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All Journal Borneo Journal of Medical Laboratory Technology Borneo Community Health Sevice Journal
Nanik Aryani Putri
Poltekkes Kemenkes Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Nursing Physics

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Tinjauan Pewarnaan Hemaktosilin-Eosin dan Periodic Acid-Schiff terhadap Kerusakan Hati Mencit yang Diinduksi Aloksan: A Review of Hematoxylin-Eosin and Periodic Acid Schiff Staining to Assess Alloxan-Induced Liver Injury in Mice Nanik Aryani Putri; Erick Khristian; Adang Durachim
Borneo Journal of Medical Laboratory Technology Vol. 5 No. 2 (2023): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v5i2.5101

Abstract

The liver is an organ that serves several functions in the body, including glucose metabolism to provide energy to other tissues. Hepatocytes are the primary functional cells of the liver, which also regulate liver glucose release via glucose transport protein-2. Hepatocyte injury could occur from toxic substances and diseases such as Diabetes Mellitus. Alloxan is an organic compound commonly used in diabetes research as a diabetogenic agent. Alloxan causes diabetes through selective inhibition of glucose-stimulated insulin secretion and induced formation of reactive oxygen species (ROS) that promotes pancreatic beta cell necrosis. Alloxan also affects the liver's histological condition, including the hepatocellular structure and glycogen content. HE and PAS are used for evaluating this condition. However, both should be reviewed to evaluate their abilities. Mice were divided into control and test groups, each consisting of 5 mice. The test group was intervein-induced with 25, 50, and 100mg/KgBB alloxan on the second day of arrival. The mice's livers were then taken on the seventh day; tissue processing was carried out to get 20 blocks of mice's livers. Two 5-μm-thick paraffin-embedded sections from each group were stained with hematoxylin-eosin, and periodic acid Schiff, respectively. Mice's liver slides are examined microscopically for the degree of injury and glycogen concentration for further evaluation using ImageJ digital imaging application. This study found that microscopical and ANOVA tests of both staining methods successfully produced significant differences between control and various dose alloxan-induced groups of mice.
PENGENDALIAN DIABETES MELITUS MELALUI EDUKASI DAN PEMERIKSAAN KADAR GULA DARAH SEWAKTU DI PERUMAHAN ROTO KENONGO SEWON Yoki Setyaji; Iin Desminay Duri; Putri Kuniasiwi; Nanik Aryani Putri
Borneo Community Health Service Journal VOLUME 3 NOMOR 2 TAHUN 2023
Publisher : Fakultas Ilmu Kesehatan Universitas Borneo Tarakan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35334/neotyce.v3i2.4227

Abstract

Diabetes Mellitus (DM) is one of many health problems that have an impact on productivity and reduce the quality of human resources. Diabetes is a metabolic disorder characterized by high blood glucose levels and several symptoms including polyuria, polydipsia, polyphagia and weight loss. This community service aims to increase knowledge and awareness in the prevention and management of Diabetes Mellitus and to find out the category of blood sugar levels in the Roto Kenongo Sewon Residential Community, Bantul District, Yogyakarta. The method used is socialization with lectures and discussions as well as checking the current blood sugar (GDS). The number of participants in this community service was attended by 30 participants. The results of this service found that 3 people got GDS results 200 mg/dl in the DM category. The results of education on management of DM, the community was enthusiastic and able to answer several questions during the discussion session.
Co-Authors Adang Durachim Erick Khristian Iin Desminay Duri Putri Kuniasiwi Yoki Setyaji