield and Secondary Metabolite Compound Levels Maramis, Rilyn Novita; Nahor, Evelina Maria; Rindengan, Elvie Rifke
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2592

Abstract

Sorghum, as a potential crop, has been promoted by the government as a national food source. Sorghum contains primary metabolites such as carbohydrates, proteins, and high fiber, as well as secondary metabolites including alkaloids, tannins and phenols, steroids, and terpenoids. The secondary metabolites produced and the yield obtained depend on the extraction method used. This study aimed to determine the yield and concentration of sorghum seed extract obtained through cold extraction (Percolation) and hot extraction (Reflux). Sorghum seed extract was obtained using cold (Percolation) and hot (Reflux) extraction methods with 96% ethanol as the solvent. The resulting yield was then calculated, followed by identification and quantification using UV-Vis spectrophotometry. The results show that the cold extraction (Percolation) method produced a yield of 3,733%, while the hot extraction (Reflux) method produced a yield of 10,133%. The identification of secondary metabolites in sorghum seed extracts from both cold (Percolation) and hot (Reflux) extraction methods reveals the presence of saponins, flavonoids, tannins, and terpenoids, but no alkaloids or steroids. The percolation method yields a total saponin content from Quillaja bark of 0,94% w/w, a total flavonoid content equivalent to quercetin of 0,84% w/w, and a total tannin content equivalent to tannic acid of 0,45% w/w. Meanwhile, the reflux extraction method yields a total saponin content from Quillaja bark of 1,07% w/w, a total flavonoid content equivalent to quercetin of 0,0615 %b/b, and a total tannin content equivalent to tannic acid of 19,44% w/w.
Pelatihan Pengolahan Limbah Ampas Kelapa menjadi Tepung Kelapa sebagai Alternatif Pengganti Tepung Terigu dalam Pembuatan Kue di Desa Utaurano Kabupaten Kepulauan Sangihe: Training on Processing Coconut Waste into Coconut Flour as an Alternative to Substitute Wheat Flour in Making Cookies in Utaurano Village, Sangihe Islands Regency Banne, Yos; Dumanauw, Jovie Mien; Maramis, Rilyn Novita; Rindengan, Elvie Rifke; Ulaen, Selfie Petronela Joice; Nahor, Evelina Maria; Gurning, Sri Handayani
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 5 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i5.8677

Abstract

Coconut flour is obtained from the processing of coconut waste and can be used as a substitute for wheat flour or as additional flour in making bread and cakes. Coconut flour has the advantages of a fairly high protein content, being gluten-free, low digestible carbohydrate content, and higher fiber (cellulose) content compared to other types of flour. Hence, it is very suitable for people who are hypersensitive to gluten or for those who are on a diet. This activity aimed to train the community on processing coconut pulp into coconut flour and its use in making cookies. Utaurano Village in Sangihe Islands Regency is known as one of the centers for making coconut oil. Coconut waste has so far only been thrown away or used as a mixture of animal feed. Community service activities by lecturers and students of the Pharmacy Department of the Manado Ministry of Health Polytechnic include training in processing coconut pulp into coconut flour and its use for making cookies. The implementation of the activity was carried out in several stages, namely preparation, implementation, and evaluation. The results showed that in Utaurano village in Sangihe Islands Regency, coconut waste was produced from the VCO manufacturing process by local UMKM. The waste can be processed into coconut flour and used as a substitute for wheat flour for making cookies. The evaluation results show that counseling and training activities can increase knowledge and skills to utilize coconut waste into products with economic value.
AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN NILAM (Pogostemon cablin Benth.) DAN DAUN KEMANGI (Ocimum basilicum L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Rindengan, Elvie Rifke; Gurning, Sri Handayani; Paputungan, Marcelia; Ulaen, Selfie Petronela Joice; Maramis, Rilyn Novita
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1503

Abstract

Infections caused by Staphylococcus aureus bacteria can lead to various health problems, including skin infections that result in redness, swelling, blisters, and pus-filled lumps. The use of herbal plants is an alternative treatment for infections. Plants known to have antibacterial potential include patchouli leaves (Pogostemon cablin Benth.) and basil leaves (Ocimum basilicum L.). This study aims to determine the antibacterial activity of a combination of patchouli leaf extract (Pogostemon cablin Benth.) and basil leaves (Ocimum basilicum L.) against the growth of Staphylococcus aureus bacteria. The type of research used is a laboratory experiment. Extraction of patchouli leaves and basil leaves was performed using the maceration method with 96% ethanol. The test solution was prepared in three concentrations: 10%, 15%, and 20%. The combination was made by mixing each concentration in 1:1 ratio. The antibacterial activity test was conducted using the disc diffusion method, with a positive control consisting of erythromycin discs and a negative control of a 1% Tween 80 solution. Observations were made for 24 hours, then the inhibition zone around the paper disc was measured using a caliper. The combination of patchouli and basil leaf extracts can inhibit the growth of Staphylococcus aureus bacteria.
POTENSI ANTIJAMUR MINYAK ATSIRI DAGING BUAH PALA (Myristica fragrans Houtt) ASAL PULAU SANGIHE PADA Malassezia furfur Nahor, Evelina Maria; Rindengan, Elvie Rifke; Maramis, Rilyn Novita; Rintjap, Djois Sugiaty; Soenjono, Steven Jacob; Kalonio, Donald Emilio
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1513

Abstract

Pityriasis versicolor or tinea versicolor is a skin disease caused by the fungus Malassezia furfur. Nutmeg fruit pulp essential oil contains myristicin compounds that have potential as antimicrobials. The purpose of this study was to determine the antifungal activity of nutmeg fruit pulp essential oil (Myristica fragrans Houtt) from Sangihe Island against Malassezia furfur fungus using the Agar Diffusion and Vapor Phase Test methods. The samples used were nutmeg fruit taken directly from the garden, isolated nutmeg fruit pulp essential oil using the water vapor distillation method. The antifungal activity test for Malassezia furfur used the Agar Diffusion method, using nutmeg oil with concentrations of 20%, 40%, 60%, 80% and 100%, while the antifungal test with the Vapor Phase Test method used nutmeg oil with volumes of 0 μL, 10 μL, 20 μL, 40 μL, 80 μL and 100 μL. Observations were made by measuring the diameter of the clear zone after 24 hours of incubation. The results showed that essential oils of nutmeg fruit flesh at concentrations of 20%, 40%, 60%, 80% and 100% using the Agar Diffusion method were able to inhibit the growth of Malassesia furfur fungus, while with the Vapor Phase Test method the antifungal activity of essential oils of nutmeg fruit flesh was at test volumes of 40 μL, 80 μL and 100 μL.
Co-Authors Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa, Anis Yohana Barung , Elisabeth Natalia Djois Sugiaty Rintjap Djois Sugiaty Rintjap Dumanauw, Jovie Mien Elisabeth Natalia Barung Evelina Maria Nahor Gurning, Sri Handayani Handayani Gurning, Sri Kalonio, Donald Emilio Maria Nahor, Evelina Marline Abdassah Marline Abdassah Marline Abdassah, Marline Nahor, Evelina Maria Paputungan, Marcelia Petronela Joice Ulaen, Selfie Pobela, Nadila Aurelia Putri Rilyn Novita Maramis Soenjono, Steven Jacob Suleman, Nurningsih Ulaen, Selfie Petronela Joice Ulaen, Selfie Petronella Joice Yos Banne Yunita, Resi